Ryan J Hartmaier

Affiliations

Foundation Medicine Inc., Cambridge, Massachusetts.

Publications (13)

ERBB3 and IGF1R Signaling Are Required for Nrf2-Dependent Growth in KEAP1-Mutant Lung Cancer.

Cancer research

Avec: Steffan Vartanian , James Lee , Christiaan Klijn , Florian Gnad , Maria Bagniewska , Gabriele Schaefer , Donglu Zhang , Jenille Tan , Sara A Watson , Liling Liu , Honglin Chen , Yuxin Liang , Colin Watanabe , Trinna Cuellar , David Kan , Ryan J Hartmaier , Ted Lau , Michael R Costa , Scott E Martin , Mark Merchant , Benjamin Haley , David Stokoe

Osimertinib plus Selumetinib in EGFR-Mutated Non-Small Cell Lung Cancer After Progression on EGFR-TKIs: A Phase Ib, Open-Label, Multicenter Trial (TATTON Part B).

Clinical cancer research : an official journal of the American Association for Cancer Research

Avec: James Chih-Hsin Yang , Yuichiro Ohe , Chao-Hua Chiu , Xiaoling Ou , Mireille Cantarini , Pasi A Jänne , Ryan J Hartmaier , Myung Ju Ahn

A Novel Next-Generation Sequencing Approach to Detecting Microsatellite Instability and Pan-Tumor Characterization of 1000 Microsatellite Instability-High Cases in 67,000 Patient Samples.

The Journal of molecular diagnostics : JMD

Avec: Sally E Trabucco , Kyle Gowen , Sophia L Maund , Eric Sanford , David A Fabrizio , Michael J Hall , Evgeny Yakirevich , Jeffrey P Gregg , Phil J Stephens , Garrett M Frampton , Priti S Hegde , Vincent A Miller , Jeffrey S Ross , Ryan J Hartmaier , Shih-Min A Huang , James X Sun

Osimertinib + Savolitinib to Overcome Acquired MET-Mediated Resistance in Epidermal Growth Factor Receptor-Mutated, MET-Amplified Non-Small Cell Lung Cancer: TATTON.

Cancer discovery

Avec: Ryan J Hartmaier , Aleksandra A Markovets , Myung Ju Ahn , Lecia V Sequist , Ji-Youn Han , Byoung Chul Cho , Helena A Yu , Sang-We Kim , James Chih-Hsin Yang , Jong-Seok Lee , Wu-Chou Su , Dariusz M Kowalski , Sergey Orlov , Song Ren , Paul Frewer , Xiaoling Ou , Darren A E Cross , Nisha Kurian , Mireille Cantarini , Pasi A Jänne

Early Clearance of Plasma Epidermal Growth Factor Receptor Mutations as a Predictor of Outcome on Osimertinib in Advanced Non-Small Cell Lung Cancer; Exploratory Analysis from AURA3 and FLAURA.

Clinical cancer research : an official journal of the American Association for Cancer Research

Avec: Jhanelle E Gray , Myung-Ju Ahn , Geoffrey R Oxnard , Frances A Shepherd , Fumio Imamura , Ying Cheng , Isamu Okamoto , Byoung Chul Cho , Meng-Chih Lin , Yi-Long Wu , Margarita Majem , Oliver Gautschi , Michael Boyer , Krishna C Bulusu , Aleksandra Markovets , J Carl Barrett , Rachel Hodge , Astrid McKeown , Ryan J Hartmaier , Juliann Chmielecki , Vassiliki A Papadimitrakopoulou , Suresh S Ramalingam

Loss of function of NF1 is a mechanism of acquired resistance to endocrine therapy in lobular breast cancer.

Annals of oncology : official journal of the European Society for Medical Oncology

Avec: E S Sokol , Y X Feng , D X Jin , A Basudan , A V Lee , J M Atkinson , J Chen , P J Stephens , G M Frampton , P B Gupta , J S Ross , J H Chung , S Oesterreich , S M Ali , R J Hartmaier

Frequent ESR1 and CDK Pathway Copy-Number Alterations in Metastatic Breast Cancer.

Molecular cancer research : MCR

Avec: Ahmed Basudan , Nolan Priedigkeit , Ryan J Hartmaier , Ethan S Sokol , Amir Bahreini , Rebecca J Watters , Michelle M Boisen , Rohit Bhargava , Kurt R Weiss , Maria M Karsten , Carsten Denkert , Jens-Uwe Blohmer , Jose P Leone , Ronald L Hamilton , Adam M Brufsky , Esther Elishaev , Peter C Lucas , Adrian V Lee , Steffi Oesterreich

The genomic landscape of metastatic breast cancer: Insights from 11,000 tumors.

PloS one

Avec: Jacob Rinaldi , Ethan S Sokol , Ryan J Hartmaier , Sally E Trabucco , Garrett M Frampton , Michael E Goldberg , Lee A Albacker , Anneleen Daemen , Gerard Manning

Analysis of acquired resistance mechanisms to osimertinib in patients with EGFR-mutated advanced non-small cell lung cancer from the AURA3 trial.

Nature communications

Avec: Juliann Chmielecki , Tony Mok , Yi-Long Wu , Ji-Youn Han , Myung-Ju Ahn , Suresh S Ramalingam , Thomas John , Isamu Okamoto , James Chih-Hsin Yang , Frances A Shepherd , Krishna C Bulusu , Gianluca Laus , Barbara Collins , J Carl Barrett , Ryan J Hartmaier , Vassiliki Papadimitrakopoulou

FGFR4 overexpression and hotspot mutations in metastatic ER+ breast cancer are enriched in the lobular subtype.

NPJ breast cancer

Avec: Kevin M Levine , Nolan Priedigkeit , Ahmed Basudan , Nilgun Tasdemir , Matthew J Sikora , Ethan S Sokol , Ryan J Hartmaier , Kai Ding , Nedah Z Ahmad , Rebecca J Watters , Kurt R Weiss , Jens-Uwe Blohmer , Carsten Denkert , Anna Machleidt , Maria M Karsten , Michelle M Boisen , Esther Elishaev , Peter C Lucas , Adrian V Lee , Steffi Oesterreich

Targeted mutation detection in breast cancer using MammaSeq™.

Breast cancer research : BCR

Avec: Nicholas G Smith , Rekha Gyanchandani , Osama S Shah , Grzegorz T Gurda , Peter C Lucas , Ryan J Hartmaier , Adam M Brufsky , Shannon Puhalla , Amir Bahreini , Karthik Kota , Abigail I Wald , Yuri E Nikiforov , Marina N Nikiforova , Steffi Oesterreich , Adrian V Lee

A Novel Mouse Model for SNP in Steroid Receptor Co-Activator-1 Reveals Role in Bone Density and Breast Cancer Metastasis.

Endocrinology

Avec: Rebecca J Watters , Kostas Verdelis , Peter C Lucas , Shiming Jiang , Yuqing Chen , Feiqi Lu , Benjamin M Martin , Lyuda Lukashova , Geoffrey Pecar , Alejandro Morales-Restrepo , Margaret Hankins , Li Zhu , Peter Mittwede , Ryan J Hartmaier , Peter G Alexander , George C Tseng , Kurt R Weiss , Deborah L Galson , Adrian V Lee , Brendan Lee , Steffi Oesterreich

Candidate mechanisms of acquired resistance to first-line osimertinib in EGFR-mutated advanced non-small cell lung cancer.

Nature communications

Avec: Juliann Chmielecki , Jhanelle E Gray , Ying Cheng , Yuichiro Ohe , Fumio Imamura , Byoung Chul Cho , Meng-Chih Lin , Margarita Majem , Riyaz Shah , Yuri Rukazenkov , Alexander Todd , Aleksandra Markovets , J Carl Barrett , Ryan J Hartmaier , Suresh S Ramalingam

Réseau de co-auteurs

Peter C Lucas 4 collaborations

Adrian V Lee 4 collaborations

Steffi Oesterreich 4 collaborations

James Chih-Hsin Yang 3 collaborations

Byoung Chul Cho 3 collaborations

J Carl Barrett 3 collaborations

Juliann Chmielecki 3 collaborations

Suresh S Ramalingam 3 collaborations

Ethan S Sokol 3 collaborations

Rebecca J Watters 3 collaborations

Kurt R Weiss 3 collaborations

Yuichiro Ohe 2 collaborations

Xiaoling Ou 2 collaborations

Mireille Cantarini 2 collaborations

Pasi A Jänne 2 collaborations

Myung Ju Ahn 2 collaborations

Sally E Trabucco 2 collaborations

Garrett M Frampton 2 collaborations

Ji-Youn Han 2 collaborations

Jhanelle E Gray 2 collaborations

Myung-Ju Ahn 2 collaborations

Frances A Shepherd 2 collaborations

Fumio Imamura 2 collaborations

Ying Cheng 2 collaborations

Isamu Okamoto 2 collaborations

Meng-Chih Lin 2 collaborations

Yi-Long Wu 2 collaborations

Margarita Majem 2 collaborations

Krishna C Bulusu 2 collaborations

Aleksandra Markovets 2 collaborations

Ahmed Basudan 2 collaborations

Nolan Priedigkeit 2 collaborations

Amir Bahreini 2 collaborations

Michelle M Boisen 2 collaborations

Maria M Karsten 2 collaborations

Carsten Denkert 2 collaborations

Jens-Uwe Blohmer 2 collaborations

Adam M Brufsky 2 collaborations

Esther Elishaev 2 collaborations

Steffan Vartanian 1 collaboration

James Lee 1 collaboration

Christiaan Klijn 1 collaboration

Florian Gnad 1 collaboration

Maria Bagniewska 1 collaboration

Gabriele Schaefer 1 collaboration

Donglu Zhang 1 collaboration

Jenille Tan 1 collaboration

Sara A Watson 1 collaboration

Liling Liu 1 collaboration

Honglin Chen 1 collaboration

Yuxin Liang 1 collaboration

Colin Watanabe 1 collaboration

Trinna Cuellar 1 collaboration

David Kan 1 collaboration

Ted Lau 1 collaboration

Michael R Costa 1 collaboration

Scott E Martin 1 collaboration

Mark Merchant 1 collaboration

Benjamin Haley 1 collaboration

David Stokoe 1 collaboration

Chao-Hua Chiu 1 collaboration

Kyle Gowen 1 collaboration

Sophia L Maund 1 collaboration

Eric Sanford 1 collaboration

David A Fabrizio 1 collaboration

Michael J Hall 1 collaboration

Evgeny Yakirevich 1 collaboration

Jeffrey P Gregg 1 collaboration

Phil J Stephens 1 collaboration

Priti S Hegde 1 collaboration

Vincent A Miller 1 collaboration

Jeffrey S Ross 1 collaboration

Shih-Min A Huang 1 collaboration

James X Sun 1 collaboration

Aleksandra A Markovets 1 collaboration

Lecia V Sequist 1 collaboration

Helena A Yu 1 collaboration

Sang-We Kim 1 collaboration

Jong-Seok Lee 1 collaboration

Wu-Chou Su 1 collaboration

Dariusz M Kowalski 1 collaboration

Sergey Orlov 1 collaboration

Song Ren 1 collaboration

Paul Frewer 1 collaboration

Darren A E Cross 1 collaboration

Nisha Kurian 1 collaboration

Geoffrey R Oxnard 1 collaboration

Oliver Gautschi 1 collaboration

Michael Boyer 1 collaboration

Rachel Hodge 1 collaboration

Astrid McKeown 1 collaboration

Vassiliki A Papadimitrakopoulou 1 collaboration

E S Sokol 1 collaboration

Y X Feng 1 collaboration

D X Jin 1 collaboration

A Basudan 1 collaboration

A V Lee 1 collaboration

J M Atkinson 1 collaboration

J Chen 1 collaboration

P J Stephens 1 collaboration

G M Frampton 1 collaboration

P B Gupta 1 collaboration

J S Ross 1 collaboration

J H Chung 1 collaboration

S Oesterreich 1 collaboration

S M Ali 1 collaboration

R J Hartmaier 1 collaboration

Rohit Bhargava 1 collaboration

Jose P Leone 1 collaboration

Ronald L Hamilton 1 collaboration

Jacob Rinaldi 1 collaboration

Michael E Goldberg 1 collaboration

Lee A Albacker 1 collaboration

Anneleen Daemen 1 collaboration

Gerard Manning 1 collaboration

Tony Mok 1 collaboration

Thomas John 1 collaboration

Gianluca Laus 1 collaboration

Barbara Collins 1 collaboration

Vassiliki Papadimitrakopoulou 1 collaboration

Kevin M Levine 1 collaboration

Nilgun Tasdemir 1 collaboration

Matthew J Sikora 1 collaboration

Kai Ding 1 collaboration

Nedah Z Ahmad 1 collaboration

Anna Machleidt 1 collaboration

Nicholas G Smith 1 collaboration

Rekha Gyanchandani 1 collaboration

Osama S Shah 1 collaboration

Grzegorz T Gurda 1 collaboration

Shannon Puhalla 1 collaboration

Karthik Kota 1 collaboration

Abigail I Wald 1 collaboration

Yuri E Nikiforov 1 collaboration

Marina N Nikiforova 1 collaboration

Kostas Verdelis 1 collaboration

Shiming Jiang 1 collaboration

Yuqing Chen 1 collaboration

Feiqi Lu 1 collaboration

Benjamin M Martin 1 collaboration

Lyuda Lukashova 1 collaboration

Geoffrey Pecar 1 collaboration

Alejandro Morales-Restrepo 1 collaboration

Margaret Hankins 1 collaboration

Li Zhu 1 collaboration

Peter Mittwede 1 collaboration

Peter G Alexander 1 collaboration

George C Tseng 1 collaboration

Deborah L Galson 1 collaboration

Brendan Lee 1 collaboration

Riyaz Shah 1 collaboration

Yuri Rukazenkov 1 collaboration

Alexander Todd 1 collaboration