Yazen Alnouti

Affiliations

Department of Pharmaceutical Sciences, College of Pharmacy, UNMC, Omaha, NE, USA.

Publications (32)

Assessing the lymphoid tissue bioavailability of antiretrovirals in human primary lymphoid endothelial cells and in mice.

The Journal of antimicrobial chemotherapy

Avec: Shetty Ravi Dyavar , Nagsen Gautam , Anthony T Podany , Lee C Winchester , Jonathan A Weinhold , Timothy M Mykris , Kayla M Campbell , Yazen Alnouti , Courtney V Fletcher

Bile acid indices as biomarkers for liver diseases I: Diagnostic markers.

World journal of hepatology

Avec: Jawaher Abdullah Alamoudi , Wenkuan Li , Nagsen Gautam , Marco Olivera , Jane Meza , Sandeep Mukherjee , Yazen Alnouti

Crosstalk of hepatocyte nuclear factor 4a and glucocorticoid receptor in the regulation of lipid metabolism in mice fed a high-fat-high-sugar diet.

Lipids in health and disease

Avec: Hong Lu , Xiaohong Lei , Rebecca Winkler , Savio John , Devendra Kumar , Wenkuan Li , Yazen Alnouti

Xenobiotica; the fate of foreign compounds in biological systems

Avec: Sohel Daria , Devendra Kumar , Nagsen Gautam , Jawaher Abdullah Alamoudi , Louise F Dow , Paul C Trippier , Yazen Alnouti

Direct and indirect quantification of phosphate metabolites of nucleoside analogs in biological samples.

Journal of pharmaceutical and biomedical analysis

Avec: Nagsen Gautam , Jawaher Abdullah Alamoudi , Sushil Kumar , Yazen Alnouti

Discovery, synthesis and characterization of a series of (1-alkyl-3-methyl-1H-pyrazol-5-yl)-2-(5-aryl-2H-tetrazol-2-yl)acetamides as novel GIRK1/2 potassium channel activators.

Bioorganic & medicinal chemistry letters

Avec: Swagat Sharma , Krystian A Kozek , Kristopher K Abney , Sushil Kumar , Nagsen Gautam , Yazen Alnouti , C David Weaver , Corey R Hopkins

A long acting nanoformulated lamivudine ProTide.

Biomaterials

Avec: Nathan Smith , Aditya N Bade , Dhruvkumar Soni , Nagsen Gautam , Yazen Alnouti , Jonathan Herskovitz , Ibrahim M Ibrahim , Melinda S Wojtkiewicz , Bhagya Laxmi Dyavar Shetty , JoEllyn McMillan , Howard E Gendelman , Benson Edagwa

A combination of Omega-3 PUFAs and COX inhibitors: A novel strategy to manage obesity-linked dyslipidemia and adipose tissue inflammation.

Journal of diabetes and its complications

Avec: Viswanathan Saraswathi , Robert Heineman , Yazen Alnouti , Vijay Shivaswamy , Cyrus V Desouza

Urinary BA Indices as Prognostic Biomarkers for Complications Associated with Liver Diseases.

International journal of hepatology

Avec: Wenkuan Li , Jawaher Abdullah Alamoudi , Nagsen Gautam , Devendra Kumar , Macro Olivera , Yeongjin Gwon , Sandeep Mukgerjee , Yazen Alnouti

Bile acid conjugation deficiency causes hypercholanemia, hyperphagia, islet dysfunction, and gut dysbiosis in mice.

Hepatology communications

Avec: Bandar D Alrehaili , Mikang Lee , Shogo Takahashi , Robert Novak , Bipin Rimal , Shannon Boehme , Samuel A J Trammell , Trisha J Grevengoed , Devendra Kumar , Yazen Alnouti , Katya Chiti , Xinwen Wang , Andrew D Patterson , John Y L Chiang , Frank J Gonzalez , Yoon-Kwang Lee

Small-molecule IKKβ activation modulator (IKAM) targets MAP3K1 and inhibits pancreatic tumor growth.

Proceedings of the National Academy of Sciences of the United States of America

Avec: John Victor Napoleon , Satish Sagar , Sydney P Kubica , Lidia Boghean , Smit Kour , Hannah M King , Yogesh A Sonawane , Ayrianne J Crawford , Nagsen Gautam , Smitha Kizhake , Pawel A Bialk , Eric Kmiec , Jayapal Reddy Mallareddy , Prathamesh P Patil , Sandeep Rana , Sarbjit Singh , Janani Prahlad , Paul M Grandgenett , Gloria E O Borgstahl , Gargi Ghosal , Yazen Alnouti , Michael A Hollingsworth , Prakash Radhakrishnan , Amarnath Natarajan

Synthesis and SAR Studies of 1

ACS medicinal chemistry letters

Avec: Anish K Vadukoot , Swagat Sharma , Christopher D Aretz , Sushil Kumar , Nagsen Gautam , Yazen Alnouti , Amy L Aldrich , Cortney E Heim , Tammy Kielian , Corey R Hopkins

Synthesis of a long acting nanoformulated emtricitabine ProTide.

Biomaterials

Avec: Dhruvkumar Soni , Aditya N Bade , Nagsen Gautam , Jonathan Herskovitz , Ibrahim M Ibrahim , Nathan Smith , Melinda S Wojtkiewicz , Bhagya Laxmi Dyavar Shetty , Yazen Alnouti , JoEllyn McMillan , Howard E Gendelman , Benson J Edagwa

Head-to-head comparative pharmacokinetic and biodistribution (PK/BD) study of two dexamethasone prodrug nanomedicines on lupus-prone NZB/WF1 mice.

Nanomedicine : nanotechnology, biology, and medicine

Avec: Xin Wei , Gang Zhao , Xiaobei Wang , Nagsen Gautam , Zhenshan Jia , Zhifeng Zhao , Dexuan Kong , Fan Zhang , Sushil Kumar , Yuanyuan Sun , Ningrong Chen , Xiaoyan Wang , Libin Yang , Rongguo Ren , Geoffrey M Thiele , Tatiana K Bronich , James R O'Dell , Yazen Alnouti , Dong Wang

The Synergistic Effect of an ATP-Competitive Inhibitor of mTOR and Metformin on Pancreatic Tumor Growth.

Current developments in nutrition

Avec: Ghada A Soliman , Surendra K Shukla , Asserewou Etekpo , Venugopal Gunda , Sharalyn M Steenson , Nagsen Gautam , Yazen Alnouti , Pankaj K Singh

Lipophilic nanocrystal prodrug-release defines the extended pharmacokinetic profiles of a year-long cabotegravir.

Nature communications

Avec: Nagsen Gautam , JoEllyn M McMillan , Devendra Kumar , Aditya N Bade , Qiaoyu Pan , Tanmay A Kulkarni , Wenkuan Li , Brady Sillman , Nathan A Smith , Bhagya L Dyavar Shetty , Adam Szlachetka , Benson J Edagwa , Howard E Gendelman , Yazen Alnouti

Direct Comparison of Chol-siRNA Polyplexes and Chol-DsiRNA Polyplexes Targeting STAT3 in a Syngeneic Murine Model of TNBC.

Non-coding RNA

Avec: Zhen Ye , Mai Mohamed Abdelmoaty , Stephen M Curran , Shetty Ravi Dyavar , Devendra Kumar , Yazen Alnouti , Don W Coulter , Anthony T Podany , Rakesh K Singh , Joseph A Vetro

Blockade of thromboxane A2 signaling attenuates ethanol-induced myocardial inflammatory response in mice.

Alcohol, clinical & experimental research

Avec: Weilun Ai , Carol A Casey , Paras Kumar Mishra , Yazen Alnouti , Sohel Daria , Viswanathan Saraswathi

The selective PPAR-delta agonist seladelpar reduces ethanol-induced liver disease by restoring gut barrier function and bile acid homeostasis in mice.

Translational research : the journal of laboratory and clinical medicine

Avec: Huikuan Chu , Lu Jiang , Bei Gao , Nagsen Gautam , Jawaher A Alamoudi , Sonja Lang , Yanhan Wang , Yi Duan , Yazen Alnouti , Edward E Cable , Bernd Schnabl

Creation of a long-acting rilpivirine prodrug nanoformulation.

Journal of controlled release : official journal of the Controlled Release Society

Avec: James R Hilaire , Aditya N Bade , Brady Sillman , Nagsen Gautam , Jonathan Herskovitz , Bhagya Laxmi Dyavar Shetty , Melinda S Wojtkiewicz , Adam Szlachetka , Benjamin G Lamberty , Sruthi Sravanam , Howard S Fox , Yazen Alnouti , Prasanta K Dash , JoEllyn M McMillan , Benson J Edagwa , Howard E Gendelman

Synthesis and characterization of a long-acting emtricitabine prodrug nanoformulation.

International journal of nanomedicine

Avec: Ibrahim M Ibrahim , Aditya N Bade , Zhiyi Lin , Dhruvkumar Soni , Melinda Wojtkiewicz , Bhagya Laxmi Dyavar Shetty , Nagsen Gautam , JoEllyn M McMillan , Yazen Alnouti , Benson J Edagwa , Howard E Gendelman

Transformation of tenofovir into stable ProTide nanocrystals with long-acting pharmacokinetic profiles.

Nature communications

Avec: Denise A Cobb , Nathan Smith , Suyash Deodhar , Aditya N Bade , Nagsen Gautam , Bhagya Laxmi Dyavar Shetty , JoEllyn McMillan , Yazen Alnouti , Samuel M Cohen , Howard E Gendelman , Benson Edagwa

Bile acid indices as biomarkers for liver diseases II: The bile acid score survival prognostic model.

World journal of hepatology

Avec: Jawaher Abdullah Alamoudi , Wenkuan Li , Nagsen Gautam , Marco Olivera , Jane Meza , Sandeep Mukherjee , Yazen Alnouti

Intramuscular and subcutaneous administration of antiretroviral drugs, compared with oral, enhances delivery to lymphoid tissues in BALB/c mice.

The Journal of antimicrobial chemotherapy

Avec: Shetty Ravi Dyavar , Sushil Kumar , Nagsen Gautam , Anthony T Podany , Lee C Winchester , Jonathan A Weinhold , Timothy M Mykris , Palanisamy Nallasamy , Yazen Alnouti , Courtney V Fletcher

Analyte recovery in LC-MS/MS bioanalysis: An old issue revisited.

Analytica chimica acta

Avec: Devendra Kumar , Nagsen Gautam , Yazen Alnouti

Synthesis and Characterization of Long-Acting Darunavir Prodrugs.

Molecular pharmaceutics

Avec: Mary G Banoub , Aditya N Bade , Zhiyi Lin , Denise Cobb , Nagsen Gautam , Bhagya Laxmi Dyavar Shetty , Melinda Wojtkiewicz , Yazen Alnouti , JoEllyn McMillan , Howard E Gendelman , Benson Edagwa

Pharmacokinetic testing of a first-generation cabotegravir prodrug in rhesus macaques.

AIDS (London, England)

Avec: JoEllyn McMillan , Adam Szlachetka , Tian Zhou , Brenda Morsey , Benjamin Lamberty , Shannon Callen , Nagsen Gautam , Yazen Alnouti , Benson Edagwa , Howard E Gendelman , Howard S Fox

A year-long extended release nanoformulated cabotegravir prodrug.

Nature materials

Avec: Tanmay A Kulkarni , Aditya N Bade , Brady Sillman , Bhagya Laxmi Dyavar Shetty , Melinda S Wojtkiewicz , Nagsen Gautam , James R Hilaire , Sruthi Sravanam , Adam Szlachetka , Benjamin G Lamberty , Brenda M Morsey , Howard S Fox , Yazen Alnouti , JoEllyn M McMillan , R Lee Mosley , Jane Meza , Paul L Domanico , Tai-Yuen Yue , Gary Moore , Benson J Edagwa , Howard E Gendelman

KVA-D-88, a Novel Preferable Phosphodiesterase 4B Inhibitor, Decreases Cocaine-Mediated Reward Properties

ACS chemical neuroscience

Avec: Maria E Burkovetskaya , Qiaoling Liu , Anish K Vadukoot , Nagsen Gautam , Yazen Alnouti , Sushil Kumar , Klaus Miczek , Shilpa Buch , Corey R Hopkins , Minglei Guo

Preliminary preclinical study of Chol-DsiRNA polyplexes formed with PLL[30]-PEG[5K] for the RNAi-based therapy of breast cancer.

Nanomedicine : nanotechnology, biology, and medicine

Avec: Zhen Ye , Mai Mohamed Abdelmoaty , Vishakha V Ambardekar , Stephen M Curran , Shetty Ravi Dyavar , Lora L Arnold , Samuel M Cohen , Devendra Kumar , Yazen Alnouti , Don W Coulter , Rakesh K Singh , Joseph A Vetro

Discovery, synthesis and biological characterization of a series of

RSC medicinal chemistry

Avec: Swagat Sharma , Lauren Lesiak , Christopher D Aretz , Yu Du , Sushil Kumar , Nagsen Gautam , Yazen Alnouti , Nikilesh V Dhuria , Yashpal S Chhonker , C David Weaver , Corey R Hopkins

Transformation of dolutegravir into an ultra-long-acting parenteral prodrug formulation.

Nature communications

Avec: Suyash Deodhar , Brady Sillman , Aditya N Bade , Sean N Avedissian , Anthony T Podany , JoEllyn M McMillan , Nagsen Gautam , Brandon Hanson , Bhagya L Dyavar Shetty , Adam Szlachetka , Morgan Johnston , Michellie Thurman , Daniel J Munt , Alekha K Dash , Milica Markovic , Arik Dahan , Yazen Alnouti , Alborz Yazdi , Bhavesh D Kevadiya , Siddappa N Byrareddy , Samuel M Cohen , Benson Edagwa , Howard E Gendelman

Réseau de co-auteurs

Nagsen Gautam 26 collaborations

Howard E Gendelman 10 collaborations

Aditya N Bade 9 collaborations

Devendra Kumar 8 collaborations

Sushil Kumar 7 collaborations

Bhagya Laxmi Dyavar Shetty 7 collaborations

Jawaher Abdullah Alamoudi 5 collaborations

Wenkuan Li 5 collaborations

JoEllyn McMillan 5 collaborations

Benson Edagwa 5 collaborations

Benson J Edagwa 5 collaborations

JoEllyn M McMillan 5 collaborations

Adam Szlachetka 5 collaborations

Shetty Ravi Dyavar 4 collaborations

Anthony T Podany 4 collaborations

Corey R Hopkins 4 collaborations

Melinda S Wojtkiewicz 4 collaborations

Brady Sillman 4 collaborations

Jane Meza 3 collaborations

Swagat Sharma 3 collaborations

Nathan Smith 3 collaborations

Dhruvkumar Soni 3 collaborations

Jonathan Herskovitz 3 collaborations

Ibrahim M Ibrahim 3 collaborations

Howard S Fox 3 collaborations

Samuel M Cohen 3 collaborations

Lee C Winchester 2 collaborations

Jonathan A Weinhold 2 collaborations

Timothy M Mykris 2 collaborations

Courtney V Fletcher 2 collaborations

Marco Olivera 2 collaborations

Sandeep Mukherjee 2 collaborations

Sohel Daria 2 collaborations

C David Weaver 2 collaborations

Viswanathan Saraswathi 2 collaborations

Anish K Vadukoot 2 collaborations

Christopher D Aretz 2 collaborations

Tanmay A Kulkarni 2 collaborations

Bhagya L Dyavar Shetty 2 collaborations

Zhen Ye 2 collaborations

Mai Mohamed Abdelmoaty 2 collaborations

Stephen M Curran 2 collaborations

Don W Coulter 2 collaborations

Rakesh K Singh 2 collaborations

Joseph A Vetro 2 collaborations

James R Hilaire 2 collaborations

Benjamin G Lamberty 2 collaborations

Sruthi Sravanam 2 collaborations

Zhiyi Lin 2 collaborations

Melinda Wojtkiewicz 2 collaborations

Suyash Deodhar 2 collaborations

Kayla M Campbell 1 collaboration

Hong Lu 1 collaboration

Xiaohong Lei 1 collaboration

Rebecca Winkler 1 collaboration

Savio John 1 collaboration

Louise F Dow 1 collaboration

Paul C Trippier 1 collaboration

Krystian A Kozek 1 collaboration

Kristopher K Abney 1 collaboration

Robert Heineman 1 collaboration

Vijay Shivaswamy 1 collaboration

Cyrus V Desouza 1 collaboration

Macro Olivera 1 collaboration

Yeongjin Gwon 1 collaboration

Sandeep Mukgerjee 1 collaboration

Bandar D Alrehaili 1 collaboration

Mikang Lee 1 collaboration

Shogo Takahashi 1 collaboration

Robert Novak 1 collaboration

Bipin Rimal 1 collaboration

Shannon Boehme 1 collaboration

Samuel A J Trammell 1 collaboration

Trisha J Grevengoed 1 collaboration

Katya Chiti 1 collaboration

Xinwen Wang 1 collaboration

Andrew D Patterson 1 collaboration

John Y L Chiang 1 collaboration

Frank J Gonzalez 1 collaboration

Yoon-Kwang Lee 1 collaboration

John Victor Napoleon 1 collaboration

Satish Sagar 1 collaboration

Sydney P Kubica 1 collaboration

Lidia Boghean 1 collaboration

Smit Kour 1 collaboration

Hannah M King 1 collaboration

Yogesh A Sonawane 1 collaboration

Ayrianne J Crawford 1 collaboration

Smitha Kizhake 1 collaboration

Pawel A Bialk 1 collaboration

Eric Kmiec 1 collaboration

Jayapal Reddy Mallareddy 1 collaboration

Prathamesh P Patil 1 collaboration

Sandeep Rana 1 collaboration

Sarbjit Singh 1 collaboration

Janani Prahlad 1 collaboration

Paul M Grandgenett 1 collaboration

Gloria E O Borgstahl 1 collaboration

Gargi Ghosal 1 collaboration

Michael A Hollingsworth 1 collaboration

Prakash Radhakrishnan 1 collaboration

Amarnath Natarajan 1 collaboration

Amy L Aldrich 1 collaboration

Cortney E Heim 1 collaboration

Tammy Kielian 1 collaboration

Xin Wei 1 collaboration

Gang Zhao 1 collaboration

Xiaobei Wang 1 collaboration

Zhenshan Jia 1 collaboration

Zhifeng Zhao 1 collaboration

Dexuan Kong 1 collaboration

Fan Zhang 1 collaboration

Yuanyuan Sun 1 collaboration

Ningrong Chen 1 collaboration

Xiaoyan Wang 1 collaboration

Libin Yang 1 collaboration

Rongguo Ren 1 collaboration

Geoffrey M Thiele 1 collaboration

Tatiana K Bronich 1 collaboration

James R O'Dell 1 collaboration

Dong Wang 1 collaboration

Ghada A Soliman 1 collaboration

Surendra K Shukla 1 collaboration

Asserewou Etekpo 1 collaboration

Venugopal Gunda 1 collaboration

Sharalyn M Steenson 1 collaboration

Pankaj K Singh 1 collaboration

Qiaoyu Pan 1 collaboration

Nathan A Smith 1 collaboration

Weilun Ai 1 collaboration

Carol A Casey 1 collaboration

Paras Kumar Mishra 1 collaboration

Huikuan Chu 1 collaboration

Lu Jiang 1 collaboration

Bei Gao 1 collaboration

Jawaher A Alamoudi 1 collaboration

Sonja Lang 1 collaboration

Yanhan Wang 1 collaboration

Yi Duan 1 collaboration

Edward E Cable 1 collaboration

Bernd Schnabl 1 collaboration

Prasanta K Dash 1 collaboration

Denise A Cobb 1 collaboration

Palanisamy Nallasamy 1 collaboration

Mary G Banoub 1 collaboration

Denise Cobb 1 collaboration

Tian Zhou 1 collaboration

Brenda Morsey 1 collaboration

Benjamin Lamberty 1 collaboration

Shannon Callen 1 collaboration

Brenda M Morsey 1 collaboration

R Lee Mosley 1 collaboration

Paul L Domanico 1 collaboration

Tai-Yuen Yue 1 collaboration

Gary Moore 1 collaboration

Maria E Burkovetskaya 1 collaboration

Qiaoling Liu 1 collaboration

Klaus Miczek 1 collaboration

Shilpa Buch 1 collaboration

Minglei Guo 1 collaboration

Vishakha V Ambardekar 1 collaboration

Lora L Arnold 1 collaboration

Lauren Lesiak 1 collaboration

Yu Du 1 collaboration

Nikilesh V Dhuria 1 collaboration

Yashpal S Chhonker 1 collaboration

Sean N Avedissian 1 collaboration

Brandon Hanson 1 collaboration

Morgan Johnston 1 collaboration

Michellie Thurman 1 collaboration

Daniel J Munt 1 collaboration

Alekha K Dash 1 collaboration

Milica Markovic 1 collaboration

Arik Dahan 1 collaboration

Alborz Yazdi 1 collaboration

Bhavesh D Kevadiya 1 collaboration

Siddappa N Byrareddy 1 collaboration