Stefan Niewiesk

Affiliations

Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, Columbus, Ohio 43210, United States.

Publications (30)

Engineering Protease-Resistant Peptides to Inhibit Human Parainfluenza Viral Respiratory Infection.

Journal of the American Chemical Society

Avec: Victor K Outlaw , Ross W Cheloha , Eric M Jurgens , Francesca T Bovier , Yun Zhu , Dale F Kreitler , Olivia Harder , Stefan Niewiesk , Matteo Porotto , Samuel H Gellman , Anne Moscona

An HTLV-1 envelope mRNA vaccine is immunogenic and protective in New Zealand rabbits.

Journal of virology

Avec: Joshua J Tu , Emily King , Victoria Maksimova , Susan Smith , Ramon Macias , Xiaogang Cheng , Tanmayee Vegesna , Lianbo Yu , Lee Ratner , Patrick L Green , Stefan Niewiesk , Justin M Richner , Amanda R Panfil

Human immune cells infiltrate the spinal cord and impair recovery after spinal cord injury in humanized mice.

Scientific reports

Avec: Randall S Carpenter , Roselyn R Jiang , Faith H Brennan , Jodie C E Hall , Manoj K Gottipati , Stefan Niewiesk , Phillip G Popovich

HTLV-1 viral oncogene HBZ drives bone destruction in adult T cell leukemia.

JCI insight

Avec: Jingyu Xiang , Daniel A Rauch , Devra D Huey , Amanda R Panfil , Xiaogang Cheng , Alison K Esser , Xinming Su , John C Harding , Yalin Xu , Gregory C Fox , Francesca Fontana , Takayuki Kobayashi , Junyi Su , Hemalatha Sundaramoorthi , Wing Hing Wong , Yizhen Jia , Thomas J Rosol , Deborah J Veis , Patrick L Green , Stefan Niewiesk , Lee Ratner , Katherine N Weilbaecher

Measles Virus Bearing Measles Inclusion Body Encephalitis-Derived Fusion Protein Is Pathogenic after Infection via the Respiratory Route.

Journal of virology

Avec: Cyrille Mathieu , Marion Ferren , Eric Jurgens , Claire Dumont , Ksenia Rybkina , Olivia Harder , Debora Stelitano , Silvia Madeddu , Giuseppina Sanna , Dayna Schwartz , Sudipta Biswas , Diana Hardie , Takao Hashiguchi , Anne Moscona , Branka Horvat , Stefan Niewiesk , Matteo Porotto

A Novel Live Attenuated Respiratory Syncytial Virus Vaccine Candidate with Mutations in the L Protein SAM Binding Site and the G Protein Cleavage Site Is Protective in Cotton Rats and a Rhesus Macaque.

Journal of virology

Avec: Tiffany Jenkins , Rongzhang Wang , Olivia Harder , Miaoge Xue , Phylip Chen , Jacqueline Corry , Christopher Walker , Michael Teng , Asuncion Mejias , Octavio Ramilo , Stefan Niewiesk , Jianrong Li , Mark E Peeples

Production of Humanized Mice through Stem Cell Transfer.

Current protocols

Avec: Cameron Phelps , Devra D Huey , Stefan Niewiesk

CX3CR1 Is a Receptor for Human Respiratory Syncytial Virus in Cotton Rats.

Journal of virology

Avec: Gia Green , Sara M Johnson , Heather Costello , Kelsey Brakel , Olivia Harder , Antonius G Oomens , Mark E Peeples , Hong M Moulton , Stefan Niewiesk

Cotton Rat Placenta Anatomy and Fc Receptor Expression and Their Roles in Maternal Antibody Transfer.

Comparative medicine

Avec: Margaret E Martinez , Stefan Niewiesk , Krista M D La Perle

Human parainfluenza virus evolution during lung infection of immunocompromised individuals promotes viral persistence.

The Journal of clinical investigation

Avec: Alexander L Greninger , Ksenia Rybkina , Michelle J Lin , Jennifer Drew-Bear , Tara C Marcink , Ryan C Shean , Negar Makhsous , Michael Boeckh , Olivia Harder , Francesca Bovier , Shana R Burstein , Stefan Niewiesk , Bert K Rima , Matteo Porotto , Anne Moscona

Immunogenicity and inflammatory properties of respiratory syncytial virus attachment G protein in cotton rats.

PloS one

Avec: Margaret E Martinez , Cristina Capella Gonzalez , Devra Huey , Mark E Peeples , Douglas McCarty , Stefan Niewiesk

Respiratory Syncytial Virus Infection Modeled in Aging Cotton Rats (

Advances in virology

Avec: Olivia E Harder , Stefan Niewiesk

HTLV-1 intragenic viral enhancer influences immortalization phenotype

Frontiers in immunology

Avec: Victoria Maksimova , Susan Smith , Jaideep Seth , Cameron Phelps , Stefan Niewiesk , Yorifumi Satou , Patrick L Green , Amanda R Panfil

Human parainfluenza virus 3 field strains undergo extracellular fusion protein cleavage to activate entry.

mBio

Avec: Kyle Stearns , George Lampe , Rachel Hanan , Tara Marcink , Stefan Niewiesk , Samuel H Sternberg , Alexander L Greninger , Matteo Porotto , Anne Moscona

Stable Attenuation of Human Respiratory Syncytial Virus for Live Vaccines by Deletion and Insertion of Amino Acids in the Hinge Region between the mRNA Capping and Methyltransferase Domains of the Large Polymerase Protein.

Journal of virology

Avec: Miaoge Xue , Rongzhang Wang , Olivia Harder , Phylip Chen , Mijia Lu , Hui Cai , Anzhong Li , Xueya Liang , Ryan Jennings , Krista La Perle , Stefan Niewiesk , Mark E Peeples , Jianrong Li

Coexpression of respiratory syncytial virus (RSV) fusion (F) protein and attachment glycoprotein (G) in a vesicular stomatitis virus (VSV) vector system provides synergistic effects against RSV infection in a cotton rat model.

Vaccine

Avec: Kelsey A Brakel , Basavaraj Binjawadagi , Kristen French-Kim , Mauria Watts , Olivia Harder , Yuanmei Ma , Jianrong Li , Stefan Niewiesk

Mucosal Delivery of Recombinant Vesicular Stomatitis Virus Vectors Expressing Envelope Proteins of Respiratory Syncytial Virus Induces Protective Immunity in Cotton Rats.

Journal of virology

Avec: Basavaraj Binjawadagi , Yuanmei Ma , Rashmi Binjawadagi , Kelsey Brakel , Olivia Harder , Mark Peeples , Jianrong Li , Stefan Niewiesk

Inhibition of Measles Viral Fusion Is Enhanced by Targeting Multiple Domains of the Fusion Protein.

ACS nano

Avec: Francesca T Bovier , Ksenia Rybkina , Sudipta Biswas , Olivia Harder , Tara C Marcink , Stefan Niewiesk , Anne Moscona , Christopher A Alabi , Matteo Porotto

Codon-optimization of the respiratory syncytial virus (RSV) G protein expressed in a vesicular stomatitis virus (VSV) vector improves immune responses in a cotton rat model.

Virology

Avec: Kelsey A Brakel , Yuanmei Ma , Rashmi Binjawadagi , Olivia Harder , Mauria Watts , Jianrong Li , Basavaraj Binjawadagi , Stefan Niewiesk

The PRMT5 inhibitor EPZ015666 is effective against HTLV-1-transformed T-cell lines

Frontiers in microbiology

Avec: Kyle Ernzen , Corrine Melvin , Lianbo Yu , Cameron Phelps , Stefan Niewiesk , Patrick L Green , Amanda R Panfil

A neutralizing antibody prevents postfusion transition of measles virus fusion protein.

Science (New York, N.Y.)

Avec: Dawid S Zyla , Roberta Della Marca , Gele Niemeyer , Gillian Zipursky , Kyle Stearns , Cameron Leedale , Elizabeth B Sobolik , Heather M Callaway , Chitra Hariharan , Weiwei Peng , Diptiben Parekh , Tara C Marcink , Ruben Diaz Avalos , Branka Horvat , Cyrille Mathieu , Joost Snijder , Alexander L Greninger , Kathryn M Hastie , Stefan Niewiesk , Anne Moscona , Matteo Porotto , Erica Ollmann Saphire

Cause and Treatment of Exophthalmos in Aged Cotton Rats (

Comparative medicine

Avec: Olivia E Harder , Kathryn M Emmer , Amanda E Sparks , Eric J Miller , Anne J Gemensky-Metzler , Dondrae J Coble , Stefan Niewiesk , Krista M D La Perle

Mathematical modelling identifies the role of adaptive immunity as a key controller of respiratory syncytial virus in cotton rats.

Journal of the Royal Society, Interface

Avec: Darren Wethington , Olivia Harder , Karthik Uppulury , William C L Stewart , Phylip Chen , Tiffany King , Susan D Reynolds , Alan S Perelson , Mark E Peeples , Stefan Niewiesk , Jayajit Das

Pulmonary function analysis in cotton rats after respiratory syncytial virus infection.

PloS one

Avec: Margaret E Martinez , Olivia E Harder , Lucia E Rosas , Lisa Joseph , Ian C Davis , Stefan Niewiesk

N

Nature microbiology

Avec: Mijia Lu , Zijie Zhang , Miaoge Xue , Boxuan Simen Zhao , Olivia Harder , Anzhong Li , Xueya Liang , Thomas Z Gao , Yunsheng Xu , Jiyong Zhou , Zongdi Feng , Stefan Niewiesk , Mark E Peeples , Chuan He , Jianrong Li

Viral N

Nature communications

Avec: Miaoge Xue , Boxuan Simen Zhao , Zijie Zhang , Mijia Lu , Olivia Harder , Phylip Chen , Zhike Lu , Anzhong Li , Yuanmei Ma , Yunsheng Xu , Xueya Liang , Jiyong Zhou , Stefan Niewiesk , Mark E Peeples , Chuan He , Jianrong Li

Viral RNA N6-methyladenosine modification modulates both innate and adaptive immune responses of human respiratory syncytial virus.

PLoS pathogens

Avec: Miaoge Xue , Yuexiu Zhang , Haitao Wang , Elizabeth L Kairis , Mijia Lu , Sadeem Ahmad , Zayed Attia , Olivia Harder , Zijie Zhang , Jiangbo Wei , Phylip Chen , Youling Gao , Mark E Peeples , Amit Sharma , Prosper Boyaka , Chuan He , Sun Hur , Stefan Niewiesk , Jianrong Li

A safe and highly efficacious measles virus-based vaccine expressing SARS-CoV-2 stabilized prefusion spike.

Proceedings of the National Academy of Sciences of the United States of America

Avec: Mijia Lu , Piyush Dravid , Yuexiu Zhang , Sheetal Trivedi , Anzhong Li , Olivia Harder , Mahesh Kc , Supranee Chaiwatpongsakorn , Ashley Zani , Adam Kenney , Cong Zeng , Chuanxi Cai , Chengjin Ye , Xueya Liang , Masako Shimamura , Shan-Lu Liu , Asuncion Mejias , Octavio Ramilo , Prosper N Boyaka , Jianming Qiu , Luis Martinez-Sobrido , Jacob S Yount , Mark E Peeples , Amit Kapoor , Stefan Niewiesk , Jianrong Li

Nonsteroidal anti-inflammatory drugs restore immune function to respiratory syncytial virus in geriatric cotton rats (Sigmodon hispidus).

Virology

Avec: Olivia E Harder , Margaret Martinez , Stefan Niewiesk

HTLV-1 Hbz protein, but not hbz mRNA secondary structure, is critical for viral persistence and disease development.

PLoS pathogens

Avec: Victoria Maksimova , Tasha Wilkie , Susan Smith , Cameron Phelps , Corrine Melvin , Lianbo Yu , Stefan Niewiesk , Patrick L Green , Amanda R Panfil

Réseau de co-auteurs

Olivia Harder 15 collaborations

Jianrong Li 9 collaborations

Mark E Peeples 9 collaborations

Matteo Porotto 6 collaborations

Anne Moscona 6 collaborations

Patrick L Green 5 collaborations

Amanda R Panfil 5 collaborations

Miaoge Xue 5 collaborations

Phylip Chen 5 collaborations

Mijia Lu 5 collaborations

Cameron Phelps 4 collaborations

Olivia E Harder 4 collaborations

Anzhong Li 4 collaborations

Xueya Liang 4 collaborations

Yuanmei Ma 4 collaborations

Victoria Maksimova 3 collaborations

Susan Smith 3 collaborations

Lianbo Yu 3 collaborations

Ksenia Rybkina 3 collaborations

Margaret E Martinez 3 collaborations

Alexander L Greninger 3 collaborations

Tara C Marcink 3 collaborations

Basavaraj Binjawadagi 3 collaborations

Zijie Zhang 3 collaborations

Chuan He 3 collaborations

Francesca T Bovier 2 collaborations

Xiaogang Cheng 2 collaborations

Lee Ratner 2 collaborations

Devra D Huey 2 collaborations

Cyrille Mathieu 2 collaborations

Sudipta Biswas 2 collaborations

Branka Horvat 2 collaborations

Rongzhang Wang 2 collaborations

Asuncion Mejias 2 collaborations

Octavio Ramilo 2 collaborations

Kelsey Brakel 2 collaborations

Krista M D La Perle 2 collaborations

Kyle Stearns 2 collaborations

Kelsey A Brakel 2 collaborations

Mauria Watts 2 collaborations

Rashmi Binjawadagi 2 collaborations

Corrine Melvin 2 collaborations

Boxuan Simen Zhao 2 collaborations

Yunsheng Xu 2 collaborations

Jiyong Zhou 2 collaborations

Yuexiu Zhang 2 collaborations

Victor K Outlaw 1 collaboration

Ross W Cheloha 1 collaboration

Eric M Jurgens 1 collaboration

Yun Zhu 1 collaboration

Dale F Kreitler 1 collaboration

Samuel H Gellman 1 collaboration

Joshua J Tu 1 collaboration

Emily King 1 collaboration

Ramon Macias 1 collaboration

Tanmayee Vegesna 1 collaboration

Justin M Richner 1 collaboration

Randall S Carpenter 1 collaboration

Roselyn R Jiang 1 collaboration

Faith H Brennan 1 collaboration

Jodie C E Hall 1 collaboration

Manoj K Gottipati 1 collaboration

Phillip G Popovich 1 collaboration

Jingyu Xiang 1 collaboration

Daniel A Rauch 1 collaboration

Alison K Esser 1 collaboration

Xinming Su 1 collaboration

John C Harding 1 collaboration

Yalin Xu 1 collaboration

Gregory C Fox 1 collaboration

Francesca Fontana 1 collaboration

Takayuki Kobayashi 1 collaboration

Junyi Su 1 collaboration

Hemalatha Sundaramoorthi 1 collaboration

Wing Hing Wong 1 collaboration

Yizhen Jia 1 collaboration

Thomas J Rosol 1 collaboration

Deborah J Veis 1 collaboration

Katherine N Weilbaecher 1 collaboration

Marion Ferren 1 collaboration

Eric Jurgens 1 collaboration

Claire Dumont 1 collaboration

Debora Stelitano 1 collaboration

Silvia Madeddu 1 collaboration

Giuseppina Sanna 1 collaboration

Dayna Schwartz 1 collaboration

Diana Hardie 1 collaboration

Takao Hashiguchi 1 collaboration

Tiffany Jenkins 1 collaboration

Jacqueline Corry 1 collaboration

Christopher Walker 1 collaboration

Michael Teng 1 collaboration

Gia Green 1 collaboration

Sara M Johnson 1 collaboration

Heather Costello 1 collaboration

Antonius G Oomens 1 collaboration

Hong M Moulton 1 collaboration

Michelle J Lin 1 collaboration

Jennifer Drew-Bear 1 collaboration

Ryan C Shean 1 collaboration

Negar Makhsous 1 collaboration

Michael Boeckh 1 collaboration

Francesca Bovier 1 collaboration

Shana R Burstein 1 collaboration

Bert K Rima 1 collaboration

Cristina Capella Gonzalez 1 collaboration

Devra Huey 1 collaboration

Douglas McCarty 1 collaboration

Jaideep Seth 1 collaboration

Yorifumi Satou 1 collaboration

George Lampe 1 collaboration

Rachel Hanan 1 collaboration

Tara Marcink 1 collaboration

Samuel H Sternberg 1 collaboration

Hui Cai 1 collaboration

Ryan Jennings 1 collaboration

Krista La Perle 1 collaboration

Kristen French-Kim 1 collaboration

Mark Peeples 1 collaboration

Christopher A Alabi 1 collaboration

Kyle Ernzen 1 collaboration

Dawid S Zyla 1 collaboration

Roberta Della Marca 1 collaboration

Gele Niemeyer 1 collaboration

Gillian Zipursky 1 collaboration

Cameron Leedale 1 collaboration

Elizabeth B Sobolik 1 collaboration

Heather M Callaway 1 collaboration

Chitra Hariharan 1 collaboration

Weiwei Peng 1 collaboration

Diptiben Parekh 1 collaboration

Ruben Diaz Avalos 1 collaboration

Joost Snijder 1 collaboration

Kathryn M Hastie 1 collaboration

Erica Ollmann Saphire 1 collaboration

Kathryn M Emmer 1 collaboration

Amanda E Sparks 1 collaboration

Eric J Miller 1 collaboration

Anne J Gemensky-Metzler 1 collaboration

Dondrae J Coble 1 collaboration

Darren Wethington 1 collaboration

Karthik Uppulury 1 collaboration

William C L Stewart 1 collaboration

Tiffany King 1 collaboration

Susan D Reynolds 1 collaboration

Alan S Perelson 1 collaboration

Jayajit Das 1 collaboration

Lucia E Rosas 1 collaboration

Lisa Joseph 1 collaboration

Ian C Davis 1 collaboration

Thomas Z Gao 1 collaboration

Zongdi Feng 1 collaboration

Zhike Lu 1 collaboration

Haitao Wang 1 collaboration

Elizabeth L Kairis 1 collaboration

Sadeem Ahmad 1 collaboration

Zayed Attia 1 collaboration

Jiangbo Wei 1 collaboration

Youling Gao 1 collaboration

Amit Sharma 1 collaboration

Prosper Boyaka 1 collaboration

Sun Hur 1 collaboration

Piyush Dravid 1 collaboration

Sheetal Trivedi 1 collaboration

Mahesh Kc 1 collaboration

Supranee Chaiwatpongsakorn 1 collaboration

Ashley Zani 1 collaboration

Adam Kenney 1 collaboration

Cong Zeng 1 collaboration

Chuanxi Cai 1 collaboration

Chengjin Ye 1 collaboration

Masako Shimamura 1 collaboration

Shan-Lu Liu 1 collaboration

Prosper N Boyaka 1 collaboration

Jianming Qiu 1 collaboration

Luis Martinez-Sobrido 1 collaboration

Jacob S Yount 1 collaboration

Amit Kapoor 1 collaboration

Margaret Martinez 1 collaboration

Tasha Wilkie 1 collaboration