Le diagnostic repose sur l'examen clinique et la biopsie cutanée des lésions.
Maladie de BowenBiopsieDermatologie
#2
Quels tests sont utilisés pour confirmer le diagnostic ?
Une biopsie est souvent réalisée pour analyser les cellules et confirmer la maladie.
Maladie de BowenBiopsieCancer de la peau
#3
Les lésions de Bowen sont-elles douloureuses ?
Les lésions sont généralement asymptomatiques, mais peuvent provoquer des démangeaisons.
Maladie de BowenSymptômesDémangeaisons
#4
Peut-on confondre la maladie de Bowen avec d'autres affections ?
Oui, elle peut être confondue avec d'autres dermatites ou carcinomes cutanés.
Maladie de BowenCarcinomeDermatite
#5
Quel est le rôle de l'examen dermatologique ?
L'examen dermatologique permet d'évaluer l'apparence des lésions et leur distribution.
Maladie de BowenExamen dermatologiqueDermatologie
Symptômes
5
#1
Quels sont les symptômes typiques de la maladie de Bowen ?
Les symptômes incluent des plaques rouges, squameuses et parfois des démangeaisons.
Maladie de BowenSymptômesPlaques cutanées
#2
Les lésions de Bowen saignent-elles ?
Les lésions peuvent saigner si elles sont irritées ou frottées, mais ce n'est pas courant.
Maladie de BowenSaignementLésions cutanées
#3
Où apparaissent généralement les lésions ?
Elles apparaissent souvent sur les zones exposées au soleil, comme le visage et les bras.
Maladie de BowenLésions cutanéesExposition au soleil
#4
Les symptômes évoluent-ils avec le temps ?
Oui, sans traitement, les lésions peuvent croître et évoluer vers un carcinome.
Maladie de BowenÉvolutionCarcinome
#5
La maladie de Bowen provoque-t-elle des douleurs ?
Généralement, elle ne provoque pas de douleurs, mais des démangeaisons peuvent survenir.
Maladie de BowenDouleurDémangeaisons
Prévention
5
#1
Comment prévenir la maladie de Bowen ?
Éviter l'exposition excessive au soleil et utiliser des écrans solaires peut aider.
Maladie de BowenPréventionExposition au soleil
#2
Le port de vêtements protecteurs est-il recommandé ?
Oui, porter des vêtements longs et des chapeaux peut réduire le risque d'apparition.
Maladie de BowenPréventionVêtements protecteurs
#3
Les visites régulières chez le dermatologue sont-elles utiles ?
Oui, des examens réguliers permettent de détecter précocement les lésions cutanées.
Maladie de BowenDermatologuePrévention
#4
Les crèmes solaires sont-elles efficaces ?
Oui, l'utilisation régulière de crèmes solaires à large spectre est recommandée.
Maladie de BowenCrème solairePrévention
#5
Fumer augmente-t-il le risque de maladie de Bowen ?
Oui, le tabagisme peut augmenter le risque de développer des cancers cutanés, y compris la maladie de Bowen.
Maladie de BowenTabagismeFacteurs de risque
Traitements
5
#1
Quels traitements sont disponibles pour la maladie de Bowen ?
Les traitements incluent la cryothérapie, la chirurgie, et les thérapies topiques.
Maladie de BowenCryothérapieChirurgie
#2
La cryothérapie est-elle efficace ?
Oui, la cryothérapie est souvent efficace pour détruire les cellules anormales.
Maladie de BowenCryothérapieTraitement
#3
Peut-on utiliser des crèmes pour traiter la maladie de Bowen ?
Oui, des crèmes contenant des agents chimiothérapeutiques peuvent être prescrites.
Maladie de BowenCrèmesChimiothérapie
#4
La chirurgie est-elle nécessaire dans tous les cas ?
Non, la chirurgie est réservée aux cas plus avancés ou lorsque d'autres traitements échouent.
Maladie de BowenChirurgieTraitement
#5
Les traitements sont-ils douloureux ?
Certains traitements peuvent causer une légère douleur ou inconfort, mais sont généralement bien tolérés.
Maladie de BowenTraitementDouleur
Complications
5
#1
Quelles complications peuvent survenir avec la maladie de Bowen ?
Sans traitement, elle peut évoluer vers un carcinome épidermoïde invasif.
Maladie de BowenComplicationsCarcinome épidermoïde
#2
La maladie de Bowen peut-elle récidiver ?
Oui, il existe un risque de récidive après traitement, nécessitant un suivi régulier.
Maladie de BowenRécidiveSuivi médical
#3
Les lésions peuvent-elles se propager ?
Les lésions de Bowen ne se propagent pas, mais peuvent apparaître sur d'autres zones.
Maladie de BowenPropagationLésions cutanées
#4
Quels sont les risques associés aux traitements ?
Les traitements peuvent entraîner des cicatrices ou des changements de pigmentation.
Maladie de BowenTraitementsCicatrices
#5
La maladie de Bowen affecte-t-elle la qualité de vie ?
Oui, les préoccupations esthétiques et les traitements peuvent affecter la qualité de vie.
Maladie de BowenQualité de viePréoccupations esthétiques
Facteurs de risque
5
#1
Quels sont les principaux facteurs de risque ?
L'exposition au soleil, le vieillissement et un système immunitaire affaibli sont des facteurs clés.
Maladie de BowenFacteurs de risqueExposition au soleil
#2
Les personnes à peau claire sont-elles plus à risque ?
Oui, les personnes à peau claire ont un risque accru de développer des cancers cutanés.
Maladie de BowenPeau claireFacteurs de risque
#3
Le vieillissement influence-t-il le risque ?
Oui, le risque augmente avec l'âge en raison de l'accumulation de dommages cutanés.
Maladie de BowenVieillissementFacteurs de risque
#4
Les antécédents familiaux jouent-ils un rôle ?
Oui, des antécédents familiaux de cancers cutanés peuvent augmenter le risque.
Maladie de BowenAntécédents familiauxFacteurs de risque
#5
Le système immunitaire affaibli est-il un facteur de risque ?
Oui, les personnes immunodéprimées ont un risque accru de développer la maladie de Bowen.
Maladie de BowenSystème immunitaireFacteurs de risque
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{
"@type": "Question",
"name": "Le vieillissement influence-t-il le risque ?",
"position": 28,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, le risque augmente avec l'âge en raison de l'accumulation de dommages cutanés."
}
},
{
"@type": "Question",
"name": "Les antécédents familiaux jouent-ils un rôle ?",
"position": 29,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des antécédents familiaux de cancers cutanés peuvent augmenter le risque."
}
},
{
"@type": "Question",
"name": "Le système immunitaire affaibli est-il un facteur de risque ?",
"position": 30,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les personnes immunodéprimées ont un risque accru de développer la maladie de Bowen."
}
}
]
}
]
}
Department of Medical Ultrasound, Shanghai Skin Disease Hospital, Ultrasound Research and Education Institute, Tongji University School of Medicine, Shanghai, China.
Department of Medical Ultrasound, Shanghai Tenth People's Hospital, Ultrasound Research and Education Institute, Tongji University School of Medicine, Shanghai, China.
Tumor Minimally Invasive Treatment Center, Tongji University Cancer Center, Shanghai, China.
Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)
2020-03-20
Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)
2021-03-10
Department of Medical Ultrasound, Shanghai Skin Disease Hospital, Ultrasound Research and Education Institute, Tongji University School of Medicine, Shanghai, China.
Department of Medical Ultrasound, Shanghai Tenth People's Hospital, Ultrasound Research and Education Institute, Tongji University School of Medicine, Shanghai, China.
Tumor Minimally Invasive Treatment Center, Tongji University Cancer Center, Shanghai, China.
Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)
2020-03-20
Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)
2021-03-10
Department of Medical Ultrasound, Shanghai Skin Disease Hospital, Ultrasound Research and Education Institute, Tongji University School of Medicine, Shanghai, China.
Department of Medical Ultrasound, Shanghai Tenth People's Hospital, Ultrasound Research and Education Institute, Tongji University School of Medicine, Shanghai, China.
Tumor Minimally Invasive Treatment Center, Tongji University Cancer Center, Shanghai, China.
Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)
2020-03-20
Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)
2021-03-10
Department of Medical Ultrasound, Shanghai Skin Disease Hospital, Ultrasound Research and Education Institute, Tongji University School of Medicine, Shanghai, China.
Department of Medical Ultrasound, Shanghai Tenth People's Hospital, Ultrasound Research and Education Institute, Tongji University School of Medicine, Shanghai, China.
Tumor Minimally Invasive Treatment Center, Tongji University Cancer Center, Shanghai, China.
Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)
2020-03-20
Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)
2021-03-10
Department of Medical Ultrasound, Shanghai Skin Disease Hospital, Ultrasound Research and Education Institute, Tongji University School of Medicine, Shanghai, China.
Department of Medical Ultrasound, Shanghai Tenth People's Hospital, Ultrasound Research and Education Institute, Tongji University School of Medicine, Shanghai, China.
Tumor Minimally Invasive Treatment Center, Tongji University Cancer Center, Shanghai, China.
Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)
2020-03-20
Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)
2021-03-10
Department of Medical Ultrasound, Clinical Research Center for Interventional Medicine, School of Medicine, Ultrasound Research and Education Institute, Shanghai Skin Disease Hospital and Shanghai Tenth People's Hospital, Tongji University, Shanghai, China.
Shanghai Engineering Research Center of Ultrasound Diagnosis and Treatment, Shanghai, China.
Department of Ultrasound, Institute of Ultrasound in Medicine and Engineering, Zhongshan Hospital, Fudan University, Shanghai, China.
Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)
2021-03-10
Department of Medical Ultrasound, Clinical Research Center for Interventional Medicine, School of Medicine, Ultrasound Research and Education Institute, Shanghai Skin Disease Hospital and Shanghai Tenth People's Hospital, Tongji University, Shanghai, China.
Shanghai Engineering Research Center of Ultrasound Diagnosis and Treatment, Shanghai, China.
Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)
2021-03-10
Melanoma Unit, Hospital Clinic Barcelona, University of Barcelona, Barcelona, Spain. CIBER de enfermedades raras, Instituto de Salud Carlos III, Barcelona, Spain.
Circumscribed palmar or plantar hypokeratosis is a focal disorder of keratinization that consists of a reduction in the thickness of the corneal layer of the epidermis of palms or soles. Although it i...
The genomic landscape of Bowen's disease (BD), with multiple manifestations, has not yet been determined. This study aimed to investigate the genomic alterations in multiple BD. We performed whole-exo...
Merkel cell carcinoma (MCC) is a rare neuroendocrine tumor of the skin, which mainly occurs in the sun exposed sites of white patients over 65 years, with a higher recurrence and metastasis rate. Clin...
We consulted databases from PubMed, ResearchGate and Google Scholar by MeSh "Merkel cell carcinoma" and "Bowen's disease", "Bowen disease" or "squamous cell carcinoma in situ", from January 2013 to De...
Total 13 cases of MCC overlapping BD were retrospectively analyzed, in whom mainly in elderly women over 70 years, the skin lesions were primarily located on the faces, followed by the extremities and...
MCC overlapping BD is a very rare skin tumor mainly predisposed on the faces, with high misdiagnosis rate and recurrence rate. Advanced disease at diagnosis is a poor prognostic factor, suggesting tha...
Bowen's disease (BD), also known as squamous cell carcinoma (SCC) in situ, should be treated actively. One of the therapy options, photodynamic (PDT) therapy, although an effective measure for the tre...
A retrospective study, comprising 11 cases of BD with large tumor areas, was conducted to analyze various aspects, such as curative effects, cosmetic effects, patient satisfaction, improvement in the ...
The recurrence rate of BD patients treated with a combination of ED and PTD was 0% after one year with a satisfactory cosmetic degree (scar score was 1.91) and a high patient satisfaction (7.91). Afte...
ET combined with PDT is effective in the treatment of BD with large patches and has the advantages of fast healing, less scar formation, and a good cosmetic effect....
The similar visual appearance of superficial basal cell carcinoma (sBCC) and Bowen's disease (BD) may cause confusion for diagnosis....
The aim of the study was to investigate the value of ultra-high-frequency ultrasound (uHFUS) in differentiating sBCC from BD....
This prospective study included a pilot cohort of 110 patients (73 BDs and 37 sBCCs) from November 2016 to October 2020 and a validation cohort of 42 patients (30 BDs and 12 sBCCs) from July 2021 to D...
uHFUS features with significant differences between sBCC and BD included lesion surface, skin layer involvement, hyperkeratosis, and hyperechoic spots (all p < 0.05). A prediction model based on th...
uHFUS provides detailed internal features of sBCC and BD, which facilitates the differentiation between sBCC and BD, and its diagnostic performance is superior to clinical diagnosis....
Multiple large lesions of Bowen's disease (BD) often appear in patients who have been under chronic exposure to arsenic. The treatment of such lesions is very challenging. Photodynamic therapy (PDT) h...
Bowen's disease is a cutaneous squamous cell carcinoma (CSCC) in situ. If left untreated, BD may progress to invasive CSCC. CSCC is one of the most common cutaneous carcinoma in the elderly and the ad...
The aim of this study was to explore the biomarkers and molecular alterations in Bowen's disease development process via analyzing the proteomics changes in tissues of CSCC, Bowen disease and healthy ...
A total of 7 individuals with CSCC (5 for proteomics study and 2 for validation), 7 individuals with Bowen disease (5 for proteomics study and 2 for validation) and 7 healthy controls (5 for proteomic...
A total of 501 proteins were differentially expressed between the CSCC and healthy skin tissues, with 332 up-regulated and 169 down-regulated at least 1.5-fold with a P value < 0.05. These DEPs involv...
This study highlights that eight proteins, TNC, FSCN1, SERPINB1, ACTN1, RAB31, COL3A1, COL1A1, CD36, were significantly associated with the mechanisms of invasion and metastasis in Bowen's disease....
Photodynamic therapy (PDT) is used to treat cutaneous cancers. It may induce cell death through direct and indirect means, including apoptosis, inflammation and certain immune mechanisms, with the dep...
To examine the pathways of apoptosis in the intralesional PDT of basal cell carcinoma (BCC) and intraepidermal squamous cell carcinoma (Bowen's disease)....
Sixteen patients with superficial or nodular BCC and Bowen's disease were treated with intralesional aminolevulinic acid-PDT. Biopsies were taken at baseline and 24 h post-PDT, and sections were exami...
Apoptotic cells stained with TUNEL showed statistically significant staining at 24 h post PDT (p < 0.01 in both BCC and Bowen's lesions). Caspase 3 (p < 0.01 in BCC and p < 0.05 in Bowen's) and granzy...
Intralesional PDT induces apoptosis in BCC and Bowen's disease via common and alternative apoptotic pathways involving granzyme B. Proapoptotic factors Bak in both BCC and Bowen and Bax in Bowen's dis...