Virginie Ropars

Affiliations

Université Paris-Saclay, CEA, CNRS, Institute for Integrative Biology of the Cell (I2BC), 91198, Gif-sur-Yvette, France.

Publications (21)

FAN1-MLH1 interaction affects repair of DNA interstrand cross-links and slipped-CAG/CTG repeats.

Science advances

Avec: Antonio Porro , Mohiuddin Mohiuddin , Christina Zurfluh , Vincent Spegg , Jingqi Dai , Florence Iehl , Virginie Ropars , Giulio Collotta , Keri M Fishwick , Nour L Mozaffari , Raphaël Guérois , Josef Jiricny , Matthias Altmeyer , Jean-Baptiste Charbonnier , Christopher E Pearson , Alessandro A Sartori

PAXX binding to the NHEJ machinery explains functional redundancy with XLF.

Science advances

Avec: Murielle Seif-El-Dahan , Antonia Kefala-Stavridi , Philippe Frit , Steven W Hardwick , Dima Y Chirgadze , Taiana Maia De Oliviera , Jessica Andreani , Sébastien Britton , Nadia Barboule , Madeleine Bossaert , Arun Prasad Pandurangan , Katheryn Meek , Tom L Blundell , Virginie Ropars , Patrick Calsou , Jean-Baptiste Charbonnier , Amanda K Chaplin

RNA:DNA hybrids from Okazaki fragments contribute to establish the Ku-mediated barrier to replication-fork degradation.

Molecular cell

Avec: Charlotte Audoynaud , Kamila Schirmeisen , Anissia Ait Saada , Armelle Gesnik , Paloma Fernández-Varela , Virginie Boucherit , Virginie Ropars , Anusha Chaudhuri , Karine Fréon , Jean-Baptiste Charbonnier , Sarah A E Lambert

Uncoupling programmed DNA cleavage and repair scrambles the Paramecium somatic genome.

Cell reports

Avec: Julien Bischerour , Olivier Arnaiz , Coralie Zangarelli , Vinciane Régnier , Florence Iehl , Virginie Ropars , Jean-Baptiste Charbonnier , Mireille Bétermier

FIGNL1-FIRRM is essential for meiotic recombination and prevents DNA damage-independent RAD51 and DMC1 loading.

Nature communications

Avec: Akbar Zainu , Pauline Dupaigne , Soumya Bouchouika , Julien Cau , Julie A J Clément , Pauline Auffret , Virginie Ropars , Jean-Baptiste Charbonnier , Bernard de Massy , Raphael Mercier , Rajeev Kumar , Frédéric Baudat

Plugged into the Ku-DNA hub: The NHEJ network.

Progress in biophysics and molecular biology

Avec: Philippe Frit , Virginie Ropars , Mauro Modesti , Jean Baptiste Charbonnier , Patrick Calsou

Modular Imaging Scaffold for Single-Particle Electron Microscopy.

ACS nano

Avec: Nesrine Aissaoui , Josephine Lai-Kee-Him , Allan Mills , Nathalie Declerck , Zakia Morichaud , Konstantin Brodolin , Sonia Baconnais , Eric Le Cam , Jean Baptiste Charbonnier , Rémy Sounier , Sébastien Granier , Virginie Ropars , Patrick Bron , Gaetan Bellot

The Multifaceted Roles of Ku70/80.

International journal of molecular sciences

Avec: Sayma Zahid , Murielle Seif El Dahan , Florence Iehl , Paloma Fernandez-Varela , Marie-Helene Le Du , Virginie Ropars , Jean Baptiste Charbonnier

A Recurrent Activating Missense Mutation in Waldenström Macroglobulinemia Affects the DNA Binding of the ETS Transcription Factor SPI1 and Enhances Proliferation.

Cancer discovery

Avec: Damien Roos-Weil , Camille Decaudin , Marine Armand , Véronique Della-Valle , M'boyba K Diop , Hussein Ghamlouch , Virginie Ropars , Cécile Hérate , Diane Lara , Eric Durot , Rima Haddad , Elena Mylonas , Frederik Damm , Francoise Pflumio , Bilyana Stoilova , Marlen Metzner , Olivier Elemento , Philippe Dessen , Valérie Camara-Clayette , François-Loïc Cosset , Els Verhoeyen , Véronique Leblond , Vincent Ribrag , Pascale Cornillet-Lefebvre , Philippe Rameau , Nabih Azar , Frédéric Charlotte , Pierre Morel , Jean-Baptiste Charbonnier , Paresh Vyas , Thomas Mercher , Said Aoufouchi , Nathalie Droin , Christel Guillouf , Florence Nguyen-Khac , Olivier A Bernard

Dynamics of Ku and bacterial non-homologous end-joining characterized using single DNA molecule analysis.

Nucleic acids research

Avec: Robin Öz , Jing L Wang , Raphael Guerois , Gaurav Goyal , Sriram Kk , Virginie Ropars , Rajhans Sharma , Firat Koca , Jean-Baptiste Charbonnier , Mauro Modesti , Terence R Strick , Fredrik Westerlund

HLTF disrupts Cas9-DNA post-cleavage complexes to allow DNA break processing.

Nature communications

Avec: Giordano Reginato , Maria Rosaria Dello Stritto , Yanbo Wang , Jingzhou Hao , Raphael Pavani , Michael Schmitz , Swagata Halder , Vincent Morin , Elda Cannavo , Ilaria Ceppi , Stefan Braunshier , Ananya Acharya , Virginie Ropars , Jean-Baptiste Charbonnier , Martin Jinek , Andrè Nussenzweig , Taekjip Ha , Petr Cejka

Cryo-EM structure of a DNA-PK trimer: higher order oligomerisation in NHEJ.

Structure (London, England : 1993)

Avec: Steven W Hardwick , Antonia Kefala Stavridi , Dimitri Y Chirgadze , Taiana Maia De Oliveira , Jean-Baptiste Charbonnier , Virginie Ropars , Katheryn Meek , Tom L Blundell , Amanda K Chaplin

BRCA2-HSF2BP oligomeric ring disassembly by BRME1 promotes homologous recombination.

Science advances

Avec: Rania Ghouil , Simona Miron , Koichi Sato , Dejan Ristic , Sari E van Rossum-Fikkert , Pierre Legrand , Malika Ouldali , Jean-Marie Winter , Virginie Ropars , Gabriel David , Ana-Andreea Arteni , Claire Wyman , Puck Knipscheer , Roland Kanaar , Alex N Zelensky , Sophie Zinn-Justin

Disordered regions and folded modules in CAF-1 promote histone deposition in

eLife

Avec: Fouad Ouasti , Maxime Audin , Karine Fréon , Jean-Pierre Quivy , Mehdi Tachekort , Elizabeth Cesard , Aurélien Thureau , Virginie Ropars , Paloma Fernández Varela , Gwenaelle Moal , Ibrahim Soumana-Amadou , Aleksandra Uryga , Pierre Legrand , Jessica Andreani , Raphaël Guerois , Geneviève Almouzni , Sarah Lambert , Francoise Ochsenbein

Pressure and Chemical Unfolding of an α-Helical Bundle Protein: The GH2 Domain of the Protein Adaptor GIPC1.

International journal of molecular sciences

Avec: Cécile Dubois , Vicente J Planelles-Herrero , Camille Tillatte-Tripodi , Stéphane Delbecq , Léa Mammri , Elena M Sirkia , Virginie Ropars , Christian Roumestand , Philippe Barthe

Molecular basis of the dual role of the Mlh1-Mlh3 endonuclease in MMR and in meiotic crossover formation.

Proceedings of the National Academy of Sciences of the United States of America

Avec: Jingqi Dai , Aurore Sanchez , Céline Adam , Lepakshi Ranjha , Giordano Reginato , Pierre Chervy , Carine Tellier-Lebegue , Jessica Andreani , Raphaël Guérois , Virginie Ropars , Marie-Hélène Le Du , Laurent Maloisel , Emmanuelle Martini , Pierre Legrand , Aurélien Thureau , Petr Cejka , Valérie Borde , Jean-Baptiste Charbonnier

The mutation R107Q alters mtSSB ssDNA compaction ability and binding dynamics.

Nucleic acids research

Avec: Martial Martucci , Amandine Moretton , Aleix Tarrés-Solé , Virginie Ropars , Louise Lambert , Patrick Vernet , Maria Solà , Maria Falkenberg , Geraldine Farge , Siet van den Wildenberg

Proper chromosome alignment depends on BRCA2 phosphorylation by PLK1.

Nature communications

Avec: Åsa Ehlén , Charlotte Martin , Simona Miron , Manon Julien , François-Xavier Theillet , Virginie Ropars , Gaetana Sessa , Romane Beaurepere , Virginie Boucherit , Patricia Duchambon , Ahmed El Marjou , Sophie Zinn-Justin , Aura Carreira

Measurements of Protein-DNA Complexes Interactions by Isothermal Titration Calorimetry (ITC) and Microscale Thermophoresis (MST).

Methods in molecular biology (Clifton, N.J.)

Avec: Amandine Gontier , Paloma F Varela , Clément Nemoz , Virginie Ropars , Magali Aumont-Nicaise , Michel Desmadril , Jean-Baptiste Charbonnier

Di-phosphorylated BAF shows altered structural dynamics and binding to DNA, but interacts with its nuclear envelope partners.

Nucleic acids research

Avec: Agathe Marcelot , Ambre Petitalot , Virginie Ropars , Marie-Hélène Le Du , Camille Samson , Stevens Dubois , Guillaume Hoffmann , Simona Miron , Philippe Cuniasse , Jose Antonio Marquez , Robert Thai , François-Xavier Theillet , Sophie Zinn-Justin

Cryo-EM of NHEJ supercomplexes provides insights into DNA repair.

Molecular cell

Avec: Amanda K Chaplin , Steven W Hardwick , Antonia Kefala Stavridi , Christopher J Buehl , Noah J Goff , Virginie Ropars , Shikang Liang , Taiana Maia De Oliveira , Dimitri Y Chirgadze , Katheryn Meek , Jean-Baptiste Charbonnier , Tom L Blundell

Réseau de co-auteurs

Jean-Baptiste Charbonnier 12 collaborations

Florence Iehl 3 collaborations

Steven W Hardwick 3 collaborations

Jessica Andreani 3 collaborations

Katheryn Meek 3 collaborations

Tom L Blundell 3 collaborations

Amanda K Chaplin 3 collaborations

Jean Baptiste Charbonnier 3 collaborations

Simona Miron 3 collaborations

Pierre Legrand 3 collaborations

Sophie Zinn-Justin 3 collaborations

Jingqi Dai 2 collaborations

Raphaël Guérois 2 collaborations

Philippe Frit 2 collaborations

Patrick Calsou 2 collaborations

Virginie Boucherit 2 collaborations

Karine Fréon 2 collaborations

Mauro Modesti 2 collaborations

Giordano Reginato 2 collaborations

Petr Cejka 2 collaborations

Antonia Kefala Stavridi 2 collaborations

Dimitri Y Chirgadze 2 collaborations

Taiana Maia De Oliveira 2 collaborations

Aurélien Thureau 2 collaborations

Marie-Hélène Le Du 2 collaborations

François-Xavier Theillet 2 collaborations

Antonio Porro 1 collaboration

Mohiuddin Mohiuddin 1 collaboration

Christina Zurfluh 1 collaboration

Vincent Spegg 1 collaboration

Giulio Collotta 1 collaboration

Keri M Fishwick 1 collaboration

Nour L Mozaffari 1 collaboration

Josef Jiricny 1 collaboration

Matthias Altmeyer 1 collaboration

Christopher E Pearson 1 collaboration

Alessandro A Sartori 1 collaboration

Murielle Seif-El-Dahan 1 collaboration

Antonia Kefala-Stavridi 1 collaboration

Dima Y Chirgadze 1 collaboration

Taiana Maia De Oliviera 1 collaboration

Sébastien Britton 1 collaboration

Nadia Barboule 1 collaboration

Madeleine Bossaert 1 collaboration

Arun Prasad Pandurangan 1 collaboration

Charlotte Audoynaud 1 collaboration

Kamila Schirmeisen 1 collaboration

Anissia Ait Saada 1 collaboration

Armelle Gesnik 1 collaboration

Paloma Fernández-Varela 1 collaboration

Anusha Chaudhuri 1 collaboration

Sarah A E Lambert 1 collaboration

Julien Bischerour 1 collaboration

Olivier Arnaiz 1 collaboration

Coralie Zangarelli 1 collaboration

Vinciane Régnier 1 collaboration

Mireille Bétermier 1 collaboration

Akbar Zainu 1 collaboration

Pauline Dupaigne 1 collaboration

Soumya Bouchouika 1 collaboration

Julien Cau 1 collaboration

Julie A J Clément 1 collaboration

Pauline Auffret 1 collaboration

Bernard de Massy 1 collaboration

Raphael Mercier 1 collaboration

Rajeev Kumar 1 collaboration

Frédéric Baudat 1 collaboration

Nesrine Aissaoui 1 collaboration

Josephine Lai-Kee-Him 1 collaboration

Allan Mills 1 collaboration

Nathalie Declerck 1 collaboration

Zakia Morichaud 1 collaboration

Konstantin Brodolin 1 collaboration

Sonia Baconnais 1 collaboration

Eric Le Cam 1 collaboration

Rémy Sounier 1 collaboration

Sébastien Granier 1 collaboration

Patrick Bron 1 collaboration

Gaetan Bellot 1 collaboration

Sayma Zahid 1 collaboration

Murielle Seif El Dahan 1 collaboration

Paloma Fernandez-Varela 1 collaboration

Marie-Helene Le Du 1 collaboration

Damien Roos-Weil 1 collaboration

Camille Decaudin 1 collaboration

Marine Armand 1 collaboration

Véronique Della-Valle 1 collaboration

M'boyba K Diop 1 collaboration

Hussein Ghamlouch 1 collaboration

Cécile Hérate 1 collaboration

Diane Lara 1 collaboration

Eric Durot 1 collaboration

Rima Haddad 1 collaboration

Elena Mylonas 1 collaboration

Frederik Damm 1 collaboration

Francoise Pflumio 1 collaboration

Bilyana Stoilova 1 collaboration

Marlen Metzner 1 collaboration

Olivier Elemento 1 collaboration

Philippe Dessen 1 collaboration

Valérie Camara-Clayette 1 collaboration

François-Loïc Cosset 1 collaboration

Els Verhoeyen 1 collaboration

Véronique Leblond 1 collaboration

Vincent Ribrag 1 collaboration

Pascale Cornillet-Lefebvre 1 collaboration

Philippe Rameau 1 collaboration

Nabih Azar 1 collaboration

Frédéric Charlotte 1 collaboration

Pierre Morel 1 collaboration

Paresh Vyas 1 collaboration

Thomas Mercher 1 collaboration

Said Aoufouchi 1 collaboration

Nathalie Droin 1 collaboration

Christel Guillouf 1 collaboration

Florence Nguyen-Khac 1 collaboration

Olivier A Bernard 1 collaboration

Robin Öz 1 collaboration

Jing L Wang 1 collaboration

Raphael Guerois 1 collaboration

Gaurav Goyal 1 collaboration

Sriram Kk 1 collaboration

Rajhans Sharma 1 collaboration

Firat Koca 1 collaboration

Terence R Strick 1 collaboration

Fredrik Westerlund 1 collaboration

Maria Rosaria Dello Stritto 1 collaboration

Yanbo Wang 1 collaboration

Jingzhou Hao 1 collaboration

Raphael Pavani 1 collaboration

Michael Schmitz 1 collaboration

Swagata Halder 1 collaboration

Vincent Morin 1 collaboration

Elda Cannavo 1 collaboration

Ilaria Ceppi 1 collaboration

Stefan Braunshier 1 collaboration

Ananya Acharya 1 collaboration

Martin Jinek 1 collaboration

Andrè Nussenzweig 1 collaboration

Taekjip Ha 1 collaboration

Rania Ghouil 1 collaboration

Koichi Sato 1 collaboration

Dejan Ristic 1 collaboration

Sari E van Rossum-Fikkert 1 collaboration

Malika Ouldali 1 collaboration

Jean-Marie Winter 1 collaboration

Gabriel David 1 collaboration

Ana-Andreea Arteni 1 collaboration

Claire Wyman 1 collaboration

Puck Knipscheer 1 collaboration

Roland Kanaar 1 collaboration

Alex N Zelensky 1 collaboration

Fouad Ouasti 1 collaboration

Maxime Audin 1 collaboration

Jean-Pierre Quivy 1 collaboration

Mehdi Tachekort 1 collaboration

Elizabeth Cesard 1 collaboration

Paloma Fernández Varela 1 collaboration

Gwenaelle Moal 1 collaboration

Ibrahim Soumana-Amadou 1 collaboration

Aleksandra Uryga 1 collaboration

Raphaël Guerois 1 collaboration

Geneviève Almouzni 1 collaboration

Sarah Lambert 1 collaboration

Francoise Ochsenbein 1 collaboration

Cécile Dubois 1 collaboration

Vicente J Planelles-Herrero 1 collaboration

Camille Tillatte-Tripodi 1 collaboration

Stéphane Delbecq 1 collaboration

Léa Mammri 1 collaboration

Elena M Sirkia 1 collaboration

Christian Roumestand 1 collaboration

Philippe Barthe 1 collaboration

Aurore Sanchez 1 collaboration

Céline Adam 1 collaboration

Lepakshi Ranjha 1 collaboration

Pierre Chervy 1 collaboration

Carine Tellier-Lebegue 1 collaboration

Laurent Maloisel 1 collaboration

Emmanuelle Martini 1 collaboration

Valérie Borde 1 collaboration

Martial Martucci 1 collaboration

Amandine Moretton 1 collaboration

Aleix Tarrés-Solé 1 collaboration

Louise Lambert 1 collaboration

Patrick Vernet 1 collaboration

Maria Solà 1 collaboration

Maria Falkenberg 1 collaboration

Geraldine Farge 1 collaboration

Siet van den Wildenberg 1 collaboration

Åsa Ehlén 1 collaboration

Charlotte Martin 1 collaboration

Manon Julien 1 collaboration

Gaetana Sessa 1 collaboration

Romane Beaurepere 1 collaboration

Patricia Duchambon 1 collaboration

Ahmed El Marjou 1 collaboration

Aura Carreira 1 collaboration

Amandine Gontier 1 collaboration

Paloma F Varela 1 collaboration

Clément Nemoz 1 collaboration

Magali Aumont-Nicaise 1 collaboration

Michel Desmadril 1 collaboration

Agathe Marcelot 1 collaboration

Ambre Petitalot 1 collaboration

Camille Samson 1 collaboration

Stevens Dubois 1 collaboration

Guillaume Hoffmann 1 collaboration

Philippe Cuniasse 1 collaboration

Jose Antonio Marquez 1 collaboration

Robert Thai 1 collaboration

Christopher J Buehl 1 collaboration

Noah J Goff 1 collaboration

Shikang Liang 1 collaboration