Stefan Willmann

Affiliations

Clinical Pharmacometrics, Bayer AG, Wuppertal, Germany.

Publications (21)

Applications of Physiologically Based Pharmacokinetic Modeling of Rivaroxaban-Renal and Hepatic Impairment and Drug-Drug Interaction Potential.

Journal of clinical pharmacology

Avec: Stefan Willmann , Katrin Coboeken , Stefanie Kapsa , Kirstin Thelen , Markus Mundhenke , Kerstin Fischer , Burkhard Hügl , Wolfgang Mück

Enhancing the Quality of Rivaroxaban Exposure Estimates Using Prothrombin Time in the Absence of Pharmacokinetic Sampling.

CPT: pharmacometrics & systems pharmacology

Avec: Alexander Solms , Matthias Frede , Scott D Berkowitz , Anne Hermanowski-Vosatka , Dagmar Kubitza , Wolfgang Mueck , Theodore E Spiro , Stefan Willmann , Xiaoyu Yan , Liping Zhang , Dirk Garmann

Bodyweight-adjusted rivaroxaban for children with venous thromboembolism (EINSTEIN-Jr): results from three multicentre, single-arm, phase 2 studies.

The Lancet. Haematology

Avec: Paul Monagle , Anthonie W A Lensing , Kirstin Thelen , Ida Martinelli , Christoph Male , Amparo Santamaría , Elena Samochatova , Riten Kumar , Susanne Holzhauer , Paola Saracco , Paolo Simioni , Jeremy Robertson , Gernot Grangl , Jacqueline Halton , Phillip Connor , Guy Young , Angelo C Molinari , Ulrike Nowak-Göttl , Gili Kenet , Stefanie Kapsa , Stefan Willmann , Akos F Pap , Michael Becka , Teresa Twomey , Jan Beyer-Westendorf , Martin H Prins , Dagmar Kubitza , Auteur inconnu

Predictive Pediatric Modeling and Simulation Using Ontogeny Information.

Journal of clinical pharmacology

Avec: Ibrahim Ince , Juri Solodenko , Sebastian Frechen , André Dallmann , Christoph Niederalt , Jan Schlender , Rolf Burghaus , Jörg Lippert , Stefan Willmann

Population pharmacokinetic analysis of rivaroxaban in children and comparison to prospective physiologically-based pharmacokinetic predictions.

CPT: pharmacometrics & systems pharmacology

Avec: Stefan Willmann , Katrin Coboeken , Yang Zhang , Hannah Mayer , Ibrahim Ince , Emir Mesic , Kirstin Thelen , Dagmar Kubitza , Anthonie W A Lensing , Haitao Yang , Peijuan Zhu , Wolfgang Mück , Henk-Jan Drenth , Jörg Lippert

Population Pharmacokinetics of Nifurtimox in Adult and Pediatric Patients With Chagas Disease.

Journal of clinical pharmacology

Avec: Ibrahim Ince , Klaas Prins , Stefan Willmann , Gabriele Sutter , Eva Hanze , Farrah Sadre-Marandi , Heino Stass , Dirk Garmann

Anticoagulation in pediatric cancer-associated venous thromboembolism: a subgroup analysis of EINSTEIN-Jr.

Blood advances

Avec: Joseph S Palumbo , Anthonie W A Lensing , Leonardo R Brandão , Hélène L Hooimeijer , Gili Kenet , Heleen van Ommen , Akos F Pap , Madhurima Majumder , Dagmar Kubitza , Kirstin Thelen , Stefan Willmann , Martin H Prins , Paul Monagle , Christoph Male

Population pharmacokinetics of riociguat in a pediatric population (aged ≥ 6 years) with pulmonary arterial hypertension.

Pediatric pulmonology

Avec: Stefan Willmann , Andrea Kerstin Keller , Michaela Meyer , Dorina van der Mey , Gabriela Wirsching , Yang Zhang , Henk-Jan Drenth , Anne Keunecke , Esmée Vendel , Soundos Saleh

Associations between model-predicted rivaroxaban exposure and patient characteristics and efficacy and safety outcomes in the prevention of venous thromboembolism.

Journal of thrombosis and thrombolysis

Avec: Isabel Reinecke , Alexander Solms , Stefan Willmann , Theodore E Spiro , Gary Peters , Jeffrey I Weitz , Wolfgang Mueck , Dirk Garmann , Stephan Schmidt , Liping Zhang , Keith A A Fox , Scott D Berkowitz

Rivaroxaban for treatment of pediatric venous thromboembolism. An Einstein-Jr phase 3 dose-exposure-response evaluation.

Journal of thrombosis and haemostasis : JTH

Avec: Guy Young , Anthonie W A Lensing , Paul Monagle , Christoph Male , Kirstin Thelen , Stefan Willmann , Joseph S Palumbo , Riten Kumar , Ildar Nurmeev , Kerry Hege , Fanny Bajolle , Philip Connor , Hélène L Hooimeijer , Marcela Torres , Anthony K C Chan , Gili Kenet , Susanne Holzhauer , Amparo Santamaría , Pascal Amedro , Jan Beyer-Westendorf , Ida Martinelli , M Patricia Massicotte , William T Smith , Scott D Berkowitz , Stephan Schmidt , Victoria Price , Martin H Prins , Dagmar Kubitza , Auteur inconnu

Application of Physiologically-Based and Population Pharmacokinetic Modeling for Dose Finding and Confirmation During the Pediatric Development of Moxifloxacin.

CPT: pharmacometrics & systems pharmacology

Avec: Stefan Willmann , Matthias Frei , Gabriele Sutter , Katrin Coboeken , Thomas Wendl , Thomas Eissing , Jörg Lippert , Heino Stass

Comparing Predictions of a PBPK Model for Cyclosporine With Drug Levels From Therapeutic Drug Monitoring.

Frontiers in pharmacology

Avec: Sonja E Zapke , Stefan Willmann , Scott-Oliver Grebe , Kristin Menke , Petra A Thürmann , Sven Schmiedl

Riociguat for the treatment of Phe508del homozygous adults with cystic fibrosis.

Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society

Avec: Nico Derichs , Jennifer L Taylor-Cousar , Jane C Davies , Isabelle Fajac , Elizabeth Tullis , Dilip Nazareth , Damian G Downey , Daniel Rosenbluth , Anne Malfroot , Clare Saunders , Renee Jensen , George M Solomon , Francois Vermeulen , Andreas Kaiser , Stefan Willmann , Soundos Saleh , Karoline Droebner , Peter Sandner , Christine E Bear , Anja Hoffmann , Felix Ratjen , Steven M Rowe , Auteur inconnu

Dosing Regimen Prediction and Confirmation With Rivaroxaban for Thromboprophylaxis in Children After the Fontan Procedure: Insights From the Phase III UNIVERSE Study.

Journal of clinical pharmacology

Avec: Peijuan Zhu , Stefan Willmann , Wangda Zhou , Haitao Yang , Alan D Michelson , Brian W McCrindle , Jennifer S Li , Kevin C Harris , Liza Miriam Pina , Traci Weber , Kimberly Nessel , Lawrence J Lesko , Dagmar Kubitza , Peter Zannikos

The Importance of Assessing Drug Pharmacokinetics and Pharmacodynamics in the Obese Population During Drug Development.

Journal of clinical pharmacology

Avec: Kenneth T Moore , Peter N Zannikos , Joanna C Masters , Stefan Willmann , Jinshan Shen , Charles Frost

Pharmacokinetics, pharmacodynamics, and safety of fesomersen, a novel antisense inhibitor of factor XI, in healthy Chinese, Japanese, and Caucasian volunteers.

Clinical and translational science

Avec: Tianxing Liu , Kensei Hashizume , Eva Krieg , Huijun Chen , Yuki Mukaida , Kirstin Thelen , Frauke Friedrichs , Stefan Willmann , Stephan Schwers , Alexander Solms , Rosie Yu

Population pharmacokinetic-pharmacodynamic model of elinzanetant based on integrated clinical phase I and II data.

CPT: pharmacometrics & systems pharmacology

Avec: Stefan Willmann , Adam Lloyd , Rupert Austin , Shiju Joseph , Alexander Solms , Yang Zhang , Annika R P Schneider , Sebastian Frechen , Marcus-Hillert Schultze-Mosgau

Associations between model-predicted rivaroxaban exposure and patient characteristics and efficacy and safety outcomes in the treatment of venous thromboembolism.

Journal of thrombosis and thrombolysis

Avec: Alexander Solms , Stefan Willmann , Isabel Reinecke , Theodore E Spiro , Gary Peters , Jeffrey I Weitz , Wolfgang Mueck , Dirk Garmann , Stephan Schmidt , Liping Zhang , Keith A A Fox , Scott D Berkowitz

Pharmacokinetics, Safety, and Tolerability of Single-Dose Intravenous Moxifloxacin in Pediatric Patients: Dose Optimization in a Phase 1 Study.

Journal of clinical pharmacology

Avec: Heino Stass , John Lettieri , Konstantina M Vanevski , Stefan Willmann , Laura P James , Janice E Sullivan , Antonio C Arrieta , John S Bradley

Nifurtimox for Treatment of Chagas Disease in Pediatric Patients: the Challenges of Applying Pharmacokinetic-Pharmacodynamic Principles to Dose Finding.

The AAPS journal

Avec: Heino Stass , Ibrahim Ince , Ulrike Grossmann , Boris Weimann , Stefan Willmann

A Phase II randomized controlled trial evaluated antithrombotic treatment with fesomersen in patients with kidney failure on hemodialysis.

Kidney international

Avec: Wolfgang C Winkelmayer , Anthonie W A Lensing , Ravi I Thadhani , Kenneth W Mahaffey , Michael Walsh , Ákos F Pap , Stefan Willmann , Kirstin Thelen , Sophie Hodge , Alexander Solms , Sheila J M Ingham , John Eikelboom , Auteur inconnu

Réseau de co-auteurs

Kirstin Thelen 7 collaborations

Alexander Solms 6 collaborations

Dagmar Kubitza 6 collaborations

Anthonie W A Lensing 5 collaborations

Scott D Berkowitz 4 collaborations

Dirk Garmann 4 collaborations

None None 4 collaborations

Ibrahim Ince 4 collaborations

Heino Stass 4 collaborations

Katrin Coboeken 3 collaborations

Wolfgang Mueck 3 collaborations

Theodore E Spiro 3 collaborations

Liping Zhang 3 collaborations

Paul Monagle 3 collaborations

Christoph Male 3 collaborations

Gili Kenet 3 collaborations

Martin H Prins 3 collaborations

Jörg Lippert 3 collaborations

Yang Zhang 3 collaborations

Stephan Schmidt 3 collaborations

Stefanie Kapsa 2 collaborations

Wolfgang Mück 2 collaborations

Ida Martinelli 2 collaborations

Amparo Santamaría 2 collaborations

Riten Kumar 2 collaborations

Susanne Holzhauer 2 collaborations

Guy Young 2 collaborations

Akos F Pap 2 collaborations

Jan Beyer-Westendorf 2 collaborations

Sebastian Frechen 2 collaborations

Haitao Yang 2 collaborations

Peijuan Zhu 2 collaborations

Henk-Jan Drenth 2 collaborations

Gabriele Sutter 2 collaborations

Joseph S Palumbo 2 collaborations

Hélène L Hooimeijer 2 collaborations

Soundos Saleh 2 collaborations

Isabel Reinecke 2 collaborations

Gary Peters 2 collaborations

Jeffrey I Weitz 2 collaborations

Keith A A Fox 2 collaborations

Markus Mundhenke 1 collaboration

Kerstin Fischer 1 collaboration

Burkhard Hügl 1 collaboration

Matthias Frede 1 collaboration

Anne Hermanowski-Vosatka 1 collaboration

Xiaoyu Yan 1 collaboration

Elena Samochatova 1 collaboration

Paola Saracco 1 collaboration

Paolo Simioni 1 collaboration

Jeremy Robertson 1 collaboration

Gernot Grangl 1 collaboration

Jacqueline Halton 1 collaboration

Phillip Connor 1 collaboration

Angelo C Molinari 1 collaboration

Ulrike Nowak-Göttl 1 collaboration

Michael Becka 1 collaboration

Teresa Twomey 1 collaboration

Juri Solodenko 1 collaboration

André Dallmann 1 collaboration

Christoph Niederalt 1 collaboration

Jan Schlender 1 collaboration

Rolf Burghaus 1 collaboration

Hannah Mayer 1 collaboration

Emir Mesic 1 collaboration

Klaas Prins 1 collaboration

Eva Hanze 1 collaboration

Farrah Sadre-Marandi 1 collaboration

Leonardo R Brandão 1 collaboration

Heleen van Ommen 1 collaboration

Madhurima Majumder 1 collaboration

Andrea Kerstin Keller 1 collaboration

Michaela Meyer 1 collaboration

Dorina van der Mey 1 collaboration

Gabriela Wirsching 1 collaboration

Anne Keunecke 1 collaboration

Esmée Vendel 1 collaboration

Ildar Nurmeev 1 collaboration

Kerry Hege 1 collaboration

Fanny Bajolle 1 collaboration

Philip Connor 1 collaboration

Marcela Torres 1 collaboration

Anthony K C Chan 1 collaboration

Pascal Amedro 1 collaboration

M Patricia Massicotte 1 collaboration

William T Smith 1 collaboration

Victoria Price 1 collaboration

Matthias Frei 1 collaboration

Thomas Wendl 1 collaboration

Thomas Eissing 1 collaboration

Sonja E Zapke 1 collaboration

Scott-Oliver Grebe 1 collaboration

Kristin Menke 1 collaboration

Petra A Thürmann 1 collaboration

Sven Schmiedl 1 collaboration

Nico Derichs 1 collaboration

Jennifer L Taylor-Cousar 1 collaboration

Jane C Davies 1 collaboration

Isabelle Fajac 1 collaboration

Elizabeth Tullis 1 collaboration

Dilip Nazareth 1 collaboration

Damian G Downey 1 collaboration

Daniel Rosenbluth 1 collaboration

Anne Malfroot 1 collaboration

Clare Saunders 1 collaboration

Renee Jensen 1 collaboration

George M Solomon 1 collaboration

Francois Vermeulen 1 collaboration

Andreas Kaiser 1 collaboration

Karoline Droebner 1 collaboration

Peter Sandner 1 collaboration

Christine E Bear 1 collaboration

Anja Hoffmann 1 collaboration

Felix Ratjen 1 collaboration

Steven M Rowe 1 collaboration

Wangda Zhou 1 collaboration

Alan D Michelson 1 collaboration

Brian W McCrindle 1 collaboration

Jennifer S Li 1 collaboration

Kevin C Harris 1 collaboration

Liza Miriam Pina 1 collaboration

Traci Weber 1 collaboration

Kimberly Nessel 1 collaboration

Lawrence J Lesko 1 collaboration

Peter Zannikos 1 collaboration

Kenneth T Moore 1 collaboration

Peter N Zannikos 1 collaboration

Joanna C Masters 1 collaboration

Jinshan Shen 1 collaboration

Charles Frost 1 collaboration

Tianxing Liu 1 collaboration

Kensei Hashizume 1 collaboration

Eva Krieg 1 collaboration

Huijun Chen 1 collaboration

Yuki Mukaida 1 collaboration

Frauke Friedrichs 1 collaboration

Stephan Schwers 1 collaboration

Rosie Yu 1 collaboration

Adam Lloyd 1 collaboration

Rupert Austin 1 collaboration

Shiju Joseph 1 collaboration

Annika R P Schneider 1 collaboration

Marcus-Hillert Schultze-Mosgau 1 collaboration

John Lettieri 1 collaboration

Konstantina M Vanevski 1 collaboration

Laura P James 1 collaboration

Janice E Sullivan 1 collaboration

Antonio C Arrieta 1 collaboration

John S Bradley 1 collaboration

Ulrike Grossmann 1 collaboration

Boris Weimann 1 collaboration

Wolfgang C Winkelmayer 1 collaboration

Ravi I Thadhani 1 collaboration

Kenneth W Mahaffey 1 collaboration

Michael Walsh 1 collaboration

Ákos F Pap 1 collaboration

Sophie Hodge 1 collaboration

Sheila J M Ingham 1 collaboration

John Eikelboom 1 collaboration