Sandrine Ruchaud

Affiliations

Sorbonne Université, CNRS, UMR 8227, Integrative Biology of Marine Models Laboratory (LBI2M), Station Biologique de Roscoff, 29680, Roscoff, France.

Publications (27)

Discovery of simplified benzazole fragments derived from the marine benzosceptrin B as necroptosis inhibitors involving the receptor interacting protein Kinase-1.

European journal of medicinal chemistry

Avec: Mohamed Benchekroun , Ludmila Ermolenko , Minh Quan Tran , Agathe Vagneux , Hristo Nedev , Claire Delehouzé , Mohamed Souab , Blandine Baratte , Béatrice Josselin , Bogdan I Iorga , Sandrine Ruchaud , Stéphane Bach , Ali Al-Mourabit

Design of new disubstituted imidazo[1,2-

Journal of enzyme inhibition and medicinal chemistry

Avec: Jonathan Elie , Omid Feizbakhsh , Nathalie Desban , Béatrice Josselin , Blandine Baratte , Amandine Bescond , Julien Duez , Xavier Fant , Stéphane Bach , Dominique Marie , Matthieu Place , Sami Ben Salah , Agnes Chartier , Sabine Berteina-Raboin , Apirat Chaikuad , Stefan Knapp , Fabrice Carles , Pascal Bonnet , Frédéric Buron , Sylvain Routier , Sandrine Ruchaud

Synthesis and Kinase Inhibitory Potencies of Pyrazolo[3,4-

Molecules (Basel, Switzerland)

Avec: Mathilde Defois , Chloé Rémondin , Béatrice Josselin , Lionel Nauton , Vincent Théry , Fabrice Anizon , Sandrine Ruchaud , Francis Giraud , Pascale Moreau

Biological Evaluation of Arylsemicarbazone Derivatives as Potential Anticancer Agents.

Pharmaceuticals (Basel, Switzerland)

Avec: Anne Cecília Nascimento da Cruz , Dalci José Brondani , Temístocles I Talo de Santana , Lucas Oliveira da Silva , Elizabeth Fernanda da Oliveira Borba , Antônio Rodolfo de Faria , Julianna Ferreira Cavalcanti de Albuquerque , Sylvie Piessard , Rafael Matos Ximenes , Blandine Baratte , Stéphane Bach , Sandrine Ruchaud , Francisco Jaime Bezerra Mendonça Junior , Marc-Antoine Bazin , Marcelo Montenegro Rabello , Marcelo Zaldini Hernandes , Pascal Marchand , Teresinha Gonçalves da Silva

Discovery of DB18, a potent inhibitor of CLK kinases with a high selectivity against DYRK1A kinase.

Bioorganic & medicinal chemistry

Avec: Dabbugoddu Brahmaiah , Anagani Kanaka Durga Bhavani , Pasula Aparna , Nangunoori Sampath Kumar , Hélène Solhi , Rémy Le Guevel , Blandine Baratte , Sandrine Ruchaud , Stéphane Bach , Surender Singh Jadav , Chada Raji Reddy , Thierry Roisnel , Paul Mosset , Nicolas Levoin , René Grée

From simple quinoxalines to potent oxazolo[5,4-f]quinoxaline inhibitors of glycogen-synthase kinase 3 (GSK3).

Organic & biomolecular chemistry

Avec: Frédéric Lassagne , Camille Duguépéroux , Carlos Roca , Concepcion Perez , Ana Martinez , Blandine Baratte , Thomas Robert , Sandrine Ruchaud , Stéphane Bach , William Erb , Thierry Roisnel , Florence Mongin

Target fishing reveals PfPYK-1 and PfRab6 as potential targets of an antiplasmodial 4-anilino-2-trichloromethylquinazoline hit compound.

Bioorganic & medicinal chemistry

Avec: C Kieffer , N Primas , S Hutter , A Merckx , L Reininger , S Bach , S Ruchaud , F Gaillard , M Laget , D Amrane , L Hervé , C Castera-Ducros , J Renault , A Dumètre , S Rault , C Doerig , P Rathelot , P Vanelle , N Azas , P Verhaeghe

Kinase inhibitions in pyrido[4,3-h] and [3,4-g]quinazolines: Synthesis, SAR and molecular modeling studies.

Bioorganic & medicinal chemistry

Avec: Wael Zeinyeh , Yannick J Esvan , Béatrice Josselin , Blandine Baratte , Stéphane Bach , Lionel Nauton , Vincent Théry , Sandrine Ruchaud , Fabrice Anizon , Francis Giraud , Pascale Moreau

Neurymenolide A, a Novel Mitotic Spindle Poison from the New Caledonian Rhodophyta

Marine drugs

Avec: Sofia-Eléna Motuhi , Omid Feizbakhsh , Béatrice Foll-Josselin , Blandine Baratte , Claire Delehouzé , Arnaud Cousseau , Xavier Fant , Jeannette Chloë Bulinski , Claude Elisabeth Payri , Sandrine Ruchaud , Mohamed Mehiri , Stéphane Bach

The Anti-

Molecules (Basel, Switzerland)

Avec: Maciej Masłyk , Monika Janeczko , Aleksandra Martyna , Sławomir Czernik , Małgorzata Tokarska-Rodak , Marta Chwedczuk , Béatrice Foll-Josselin , Sandrine Ruchaud , Stéphane Bach , Oleg M Demchuk , Konrad Kubiński

From Synthetic Simplified Marine Metabolite Analogues to New Selective Allosteric Inhibitor of Aurora B Kinase.

Journal of medicinal chemistry

Avec: Charlotte Juillet , Ludmila Ermolenko , Dina Boyarskaya , Blandine Baratte , Béatrice Josselin , Hristo Nedev , Stéphane Bach , Bogdan I Iorga , Jérôme Bignon , Sandrine Ruchaud , Ali Al-Mourabit

Exploration of 7-azaindole-coumaranone hybrids and their analogues as protein kinase inhibitors.

Chemico-biological interactions

Avec: Malikotsi A Qhobosheane , Richard M Beteck , Blandine Baratte , Thomas Robert , Sandrine Ruchaud , Stéphane Bach , Lesetja J Legoabe

Kinase-Based Screening of Marine Natural Extracts Leads to the Identification of a Cytotoxic High Molecular Weight Metabolite from the Mediterranean Sponge

Marine drugs

Avec: Thi-Ngoc-Dung Nguyen , Omid Feizbakhsh , Estelle Sfecci , Blandine Baratte , Claire Delehouzé , Adrien Garcia , Corentin Moulin , Pierre Colas , Sandrine Ruchaud , Mohamed Mehiri , Stéphane Bach

Cell cycle-independent furrowing triggered by phosphomimetic mutations of the INCENP STD motif requires Plk1.

Journal of cell science

Avec: Diana Papini , Xavier Fant , Hiromi Ogawa , Nathalie Desban , Kumiko Samejima , Omid Feizbakhsh , Bilge Askin , Tony Ly , William C Earnshaw , Sandrine Ruchaud

Synthesis and evaluation of 7-azaindole derivatives bearing benzocycloalkanone motifs as protein kinase inhibitors.

Bioorganic & medicinal chemistry

Avec: Malikotsi A Qhobosheane , Lesetja J Legoabe , Béatrice Josselin , Stéphane Bach , Sandrine Ruchaud , Jacobus P Petzer , Richard M Beteck

A Peak of H3T3 Phosphorylation Occurs in Synchrony with Mitosis in Sea Urchin Early Embryos.

Cells

Avec: Omid Feizbakhsh , Florian Pontheaux , Virginie Glippa , Julia Morales , Sandrine Ruchaud , Patrick Cormier , Fernando Roch

Synthesis and evaluation of C3 substituted chalcone-based derivatives of 7-azaindole as protein kinase inhibitors.

Chemical biology & drug design

Avec: Malikotsi A Qhobosheane , Lesetja J Legoabe , Béatrice Josselin , Stéphane Bach , Sandrine Ruchaud , Richard M Beteck

Discovery of thiazolidin-4-one analogue as selective GSK-3β inhibitor through structure based virtual screening.

Bioorganic & medicinal chemistry letters

Avec: Bhanwar Singh Choudhary , Sukanya , Pakhuri Mehta , Stephane Bach , Sandrine Ruchaud , Thomas Robert , Beatrice Josselin , Slawomir Filipek , Ruchi Malik

Tetrahydropyridine LIMK inhibitors: Structure activity studies and biological characterization.

European journal of medicinal chemistry

Avec: Anthony Champiré , Rayan Berabez , Abdennour Braka , Aurélie Cosson , Justine Corret , Caroline Girardin , Amandine Serrano , Samia Aci-Sèche , Pascal Bonnet , Béatrice Josselin , Pierre Brindeau , Sandrine Ruchaud , Rémy Leguevel , Deep Chatterjee , Sebastian Mathea , Stefan Knapp , Régis Brion , Franck Verrecchia , Béatrice Vallée , Karen Plé , Hélène Bénédetti , Sylvain Routier

New pyrido[3,4-g]quinazoline derivatives as CLK1 and DYRK1A inhibitors: synthesis, biological evaluation and binding mode analysis.

European journal of medicinal chemistry

Avec: Helmi Tazarki , Wael Zeinyeh , Yannick J Esvan , Stefan Knapp , Deep Chatterjee , Martin Schröder , Andreas C Joerger , Jameleddine Khiari , Béatrice Josselin , Blandine Baratte , Stéphane Bach , Sandrine Ruchaud , Fabrice Anizon , Francis Giraud , Pascale Moreau

Design, biological evaluation and X-ray crystallography of nanomolar multifunctional ligands targeting simultaneously acetylcholinesterase and glycogen synthase kinase-3.

European journal of medicinal chemistry

Avec: Killian Oukoloff , Nicolas Coquelle , Manuela Bartolini , Marina Naldi , Rémy Le Guevel , Stéphane Bach , Béatrice Josselin , Sandrine Ruchaud , Marco Catto , Leonardo Pisani , Nunzio Denora , Rosa Maria Iacobazzi , Israel Silman , Joel L Sussman , Frédéric Buron , Jacques-Philippe Colletier , Ludovic Jean , Sylvain Routier , Pierre-Yves Renard

Functionalization of 9-thioxanthone at the 1-position: From arylamino derivatives to [1]benzo(thio)pyrano[4,3,2-de]benzothieno[2,3-b]quinolines of biological interest.

Bioorganic chemistry

Avec: Nahida Mokhtari Brikci-Nigassa , Lionel Nauton , Pascale Moreau , Olivier Mongin , Raphaël E Duval , Laurent Picot , Valérie Thiéry , Mohamed Souab , Blandine Baratte , Sandrine Ruchaud , Stéphane Bach , Rémy Le Guevel , Ghenia Bentabed-Ababsa , William Erb , Thierry Roisnel , Vincent Dorcet , Florence Mongin

Synthesis and biological evaluation of Haspin inhibitors: Kinase inhibitory potency and cellular activity.

European journal of medicinal chemistry

Avec: Wael Zeinyeh , Yannick J Esvan , Béatrice Josselin , Mathilde Defois , Blandine Baratte , Stefan Knapp , Apirat Chaikuad , Fabrice Anizon , Francis Giraud , Sandrine Ruchaud , Pascale Moreau

Design and biological evaluation of substituted 5,7-dihydro-6

Journal of enzyme inhibition and medicinal chemistry

Avec: Sreenivas Avula , Xudan Peng , Xingfen Lang , Micky Tortorella , Béatrice Josselin , Stéphane Bach , Stephane Bourg , Pascal Bonnet , Frédéric Buron , Sandrine Ruchaud , Sylvain Routier , Cleopatra Neagoie

Synthesis and biological evaluation of selected 7H-pyrrolo[2,3-d]pyrimidine derivatives as novel CDK9/CyclinT and Haspin inhibitors.

Chemico-biological interactions

Avec: Lianie Pieterse , Richard M Beteck , Blandine Baratte , Omobolanle J Jesumoroti , Thomas Robert , Sandrine Ruchaud , Stéphane Bach , Lesetja J Legoabe

Structure Activity Relationship Studies around

Molecules (Basel, Switzerland)

Avec: Dabbugoddu Brahmaiah , Anagani Kanaka Durga Bhavani , Pasula Aparna , Nangunoori Sampath Kumar , Hélène Solhi , Rémy Le Guevel , Blandine Baratte , Thomas Robert , Sandrine Ruchaud , Stéphane Bach , Surender Singh Jadav , Chada Raji Reddy , Paul Mosset , Nicolas Gouault , Nicolas Levoin , René Grée

Synthesis and biological evaluation of 1H-pyrrolo[3,2-g]isoquinolines.

Bioorganic & medicinal chemistry

Avec: Mathilde Defois , Béatrice Josselin , Pierre Brindeau , Andreas Krämer , Stefan Knapp , Fabrice Anizon , Francis Giraud , Sandrine Ruchaud , Pascale Moreau

Réseau de co-auteurs

Stéphane Bach 19 collaborations

Blandine Baratte 15 collaborations

Béatrice Josselin 13 collaborations

Pascale Moreau 6 collaborations

Omid Feizbakhsh 5 collaborations

Stefan Knapp 5 collaborations

Fabrice Anizon 5 collaborations

Francis Giraud 5 collaborations

Thomas Robert 5 collaborations

Sylvain Routier 4 collaborations

Rémy Le Guevel 4 collaborations

Richard M Beteck 4 collaborations

Lesetja J Legoabe 4 collaborations

Claire Delehouzé 3 collaborations

Xavier Fant 3 collaborations

Pascal Bonnet 3 collaborations

Frédéric Buron 3 collaborations

Mathilde Defois 3 collaborations

Lionel Nauton 3 collaborations

Thierry Roisnel 3 collaborations

Wael Zeinyeh 3 collaborations

Yannick J Esvan 3 collaborations

Malikotsi A Qhobosheane 3 collaborations

Ludmila Ermolenko 2 collaborations

Hristo Nedev 2 collaborations

Mohamed Souab 2 collaborations

Bogdan I Iorga 2 collaborations

Ali Al-Mourabit 2 collaborations

Nathalie Desban 2 collaborations

Apirat Chaikuad 2 collaborations

Vincent Théry 2 collaborations

Dabbugoddu Brahmaiah 2 collaborations

Anagani Kanaka Durga Bhavani 2 collaborations

Pasula Aparna 2 collaborations

Nangunoori Sampath Kumar 2 collaborations

Hélène Solhi 2 collaborations

Surender Singh Jadav 2 collaborations

Chada Raji Reddy 2 collaborations

Paul Mosset 2 collaborations

Nicolas Levoin 2 collaborations

René Grée 2 collaborations

William Erb 2 collaborations

Florence Mongin 2 collaborations

Béatrice Foll-Josselin 2 collaborations

Mohamed Mehiri 2 collaborations

Pierre Brindeau 2 collaborations

Deep Chatterjee 2 collaborations

Mohamed Benchekroun 1 collaboration

Minh Quan Tran 1 collaboration

Agathe Vagneux 1 collaboration

Jonathan Elie 1 collaboration

Amandine Bescond 1 collaboration

Julien Duez 1 collaboration

Dominique Marie 1 collaboration

Matthieu Place 1 collaboration

Sami Ben Salah 1 collaboration

Agnes Chartier 1 collaboration

Sabine Berteina-Raboin 1 collaboration

Fabrice Carles 1 collaboration

Chloé Rémondin 1 collaboration

Anne Cecília Nascimento da Cruz 1 collaboration

Dalci José Brondani 1 collaboration

Temístocles I Talo de Santana 1 collaboration

Lucas Oliveira da Silva 1 collaboration

Elizabeth Fernanda da Oliveira Borba 1 collaboration

Antônio Rodolfo de Faria 1 collaboration

Julianna Ferreira Cavalcanti de Albuquerque 1 collaboration

Sylvie Piessard 1 collaboration

Rafael Matos Ximenes 1 collaboration

Francisco Jaime Bezerra Mendonça Junior 1 collaboration

Marc-Antoine Bazin 1 collaboration

Marcelo Montenegro Rabello 1 collaboration

Marcelo Zaldini Hernandes 1 collaboration

Pascal Marchand 1 collaboration

Teresinha Gonçalves da Silva 1 collaboration

Frédéric Lassagne 1 collaboration

Camille Duguépéroux 1 collaboration

Carlos Roca 1 collaboration

Concepcion Perez 1 collaboration

Ana Martinez 1 collaboration

C Kieffer 1 collaboration

N Primas 1 collaboration

S Hutter 1 collaboration

A Merckx 1 collaboration

L Reininger 1 collaboration

S Bach 1 collaboration

S Ruchaud 1 collaboration

F Gaillard 1 collaboration

M Laget 1 collaboration

D Amrane 1 collaboration

L Hervé 1 collaboration

C Castera-Ducros 1 collaboration

J Renault 1 collaboration

A Dumètre 1 collaboration

S Rault 1 collaboration

C Doerig 1 collaboration

P Rathelot 1 collaboration

P Vanelle 1 collaboration

N Azas 1 collaboration

P Verhaeghe 1 collaboration

Sofia-Eléna Motuhi 1 collaboration

Arnaud Cousseau 1 collaboration

Jeannette Chloë Bulinski 1 collaboration

Claude Elisabeth Payri 1 collaboration

Maciej Masłyk 1 collaboration

Monika Janeczko 1 collaboration

Aleksandra Martyna 1 collaboration

Sławomir Czernik 1 collaboration

Małgorzata Tokarska-Rodak 1 collaboration

Marta Chwedczuk 1 collaboration

Oleg M Demchuk 1 collaboration

Konrad Kubiński 1 collaboration

Charlotte Juillet 1 collaboration

Dina Boyarskaya 1 collaboration

Jérôme Bignon 1 collaboration

Thi-Ngoc-Dung Nguyen 1 collaboration

Estelle Sfecci 1 collaboration

Adrien Garcia 1 collaboration

Corentin Moulin 1 collaboration

Pierre Colas 1 collaboration

Diana Papini 1 collaboration

Hiromi Ogawa 1 collaboration

Kumiko Samejima 1 collaboration

Bilge Askin 1 collaboration

Tony Ly 1 collaboration

William C Earnshaw 1 collaboration

Jacobus P Petzer 1 collaboration

Florian Pontheaux 1 collaboration

Virginie Glippa 1 collaboration

Julia Morales 1 collaboration

Patrick Cormier 1 collaboration

Fernando Roch 1 collaboration

Bhanwar Singh Choudhary 1 collaboration

None Sukanya 1 collaboration

Pakhuri Mehta 1 collaboration

Stephane Bach 1 collaboration

Beatrice Josselin 1 collaboration

Slawomir Filipek 1 collaboration

Ruchi Malik 1 collaboration

Anthony Champiré 1 collaboration

Rayan Berabez 1 collaboration

Abdennour Braka 1 collaboration

Aurélie Cosson 1 collaboration

Justine Corret 1 collaboration

Caroline Girardin 1 collaboration

Amandine Serrano 1 collaboration

Samia Aci-Sèche 1 collaboration

Rémy Leguevel 1 collaboration

Sebastian Mathea 1 collaboration

Régis Brion 1 collaboration

Franck Verrecchia 1 collaboration

Béatrice Vallée 1 collaboration

Karen Plé 1 collaboration

Hélène Bénédetti 1 collaboration

Helmi Tazarki 1 collaboration

Martin Schröder 1 collaboration

Andreas C Joerger 1 collaboration

Jameleddine Khiari 1 collaboration

Killian Oukoloff 1 collaboration

Nicolas Coquelle 1 collaboration

Manuela Bartolini 1 collaboration

Marina Naldi 1 collaboration

Marco Catto 1 collaboration

Leonardo Pisani 1 collaboration

Nunzio Denora 1 collaboration

Rosa Maria Iacobazzi 1 collaboration

Israel Silman 1 collaboration

Joel L Sussman 1 collaboration

Jacques-Philippe Colletier 1 collaboration

Ludovic Jean 1 collaboration

Pierre-Yves Renard 1 collaboration

Nahida Mokhtari Brikci-Nigassa 1 collaboration

Olivier Mongin 1 collaboration

Raphaël E Duval 1 collaboration

Laurent Picot 1 collaboration

Valérie Thiéry 1 collaboration

Ghenia Bentabed-Ababsa 1 collaboration

Vincent Dorcet 1 collaboration

Sreenivas Avula 1 collaboration

Xudan Peng 1 collaboration

Xingfen Lang 1 collaboration

Micky Tortorella 1 collaboration

Stephane Bourg 1 collaboration

Cleopatra Neagoie 1 collaboration

Lianie Pieterse 1 collaboration

Omobolanle J Jesumoroti 1 collaboration

Nicolas Gouault 1 collaboration

Andreas Krämer 1 collaboration