Titre : Afatinib

Afatinib : Questions médicales fréquentes

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"inLanguage": "fr", "hasPart": [ { "@type": "MedicalWebPage", "name": "Diagnostic", "headline": "Diagnostic sur Afatinib", "description": "Comment l'afatinib est-il prescrit ?\nQuels tests sont nécessaires avant de commencer l'afatinib ?\nL'afatinib est-il utilisé pour tous les types de cancer ?\nQuels symptômes indiquent un besoin d'afatinib ?\nComment évaluer l'efficacité de l'afatinib ?", "url": "https://recherchemedicale.com/mesh/D000077716?page=3#section-diagnostic" }, { "@type": "MedicalWebPage", "name": "Symptômes", "headline": "Symptômes sur Afatinib", "description": "Quels sont les effets secondaires courants de l'afatinib ?\nL'afatinib cause-t-il des problèmes respiratoires ?\nComment gérer les éruptions cutanées causées par l'afatinib ?\nL'afatinib peut-il provoquer des nausées ?\nQuels signes d'allergie peuvent apparaître avec l'afatinib ?", "url": "https://recherchemedicale.com/mesh/D000077716?page=3#section-symptômes" }, { "@type": "MedicalWebPage", "name": "Prévention", 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"description": "Quelles complications peuvent survenir avec l'afatinib ?\nL'afatinib augmente-t-il le risque de thrombose ?\nComment gérer une pneumonite causée par l'afatinib ?\nDes problèmes hépatiques peuvent-ils survenir avec l'afatinib ?\nL'afatinib peut-il causer des problèmes cardiaques ?", "url": "https://recherchemedicale.com/mesh/D000077716?page=3#section-complications" }, { "@type": "MedicalWebPage", "name": "Facteurs de risque", "headline": "Facteurs de risque sur Afatinib", "description": "Qui est à risque de complications avec l'afatinib ?\nLe tabagisme influence-t-il l'efficacité de l'afatinib ?\nY a-t-il des facteurs génétiques influençant l'afatinib ?\nL'âge est-il un facteur de risque pour l'afatinib ?\nLes comorbidités affectent-elles le traitement par afatinib ?", "url": "https://recherchemedicale.com/mesh/D000077716?page=3#section-facteurs de risque" } ] }, { "@type": "FAQPage", "mainEntity": [ { "@type": "Question", "name": "Comment l'afatinib est-il prescrit ?", "position": 1, "acceptedAnswer": { "@type": "Answer", "text": "L'afatinib est prescrit après un diagnostic de cancer du poumon avec mutation EGFR." } }, { "@type": "Question", "name": "Quels tests sont nécessaires avant de commencer l'afatinib ?", "position": 2, "acceptedAnswer": { "@type": "Answer", "text": "Des tests génétiques pour détecter les mutations de l'EGFR sont nécessaires." } }, { "@type": "Question", "name": "L'afatinib est-il utilisé pour tous les types de cancer ?", "position": 3, "acceptedAnswer": { "@type": "Answer", "text": "Non, il est principalement utilisé pour le cancer du poumon non à petites cellules." } }, { "@type": "Question", "name": "Quels symptômes indiquent un besoin d'afatinib ?", "position": 4, "acceptedAnswer": { "@type": "Answer", "text": "Les symptômes incluent la toux persistante, la dyspnée et la perte de poids inexpliquée." } }, { "@type": "Question", "name": "Comment évaluer l'efficacité de l'afatinib ?", "position": 5, "acceptedAnswer": { "@type": "Answer", "text": "L'efficacité est évaluée par des examens d'imagerie et des tests de fonction pulmonaire." } }, { "@type": "Question", "name": "Quels sont les effets secondaires courants de l'afatinib ?", "position": 6, "acceptedAnswer": { "@type": "Answer", "text": "Les effets secondaires incluent éruptions cutanées, diarrhée et stomatite." } }, { "@type": "Question", "name": "L'afatinib cause-t-il des problèmes respiratoires ?", "position": 7, "acceptedAnswer": { "@type": "Answer", "text": "Oui, il peut provoquer des problèmes respiratoires comme la pneumonite." } }, { "@type": "Question", "name": "Comment gérer les éruptions cutanées causées par l'afatinib ?", "position": 8, "acceptedAnswer": { "@type": "Answer", "text": "Utiliser des crèmes hydratantes et des médicaments topiques peut aider." } }, { "@type": "Question", "name": "L'afatinib peut-il provoquer des nausées ?", "position": 9, "acceptedAnswer": { "@type": "Answer", "text": "Oui, des nausées peuvent survenir, mais elles sont généralement légères." } }, { "@type": "Question", "name": "Quels signes d'allergie peuvent apparaître avec l'afatinib ?", "position": 10, "acceptedAnswer": { "@type": "Answer", "text": "Des démangeaisons, des rougeurs ou un gonflement peuvent indiquer une allergie." } }, { "@type": "Question", "name": "Peut-on prévenir les effets secondaires de l'afatinib ?", "position": 11, "acceptedAnswer": { "@type": "Answer", "text": "Certaines mesures préventives comme l'hydratation et les soins de la peau peuvent aider." } }, { "@type": "Question", "name": "Y a-t-il des recommandations alimentaires avec l'afatinib ?", "position": 12, "acceptedAnswer": { "@type": "Answer", "text": "Une alimentation équilibrée et riche en nutriments est recommandée pour soutenir le traitement." } }, { "@type": "Question", "name": "Comment éviter les interactions médicamenteuses avec l'afatinib ?", "position": 13, "acceptedAnswer": { "@type": "Answer", "text": "Informer le médecin de tous les médicaments pris pour éviter les interactions." } }, { "@type": "Question", "name": "Des vaccinations sont-elles recommandées pendant le traitement ?", "position": 14, "acceptedAnswer": { "@type": "Answer", "text": "Des vaccinations peuvent être recommandées, mais consultez votre médecin d'abord." } }, { "@type": "Question", "name": "L'exercice physique est-il conseillé avec l'afatinib ?", "position": 15, "acceptedAnswer": { "@type": "Answer", "text": "Un exercice modéré peut être bénéfique, mais il faut éviter les efforts excessifs." } }, { "@type": "Question", "name": "Comment l'afatinib est-il administré ?", "position": 16, "acceptedAnswer": { "@type": "Answer", "text": "L'afatinib est administré par voie orale sous forme de comprimés." } }, { "@type": "Question", "name": "Quelle est la posologie standard de l'afatinib ?", "position": 17, "acceptedAnswer": { "@type": "Answer", "text": "La posologie standard est généralement de 40 mg par jour, ajustée selon la tolérance." } }, { "@type": "Question", "name": "L'afatinib peut-il être combiné avec d'autres traitements ?", "position": 18, "acceptedAnswer": { "@type": "Answer", "text": "Oui, il peut être combiné avec d'autres thérapies ciblées ou chimiothérapies." } }, { "@type": "Question", "name": "Quels sont les critères d'arrêt du traitement par afatinib ?", "position": 19, "acceptedAnswer": { "@type": "Answer", "text": "Le traitement peut être arrêté en cas de progression de la maladie ou d'effets indésirables graves." } }, { "@type": "Question", "name": "L'afatinib nécessite-t-il un suivi régulier ?", "position": 20, "acceptedAnswer": { "@type": "Answer", "text": "Oui, un suivi régulier est nécessaire pour surveiller les effets et l'efficacité." } }, { "@type": "Question", "name": "Quelles complications peuvent survenir avec l'afatinib ?", "position": 21, "acceptedAnswer": { "@type": "Answer", "text": "Des complications comme la pneumonite et des infections pulmonaires peuvent survenir." } }, { "@type": "Question", "name": "L'afatinib augmente-t-il le risque de thrombose ?", "position": 22, "acceptedAnswer": { "@type": "Answer", "text": "Oui, il peut augmenter le risque de thrombose, nécessitant une surveillance." } }, { "@type": "Question", "name": "Comment gérer une pneumonite causée par l'afatinib ?", "position": 23, "acceptedAnswer": { "@type": "Answer", "text": "La pneumonite nécessite un arrêt du traitement et un traitement corticostéroïde." } }, { "@type": "Question", "name": "Des problèmes hépatiques peuvent-ils survenir avec l'afatinib ?", "position": 24, "acceptedAnswer": { "@type": "Answer", "text": "Oui, des anomalies hépatiques peuvent se produire, nécessitant un suivi des tests hépatiques." } }, { "@type": "Question", "name": "L'afatinib peut-il causer des problèmes cardiaques ?", "position": 25, "acceptedAnswer": { "@type": "Answer", "text": "Des problèmes cardiaques sont rares mais possibles, nécessitant une évaluation régulière." } }, { "@type": "Question", "name": "Qui est à risque de complications avec l'afatinib ?", "position": 26, "acceptedAnswer": { "@type": "Answer", "text": "Les patients avec des antécédents de maladies pulmonaires ou cardiaques sont à risque." } }, { "@type": "Question", "name": "Le tabagisme influence-t-il l'efficacité de l'afatinib ?", "position": 27, "acceptedAnswer": { "@type": "Answer", "text": "Oui, le tabagisme peut réduire l'efficacité du traitement par afatinib." } }, { "@type": "Question", "name": "Y a-t-il des facteurs génétiques influençant l'afatinib ?", "position": 28, "acceptedAnswer": { "@type": "Answer", "text": "Oui, certaines mutations génétiques peuvent influencer la réponse au traitement." } }, { "@type": "Question", "name": "L'âge est-il un facteur de risque pour l'afatinib ?", "position": 29, "acceptedAnswer": { "@type": "Answer", "text": "Oui, les patients plus âgés peuvent avoir un risque accru d'effets secondaires." } }, { "@type": "Question", "name": "Les comorbidités affectent-elles le traitement par afatinib ?", "position": 30, "acceptedAnswer": { "@type": "Answer", "text": "Oui, les comorbidités peuvent augmenter le risque d'effets indésirables et de complications." } } ] } ] }

Sources (162 au total)

NRG1 promotes tumorigenesis and metastasis and afatinib treatment efficiency is enhanced by NRG1 inhibition in esophageal squamous cell carcinoma.

Esophageal squamous cell carcinoma (ESCC) is a highly aggressive tumor with significant heterogeneity in incidence and outcomes. The role of Neuregulin 1 (NRG1) in ESCC and its contribution to aggress...

Afatinib for the treatment of non-small-cell lung cancer with unusual EGFR mutations: a plain language summary.

EGFR is a protein on cells that helps control their growth and division. Mutations in the gene for EGFR can cause cancer, including some cases of non-small-cell lung cancer (NSCLC). Afatinib is a medi... This is a summary of a study reporting findings from a large database of people with non-small-cell lung cancer (also called NSCLC) who have unusual or uncommon changes in a gene called... The researchers found that afatinib works well in most people with NSCLC who have unusual/uncommon... The researchers concluded that afatinib is a treatment option for most people with NSCLC and unusual/uncommon...

A randomized, open-label, two-cycle, two-crossover phase I clinical trial comparing the bioequivalence and safety of afatinib and Giotrif

Afatinib is an oral, irreversible ErbB family blocker. It binds covalently to the kinase domains of epidermal growth factor (EGFR), HER2 and HER4, resulting in irreversible inhibition of tyrosine kina... Healthy Chinese subjects (N = 36) were randomly divided into two groups at a ratio of 1:1. There was a single dose per period of afatinib and Giotrif... The geometric mean ratios (GMRs) of C... This study showed that afatinib was bioequivalent to Giotrif... This trial is registered at the Chinese Clinical Trial website ( http://www.chinadrugtrials.org.cn/index.html # CTR20171160)....

A real-world study of Afatinib plus ramucirumab in treatment-naïve, EGFR-mutated, non-small cell lung cancer.

Recent reports suggested combining ramucirumab with epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors (TKIs) to overcome EGFR resistance in non-small cell lung cancer (NSCLC). Nonethe... The medical records of patients with EGFR-mutated NSCLC were retrospectively retrieved. Patients who received first-line sequential afatinib followed by ramucirumab and the first-line combination of a... Thirty-three patients were included (25 women; median age: 63 [45-82] years). The median follow-up of the included patients was 17 months (range 6-89 months). the median PFS for the whole cohort was 7... Afatinib plus ramucirumab could improve the PFS of patients with EGFR-positive NSCLC at a predictable safety profile. Our data also suggest a survival benefit of adding ramucirumab to afatinib in pati...

Afatinib plus osimertinib in the treatment of osimertinib-resistant non-small cell lung carcinoma: a phase I clinical trial.

Conquering acquired resistance to osimertinib remains a major challenge in treating patients with epidermal growth factor receptor (EGFR) mutation-positive non-small-cell lung cancer (NSCLC). Thus, we... This open-label phase I study was a feasibility study of the combination of afatinib and osimertinib for patients with advanced EGFR-positive NSCLC who had progressive disease after receiving osimerti... Thirteen patients were enrolled in this study. The MTD was defined as 30 mg afatinib when combined with daily oral administration of osimertinib (80 mg). The most frequent adverse events were diarrhea... Combination therapy with osimertinib and afatinib was tolerable; however, the synergistic effect of afatinib with osimertinib may be limited in osimertinib-resistant patients.... Japan Registry of Clinical Trials ID: jRCTs051180008, registered date: 08/11/2018....

Plain language summary of outcomes in people treated for lung squamous cell cancer with afatinib after receiving pembrolizumab with chemotherapy.

Afatinib can be used as a treatment for people with metastatic squamous cell carcinoma (shortened to SqCC) of the lung, after they have been treated with chemotherapy. Nowadays, people with SqCC are t... After initial treatment with pembrolizumab plus chemotherapy, people receiving follow-up treatment with afatinib continued taking the drug for about 7 months on average, which is similar to what resea... The length of time people stay on treatment is important because treatment is generally stopped if the cancer progresses or if side effects become too hard to tolerate. Therefore, a longer time on tre...

Afatinib, an effective treatment for patient with lung squamous cell carcinoma harboring uncommon EGFR G719A and R776C co-mutations.

Epidermal growth factor receptor (EGFR) is a crucial driven gene in non-small cell lung cancer (NSCLC), and the EGFR mutation rate in lung squamous cell carcinoma (SCC) is only 3 ~ 6.92%. Uncommon EGF... A case of a lung SCC patient harboring uncommon compound EGFR mutation (G719A and R776C) benefited from afatinib, and new MYC amplification was detected by next-generation sequencing (NGS) after disea... This case first identified a patient with lung squamous cell carcinoma harboring uncommon compound EGFR mutation (G719A and R776C) benefited from afatinib and achieved 11 months of progression-free su...

Clinical efficacy and identification of factors confer resistance to afatinib (tyrosine kinase inhibitor) in EGFR-overexpressing esophageal squamous cell carcinoma.

Epidermal growth factor receptor (EGFR) is reportedly overexpressed in most esophageal squamous cell carcinoma (ESCC) patients, but anti-EGFR treatments offer limited survival benefits. Our preclinica...