Shivashankar Othy

Affiliations

Department of Physiology and Biophysics, University of California Irvine, USA.
Institute for Immunology, University of California Irvine, USA.

Publications (16)

Single-cell and spatial transcriptomics identify a macrophage population associated with skeletal muscle fibrosis.

bioRxiv : the preprint server for biology

Avec: Gerald Coulis , Diego Jaime , Christian Guerrero-Juarez , Jenna M Kastenschmidt , Philip K Farahat , Quy Nguyen , Nicholas Pervolarakis , Katherine McLinden , Lauren Thurlow , Saba Movahedi , Jorge Duarte , Andrew Sorn , Elizabeth Montoya , Izza Mozaffar , Morgan Dragan , Shivashankar Othy , Trupti Joshi , Chetan P Hans , Virginia Kimonis , Adam L MacLean , Qing Nie , Lindsay M Wallace , Scott Q Harper , Tahseen Mozaffar , Marshall W Hogarth , Surajit Bhattacharya , Jyoti K Jaiswal , David R Golann , Qi Su , Kai Kessenbrock , Michael Stec , Melissa J Spencer , Jesse R Zamudio , S Armando Villalta

Mechanically activated ion channel Piezo1 modulates macrophage polarization and stiffness sensing.

Nature communications

Avec: Hamza Atcha , Amit Jairaman , Jesse R Holt , Vijaykumar S Meli , Raji R Nagalla , Praveen Krishna Veerasubramanian , Kyle T Brumm , Huy E Lim , Shivashankar Othy , Michael D Cahalan , Medha M Pathak , Wendy F Liu

Early stress-induced impaired microglial pruning of excitatory synapses on immature CRH-expressing neurons provokes aberrant adult stress responses.

Cell reports

Avec: Jessica L Bolton , Annabel K Short , Shivashankar Othy , Cassandra L Kooiker , Manlin Shao , Benjamin G Gunn , Jaclyn Beck , Xinglong Bai , Stephanie M Law , Julie C Savage , Jeremy J Lambert , Delia Belelli , Marie-Ève Tremblay , Michael D Cahalan , Tallie Z Baram

TREM2 regulates purinergic receptor-mediated calcium signaling and motility in human iPSC-derived microglia.

eLife

Avec: Amit Jairaman , Amanda McQuade , Alberto Granzotto , You Jung Kang , Jean Paul Chadarevian , Sunil Gandhi , Ian Parker , Ian Smith , Hansang Cho , Stefano L Sensi , Shivashankar Othy , Mathew Blurton-Jones , Michael D Cahalan

Single-cell and spatial transcriptomics identify a macrophage population associated with skeletal muscle fibrosis.

Science advances

Avec: Gerald Coulis , Diego Jaime , Christian Guerrero-Juarez , Jenna M Kastenschmidt , Philip K Farahat , Quy Nguyen , Nicholas Pervolarakis , Katherine McLinden , Lauren Thurlow , Saba Movahedi , Brandon S Hughes , Jorge Duarte , Andrew Sorn , Elizabeth Montoya , Izza Mozaffar , Morgan Dragan , Shivashankar Othy , Trupti Joshi , Chetan P Hans , Virginia Kimonis , Adam L MacLean , Qing Nie , Lindsay M Wallace , Scott Q Harper , Tahseen Mozaffar , Marshall W Hogarth , Surajit Bhattacharya , Jyoti K Jaiswal , David R Golann , Qi Su , Kai Kessenbrock , Michael Stec , Melissa J Spencer , Jesse R Zamudio , S Armando Villalta

Immune Checkpoint Inhibition-related Neuroinflammation Disrupts Cognitive Function.

bioRxiv : the preprint server for biology

Avec: Onwodi V Ifejeokwu , An Do , Sanad M El Khatib , Nhu H Ho , Angel Zavala , Shivashankar Othy , Munjal M Acharya

Calcium Dynamics in Astrocytes During Cell Injury.

Frontiers in bioengineering and biotechnology

Avec: Nicole M Wakida , Veronica Gomez-Godinez , Huayan Li , Jessica Nguyen , Edward K Kim , Joseph L Dynes , Shivashankar Othy , Alice L Lau , Peng Ding , Linda Shi , Christopher Carmona , Leslie M Thompson , Michael D Cahalan , Michael W Berns

Regulatory T cells suppress Th17 cell Ca

Proceedings of the National Academy of Sciences of the United States of America

Avec: Shivashankar Othy , Amit Jairaman , Joseph L Dynes , Tobias X Dong , Cornelia Tune , Andriy V Yeromin , Angel Zavala , Chijioke Akunwafo , Fangyi Chen , Ian Parker , Michael D Cahalan

Interruption of the Intratumor CD8:Treg Crosstalk Improves the Efficacy of PD-1 Immunotherapy.

bioRxiv : the preprint server for biology

Avec: Shannon N Geels , Alexander Moshensky , Rachel S Sousa , Benjamin L Walker , Rima Singh , Giselle Gutierrez , Michael Hwang , Thorsten R Mempel , Qing Nie , Shivashankar Othy , Francesco Marangoni

Protocol to quantify the activation dynamics of tumor-associated T cells in mice by functional intravital microscopy.

STAR protocols

Avec: Shannon N Geels , Claire Murat , Alexander Moshensky , Shivashankar Othy , Francesco Marangoni

Regulatory T cells promote remyelination in the murine experimental autoimmune encephalomyelitis model of multiple sclerosis following human neural stem cell transplant.

Neurobiology of disease

Avec: Laura L McIntyre , Scott A Greilach , Shivashankar Othy , Ilse Sears-Kraxberger , Brian Wi , Julio Ayala-Angulo , Estelle Vu , Quan Pham , Jorge Silva , Kody Dang , Fady Rezk , Oswald Steward , Michael D Cahalan , Thomas E Lane , Craig M Walsh

Cxcl17

Journal of leukocyte biology

Avec: Marcela Hernández-Ruiz , Shivashankar Othy , Carolina Herrera , Hong-Tam Nguyen , Gerardo Arrevillaga-Boni , Jovani Catalan-Dibene , Michael D Cahalan , Albert Zlotnik

Expansion of tumor-associated Treg cells upon disruption of a CTLA-4-dependent feedback loop.

Cell

Avec: Francesco Marangoni , Ademi Zhakyp , Michela Corsini , Shannon N Geels , Esteban Carrizosa , Martin Thelen , Vinidhra Mani , Jasper N Prüßmann , Ross D Warner , Aleksandra J Ozga , Mauro Di Pilato , Shivashankar Othy , Thorsten R Mempel

Piezo1 channels restrain regulatory T cells but are dispensable for effector CD4

Science advances

Avec: Amit Jairaman , Shivashankar Othy , Joseph L Dynes , Andriy V Yeromin , Angel Zavala , Milton L Greenberg , Jamison L Nourse , Jesse R Holt , Stuart M Cahalan , Francesco Marangoni , Ian Parker , Medha M Pathak , Michael D Cahalan

Interruption of the intratumor CD8

Cancer cell

Avec: Shannon N Geels , Alexander Moshensky , Rachel S Sousa , Claire Murat , Matias A Bustos , Benjamin L Walker , Rima Singh , Stacey N Harbour , Giselle Gutierrez , Michael Hwang , Thorsten R Mempel , Casey T Weaver , Qing Nie , Dave S B Hoon , Anand K Ganesan , Shivashankar Othy , Francesco Marangoni

Polymodal K

Communications biology

Avec: Rían W Manville , Ryan F Yoshimura , Andriy V Yeromin , Derk Hogenkamp , Jennifer van der Horst , Angel Zavala , Sonia Chinedu , Grey Arena , Emma Lasky , Mark Fisher , Christopher R Tracy , Shivashankar Othy , Thomas A Jepps , Michael D Cahalan , Geoffrey W Abbott

Réseau de co-auteurs

Michael D Cahalan 9 collaborations

Francesco Marangoni 5 collaborations

Qing Nie 4 collaborations

Amit Jairaman 4 collaborations

Angel Zavala 4 collaborations

Shannon N Geels 4 collaborations

Ian Parker 3 collaborations

Joseph L Dynes 3 collaborations

Andriy V Yeromin 3 collaborations

Alexander Moshensky 3 collaborations

Thorsten R Mempel 3 collaborations

Gerald Coulis 2 collaborations

Diego Jaime 2 collaborations

Christian Guerrero-Juarez 2 collaborations

Jenna M Kastenschmidt 2 collaborations

Philip K Farahat 2 collaborations

Quy Nguyen 2 collaborations

Nicholas Pervolarakis 2 collaborations

Katherine McLinden 2 collaborations

Lauren Thurlow 2 collaborations

Saba Movahedi 2 collaborations

Jorge Duarte 2 collaborations

Andrew Sorn 2 collaborations

Elizabeth Montoya 2 collaborations

Izza Mozaffar 2 collaborations

Morgan Dragan 2 collaborations

Trupti Joshi 2 collaborations

Chetan P Hans 2 collaborations

Virginia Kimonis 2 collaborations

Adam L MacLean 2 collaborations

Lindsay M Wallace 2 collaborations

Scott Q Harper 2 collaborations

Tahseen Mozaffar 2 collaborations

Marshall W Hogarth 2 collaborations

Surajit Bhattacharya 2 collaborations

Jyoti K Jaiswal 2 collaborations

David R Golann 2 collaborations

Qi Su 2 collaborations

Kai Kessenbrock 2 collaborations

Michael Stec 2 collaborations

Melissa J Spencer 2 collaborations

Jesse R Zamudio 2 collaborations

S Armando Villalta 2 collaborations

Jesse R Holt 2 collaborations

Medha M Pathak 2 collaborations

Rachel S Sousa 2 collaborations

Benjamin L Walker 2 collaborations

Rima Singh 2 collaborations

Giselle Gutierrez 2 collaborations

Michael Hwang 2 collaborations

Claire Murat 2 collaborations

Hamza Atcha 1 collaboration

Vijaykumar S Meli 1 collaboration

Raji R Nagalla 1 collaboration

Praveen Krishna Veerasubramanian 1 collaboration

Kyle T Brumm 1 collaboration

Huy E Lim 1 collaboration

Wendy F Liu 1 collaboration

Jessica L Bolton 1 collaboration

Annabel K Short 1 collaboration

Cassandra L Kooiker 1 collaboration

Manlin Shao 1 collaboration

Benjamin G Gunn 1 collaboration

Jaclyn Beck 1 collaboration

Xinglong Bai 1 collaboration

Stephanie M Law 1 collaboration

Julie C Savage 1 collaboration

Jeremy J Lambert 1 collaboration

Delia Belelli 1 collaboration

Marie-Ève Tremblay 1 collaboration

Tallie Z Baram 1 collaboration

Amanda McQuade 1 collaboration

Alberto Granzotto 1 collaboration

You Jung Kang 1 collaboration

Jean Paul Chadarevian 1 collaboration

Sunil Gandhi 1 collaboration

Ian Smith 1 collaboration

Hansang Cho 1 collaboration

Stefano L Sensi 1 collaboration

Mathew Blurton-Jones 1 collaboration

Brandon S Hughes 1 collaboration

Onwodi V Ifejeokwu 1 collaboration

An Do 1 collaboration

Sanad M El Khatib 1 collaboration

Nhu H Ho 1 collaboration

Munjal M Acharya 1 collaboration

Nicole M Wakida 1 collaboration

Veronica Gomez-Godinez 1 collaboration

Huayan Li 1 collaboration

Jessica Nguyen 1 collaboration

Edward K Kim 1 collaboration

Alice L Lau 1 collaboration

Peng Ding 1 collaboration

Linda Shi 1 collaboration

Christopher Carmona 1 collaboration

Leslie M Thompson 1 collaboration

Michael W Berns 1 collaboration

Tobias X Dong 1 collaboration

Cornelia Tune 1 collaboration

Chijioke Akunwafo 1 collaboration

Fangyi Chen 1 collaboration

Laura L McIntyre 1 collaboration

Scott A Greilach 1 collaboration

Ilse Sears-Kraxberger 1 collaboration

Brian Wi 1 collaboration

Julio Ayala-Angulo 1 collaboration

Estelle Vu 1 collaboration

Quan Pham 1 collaboration

Jorge Silva 1 collaboration

Kody Dang 1 collaboration

Fady Rezk 1 collaboration

Oswald Steward 1 collaboration

Thomas E Lane 1 collaboration

Craig M Walsh 1 collaboration

Marcela Hernández-Ruiz 1 collaboration

Carolina Herrera 1 collaboration

Hong-Tam Nguyen 1 collaboration

Gerardo Arrevillaga-Boni 1 collaboration

Jovani Catalan-Dibene 1 collaboration

Albert Zlotnik 1 collaboration

Ademi Zhakyp 1 collaboration

Michela Corsini 1 collaboration

Esteban Carrizosa 1 collaboration

Martin Thelen 1 collaboration

Vinidhra Mani 1 collaboration

Jasper N Prüßmann 1 collaboration

Ross D Warner 1 collaboration

Aleksandra J Ozga 1 collaboration

Mauro Di Pilato 1 collaboration

Milton L Greenberg 1 collaboration

Jamison L Nourse 1 collaboration

Stuart M Cahalan 1 collaboration

Matias A Bustos 1 collaboration

Stacey N Harbour 1 collaboration

Casey T Weaver 1 collaboration

Dave S B Hoon 1 collaboration

Anand K Ganesan 1 collaboration

Rían W Manville 1 collaboration

Ryan F Yoshimura 1 collaboration

Derk Hogenkamp 1 collaboration

Jennifer van der Horst 1 collaboration

Sonia Chinedu 1 collaboration

Grey Arena 1 collaboration

Emma Lasky 1 collaboration

Mark Fisher 1 collaboration

Christopher R Tracy 1 collaboration

Thomas A Jepps 1 collaboration

Geoffrey W Abbott 1 collaboration