Walter Birchmeier

Affiliations

Max Delbrück Center for Molecular Medicine, Berlin, Germany.

Publications (21)

A C/EBPα-Wnt connection in gut homeostasis and carcinogenesis.

Life science alliance

Avec: Julian Heuberger , Undine Hill , Susann Förster , Karin Zimmermann , Victoria Malchin , Anja A Kühl , Ulrike Stein , Michael Vieth , Walter Birchmeier , Achim Leutz

Tracing tumorigenesis in a solid tumor model at single-cell resolution.

Nature communications

Avec: Samantha D Praktiknjo , Benedikt Obermayer , Qionghua Zhu , Liang Fang , Haiyue Liu , Hazel Quinn , Marlon Stoeckius , Christine Kocks , Walter Birchmeier , Nikolaus Rajewsky

Oxidized LDL-dependent pathway as new pathogenic trigger in arrhythmogenic cardiomyopathy.

EMBO molecular medicine

Avec: Elena Sommariva , Ilaria Stadiotti , Michela Casella , Valentina Catto , Antonio Dello Russo , Corrado Carbucicchio , Lorenzo Arnaboldi , Simona De Metrio , Giuseppina Milano , Alessandro Scopece , Manuel Casaburo , Daniele Andreini , Saima Mushtaq , Edoardo Conte , Mattia Chiesa , Walter Birchmeier , Elisa Cogliati , Adolfo Paolin , Eva König , Viviana Meraviglia , Monica De Musso , Chiara Volani , Giada Cattelan , Werner Rauhe , Linda Turnu , Benedetta Porro , Matteo Pedrazzini , Marina Camera , Alberto Corsini , Claudio Tondo , Alessandra Rossini , Giulio Pompilio

Concomitant deletion of Ptpn6 and Ptpn11 in T cells fails to improve anticancer responses.

EMBO reports

Avec: Pedro M O Ventura , Milica Gakovic , Berenice A Fischer , Laura Spinelli , Giorgia Rota , Shalini Pathak , Hanif J Khameneh , Alessandro Zenobi , Sarah Thomson , Walter Birchmeier , Doreen A Cantrell , Greta Guarda

The Wnt-Driven Mll1 Epigenome Regulates Salivary Gland and Head and Neck Cancer.

Cell reports

Avec: Qionghua Zhu , Liang Fang , Julian Heuberger , Andrea Kranz , Jörg Schipper , Kathrin Scheckenbach , Ramon Oliveira Vidal , Daniele Yumi Sunaga-Franze , Marion Müller , Annika Wulf-Goldenberg , Sascha Sauer , Walter Birchmeier

Targeting Wnt/β-Catenin Signaling by TET1/FOXO4 Inhibits Metastatic Spreading and Self-Renewal of Cancer Stem Cells in Gastric Cancer.

Cancers

Avec: Jingjing Qi , Di Cui , Qi-Nian Wu , Qi Zhao , Zhan-Hong Chen , Lianjie Li , Walter Birchmeier , Yong Yu , Ran Tao

Impaired Plakophilin-2 in obesity breaks cell cycle dynamics to breed adipocyte senescence.

Nature communications

Avec: Aina Lluch , Jessica Latorre , Angela Serena-Maione , Isabel Espadas , Estefanía Caballano-Infantes , José M Moreno-Navarrete , Núria Oliveras-Cañellas , Wifredo Ricart , María M Malagón , Alejandro Martin-Montalvo , Walter Birchmeier , Witold Szymanski , Johannes Graumann , María Gómez-Serrano , Elena Sommariva , José M Fernández-Real , Francisco J Ortega

Shp-2 is critical for ERK and metabolic engagement downstream of IL-15 receptor in NK cells.

Nature communications

Avec: Charlène Niogret , S M Shahjahan Miah , Giorgia Rota , Nicolas P Fonta , Haiping Wang , Werner Held , Walter Birchmeier , Veronica Sexl , Wentian Yang , Eric Vivier , Ping-Chih Ho , Laurent Brossay , Greta Guarda

Spatially Restricted Stromal Wnt Signaling Restrains Prostate Epithelial Progenitor Growth through Direct and Indirect Mechanisms.

Cell stem cell

Avec: Xing Wei , Li Zhang , Zhicheng Zhou , Oh-Joon Kwon , Yiqun Zhang , Hoang Nguyen , Ruth Dumpit , Lawrence True , Peter Nelson , Baijun Dong , Wei Xue , Walter Birchmeier , Makoto M Taketo , Feng Xu , Chad J Creighton , Michael M Ittmann , Li Xin

From Pyrazolones to Azaindoles: Evolution of Active-Site SHP2 Inhibitors Based on Scaffold Hopping and Bioisosteric Replacement.

Journal of medicinal chemistry

Avec: Yelena Mostinski , Guus J J E Heynen , Maria Pascual López-Alberca , Jerome Paul , Sandra Miksche , Silke Radetzki , David Schaller , Elena Shanina , Carola Seyffarth , Yuliya Kolomeets , Nandor Ziebart , Judith de Schryver , Sylvia Oestreich , Martin Neuenschwander , Yvette Roske , Udo Heinemann , Christoph Rademacher , Andrea Volkamer , Jens Peter von Kries , Walter Birchmeier , Marc Nazaré

YAP and β-Catenin Cooperate to Drive Oncogenesis in Basal Breast Cancer.

Cancer research

Avec: Hazel M Quinn , Regina Vogel , Oliver Popp , Philipp Mertins , Linxiang Lan , Clemens Messerschmidt , Alexandro Landshammer , Kamil Lisek , Sophie Château-Joubert , Elisabetta Marangoni , Elle Koren , Yaron Fuchs , Walter Birchmeier

Inhibiting WNT and NOTCH in renal cancer stem cells and the implications for human patients.

Nature communications

Avec: Annika Fendler , Daniel Bauer , Jonas Busch , Klaus Jung , Annika Wulf-Goldenberg , Severine Kunz , Kun Song , Adam Myszczyszyn , Sefer Elezkurtaj , Bettina Erguen , Simone Jung , Wei Chen , Walter Birchmeier

SHP-2 in Lymphocytes' Cytokine and Inhibitory Receptor Signaling.

Frontiers in immunology

Avec: Charlène Niogret , Walter Birchmeier , Greta Guarda

Decreased microglial Wnt/β-catenin signalling drives microglial pro-inflammatory activation in the developing brain.

Brain : a journal of neurology

Avec: Juliette Van Steenwinckel , Anne-Laure Schang , Michelle L Krishnan , Vincent Degos , Andrée Delahaye-Duriez , Cindy Bokobza , Zsolt Csaba , Franck Verdonk , Amélie Montané , Stéphanie Sigaut , Olivier Hennebert , Sophie Lebon , Leslie Schwendimann , Tifenn Le Charpentier , Rahma Hassan-Abdi , Gareth Ball , Paul Aljabar , Alka Saxena , Rebecca K Holloway , Walter Birchmeier , Olivier Baud , David Rowitch , Veronique Miron , Fabrice Chretien , Claire Leconte , Valérie C Besson , Enrico G Petretto , A David Edwards , Henrik Hagberg , Nadia Soussi-Yanicostas , Bobbi Fleiss , Pierre Gressens

Beneficial effect of voluntary physical exercise in Plakophilin2 transgenic mice.

PloS one

Avec: Karin P Hammer , Julian Mustroph , Teresa Stauber , Walter Birchmeier , Stefan Wagner , Lars S Maier

High Yap and Mll1 promote a persistent regenerative cell state induced by Notch signaling and loss of p53.

Proceedings of the National Academy of Sciences of the United States of America

Avec: Julian Heuberger , Johanna Grinat , Frauke Kosel , Lichao Liu , Séverine Kunz , Ramon Oliveira Vidal , Marlen Keil , Johannes Haybaeck , Sylvie Robine , Daniel Louvard , Christian Regenbrecht , Anje Sporbert , Sascha Sauer , Björn von Eyss , Michael Sigal , Walter Birchmeier

MLL1 is required for maintenance of intestinal stem cells.

PLoS genetics

Avec: Neha Goveas , Claudia Waskow , Kathrin Arndt , Julian Heuberger , Qinyu Zhang , Dimitra Alexopoulou , Andreas Dahl , Walter Birchmeier , Konstantinos Anastassiadis , A Francis Stewart , Andrea Kranz

The epigenetic regulator Mll1 is required for Wnt-driven intestinal tumorigenesis and cancer stemness.

Nature communications

Avec: Johanna Grinat , Julian Heuberger , Ramon Oliveira Vidal , Neha Goveas , Frauke Kosel , Antoni Berenguer-Llergo , Andrea Kranz , Annika Wulf-Goldenberg , Diana Behrens , Bálint Melcher , Sascha Sauer , Michael Vieth , Eduard Batlle , A Francis Stewart , Walter Birchmeier

Targeting SHP2 phosphatase in breast cancer overcomes RTK-mediated resistance to PI3K inhibitors.

Breast cancer research : BCR

Avec: Guus J J E Heynen , Kamil Lisek , Regina Vogel , Annika Wulf-Goldenberg , Joshua Alcaniz , Elodie Montaudon , Elisabetta Marangoni , Walter Birchmeier

Small-molecule inhibitors of the PDZ domain of Dishevelled proteins interrupt Wnt signalling.

Magnetic resonance (Gottingen, Germany)

Avec: Nestor Kamdem , Yvette Roske , Dmytro Kovalskyy , Maxim O Platonov , Oleksii Balinskyi , Annika Kreuchwig , Jörn Saupe , Liang Fang , Anne Diehl , Peter Schmieder , Gerd Krause , Jörg Rademann , Udo Heinemann , Walter Birchmeier , Hartmut Oschkinat

Mice with renal-specific alterations of stem cell-associated signaling develop symptoms of chronic kidney disease but surprisingly no tumors.

PloS one

Avec: Adam Myszczyszyn , Oliver Popp , Severine Kunz , Anje Sporbert , Simone Jung , Louis C Penning , Annika Fendler , Philipp Mertins , Walter Birchmeier

Réseau de co-auteurs

Julian Heuberger 5 collaborations

Annika Wulf-Goldenberg 4 collaborations

Liang Fang 3 collaborations

Greta Guarda 3 collaborations

Andrea Kranz 3 collaborations

Ramon Oliveira Vidal 3 collaborations

Sascha Sauer 3 collaborations

Michael Vieth 2 collaborations

Qionghua Zhu 2 collaborations

Elena Sommariva 2 collaborations

Giorgia Rota 2 collaborations

Charlène Niogret 2 collaborations

Guus J J E Heynen 2 collaborations

Yvette Roske 2 collaborations

Udo Heinemann 2 collaborations

Regina Vogel 2 collaborations

Oliver Popp 2 collaborations

Philipp Mertins 2 collaborations

Kamil Lisek 2 collaborations

Elisabetta Marangoni 2 collaborations

Annika Fendler 2 collaborations

Severine Kunz 2 collaborations

Adam Myszczyszyn 2 collaborations

Simone Jung 2 collaborations

Johanna Grinat 2 collaborations

Frauke Kosel 2 collaborations

Anje Sporbert 2 collaborations

Neha Goveas 2 collaborations

A Francis Stewart 2 collaborations

Undine Hill 1 collaboration

Susann Förster 1 collaboration

Karin Zimmermann 1 collaboration

Victoria Malchin 1 collaboration

Anja A Kühl 1 collaboration

Ulrike Stein 1 collaboration

Achim Leutz 1 collaboration

Samantha D Praktiknjo 1 collaboration

Benedikt Obermayer 1 collaboration

Haiyue Liu 1 collaboration

Hazel Quinn 1 collaboration

Marlon Stoeckius 1 collaboration

Christine Kocks 1 collaboration

Nikolaus Rajewsky 1 collaboration

Ilaria Stadiotti 1 collaboration

Michela Casella 1 collaboration

Valentina Catto 1 collaboration

Antonio Dello Russo 1 collaboration

Corrado Carbucicchio 1 collaboration

Lorenzo Arnaboldi 1 collaboration

Simona De Metrio 1 collaboration

Giuseppina Milano 1 collaboration

Alessandro Scopece 1 collaboration

Manuel Casaburo 1 collaboration

Daniele Andreini 1 collaboration

Saima Mushtaq 1 collaboration

Edoardo Conte 1 collaboration

Mattia Chiesa 1 collaboration

Elisa Cogliati 1 collaboration

Adolfo Paolin 1 collaboration

Eva König 1 collaboration

Viviana Meraviglia 1 collaboration

Monica De Musso 1 collaboration

Chiara Volani 1 collaboration

Giada Cattelan 1 collaboration

Werner Rauhe 1 collaboration

Linda Turnu 1 collaboration

Benedetta Porro 1 collaboration

Matteo Pedrazzini 1 collaboration

Marina Camera 1 collaboration

Alberto Corsini 1 collaboration

Claudio Tondo 1 collaboration

Alessandra Rossini 1 collaboration

Giulio Pompilio 1 collaboration

Pedro M O Ventura 1 collaboration

Milica Gakovic 1 collaboration

Berenice A Fischer 1 collaboration

Laura Spinelli 1 collaboration

Shalini Pathak 1 collaboration

Hanif J Khameneh 1 collaboration

Alessandro Zenobi 1 collaboration

Sarah Thomson 1 collaboration

Doreen A Cantrell 1 collaboration

Jörg Schipper 1 collaboration

Kathrin Scheckenbach 1 collaboration

Daniele Yumi Sunaga-Franze 1 collaboration

Marion Müller 1 collaboration

Jingjing Qi 1 collaboration

Di Cui 1 collaboration

Qi-Nian Wu 1 collaboration

Qi Zhao 1 collaboration

Zhan-Hong Chen 1 collaboration

Lianjie Li 1 collaboration

Yong Yu 1 collaboration

Ran Tao 1 collaboration

Aina Lluch 1 collaboration

Jessica Latorre 1 collaboration

Angela Serena-Maione 1 collaboration

Isabel Espadas 1 collaboration

Estefanía Caballano-Infantes 1 collaboration

José M Moreno-Navarrete 1 collaboration

Núria Oliveras-Cañellas 1 collaboration

Wifredo Ricart 1 collaboration

María M Malagón 1 collaboration

Alejandro Martin-Montalvo 1 collaboration

Witold Szymanski 1 collaboration

Johannes Graumann 1 collaboration

María Gómez-Serrano 1 collaboration

José M Fernández-Real 1 collaboration

Francisco J Ortega 1 collaboration

S M Shahjahan Miah 1 collaboration

Nicolas P Fonta 1 collaboration

Haiping Wang 1 collaboration

Werner Held 1 collaboration

Veronica Sexl 1 collaboration

Wentian Yang 1 collaboration

Eric Vivier 1 collaboration

Ping-Chih Ho 1 collaboration

Laurent Brossay 1 collaboration

Xing Wei 1 collaboration

Li Zhang 1 collaboration

Zhicheng Zhou 1 collaboration

Oh-Joon Kwon 1 collaboration

Yiqun Zhang 1 collaboration

Hoang Nguyen 1 collaboration

Ruth Dumpit 1 collaboration

Lawrence True 1 collaboration

Peter Nelson 1 collaboration

Baijun Dong 1 collaboration

Wei Xue 1 collaboration

Makoto M Taketo 1 collaboration

Feng Xu 1 collaboration

Chad J Creighton 1 collaboration

Michael M Ittmann 1 collaboration

Li Xin 1 collaboration

Yelena Mostinski 1 collaboration

Maria Pascual López-Alberca 1 collaboration

Jerome Paul 1 collaboration

Sandra Miksche 1 collaboration

Silke Radetzki 1 collaboration

David Schaller 1 collaboration

Elena Shanina 1 collaboration

Carola Seyffarth 1 collaboration

Yuliya Kolomeets 1 collaboration

Nandor Ziebart 1 collaboration

Judith de Schryver 1 collaboration

Sylvia Oestreich 1 collaboration

Martin Neuenschwander 1 collaboration

Christoph Rademacher 1 collaboration

Andrea Volkamer 1 collaboration

Jens Peter von Kries 1 collaboration

Marc Nazaré 1 collaboration

Hazel M Quinn 1 collaboration

Linxiang Lan 1 collaboration

Clemens Messerschmidt 1 collaboration

Alexandro Landshammer 1 collaboration

Sophie Château-Joubert 1 collaboration

Elle Koren 1 collaboration

Yaron Fuchs 1 collaboration

Daniel Bauer 1 collaboration

Jonas Busch 1 collaboration

Klaus Jung 1 collaboration

Kun Song 1 collaboration

Sefer Elezkurtaj 1 collaboration

Bettina Erguen 1 collaboration

Wei Chen 1 collaboration

Juliette Van Steenwinckel 1 collaboration

Anne-Laure Schang 1 collaboration

Michelle L Krishnan 1 collaboration

Vincent Degos 1 collaboration

Andrée Delahaye-Duriez 1 collaboration

Cindy Bokobza 1 collaboration

Zsolt Csaba 1 collaboration

Franck Verdonk 1 collaboration

Amélie Montané 1 collaboration

Stéphanie Sigaut 1 collaboration

Olivier Hennebert 1 collaboration

Sophie Lebon 1 collaboration

Leslie Schwendimann 1 collaboration

Tifenn Le Charpentier 1 collaboration

Rahma Hassan-Abdi 1 collaboration

Gareth Ball 1 collaboration

Paul Aljabar 1 collaboration

Alka Saxena 1 collaboration

Rebecca K Holloway 1 collaboration

Olivier Baud 1 collaboration

David Rowitch 1 collaboration

Veronique Miron 1 collaboration

Fabrice Chretien 1 collaboration

Claire Leconte 1 collaboration

Valérie C Besson 1 collaboration

Enrico G Petretto 1 collaboration

A David Edwards 1 collaboration

Henrik Hagberg 1 collaboration

Nadia Soussi-Yanicostas 1 collaboration

Bobbi Fleiss 1 collaboration

Pierre Gressens 1 collaboration

Karin P Hammer 1 collaboration

Julian Mustroph 1 collaboration

Teresa Stauber 1 collaboration

Stefan Wagner 1 collaboration

Lars S Maier 1 collaboration

Lichao Liu 1 collaboration

Séverine Kunz 1 collaboration

Marlen Keil 1 collaboration

Johannes Haybaeck 1 collaboration

Sylvie Robine 1 collaboration

Daniel Louvard 1 collaboration

Christian Regenbrecht 1 collaboration

Björn von Eyss 1 collaboration

Michael Sigal 1 collaboration

Claudia Waskow 1 collaboration

Kathrin Arndt 1 collaboration

Qinyu Zhang 1 collaboration

Dimitra Alexopoulou 1 collaboration

Andreas Dahl 1 collaboration

Konstantinos Anastassiadis 1 collaboration

Antoni Berenguer-Llergo 1 collaboration

Diana Behrens 1 collaboration

Bálint Melcher 1 collaboration

Eduard Batlle 1 collaboration

Joshua Alcaniz 1 collaboration

Elodie Montaudon 1 collaboration

Nestor Kamdem 1 collaboration

Dmytro Kovalskyy 1 collaboration

Maxim O Platonov 1 collaboration

Oleksii Balinskyi 1 collaboration

Annika Kreuchwig 1 collaboration

Jörn Saupe 1 collaboration

Anne Diehl 1 collaboration

Peter Schmieder 1 collaboration

Gerd Krause 1 collaboration

Jörg Rademann 1 collaboration

Hartmut Oschkinat 1 collaboration

Louis C Penning 1 collaboration