Rohit V Pappu

Affiliations

Department of Biomedical Engineering and Center for Science & Engineering of Living Systems (CSELS) , Washington University in St. Louis , One Brookings Drive , Campus Box 1097, St. Louis , Missouri 63130 , United States.

ORCID: 0000-0003-2568-1378

Publications (46)

The journal of physical chemistry. B

Avec: Martin J Fossat , Rohit V Pappu

Connecting Coil-to-Globule Transitions to Full Phase Diagrams for Intrinsically Disordered Proteins.

Biophysical journal

Avec: Xiangze Zeng , Alex S Holehouse , Ashutosh Chilkoti , Tanja Mittag , Rohit V Pappu

Quantifying charge state heterogeneity for proteins with multiple ionizable residues.

Biophysical journal

Avec: Martin J Fossat , Ammon E Posey , Rohit V Pappu

Glycine-Rich Peptides from FUS Have an Intrinsic Ability to Self-Assemble into Fibers and Networked Fibrils.

Biochemistry

Avec: Mrityunjoy Kar , Ammon E Posey , Furqan Dar , Anthony A Hyman , Rohit V Pappu

Directed mutational scanning reveals a balance between acidic and hydrophobic residues in strong human activation domains.

Cell systems

Avec: Max V Staller , Eddie Ramirez , Sanjana R Kotha , Alex S Holehouse , Rohit V Pappu , Barak A Cohen

Biomolecular condensates are characterized by interphase electric potentials.

bioRxiv : the preprint server for biology

Avec: Ammon E Posey , Anne Bremer , Nadia A Erkamp , Avnika Pant , Tuomas P J Knowles , Yifan Dai , Tanja Mittag , Rohit V Pappu

Biomolecular condensates can function as inherent catalysts.

bioRxiv : the preprint server for biology

Avec: Xiao Guo , Mina Farag , Naixin Qian , Xia Yu , Anton Ni , Yuefeng Ma , Wen Yu , Matthew R King , Vicky Liu , Joonho Lee , Richard N Zare , Wei Min , Rohit V Pappu , Yifan Dai

Dynamical control enables the formation of demixed biomolecular condensates.

bioRxiv : the preprint server for biology

Avec: Andrew Z Lin , Kiersten M Ruff , Ameya Jalihal , Furqan Dar , Matthew R King , Jared M Lalmansingh , Ammon E Posey , Ian Seim , Amy S Gladfelter , Rohit V Pappu

Sequence-encoded grammars determine material properties and physical aging of protein condensates.

bioRxiv : the preprint server for biology

Avec: Ibraheem Alshareedah , Wade M Borcherds , Samuel R Cohen , Mina Farag , Anurag Singh , Anne Bremer , Rohit V Pappu , Tanja Mittag , Priya R Banerjee

FIREBALL: A tool to fit protein phase diagrams based on mean-field theories for polymer solutions.

Biophysical journal

Avec: Mina Farag , Alex S Holehouse , Xiangze Zeng , Rohit V Pappu

Dynamical control enables the formation of demixed biomolecular condensates.

Nature communications

Avec: Andrew Z Lin , Kiersten M Ruff , Furqan Dar , Ameya Jalihal , Matthew R King , Jared M Lalmansingh , Ammon E Posey , Nadia A Erkamp , Ian Seim , Amy S Gladfelter , Rohit V Pappu

Dissecting the Functional Contributions of the Intrinsically Disordered C-terminal Tail of Bacillus subtilis FtsZ.

Journal of molecular biology

Avec: Megan C Cohan , Anna M P Eddelbuettel , Petra A Levin , Rohit V Pappu

Making the Case for Disordered Proteins and Biomolecular Condensates in Bacteria.

Trends in biochemical sciences

Avec: Megan C Cohan , Rohit V Pappu

Arginine-Enriched Mixed-Charge Domains Provide Cohesion for Nuclear Speckle Condensation.

Molecular cell

Avec: Jamie A Greig , Tu Anh Nguyen , Michelle Lee , Alex S Holehouse , Ammon E Posey , Rohit V Pappu , Gregory Jedd

Physical Principles Underlying the Complex Biology of Intracellular Phase Transitions.

Annual review of biophysics

Avec: Jeong-Mo Choi , Alex S Holehouse , Rohit V Pappu

Deciphering how naturally occurring sequence features impact the phase behaviours of disordered prion-like domains.

Nature chemistry

Avec: Anne Bremer , Mina Farag , Wade M Borcherds , Ivan Peran , Erik W Martin , Rohit V Pappu , Tanja Mittag

Endocytic proteins with prion-like domains form viscoelastic condensates that enable membrane remodeling.

Proceedings of the National Academy of Sciences of the United States of America

Avec: Louis-Philippe Bergeron-Sandoval , Sandeep Kumar , Hossein Khadivi Heris , Catherine L A Chang , Caitlin E Cornell , Sarah L Keller , Paul François , Adam G Hendricks , Allen J Ehrlicher , Rohit V Pappu , Stephen W Michnick

Ligand effects on phase separation of multivalent macromolecules.

Proceedings of the National Academy of Sciences of the United States of America

Avec: Kiersten M Ruff , Furqan Dar , Rohit V Pappu

Phase Separation-A Physical Mechanism for Organizing Information and Biochemical Reactions.

Developmental cell

Avec: Rohit V Pappu

A conceptual framework for understanding phase separation and addressing open questions and challenges.

Molecular cell

Avec: Tanja Mittag , Rohit V Pappu

AlphaFold and Implications for Intrinsically Disordered Proteins.

Journal of molecular biology

Avec: Kiersten M Ruff , Rohit V Pappu

Connecting sequence features within the disordered C-terminal linker of

Proceedings of the National Academy of Sciences of the United States of America

Avec: Min Kyung Shinn , Megan C Cohan , Jessie L Bullock , Kiersten M Ruff , Petra A Levin , Rohit V Pappu

Sequence grammar underlying the unfolding and phase separation of globular proteins.

Molecular cell

Avec: Kiersten M Ruff , Yoon Hee Choi , Dezerae Cox , Angelique R Ormsby , Yoochan Myung , David B Ascher , Sheena E Radford , Rohit V Pappu , Danny M Hatters

Quantifying Coexistence Concentrations in Multi-Component Phase-Separating Systems Using Analytical HPLC.

Biomolecules

Avec: Anne Bremer , Ammon E Posey , Madeleine B Borgia , Wade M Borcherds , Mina Farag , Rohit V Pappu , Tanja Mittag

Dynamical control enables the formation of demixed biomolecular condensates.

Research square

Avec: Andrew Z Lin , Kiersten M Ruff , Ameya Jalihal , Furqan Dar , Matthew R King , Jared M Lalmansingh , Ammon E Posey , Ian Seim , Amy S Gladfelter , Rohit V Pappu

SOURSOP: A Python package for the analysis of simulations of intrinsically disordered proteins.

bioRxiv : the preprint server for biology

Avec: Jared M Lalmansingh , Alex T Keeley , Kiersten M Ruff , Rohit V Pappu , Alex S Holehouse

Condensates formed by prion-like low-complexity domains have small-world network structures and interfaces defined by expanded conformations.

Nature communications

Avec: Mina Farag , Samuel R Cohen , Wade M Borcherds , Anne Bremer , Tanja Mittag , Rohit V Pappu

Tear down this wall: phosphorylation regulates the internal interfaces of postsynaptic condensates.

Trends in cell biology

Avec: Gerard Aguilar Pérez , Rohit V Pappu , Dragomir Milovanovic

Biomolecular Condensates are Characterized by Interphase Electric Potentials.

Journal of the American Chemical Society

Avec: Ammon E Posey , Anne Bremer , Nadia A Erkamp , Avnika Pant , Tuomas P J Knowles , Yifan Dai , Tanja Mittag , Rohit V Pappu

Sequence-specific interactions determine viscoelasticity and aging dynamics of protein condensates.

Nature physics

Avec: Ibraheem Alshareedah , Wade M Borcherds , Samuel R Cohen , Anurag Singh , Ammon E Posey , Mina Farag , Anne Bremer , Gregory W Strout , Dylan T Tomares , Rohit V Pappu , Tanja Mittag , Priya R Banerjee

Nucleo-cytoplasmic Partitioning of ARF Proteins Controls Auxin Responses in Arabidopsis thaliana.

Molecular cell

Avec: Samantha K Powers , Alex S Holehouse , David A Korasick , Katherine H Schreiber , Natalie M Clark , Hongwei Jing , Ryan Emenecker , Soeun Han , Eric Tycksen , Ildoo Hwang , Rosangela Sozzani , Joseph M Jez , Rohit V Pappu , Lucia C Strader

Improvements to the ABSINTH Force Field for Proteins Based on Experimentally Derived Amino Acid Specific Backbone Conformational Statistics.

Journal of chemical theory and computation

Avec: Jeong-Mo Choi , Rohit V Pappu

Spontaneous driving forces give rise to protein-RNA condensates with coexisting phases and complex material properties.

Proceedings of the National Academy of Sciences of the United States of America

Avec: Steven Boeynaems , Alex S Holehouse , Venera Weinhardt , Denes Kovacs , Joris Van Lindt , Carolyn Larabell , Ludo Van Den Bosch , Rhiju Das , Peter S Tompa , Rohit V Pappu , Aaron D Gitler

Uncovering Differences in Hydration Free Energies and Structures for Model Compound Mimics of Charged Side Chains of Amino Acids.

The journal of physical chemistry. B

Avec: Martin J Fossat , Xiangze Zeng , Rohit V Pappu

Proteomic and functional mapping of cardiac NaV1.5 channel phosphorylation sites.

The Journal of general physiology

Avec: Maxime Lorenzini , Sophie Burel , Adrien Lesage , Emily Wagner , Camille Charrière , Pierre-Marie Chevillard , Bérangère Evrard , Dan Maloney , Kiersten M Ruff , Rohit V Pappu , Stefan Wagner , Jeanne M Nerbonne , Jonathan R Silva , R Reid Townsend , Lars S Maier , Céline Marionneau

PED in 2021: a major update of the protein ensemble database for intrinsically disordered proteins.

Nucleic acids research

Avec: Tamas Lazar , Elizabeth Martínez-Pérez , Federica Quaglia , András Hatos , Lucía B Chemes , Javier A Iserte , Nicolás A Méndez , Nicolás A Garrone , Tadeo E Saldaño , Julia Marchetti , Ana Julia Velez Rueda , Pau Bernadó , Martin Blackledge , Tiago N Cordeiro , Eric Fagerberg , Julie D Forman-Kay , Maria S Fornasari , Toby J Gibson , Gregory-Neal W Gomes , Claudiu C Gradinaru , Teresa Head-Gordon , Malene Ringkjøbing Jensen , Edward A Lemke , Sonia Longhi , Cristina Marino-Buslje , Giovanni Minervini , Tanja Mittag , Alexander Miguel Monzon , Rohit V Pappu , Gustavo Parisi , Sylvie Ricard-Blum , Kiersten M Ruff , Edoardo Salladini , Marie Skepö , Dmitri Svergun , Sylvain D Vallet , Mihaly Varadi , Peter Tompa , Silvio C E Tosatto , Damiano Piovesan

Mechanistic Inferences From Analysis of Measurements of Protein Phase Transitions in Live Cells.

Journal of molecular biology

Avec: Ammon E Posey , Kiersten M Ruff , Jared M Lalmansingh , Tejbir S Kandola , Jeffrey J Lange , Randal Halfmann , Rohit V Pappu

Beyond aggregation: Pathological phase transitions in neurodegenerative disease.

Science (New York, N.Y.)

Avec: Cécile Mathieu , Rohit V Pappu , J Paul Taylor

Dilute phase oligomerization can oppose phase separation and modulate material properties of a ribonucleoprotein condensate.

Proceedings of the National Academy of Sciences of the United States of America

Avec: Ian Seim , Ammon E Posey , Wilton T Snead , Benjamin M Stormo , Daphne Klotsa , Rohit V Pappu , Amy S Gladfelter

Developments in describing equilibrium phase transitions of multivalent associative macromolecules.

Current opinion in structural biology

Avec: Xiangze Zeng , Rohit V Pappu

Glutamate helps unmask the differences in driving forces for phase separation versus clustering of FET family proteins in sub-saturated solutions.

bioRxiv : the preprint server for biology

Avec: Mrityunjoy Kar , Laura T Vogel , Gaurav Chauhan , Hannes Ausserwöger , Timothy J Welsh , Anjana R Kamath , Tuomas P J Knowles , Anthony A Hyman , Claus A M Seidel , Rohit V Pappu

Dominance Analysis: A formalism to uncover dominant energetic contributions to biomolecular condensate formation in multicomponent systems.

bioRxiv : the preprint server for biology

Avec: Daoyuan Qian , Hannes Ausserwoger , Tomas Sneideris , Mina Farag , Rohit V Pappu , Tuomas P J Knowles

Uncovering the Contributions of Charge Regulation to the Stability of Single Alpha Helices.

Chemphyschem : a European journal of chemical physics and physical chemistry

Avec: Martin J Fossat , Ammon E Posey , Rohit V Pappu

Phase Separation in Mixtures of Prion-Like Low Complexity Domains is Driven by the Interplay of Homotypic and Heterotypic Interactions.

bioRxiv : the preprint server for biology

Avec: Mina Farag , Wade M Borcherds , Anne Bremer , Tanja Mittag , Rohit V Pappu

Phase separation of protein mixtures is driven by the interplay of homotypic and heterotypic interactions.

Nature communications

Avec: Mina Farag , Wade M Borcherds , Anne Bremer , Tanja Mittag , Rohit V Pappu

SOURSOP: A Python Package for the Analysis of Simulations of Intrinsically Disordered Proteins.

Journal of chemical theory and computation

Avec: Jared M Lalmansingh , Alex T Keeley , Kiersten M Ruff , Rohit V Pappu , Alex S Holehouse

Réseau de co-auteurs

Ammon E Posey 13 collaborations

Tanja Mittag 12 collaborations

Kiersten M Ruff 12 collaborations

Mina Farag 10 collaborations

Alex S Holehouse 9 collaborations

Anne Bremer 9 collaborations

Wade M Borcherds 7 collaborations

Jared M Lalmansingh 6 collaborations

Furqan Dar 5 collaborations

Martin J Fossat 4 collaborations

Xiangze Zeng 4 collaborations

Tuomas P J Knowles 4 collaborations

Matthew R King 4 collaborations

Ian Seim 4 collaborations

Amy S Gladfelter 4 collaborations

Nadia A Erkamp 3 collaborations

Yifan Dai 3 collaborations

Andrew Z Lin 3 collaborations

Ameya Jalihal 3 collaborations

Samuel R Cohen 3 collaborations

Megan C Cohan 3 collaborations

Mrityunjoy Kar 2 collaborations

Anthony A Hyman 2 collaborations

Avnika Pant 2 collaborations

Ibraheem Alshareedah 2 collaborations

Anurag Singh 2 collaborations

Priya R Banerjee 2 collaborations

Petra A Levin 2 collaborations

Jeong-Mo Choi 2 collaborations

Alex T Keeley 2 collaborations

Ashutosh Chilkoti 1 collaboration

Max V Staller 1 collaboration

Eddie Ramirez 1 collaboration

Sanjana R Kotha 1 collaboration

Barak A Cohen 1 collaboration

Xiao Guo 1 collaboration

Naixin Qian 1 collaboration

Xia Yu 1 collaboration

Anton Ni 1 collaboration

Yuefeng Ma 1 collaboration

Wen Yu 1 collaboration

Vicky Liu 1 collaboration

Joonho Lee 1 collaboration

Richard N Zare 1 collaboration

Wei Min 1 collaboration

Anna M P Eddelbuettel 1 collaboration

Jamie A Greig 1 collaboration

Tu Anh Nguyen 1 collaboration

Michelle Lee 1 collaboration

Gregory Jedd 1 collaboration

Ivan Peran 1 collaboration

Erik W Martin 1 collaboration

Louis-Philippe Bergeron-Sandoval 1 collaboration

Sandeep Kumar 1 collaboration

Hossein Khadivi Heris 1 collaboration

Catherine L A Chang 1 collaboration

Caitlin E Cornell 1 collaboration

Sarah L Keller 1 collaboration

Paul François 1 collaboration

Adam G Hendricks 1 collaboration

Allen J Ehrlicher 1 collaboration

Stephen W Michnick 1 collaboration

Min Kyung Shinn 1 collaboration

Jessie L Bullock 1 collaboration

Yoon Hee Choi 1 collaboration

Dezerae Cox 1 collaboration

Angelique R Ormsby 1 collaboration

Yoochan Myung 1 collaboration

David B Ascher 1 collaboration

Sheena E Radford 1 collaboration

Danny M Hatters 1 collaboration

Madeleine B Borgia 1 collaboration

Gerard Aguilar Pérez 1 collaboration

Dragomir Milovanovic 1 collaboration

Gregory W Strout 1 collaboration

Dylan T Tomares 1 collaboration

Samantha K Powers 1 collaboration

David A Korasick 1 collaboration

Katherine H Schreiber 1 collaboration

Natalie M Clark 1 collaboration

Hongwei Jing 1 collaboration

Ryan Emenecker 1 collaboration

Soeun Han 1 collaboration

Eric Tycksen 1 collaboration

Ildoo Hwang 1 collaboration

Rosangela Sozzani 1 collaboration

Joseph M Jez 1 collaboration

Lucia C Strader 1 collaboration

Steven Boeynaems 1 collaboration

Venera Weinhardt 1 collaboration

Denes Kovacs 1 collaboration

Joris Van Lindt 1 collaboration

Carolyn Larabell 1 collaboration

Ludo Van Den Bosch 1 collaboration

Rhiju Das 1 collaboration

Peter S Tompa 1 collaboration

Aaron D Gitler 1 collaboration

Maxime Lorenzini 1 collaboration

Sophie Burel 1 collaboration

Adrien Lesage 1 collaboration

Emily Wagner 1 collaboration

Camille Charrière 1 collaboration

Pierre-Marie Chevillard 1 collaboration

Bérangère Evrard 1 collaboration

Dan Maloney 1 collaboration

Stefan Wagner 1 collaboration

Jeanne M Nerbonne 1 collaboration

Jonathan R Silva 1 collaboration

R Reid Townsend 1 collaboration

Lars S Maier 1 collaboration

Céline Marionneau 1 collaboration

Tamas Lazar 1 collaboration

Elizabeth Martínez-Pérez 1 collaboration

Federica Quaglia 1 collaboration

András Hatos 1 collaboration

Lucía B Chemes 1 collaboration

Javier A Iserte 1 collaboration

Nicolás A Méndez 1 collaboration

Nicolás A Garrone 1 collaboration

Tadeo E Saldaño 1 collaboration

Julia Marchetti 1 collaboration

Ana Julia Velez Rueda 1 collaboration

Pau Bernadó 1 collaboration

Martin Blackledge 1 collaboration

Tiago N Cordeiro 1 collaboration

Eric Fagerberg 1 collaboration

Julie D Forman-Kay 1 collaboration

Maria S Fornasari 1 collaboration

Toby J Gibson 1 collaboration

Gregory-Neal W Gomes 1 collaboration

Claudiu C Gradinaru 1 collaboration

Teresa Head-Gordon 1 collaboration

Malene Ringkjøbing Jensen 1 collaboration

Edward A Lemke 1 collaboration

Sonia Longhi 1 collaboration

Cristina Marino-Buslje 1 collaboration

Giovanni Minervini 1 collaboration

Alexander Miguel Monzon 1 collaboration

Gustavo Parisi 1 collaboration

Sylvie Ricard-Blum 1 collaboration

Edoardo Salladini 1 collaboration

Marie Skepö 1 collaboration

Dmitri Svergun 1 collaboration

Sylvain D Vallet 1 collaboration

Mihaly Varadi 1 collaboration

Peter Tompa 1 collaboration

Silvio C E Tosatto 1 collaboration

Damiano Piovesan 1 collaboration

Tejbir S Kandola 1 collaboration

Jeffrey J Lange 1 collaboration

Randal Halfmann 1 collaboration

Cécile Mathieu 1 collaboration

J Paul Taylor 1 collaboration

Wilton T Snead 1 collaboration

Benjamin M Stormo 1 collaboration

Daphne Klotsa 1 collaboration

Laura T Vogel 1 collaboration

Gaurav Chauhan 1 collaboration

Hannes Ausserwöger 1 collaboration

Timothy J Welsh 1 collaboration

Anjana R Kamath 1 collaboration

Claus A M Seidel 1 collaboration

Daoyuan Qian 1 collaboration

Hannes Ausserwoger 1 collaboration

Tomas Sneideris 1 collaboration