Thomas L Leto

Affiliations

Molecular Defenses Section, Laboratory of Clinical Immunology and Microbiology (LCIM), National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD.

Publications (17)

Dominant activating RAC2 mutation with lymphopenia, immunodeficiency, and cytoskeletal defects.

Blood

Avec: Amy P Hsu , Agnes Donkó , Megan E Arrington , Muthulekha Swamydas , Danielle Fink , Arundhoti Das , Omar Escobedo , Vincent Bonagura , Paul Szabolcs , Harry N Steinberg , Jenna Bergerson , Amanda Skoskiewicz , Melanie Makhija , Joie Davis , Ladan Foruraghi , Cindy Palmer , Ramsay L Fuleihan , Joseph A Church , Avinash Bhandoola , Michail S Lionakis , Sharon Campbell , Thomas L Leto , Douglas B Kuhns , Steven M Holland

Pan-Cancer Analysis Shows

Antioxidants (Basel, Switzerland)

Avec: Wei Feng Ma , Howard E Boudreau , Thomas L Leto

NOX1 and PRDX6 synergistically support migration and invasiveness of hepatocellular carcinoma cells through enhanced NADPH oxidase activity.

Advances in redox research : an official journal of the Society for Redox Biology and Medicine and the Society for Free Radical Research-Europe

Avec: Daniel J Lagal , J Antonio Bárcena , Raquel Requejo-Aguilar , C Alicia Padilla , Thomas L Leto

Case Report: Profound newborn leukopenia related to a novel RAC2 variant.

Frontiers in pediatrics

Avec: Geoffrey Hall , Ágnes Donkó , Cristina Pratt , Julie J Kim-Chang , Paul L Martin , Amy P Stallings , John W Sleasman , Steven M Holland , Amy P Hsu , Thomas L Leto , Talal Mousallem

PAC1 regulates receptor tyrosine kinase transactivation in a reactive oxygen species-dependent manner.

Peptides

Avec: Terry W Moody , Lingaku Lee , Tatiana Iordanskaia , Irene Ramos-Alvarez , Paola Moreno , Howard E Boudreau , Thomas L Leto , Robert T Jensen

Clinical and functional spectrum of RAC2-related immunodeficiency.

Blood

Avec: Agnes Donkó , Svetlana O Sharapova , Juraj Kabat , Sundar Ganesan , Fabian Hauck , Louis Marois , Jordan Abbott , Despina Moshous , Kelli W Williams , Nicholas Campbell , Paul L Martin , Chantal Lagresle-Peyrou , Timothy David Trojan , Natalia Kuzmenko , Ekaterina Deordieva , Elena Raykina , Michael S Abers , Hassan Abolhassani , Vincent Barlogis , Carlos Carlos Milla Milla , Geoffrey Hall , Talal Mousallem , Joseph A Church , Neena Kapoor , Guilhem Cros , Hugo Chapdelaine , Clara Franco-Jarava , Ingrid Lopez-Lerma , Maurizio Miano , Jennifer W Leiding , Christoph Klein , Stasia Marie José , Alain Fischer , Kuang-Chih Hsiao , Timi Martelius , Mikko R J Seppänen , Sara Barmettler , Jolan E Walter , Tania Nicole Masmas , Anna Mukhina , Emilia Liana Falcone , Sven Kracker , Anna Shcherbina , Steven M Holland , Thomas L Leto , Amy P Hsu

Homozygous variant p. Arg90His in NCF1 is associated with early-onset Interferonopathy: a case report.

Pediatric rheumatology online journal

Avec: Oskar Schnappauf , Liane Heale , Dilan Dissanayake , Wanxia L Tsai , Massimo Gadina , Thomas L Leto , Daniel L Kastner , Harry L Malech , Douglas B Kuhns , Ivona Aksentijevich , Ronald M Laxer

Duox1 Regulates Primary B Cell Function under the Influence of IL-4 through BCR-Mediated Generation of Hydrogen Peroxide.

Journal of immunology (Baltimore, Md. : 1950)

Avec: Ryuichi Sugamata , Agnes Donko , Yousuke Murakami , Howard E Boudreau , Chen-Feng Qi , Jaeyul Kwon , Thomas L Leto

Development of an improved and specific inhibitor of NADPH oxidase 2 to treat traumatic brain injury.

Redox biology

Avec: Hannah Mason , Ganesha Rai , Arina Kozyr , Nathaniel De Jonge , Emily Gliniewicz , Lars J Berg , Gal Wald , Cayce Dorrier , Mark J Henderson , Alexey Zakharov , Tristan Dyson , John Audley , Anthony M Pettinato , Elias Carvalho Padilha , Pranav Shah , Xin Xu , Thomas L Leto , Anton Simeonov , Kol A Zarember , Dorian B McGavern , John I Gallin

Mutant p53 and NOX4 are modulators of a CCL5-driven pro-migratory secretome.

Free radical biology & medicine

Avec: Howard E Boudreau , Agnieszka Korzeniowska , Thomas L Leto

Interpretation of Dihydrorhodamine-1,2,3 Flow Cytometry in Chronic Granulomatous Disease: an Atypical Exemplar.

Journal of clinical immunology

Avec: Agnes Donko , Douglas B Kuhns , Margot A Cousin , Matthew J Smith , Keith A Sacco , Eric W Klee , Avni Y Joshi , Ralitza H Gavrilova , Steven M Holland , Thomas L Leto , Roshini S Abraham

BTK drives neutrophil activation for sterilizing antifungal immunity.

The Journal of clinical investigation

Avec: Jigar V Desai , Marissa A Zarakas , Andrew L Wishart , Mark Roschewski , Mariano A Aufiero , Ágnes Donkó , Gustaf Wigerblad , Neta Shlezinger , Markus Plate , Matthew R James , Jean K Lim , Gulbu Uzel , Jenna Re Bergerson , Ivan Fuss , Robert A Cramer , Luis M Franco , Emily S Clark , Wasif N Khan , Daisuke Yamanaka , Georgios Chamilos , Jamel El-Benna , Mariana J Kaplan , Louis M Staudt , Thomas L Leto , Steven M Holland , Wyndham H Wilson , Tobias M Hohl , Michail S Lionakis

Immunogenetics associated with severe coccidioidomycosis.

JCI insight

Avec: Amy P Hsu , Agnieszka Korzeniowska , Cynthia C Aguilar , Jingwen Gu , Eric Karlins , Andrew J Oler , Gang Chen , Glennys V Reynoso , Joie Davis , Alexandria Chaput , Tao Peng , Ling Sun , Justin B Lack , Derek J Bays , Ethan R Stewart , Sarah E Waldman , Daniel A Powell , Fariba M Donovan , Jigar V Desai , Nima Pouladi , Debra A Long Priel , Daisuke Yamanaka , Sergio D Rosenzweig , Julie E Niemela , Jennifer Stoddard , Alexandra F Freeman , Christa S Zerbe , Douglas B Kuhns , Yves A Lussier , Kenneth N Olivier , Richard C Boucher , Heather D Hickman , Jeffrey Frelinger , Joshua Fierer , Lisa F Shubitz , Thomas L Leto , George R Thompson , John N Galgiani , Michail S Lionakis , Steven M Holland

Functional Characterization of DUOX Enzymes in Reconstituted Cell Models.

Methods in molecular biology (Clifton, N.J.)

Avec: Agnieszka Korzeniowska , Ágnes P Donkó , Stanislas Morand , Thomas L Leto

Model Systems to Investigate NOX-Dependent Cell Migration and Invasiveness.

Methods in molecular biology (Clifton, N.J.)

Avec: Howard E Boudreau , Thomas L Leto

Heterozygous activating mutation in RAC2 causes infantile-onset combined immunodeficiency with susceptibility to viral infections.

Clinical immunology (Orlando, Fla.)

Avec: Svetlana O Sharapova , Emma Haapaniemi , Inga S Sakovich , Larysa V Kostyuchenko , Agnes Donkó , Alina Dulau-Florea , Oksana Malko , Anastasia V Bondarenko , Maria V Stegantseva , Thomas L Leto , Vedat Uygun , Gulsun Tezcan Karasu , Steven M Holland , Amy P Hsu , Olga V Aleinikova

Loss of PRDX6 Aborts Proliferative and Migratory Signaling in Hepatocarcinoma Cell Lines.

Antioxidants (Basel, Switzerland)

Avec: Daniel J Lagal , María J López-Grueso , José R Pedrajas , Thomas L Leto , J Antonio Bárcena , Raquel Requejo-Aguilar , C Alicia Padilla

Réseau de co-auteurs

Steven M Holland 7 collaborations

Amy P Hsu 5 collaborations

Howard E Boudreau 5 collaborations

Douglas B Kuhns 4 collaborations

Agnes Donkó 3 collaborations

Michail S Lionakis 3 collaborations

Agnieszka Korzeniowska 3 collaborations

Joie Davis 2 collaborations

Joseph A Church 2 collaborations

Daniel J Lagal 2 collaborations

J Antonio Bárcena 2 collaborations

Raquel Requejo-Aguilar 2 collaborations

C Alicia Padilla 2 collaborations

Geoffrey Hall 2 collaborations

Ágnes Donkó 2 collaborations

Paul L Martin 2 collaborations

Talal Mousallem 2 collaborations

Svetlana O Sharapova 2 collaborations

Agnes Donko 2 collaborations

Jigar V Desai 2 collaborations

Daisuke Yamanaka 2 collaborations

Megan E Arrington 1 collaboration

Muthulekha Swamydas 1 collaboration

Danielle Fink 1 collaboration

Arundhoti Das 1 collaboration

Omar Escobedo 1 collaboration

Vincent Bonagura 1 collaboration

Paul Szabolcs 1 collaboration

Harry N Steinberg 1 collaboration

Jenna Bergerson 1 collaboration

Amanda Skoskiewicz 1 collaboration

Melanie Makhija 1 collaboration

Ladan Foruraghi 1 collaboration

Cindy Palmer 1 collaboration

Ramsay L Fuleihan 1 collaboration

Avinash Bhandoola 1 collaboration

Sharon Campbell 1 collaboration

Wei Feng Ma 1 collaboration

Cristina Pratt 1 collaboration

Julie J Kim-Chang 1 collaboration

Amy P Stallings 1 collaboration

John W Sleasman 1 collaboration

Terry W Moody 1 collaboration

Lingaku Lee 1 collaboration

Tatiana Iordanskaia 1 collaboration

Irene Ramos-Alvarez 1 collaboration

Paola Moreno 1 collaboration

Robert T Jensen 1 collaboration

Juraj Kabat 1 collaboration

Sundar Ganesan 1 collaboration

Fabian Hauck 1 collaboration

Louis Marois 1 collaboration

Jordan Abbott 1 collaboration

Despina Moshous 1 collaboration

Kelli W Williams 1 collaboration

Nicholas Campbell 1 collaboration

Chantal Lagresle-Peyrou 1 collaboration

Timothy David Trojan 1 collaboration

Natalia Kuzmenko 1 collaboration

Ekaterina Deordieva 1 collaboration

Elena Raykina 1 collaboration

Michael S Abers 1 collaboration

Hassan Abolhassani 1 collaboration

Vincent Barlogis 1 collaboration

Carlos Carlos Milla Milla 1 collaboration

Neena Kapoor 1 collaboration

Guilhem Cros 1 collaboration

Hugo Chapdelaine 1 collaboration

Clara Franco-Jarava 1 collaboration

Ingrid Lopez-Lerma 1 collaboration

Maurizio Miano 1 collaboration

Jennifer W Leiding 1 collaboration

Christoph Klein 1 collaboration

Stasia Marie José 1 collaboration

Alain Fischer 1 collaboration

Kuang-Chih Hsiao 1 collaboration

Timi Martelius 1 collaboration

Mikko R J Seppänen 1 collaboration

Sara Barmettler 1 collaboration

Jolan E Walter 1 collaboration

Tania Nicole Masmas 1 collaboration

Anna Mukhina 1 collaboration

Emilia Liana Falcone 1 collaboration

Sven Kracker 1 collaboration

Anna Shcherbina 1 collaboration

Oskar Schnappauf 1 collaboration

Liane Heale 1 collaboration

Dilan Dissanayake 1 collaboration

Wanxia L Tsai 1 collaboration

Massimo Gadina 1 collaboration

Daniel L Kastner 1 collaboration

Harry L Malech 1 collaboration

Ivona Aksentijevich 1 collaboration

Ronald M Laxer 1 collaboration

Ryuichi Sugamata 1 collaboration

Yousuke Murakami 1 collaboration

Chen-Feng Qi 1 collaboration

Jaeyul Kwon 1 collaboration

Hannah Mason 1 collaboration

Ganesha Rai 1 collaboration

Arina Kozyr 1 collaboration

Nathaniel De Jonge 1 collaboration

Emily Gliniewicz 1 collaboration

Lars J Berg 1 collaboration

Gal Wald 1 collaboration

Cayce Dorrier 1 collaboration

Mark J Henderson 1 collaboration

Alexey Zakharov 1 collaboration

Tristan Dyson 1 collaboration

John Audley 1 collaboration

Anthony M Pettinato 1 collaboration

Elias Carvalho Padilha 1 collaboration

Pranav Shah 1 collaboration

Xin Xu 1 collaboration

Anton Simeonov 1 collaboration

Kol A Zarember 1 collaboration

Dorian B McGavern 1 collaboration

John I Gallin 1 collaboration

Margot A Cousin 1 collaboration

Matthew J Smith 1 collaboration

Keith A Sacco 1 collaboration

Eric W Klee 1 collaboration

Avni Y Joshi 1 collaboration

Ralitza H Gavrilova 1 collaboration

Roshini S Abraham 1 collaboration

Marissa A Zarakas 1 collaboration

Andrew L Wishart 1 collaboration

Mark Roschewski 1 collaboration

Mariano A Aufiero 1 collaboration

Gustaf Wigerblad 1 collaboration

Neta Shlezinger 1 collaboration

Markus Plate 1 collaboration

Matthew R James 1 collaboration

Jean K Lim 1 collaboration

Gulbu Uzel 1 collaboration

Jenna Re Bergerson 1 collaboration

Ivan Fuss 1 collaboration

Robert A Cramer 1 collaboration

Luis M Franco 1 collaboration

Emily S Clark 1 collaboration

Wasif N Khan 1 collaboration

Georgios Chamilos 1 collaboration

Jamel El-Benna 1 collaboration

Mariana J Kaplan 1 collaboration

Louis M Staudt 1 collaboration

Wyndham H Wilson 1 collaboration

Tobias M Hohl 1 collaboration

Cynthia C Aguilar 1 collaboration

Jingwen Gu 1 collaboration

Eric Karlins 1 collaboration

Andrew J Oler 1 collaboration

Gang Chen 1 collaboration

Glennys V Reynoso 1 collaboration

Alexandria Chaput 1 collaboration

Tao Peng 1 collaboration

Ling Sun 1 collaboration

Justin B Lack 1 collaboration

Derek J Bays 1 collaboration

Ethan R Stewart 1 collaboration

Sarah E Waldman 1 collaboration

Daniel A Powell 1 collaboration

Fariba M Donovan 1 collaboration

Nima Pouladi 1 collaboration

Debra A Long Priel 1 collaboration

Sergio D Rosenzweig 1 collaboration

Julie E Niemela 1 collaboration

Jennifer Stoddard 1 collaboration

Alexandra F Freeman 1 collaboration

Christa S Zerbe 1 collaboration

Yves A Lussier 1 collaboration

Kenneth N Olivier 1 collaboration

Richard C Boucher 1 collaboration

Heather D Hickman 1 collaboration

Jeffrey Frelinger 1 collaboration

Joshua Fierer 1 collaboration

Lisa F Shubitz 1 collaboration

George R Thompson 1 collaboration

John N Galgiani 1 collaboration

Ágnes P Donkó 1 collaboration

Stanislas Morand 1 collaboration

Emma Haapaniemi 1 collaboration

Inga S Sakovich 1 collaboration

Larysa V Kostyuchenko 1 collaboration

Alina Dulau-Florea 1 collaboration

Oksana Malko 1 collaboration

Anastasia V Bondarenko 1 collaboration

Maria V Stegantseva 1 collaboration

Vedat Uygun 1 collaboration

Gulsun Tezcan Karasu 1 collaboration

Olga V Aleinikova 1 collaboration

María J López-Grueso 1 collaboration

José R Pedrajas 1 collaboration