T Straetemans

Affiliations

Department of Hematology, University Medical Center Utrecht, Utrecht.
Center for Translational Immunology, University Medical Center Utrecht, Utrecht.

Publications (14)

Evaluating in vivo efficacy - toxicity profile of TEG001 in humanized mice xenografts against primary human AML disease and healthy hematopoietic cells.

Journal for immunotherapy of cancer

Avec: Inez Johanna , Trudy Straetemans , Sabine Heijhuurs , Tineke Aarts-Riemens , Håkan Norell , Laura Bongiovanni , Alain de Bruin , Zsolt Sebestyen , Jürgen Kuball

TEG011 persistence averts extramedullary tumor growth without exerting off-target toxicity against healthy tissues in a humanized HLA-A*24:02 transgenic mice.

Journal of leukocyte biology

Avec: Inez Johanna , Patricia Hernández-López , Sabine Heijhuurs , Laura Bongiovanni , Alain de Bruin , Dennis Beringer , Sanne van Dooremalen , Leonard D Shultz , Fumihiko Ishikawa , Zsolt Sebestyen , Trudy Straetemans , Jürgen Kuball

γ9δ2 T-Cell Expansion and Phenotypic Profile Are Reflected in the CDR3δ Repertoire of Healthy Adults.

Frontiers in immunology

Avec: Anna Vyborova , Anke Janssen , Lucrezia Gatti , Froso Karaiskaki , Austin Yonika , Sanne van Dooremalen , Jasper Sanders , Dennis X Beringer , Trudy Straetemans , Zsolt Sebestyen , Jürgen Kuball

γ9δ2T cell diversity and the receptor interface with tumor cells.

The Journal of clinical investigation

Avec: Anna Vyborova , Dennis X Beringer , Domenico Fasci , Froso Karaiskaki , Eline van Diest , Lovro Kramer , Aram de Haas , Jasper Sanders , Anke Janssen , Trudy Straetemans , Daniel Olive , Jeanette Leusen , Lola Boutin , Steven Nedellec , Samantha L Schwartz , Michael J Wester , Keith A Lidke , Emmanuel Scotet , Diane S Lidke , Albert Jr Heck , Zsolt Sebestyen , Jürgen Kuball

Characterization and modulation of anti-αβTCR antibodies and their respective binding sites at the βTCR chain to enrich engineered T cells.

Molecular therapy. Methods & clinical development

Avec: Guido J J Kierkels , Eline van Diest , Patricia Hernández-López , Wouter Scheper , Anja C M de Bruin , Elselien Frijlink , Tineke Aarts-Riemens , Sanne F J van Dooremalen , Dennis X Beringer , Rimke Oostvogels , Lovro Kramer , Trudy Straetemans , Wolfgang Uckert , Zsolt Sebestyén , Jürgen Kuball

γδ T-cell Receptors Derived from Breast Cancer-Infiltrating T Lymphocytes Mediate Antitumor Reactivity.

Cancer immunology research

Avec: Anke Janssen , Jose Villacorta Hidalgo , Dennis X Beringer , Sanne van Dooremalen , Febilla Fernando , Eline van Diest , Antonela R Terrizi , Peter Bronsert , Sylvia Kock , Annette Schmitt-Gräff , Martin Werner , Kerstin Heise , Marie Follo , Trudy Straetemans , Zsolt Sebestyen , Dmitry M Chudakov , Sofya A Kasatskaya , Felix E Frenkel , Sarina Ravens , Eric Spierings , Immo Prinz , Ralf Küppers , Miroslav Malkovsky , Paul Fisch , Jürgen Kuball

The Role of γδ T Cells as a Line of Defense in Viral Infections after Allogeneic Stem Cell Transplantation: Opportunities and Challenges.

Viruses

Avec: Anke Janssen , Eline van Diest , Anna Vyborova , Lenneke Schrier , Anke Bruns , Zsolt Sebestyen , Trudy Straetemans , Moniek de Witte , Jürgen Kuball

Basics of advanced therapy medicinal product development in academic pharma and the role of a GMP simulation unit.

Immuno-oncology technology

Avec: I Johanna , A Daudeij , F Devina , C Nijenhuis , B Nuijen , B Romberg , C de Haar , J Haanen , H Dolstra , E Bremer , Z Sebestyen , T Straetemans , I Jedema , J Kuball

Uncovering the mode of action of engineered T cells in patient cancer organoids.

Nature biotechnology

Avec: Johanna F Dekkers , Maria Alieva , Astrid Cleven , Farid Keramati , Amber K L Wezenaar , Esmée J van Vliet , Jens Puschhof , Peter Brazda , Inez Johanna , Angelo D Meringa , Heggert G Rebel , Maj-Britt Buchholz , Mario Barrera Román , Amber L Zeeman , Sam de Blank , Domenico Fasci , Maarten H Geurts , Annelisa M Cornel , Else Driehuis , Rosemary Millen , Trudy Straetemans , Mara J T Nicolasen , Tineke Aarts-Riemens , Hendrikus C R Ariese , Hannah R Johnson , Ravian L van Ineveld , Froso Karaiskaki , Oded Kopper , Yotam E Bar-Ephraim , Kai Kretzschmar , Alexander M M Eggermont , Stefan Nierkens , Ellen J Wehrens , Henk G Stunnenberg , Hans Clevers , Jürgen Kuball , Zsolt Sebestyen , Anne C Rios

αβ T-cell graft depletion for allogeneic HSCT in adults with hematological malignancies.

Blood advances

Avec: Moniek A de Witte , Anke Janssen , Klaartje Nijssen , Froso Karaiskaki , Luuk Swanenberg , Anna van Rhenen , Rick Admiraal , Lotte van der Wagen , Monique C Minnema , Eefke Petersen , Reinier A P Raymakers , Kasper Westinga , Trudy Straetemans , Constantijn J M Halkes , Jaap-Jan Boelens , Jürgen Kuball

Identification of a tumor-specific allo-HLA-restricted γδTCR.

Blood advances

Avec: G J J Kierkels , W Scheper , A D Meringa , I Johanna , D X Beringer , A Janssen , M Schiffler , T Aarts-Riemens , L Kramer , T Straetemans , S Heijhuurs , J H W Leusen , E San José , K Fuchs , M Griffioen , J H Falkenburg , L Bongiovanni , A de Bruin , D Vargas-Diaz , M Altelaar , A J R Heck , L D Shultz , F Ishikawa , M I Nishimura , Z Sebestyén , J Kuball

TEG001 Insert Integrity from Vector Producer Cells until Medicinal Product.

Molecular therapy : the journal of the American Society of Gene Therapy

Avec: Trudy Straetemans , Anke Janssen , Koen Jansen , Ruud Doorn , Tineke Aarts , Anna D D van Muyden , Marieke Simonis , Judith Bergboer , Moniek de Witte , Zsolt Sebestyen , Jurgen Kuball

Adding Help to an HLA-A*24:02 Tumor-Reactive γδTCR Increases Tumor Control.

Frontiers in immunology

Avec: Inez Johanna , Patricia Hernández-López , Sabine Heijhuurs , Wouter Scheper , Laura Bongiovanni , Alain de Bruin , Dennis X Beringer , Rimke Oostvogels , Trudy Straetemans , Zsolt Sebestyen , Jürgen Kuball

Dual targeting of cancer metabolome and stress antigens affects transcriptomic heterogeneity and efficacy of engineered T cells.

Nature immunology

Avec: Patricia Hernández-López , Eline van Diest , Peter Brazda , Sabine Heijhuurs , Angelo Meringa , Lauren Hoorens van Heyningen , Caterina Riillo , Caroline Schwenzel , Marina Zintchenko , Inez Johanna , Mara J T Nicolasen , Astrid Cleven , Thomas A Kluiver , Rosemary Millen , Jiali Zheng , Froso Karaiskaki , Trudy Straetemans , Hans Clevers , Remco de Bree , Hendrik G Stunnenberg , Weng Chuan Peng , Jeanine Roodhart , Susana Minguet , Zsolt Sebestyén , Dennis X Beringer , Jürgen Kuball

Réseau de co-auteurs

Trudy Straetemans 12 collaborations

Jürgen Kuball 11 collaborations

Zsolt Sebestyen 9 collaborations

Anke Janssen 6 collaborations

Dennis X Beringer 6 collaborations

Inez Johanna 5 collaborations

Froso Karaiskaki 5 collaborations

Eline van Diest 5 collaborations

Sabine Heijhuurs 4 collaborations

Patricia Hernández-López 4 collaborations

Tineke Aarts-Riemens 3 collaborations

Laura Bongiovanni 3 collaborations

Alain de Bruin 3 collaborations

Sanne van Dooremalen 3 collaborations

Anna Vyborova 3 collaborations

Jasper Sanders 2 collaborations

Domenico Fasci 2 collaborations

Lovro Kramer 2 collaborations

Wouter Scheper 2 collaborations

Rimke Oostvogels 2 collaborations

Zsolt Sebestyén 2 collaborations

Moniek de Witte 2 collaborations

I Johanna 2 collaborations

J Kuball 2 collaborations

Astrid Cleven 2 collaborations

Peter Brazda 2 collaborations

Rosemary Millen 2 collaborations

Mara J T Nicolasen 2 collaborations

Hans Clevers 2 collaborations

Håkan Norell 1 collaboration

Dennis Beringer 1 collaboration

Leonard D Shultz 1 collaboration

Fumihiko Ishikawa 1 collaboration

Lucrezia Gatti 1 collaboration

Austin Yonika 1 collaboration

Aram de Haas 1 collaboration

Daniel Olive 1 collaboration

Jeanette Leusen 1 collaboration

Lola Boutin 1 collaboration

Steven Nedellec 1 collaboration

Samantha L Schwartz 1 collaboration

Michael J Wester 1 collaboration

Keith A Lidke 1 collaboration

Emmanuel Scotet 1 collaboration

Diane S Lidke 1 collaboration

Albert Jr Heck 1 collaboration

Guido J J Kierkels 1 collaboration

Anja C M de Bruin 1 collaboration

Elselien Frijlink 1 collaboration

Sanne F J van Dooremalen 1 collaboration

Wolfgang Uckert 1 collaboration

Jose Villacorta Hidalgo 1 collaboration

Febilla Fernando 1 collaboration

Antonela R Terrizi 1 collaboration

Peter Bronsert 1 collaboration

Sylvia Kock 1 collaboration

Annette Schmitt-Gräff 1 collaboration

Martin Werner 1 collaboration

Kerstin Heise 1 collaboration

Marie Follo 1 collaboration

Dmitry M Chudakov 1 collaboration

Sofya A Kasatskaya 1 collaboration

Felix E Frenkel 1 collaboration

Sarina Ravens 1 collaboration

Eric Spierings 1 collaboration

Immo Prinz 1 collaboration

Ralf Küppers 1 collaboration

Miroslav Malkovsky 1 collaboration

Paul Fisch 1 collaboration

Lenneke Schrier 1 collaboration

Anke Bruns 1 collaboration

A Daudeij 1 collaboration

F Devina 1 collaboration

C Nijenhuis 1 collaboration

B Nuijen 1 collaboration

B Romberg 1 collaboration

C de Haar 1 collaboration

J Haanen 1 collaboration

H Dolstra 1 collaboration

E Bremer 1 collaboration

Z Sebestyen 1 collaboration

I Jedema 1 collaboration

Johanna F Dekkers 1 collaboration

Maria Alieva 1 collaboration

Farid Keramati 1 collaboration

Amber K L Wezenaar 1 collaboration

Esmée J van Vliet 1 collaboration

Jens Puschhof 1 collaboration

Angelo D Meringa 1 collaboration

Heggert G Rebel 1 collaboration

Maj-Britt Buchholz 1 collaboration

Mario Barrera Román 1 collaboration

Amber L Zeeman 1 collaboration

Sam de Blank 1 collaboration

Maarten H Geurts 1 collaboration

Annelisa M Cornel 1 collaboration

Else Driehuis 1 collaboration

Hendrikus C R Ariese 1 collaboration

Hannah R Johnson 1 collaboration

Ravian L van Ineveld 1 collaboration

Oded Kopper 1 collaboration

Yotam E Bar-Ephraim 1 collaboration

Kai Kretzschmar 1 collaboration

Alexander M M Eggermont 1 collaboration

Stefan Nierkens 1 collaboration

Ellen J Wehrens 1 collaboration

Henk G Stunnenberg 1 collaboration

Anne C Rios 1 collaboration

Moniek A de Witte 1 collaboration

Klaartje Nijssen 1 collaboration

Luuk Swanenberg 1 collaboration

Anna van Rhenen 1 collaboration

Rick Admiraal 1 collaboration

Lotte van der Wagen 1 collaboration

Monique C Minnema 1 collaboration

Eefke Petersen 1 collaboration

Reinier A P Raymakers 1 collaboration

Kasper Westinga 1 collaboration

Constantijn J M Halkes 1 collaboration

Jaap-Jan Boelens 1 collaboration

G J J Kierkels 1 collaboration

W Scheper 1 collaboration

A D Meringa 1 collaboration

D X Beringer 1 collaboration

A Janssen 1 collaboration

M Schiffler 1 collaboration

T Aarts-Riemens 1 collaboration

L Kramer 1 collaboration

S Heijhuurs 1 collaboration

J H W Leusen 1 collaboration

E San José 1 collaboration

K Fuchs 1 collaboration

M Griffioen 1 collaboration

J H Falkenburg 1 collaboration

L Bongiovanni 1 collaboration

A de Bruin 1 collaboration

D Vargas-Diaz 1 collaboration

M Altelaar 1 collaboration

A J R Heck 1 collaboration

L D Shultz 1 collaboration

F Ishikawa 1 collaboration

M I Nishimura 1 collaboration

Z Sebestyén 1 collaboration

Koen Jansen 1 collaboration

Ruud Doorn 1 collaboration

Tineke Aarts 1 collaboration

Anna D D van Muyden 1 collaboration

Marieke Simonis 1 collaboration

Judith Bergboer 1 collaboration

Jurgen Kuball 1 collaboration

Angelo Meringa 1 collaboration

Lauren Hoorens van Heyningen 1 collaboration

Caterina Riillo 1 collaboration

Caroline Schwenzel 1 collaboration

Marina Zintchenko 1 collaboration

Thomas A Kluiver 1 collaboration

Jiali Zheng 1 collaboration

Remco de Bree 1 collaboration

Hendrik G Stunnenberg 1 collaboration

Weng Chuan Peng 1 collaboration

Jeanine Roodhart 1 collaboration

Susana Minguet 1 collaboration