Robert I Lechler

Affiliations

MRC Centre for Transplantation, Peter Gorer Department of Immunobiology, School of Immunology & Microbial Sciences, King's College London, London, SE1 9RT, UK.

Publications (19)

Author Correction: Diversity of gut microflora is required for the generation of B cell with regulatory properties in a skin graft model.

Scientific reports

Avec: R Alhabbab , P Blair , R Elgueta , E Stolarczyk , E Marks , P D Becker , K Ratnasothy , L Smyth , N Safinia , E Sharif-Paghaleh , S O'Connell , R J Noelle , G M Lord , J K Howard , J Spencer , R I Lechler , G Lombardi

B lymphocytes contribute to indirect pathway T cell sensitization via acquisition of extracellular vesicles.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons

Avec: Pablo D Becker , Kulachelvy Ratnasothy , Monica Sen , Qi Peng , Marco Romano , Jordan Bazoer , Erik Suvitra , Anas Stout , Shannon G Hylton , Anthony Dorling , Robert I Lechler , Lesley A Smyth , Giovanna Lombardi

IL-2 therapy preferentially expands adoptively transferred donor-specific Tregs improving skin allograft survival.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons

Avec: Kulachelvy Ratnasothy , Jacintha Jacob , Sim Tung , Dominic Boardman , Robert Ian Lechler , Alberto Sanchez-Fueyo , Marc Martinez-Llordella , Giovanna Lombardi

Feasibility, long-term safety, and immune monitoring of regulatory T cell therapy in living donor kidney transplant recipients.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons

Avec: Paul N Harden , David S Game , Birgit Sawitzki , Jeroen B Van der Net , Joanna Hester , Andrew Bushell , Fadi Issa , Matthew O Brook , Alaa Alzhrani , Stephan Schlickeiser , Cristiano Scotta , William Petchey , Mathias Streitz , Gilles Blancho , Quizhi Tang , James Markmann , Robert I Lechler , Ian S D Roberts , Peter J Friend , Rachel Hilton , Edward K Geissler , Kathryn J Wood , Giovanna Lombardi

Dysregulated anti-oxidant signalling and compromised mitochondrial integrity negatively influence regulatory T cell function and viability in liver disease.

EBioMedicine

Avec: Trishan Vaikunthanathan , Emmanuelle Landmann , Diana Marin Correa , Marco Romano , Silvia Cellone Trevelin , Qi Peng , Elena Crespo , Mauro Corrado , Juan-José Lozano , Erika L Pearce , Elena Perpinan , Anna Zoccarato , Leonard Siew , Joy Edwards-Hicks , Reenam Khan , Nguyet-Thin Luu , Mark R Thursz , Philip N Newsome , Marc Martinez-Llordella , Naina Shah , Robert I Lechler , Ajay M Shah , Alberto Sanchez-Fueyo , Giovanna Lombardi , Niloufar Safinia

The Future of Regulatory T Cell Therapy: Promises and Challenges of Implementing CAR Technology.

Frontiers in immunology

Avec: Yasmin R Mohseni , Sim L Tung , Caroline Dudreuilh , Robert I Lechler , Gilbert O Fruhwirth , Giovanna Lombardi

Regulatory B cells: Development, phenotypes, functions, and role in transplantation.

Immunological reviews

Avec: Rowa Y Alhabbab , Estefanía Nova-Lamperti , Octavio Aravena , Hannah M Burton , Robert I Lechler , Anthony Dorling , Giovanna Lombardi

Protease Activated Receptor 4 as a Novel Modulator of Regulatory T Cell Function.

Frontiers in immunology

Avec: Qi Peng , Kulachelvy Ratnasothy , Dominic A Boardman , Jacinta Jacob , Sim Lai Tung , Daniel McCluskey , Lesley A Smyth , Robert I Lechler , Anthony Dorling , Giovanna Lombardi

Spatiotemporal

Molecular therapy. Methods & clinical development

Avec: Jacinta Jacob , Suchita Nadkarni , Alessia Volpe , Qi Peng , Sim L Tung , Rosalind F Hannen , Yasmin R Mohseni , Cristiano Scotta , Federica M Marelli-Berg , Robert I Lechler , Lesley A Smyth , Gilbert O Fruhwirth , Giovanna Lombardi

Nox2-deficient Tregs improve heart transplant outcomes via their increased graft recruitment and enhanced potency.

JCI insight

Avec: Silvia C Trevelin , Anna Zampetaki , Greta Sawyer , Aleksandar Ivetic , Alison C Brewer , Lesley Ann Smyth , Federica Marelli-Berg , Robert Köchl , Robert I Lechler , Ajay M Shah , Giovanna Lombardi

Mesenchymal stem cells inhibit T-cell function through conserved induction of cellular stress.

PloS one

Avec: Adam G Laing , Giorgia Fanelli , Andrei Ramirez-Valdez , Robert I Lechler , Giovanna Lombardi , Paul T Sharpe

PD-L1 signaling on human memory CD4+ T cells induces a regulatory phenotype.

PLoS biology

Avec: Giorgia Fanelli , Marco Romano , Estefania Nova-Lamperti , Mariana Werner Sunderland , Alessandra Nerviani , Cristiano Scottà , Michele Bombardieri , Sergio A Quezada , Steven H Sacks , Randolph J Noelle , Costantino Pitzalis , Robert I Lechler , Giovanna Lombardi , Pablo D Becker

Advances in Liver Transplantation: where are we in the pursuit of transplantation tolerance?

European journal of immunology

Avec: Niloufar Safinia , Trishan Vaikunthanathan , Robert Ian Lechler , Alberto Sanchez-Fueyo , Giovanna Lombardi

Chimeric antigen receptor-modified human regulatory T cells that constitutively express IL-10 maintain their phenotype and are potently suppressive.

European journal of immunology

Avec: Yasmin R Mohseni , Adeel Saleem , Sim L Tung , Caroline Dudreuilh , Cameron Lang , Qi Peng , Alessia Volpe , George Adigbli , Amy Cross , Joanna Hester , Farzin Farzaneh , Cristiano Scotta , Robert I Lechler , Fadi Issa , Gilbert O Fruhwirth , Giovanna Lombardi

Inhibition of thrombin on endothelium enhances recruitment of regulatory T cells during IRI and when combined with adoptive Treg transfer, significantly protects against acute tissue injury and prolongs allograft survival.

Frontiers in immunology

Avec: Qi Peng , Anna Nowocin , Kulachelvy Ratnasothy , Richard A Smith , Lesley A Smyth , Robert I Lechler , Anthony Dorling , Giovanna Lombardi

Isolation and expansion of thymus-derived regulatory T cells for use in pediatric heart transplant patients.

European journal of immunology

Avec: Marco Romano , Monica Sen , Cristiano Scottà , Rowa Y Alhabbab , Andres Rico-Armada , Robert I Lechler , Michael Burch , Giovanna Lombardi

Regulatory cell therapy in kidney transplantation (The ONE Study): a harmonised design and analysis of seven non-randomised, single-arm, phase 1/2A trials.

Lancet (London, England)

Avec: Birgit Sawitzki , Paul N Harden , Petra Reinke , Aurélie Moreau , James A Hutchinson , David S Game , Qizhi Tang , Eva C Guinan , Manuela Battaglia , William J Burlingham , Ian S D Roberts , Mathias Streitz , Régis Josien , Carsten A Böger , Cristiano Scottà , James F Markmann , Joanna L Hester , Karsten Juerchott , Cecile Braudeau , Ben James , Laura Contreras-Ruiz , Jeroen B van der Net , Tobias Bergler , Rossana Caldara , William Petchey , Matthias Edinger , Nathalie Dupas , Michael Kapinsky , Ingrid Mutzbauer , Natalie M Otto , Robert Öllinger , Maria P Hernandez-Fuentes , Fadi Issa , Norbert Ahrens , Christoph Meyenberg , Sandra Karitzky , Ulrich Kunzendorf , Stuart J Knechtle , Josep Grinyó , Peter J Morris , Leslie Brent , Andrew Bushell , Laurence A Turka , Jeffrey A Bluestone , Robert I Lechler , Hans J Schlitt , Maria C Cuturi , Stephan Schlickeiser , Peter J Friend , Tewfik Miloud , Alexander Scheffold , Antonio Secchi , Kerry Crisalli , Sang-Mo Kang , Rachel Hilton , Bernhard Banas , Gilles Blancho , Hans-Dieter Volk , Giovanna Lombardi , Kathryn J Wood , Edward K Geissler

Development and validation of the first consensus gene-expression signature of operational tolerance in kidney transplantation, incorporating adjustment for immunosuppressive drug therapy.

EBioMedicine

Avec: Sofia Christakoudi , Manohursingh Runglall , Paula Mobillo , Irene Rebollo-Mesa , Tjir-Li Tsui , Estefania Nova-Lamperti , Catharine Taube , Sonia Norris , Yogesh Kamra , Rachel Hilton , Titus Augustine , Sunil Bhandari , Richard Baker , David Berglund , Sue Carr , David Game , Sian Griffin , Philip A Kalra , Robert Lewis , Patrick B Mark , Stephen D Marks , Iain MacPhee , William McKane , Markus G Mohaupt , Estela Paz-Artal , Sui Phin Kon , Daniel Serón , Manish D Sinha , Beatriz Tucker , Ondrej Viklický , Daniel Stahl , Robert I Lechler , Graham M Lord , Maria P Hernandez-Fuentes

Radiolabelling of Polyclonally Expanded Human Regulatory T Cells (Treg) with

Molecules (Basel, Switzerland)

Avec: Jacinta Jacob , Alessia Volpe , Qi Peng , Robert I Lechler , Lesley A Smyth , Giovanna Lombardi , Gilbert O Fruhwirth

Réseau de co-auteurs

Giovanna Lombardi 17 collaborations

Qi Peng 7 collaborations

Lesley A Smyth 5 collaborations

Kulachelvy Ratnasothy 4 collaborations

Marco Romano 4 collaborations

Anthony Dorling 4 collaborations

Gilbert O Fruhwirth 4 collaborations

Alberto Sanchez-Fueyo 3 collaborations

Fadi Issa 3 collaborations

Cristiano Scotta 3 collaborations

Rachel Hilton 3 collaborations

Yasmin R Mohseni 3 collaborations

Sim L Tung 3 collaborations

Jacinta Jacob 3 collaborations

Alessia Volpe 3 collaborations

Cristiano Scottà 3 collaborations

Pablo D Becker 2 collaborations

Monica Sen 2 collaborations

Robert Ian Lechler 2 collaborations

Marc Martinez-Llordella 2 collaborations

Paul N Harden 2 collaborations

David S Game 2 collaborations

Birgit Sawitzki 2 collaborations

Joanna Hester 2 collaborations

Andrew Bushell 2 collaborations

Stephan Schlickeiser 2 collaborations

William Petchey 2 collaborations

Mathias Streitz 2 collaborations

Gilles Blancho 2 collaborations

Ian S D Roberts 2 collaborations

Peter J Friend 2 collaborations

Edward K Geissler 2 collaborations

Kathryn J Wood 2 collaborations

Trishan Vaikunthanathan 2 collaborations

Ajay M Shah 2 collaborations

Niloufar Safinia 2 collaborations

Caroline Dudreuilh 2 collaborations

Rowa Y Alhabbab 2 collaborations

Giorgia Fanelli 2 collaborations

Estefania Nova-Lamperti 2 collaborations

Maria P Hernandez-Fuentes 2 collaborations

R Alhabbab 1 collaboration

P Blair 1 collaboration

R Elgueta 1 collaboration

E Stolarczyk 1 collaboration

E Marks 1 collaboration

P D Becker 1 collaboration

K Ratnasothy 1 collaboration

L Smyth 1 collaboration

N Safinia 1 collaboration

E Sharif-Paghaleh 1 collaboration

S O'Connell 1 collaboration

R J Noelle 1 collaboration

G M Lord 1 collaboration

J K Howard 1 collaboration

J Spencer 1 collaboration

R I Lechler 1 collaboration

G Lombardi 1 collaboration

Jordan Bazoer 1 collaboration

Erik Suvitra 1 collaboration

Anas Stout 1 collaboration

Shannon G Hylton 1 collaboration

Jacintha Jacob 1 collaboration

Sim Tung 1 collaboration

Dominic Boardman 1 collaboration

Jeroen B Van der Net 1 collaboration

Matthew O Brook 1 collaboration

Alaa Alzhrani 1 collaboration

Quizhi Tang 1 collaboration

James Markmann 1 collaboration

Emmanuelle Landmann 1 collaboration

Diana Marin Correa 1 collaboration

Silvia Cellone Trevelin 1 collaboration

Elena Crespo 1 collaboration

Mauro Corrado 1 collaboration

Juan-José Lozano 1 collaboration

Erika L Pearce 1 collaboration

Elena Perpinan 1 collaboration

Anna Zoccarato 1 collaboration

Leonard Siew 1 collaboration

Joy Edwards-Hicks 1 collaboration

Reenam Khan 1 collaboration

Nguyet-Thin Luu 1 collaboration

Mark R Thursz 1 collaboration

Philip N Newsome 1 collaboration

Naina Shah 1 collaboration

Estefanía Nova-Lamperti 1 collaboration

Octavio Aravena 1 collaboration

Hannah M Burton 1 collaboration

Dominic A Boardman 1 collaboration

Sim Lai Tung 1 collaboration

Daniel McCluskey 1 collaboration

Suchita Nadkarni 1 collaboration

Rosalind F Hannen 1 collaboration

Federica M Marelli-Berg 1 collaboration

Silvia C Trevelin 1 collaboration

Anna Zampetaki 1 collaboration

Greta Sawyer 1 collaboration

Aleksandar Ivetic 1 collaboration

Alison C Brewer 1 collaboration

Lesley Ann Smyth 1 collaboration

Federica Marelli-Berg 1 collaboration

Robert Köchl 1 collaboration

Adam G Laing 1 collaboration

Andrei Ramirez-Valdez 1 collaboration

Paul T Sharpe 1 collaboration

Mariana Werner Sunderland 1 collaboration

Alessandra Nerviani 1 collaboration

Michele Bombardieri 1 collaboration

Sergio A Quezada 1 collaboration

Steven H Sacks 1 collaboration

Randolph J Noelle 1 collaboration

Costantino Pitzalis 1 collaboration

Adeel Saleem 1 collaboration

Cameron Lang 1 collaboration

George Adigbli 1 collaboration

Amy Cross 1 collaboration

Farzin Farzaneh 1 collaboration

Anna Nowocin 1 collaboration

Richard A Smith 1 collaboration

Andres Rico-Armada 1 collaboration

Michael Burch 1 collaboration

Petra Reinke 1 collaboration

Aurélie Moreau 1 collaboration

James A Hutchinson 1 collaboration

Qizhi Tang 1 collaboration

Eva C Guinan 1 collaboration

Manuela Battaglia 1 collaboration

William J Burlingham 1 collaboration

Régis Josien 1 collaboration

Carsten A Böger 1 collaboration

James F Markmann 1 collaboration

Joanna L Hester 1 collaboration

Karsten Juerchott 1 collaboration

Cecile Braudeau 1 collaboration

Ben James 1 collaboration

Laura Contreras-Ruiz 1 collaboration

Jeroen B van der Net 1 collaboration

Tobias Bergler 1 collaboration

Rossana Caldara 1 collaboration

Matthias Edinger 1 collaboration

Nathalie Dupas 1 collaboration

Michael Kapinsky 1 collaboration

Ingrid Mutzbauer 1 collaboration

Natalie M Otto 1 collaboration

Robert Öllinger 1 collaboration

Norbert Ahrens 1 collaboration

Christoph Meyenberg 1 collaboration

Sandra Karitzky 1 collaboration

Ulrich Kunzendorf 1 collaboration

Stuart J Knechtle 1 collaboration

Josep Grinyó 1 collaboration

Peter J Morris 1 collaboration

Leslie Brent 1 collaboration

Laurence A Turka 1 collaboration

Jeffrey A Bluestone 1 collaboration

Hans J Schlitt 1 collaboration

Maria C Cuturi 1 collaboration

Tewfik Miloud 1 collaboration

Alexander Scheffold 1 collaboration

Antonio Secchi 1 collaboration

Kerry Crisalli 1 collaboration

Sang-Mo Kang 1 collaboration

Bernhard Banas 1 collaboration

Hans-Dieter Volk 1 collaboration

Sofia Christakoudi 1 collaboration

Manohursingh Runglall 1 collaboration

Paula Mobillo 1 collaboration

Irene Rebollo-Mesa 1 collaboration

Tjir-Li Tsui 1 collaboration

Catharine Taube 1 collaboration

Sonia Norris 1 collaboration

Yogesh Kamra 1 collaboration

Titus Augustine 1 collaboration

Sunil Bhandari 1 collaboration

Richard Baker 1 collaboration

David Berglund 1 collaboration

Sue Carr 1 collaboration

David Game 1 collaboration

Sian Griffin 1 collaboration

Philip A Kalra 1 collaboration

Robert Lewis 1 collaboration

Patrick B Mark 1 collaboration

Stephen D Marks 1 collaboration

Iain MacPhee 1 collaboration

William McKane 1 collaboration

Markus G Mohaupt 1 collaboration

Estela Paz-Artal 1 collaboration

Sui Phin Kon 1 collaboration

Daniel Serón 1 collaboration

Manish D Sinha 1 collaboration

Beatriz Tucker 1 collaboration

Ondrej Viklický 1 collaboration

Daniel Stahl 1 collaboration

Graham M Lord 1 collaboration