Sigrun Häge

Affiliations

Institute for Clinical and Molecular Virology, Friedrich-Alexander University of Erlangen-Nürnberg (FAU), 91054 Erlangen, Germany.

Publications (18)

Phenotypical Characterization of the Nuclear Egress of Recombinant Cytomegaloviruses Reveals Defective Replication upon ORF-UL50 Deletion but Not pUL50 Phosphosite Mutation.

Viruses

Avec: Sigrun Häge , Eric Sonntag , Adriana Svrlanska , Eva Maria Borst , Anne-Charlotte Stilp , Deborah Horsch , Regina Müller , Barbara Kropff , Jens Milbradt , Thomas Stamminger , Ursula Schlötzer-Schrehardt , Manfred Marschall

Nuclear Egress Complexes of HCMV and Other Herpesviruses: Solving the Puzzle of Sequence Coevolution, Conserved Structures and Subfamily-Spanning Binding Properties.

Viruses

Avec: Manfred Marschall , Sigrun Häge , Marcus Conrad , Sewar Alkhashrom , Jintawee Kicuntod , Johannes Schweininger , Mark Kriegel , Josephine Lösing , Julia Tillmanns , Frank Neipel , Jutta Eichler , Yves A Muller , Heinrich Sticht

The Oligomeric Assemblies of Cytomegalovirus Core Nuclear Egress Proteins Are Associated with Host Kinases and Show Sensitivity to Antiviral Kinase Inhibitors.

Viruses

Avec: Jintawee Kicuntod , Sigrun Häge , Friedrich Hahn , Heinrich Sticht , Manfred Marschall

Synthesis and Characterization of DHODH Inhibitors Based on the Vidofludimus Scaffold with Pronounced Anti-SARS-CoV-2 Activity.

ChemMedChem

Avec: Christian Gege , Friedrich Hahn , Christina Wangen , Sigrun Häge , Alexandra Herrmann , Nadja Uhlig , Valentina Eberlein , Leila Issmail , Robert Klopfleisch , Thomas Grunwald , Manfred Marschall , Hella Kohlhof , Daniel Vitt

'Shared-Hook' and 'Changed-Hook' Binding Activities of Herpesviral Core Nuclear Egress Complexes Identified by Random Mutagenesis.

Cells

Avec: Josephine Lösing , Sigrun Häge , Martin Schütz , Sabrina Wagner , Julia Wardin , Heinrich Sticht , Manfred Marschall

Patterns of Autologous and Nonautologous Interactions Between Core Nuclear Egress Complex (NEC) Proteins of α-, β- and γ-Herpesviruses.

Viruses

Avec: Sigrun Häge , Eric Sonntag , Eva Maria Borst , Pierre Tannig , Lisa Seyler , Tobias Bäuerle , Susanne M Bailer , Chung-Pei Lee , Regina Müller , Christina Wangen , Jens Milbradt , Manfred Marschall

Methodological Development of a Multi-Readout Assay for the Assessment of Antiviral Drugs against SARS-CoV-2.

Pathogens (Basel, Switzerland)

Avec: Friedrich Hahn , Sigrun Häge , Alexandra Herrmann , Christina Wangen , Jintawee Kicuntod , Doris Jungnickl , Julia Tillmanns , Regina Müller , Kirsten Fraedrich , Klaus Überla , Hella Kohlhof , Armin Ensser , Manfred Marschall

Exploring the Human Cytomegalovirus Core Nuclear Egress Complex as a Novel Antiviral Target: A New Type of Small Molecule Inhibitors.

Viruses

Avec: Sewar Alkhashrom , Jintawee Kicuntod , Sigrun Häge , Johannes Schweininger , Yves A Muller , Peter Lischka , Manfred Marschall , Jutta Eichler

Assessment of Covalently Binding Warhead Compounds in the Validation of the Cytomegalovirus Nuclear Egress Complex as an Antiviral Target.

Cells

Avec: Julia Tillmanns , Sigrun Häge , Eva Maria Borst , Julia Wardin , Jan Eickhoff , Bert Klebl , Sabrina Wagner , Christina Wangen , Friedrich Hahn , Eileen Socher , Manfred Marschall

High-resolution crystal structures of two prototypical β- and γ-herpesviral nuclear egress complexes unravel the determinants of subfamily specificity.

The Journal of biological chemistry

Avec: Yves A Muller , Sigrun Häge , Sewar Alkhashrom , Tobias Höllriegl , Sebastian Weigert , Simon Dolles , Kerstin Hof , Sascha A Walzer , Claudia Egerer-Sieber , Marcus Conrad , Stephanie Holst , Josephine Lösing , Eric Sonntag , Heinrich Sticht , Jutta Eichler , Manfred Marschall

Properties of Oligomeric Interaction of the Cytomegalovirus Core Nuclear Egress Complex (NEC) and Its Sensitivity to an NEC Inhibitory Small Molecule.

Viruses

Avec: Jintawee Kicuntod , Sewar Alkhashrom , Sigrun Häge , Benedikt Diewald , Regina Müller , Friedrich Hahn , Peter Lischka , Heinrich Sticht , Jutta Eichler , Manfred Marschall

The crystal structure of the varicella-zoster Orf24-Orf27 nuclear egress complex spotlights multiple determinants of herpesvirus subfamily specificity.

The Journal of biological chemistry

Avec: Johannes Schweininger , Mark Kriegel , Sigrun Häge , Marcus Conrad , Sewar Alkhashrom , Josephine Lösing , Sigrid Weiler , Julia Tillmanns , Claudia Egerer-Sieber , Andrea Decker , Tihana Lenac Roviš , Jutta Eichler , Heinrich Sticht , Manfred Marschall , Yves A Muller

An antiviral targeting strategy based on the inducible interference with cytomegalovirus nuclear egress complex.

Antiviral research

Avec: Jintawee Kicuntod , Sigrun Häge , Josephine Lösing , Serli Kopar , Yves A Muller , Manfred Marschall

A quantitative nuclear egress assay to investigate the nucleocytoplasmic capsid release of human cytomegalovirus.

Journal of virological methods

Avec: Sigrun Häge , Deborah Horsch , Anne-Charlotte Stilp , Jintawee Kicuntod , Regina Müller , Stuart T Hamilton , Ece Egilmezer , William D Rawlinson , Thomas Stamminger , Eric Sonntag , Manfred Marschall

The Complex Regulatory Role of Cytomegalovirus Nuclear Egress Protein pUL50 in the Production of Infectious Virus.

Cells

Avec: Sigrun Häge , Nicole Büscher , Victoria Pakulska , Friedrich Hahn , Annie Adrait , Steffi Krauter , Eva Maria Borst , Ursula Schlötzer-Schrehardt , Yohann Couté , Bodo Plachter , Manfred Marschall

IMU-838, a Developmental DHODH Inhibitor in Phase II for Autoimmune Disease, Shows Anti-SARS-CoV-2 and Broad-Spectrum Antiviral Efficacy In Vitro.

Viruses

Avec: Friedrich Hahn , Christina Wangen , Sigrun Häge , Antonia Sophia Peter , Gerhard Dobler , Brett Hurst , Justin Julander , Jonas Fuchs , Zsolt Ruzsics , Klaus Überla , Hans-Martin Jäck , Roger Ptak , Andreas Muehler , Manfred Gröppel , Daniel Vitt , Evelyn Peelen , Hella Kohlhof , Manfred Marschall

'Come together'-The Regulatory Interaction of Herpesviral Nuclear Egress Proteins Comprises Both Essential and Accessory Functions.

Cells

Avec: Sigrun Häge , Manfred Marschall

The Trimeric Artesunate Analog TF27, a Broadly Acting Anti-Infective Model Drug, Exerts Pronounced Anti-SARS-CoV-2 Activity Spanning Variants and Host Cell Types.

Pharmaceutics

Avec: Friedrich Hahn , Christina Wangen , Sigrun Häge , Lars Herrmann , Alexandra Herrmann , Svetlana B Tsogoeva , Manfred Marschall

Réseau de co-auteurs

Manfred Marschall 18 collaborations

Friedrich Hahn 8 collaborations

Jintawee Kicuntod 7 collaborations

Heinrich Sticht 6 collaborations

Christina Wangen 6 collaborations

Regina Müller 5 collaborations

Sewar Alkhashrom 5 collaborations

Josephine Lösing 5 collaborations

Jutta Eichler 5 collaborations

Yves A Muller 5 collaborations

Eric Sonntag 4 collaborations

Eva Maria Borst 4 collaborations

Julia Tillmanns 4 collaborations

Marcus Conrad 3 collaborations

Johannes Schweininger 3 collaborations

Alexandra Herrmann 3 collaborations

Hella Kohlhof 3 collaborations

Anne-Charlotte Stilp 2 collaborations

Deborah Horsch 2 collaborations

Jens Milbradt 2 collaborations

Thomas Stamminger 2 collaborations

Ursula Schlötzer-Schrehardt 2 collaborations

Mark Kriegel 2 collaborations

Daniel Vitt 2 collaborations

Sabrina Wagner 2 collaborations

Julia Wardin 2 collaborations

Klaus Überla 2 collaborations

Peter Lischka 2 collaborations

Claudia Egerer-Sieber 2 collaborations

Adriana Svrlanska 1 collaboration

Barbara Kropff 1 collaboration

Frank Neipel 1 collaboration

Christian Gege 1 collaboration

Nadja Uhlig 1 collaboration

Valentina Eberlein 1 collaboration

Leila Issmail 1 collaboration

Robert Klopfleisch 1 collaboration

Thomas Grunwald 1 collaboration

Martin Schütz 1 collaboration

Pierre Tannig 1 collaboration

Lisa Seyler 1 collaboration

Tobias Bäuerle 1 collaboration

Susanne M Bailer 1 collaboration

Chung-Pei Lee 1 collaboration

Doris Jungnickl 1 collaboration

Kirsten Fraedrich 1 collaboration

Armin Ensser 1 collaboration

Jan Eickhoff 1 collaboration

Bert Klebl 1 collaboration

Eileen Socher 1 collaboration

Tobias Höllriegl 1 collaboration

Sebastian Weigert 1 collaboration

Simon Dolles 1 collaboration

Kerstin Hof 1 collaboration

Sascha A Walzer 1 collaboration

Stephanie Holst 1 collaboration

Benedikt Diewald 1 collaboration

Sigrid Weiler 1 collaboration

Andrea Decker 1 collaboration

Tihana Lenac Roviš 1 collaboration

Serli Kopar 1 collaboration

Stuart T Hamilton 1 collaboration

Ece Egilmezer 1 collaboration

William D Rawlinson 1 collaboration

Nicole Büscher 1 collaboration

Victoria Pakulska 1 collaboration

Annie Adrait 1 collaboration

Steffi Krauter 1 collaboration

Yohann Couté 1 collaboration

Bodo Plachter 1 collaboration

Antonia Sophia Peter 1 collaboration

Gerhard Dobler 1 collaboration

Brett Hurst 1 collaboration

Justin Julander 1 collaboration

Jonas Fuchs 1 collaboration

Zsolt Ruzsics 1 collaboration

Hans-Martin Jäck 1 collaboration

Roger Ptak 1 collaboration

Andreas Muehler 1 collaboration

Manfred Gröppel 1 collaboration

Evelyn Peelen 1 collaboration

Lars Herrmann 1 collaboration

Svetlana B Tsogoeva 1 collaboration