Riikka Havunen

Affiliations
  • Cancer Gene Therapy Group, Faculty of Medicine, Translational Immunology Research Program, University of Helsinki, 00290 Helsinki, Finland.
  • TILT Biotherapeutics Ltd., 00290 Helsinki, Finland.

Publications (24)

Systemic Delivery of Oncolytic Adenovirus to Tumors Using Tumor-Infiltrating Lymphocytes as Carriers.

Cells
Avec: Joao Santos , Camilla Heiniö , Dafne Quixabeira , Sadia Zafar , James Clubb , Santeri Pakola , Victor Cervera-Carrascon , Riikka Havunen , Anna Kanerva , Akseli Hemminki

Adenovirus Armed With TNFa and IL2 Added to aPD-1 Regimen Mediates Antitumor Efficacy in Tumors Refractory to aPD-1.

Frontiers in immunology
Avec: Victor Cervera-Carrascon , Dafne C A Quixabeira , Joao M Santos , Riikka Havunen , Ioanna Milenova , Jan Verhoeff , Camilla Heiniö , Sadia Zafar , Juan J Garcia-Vallejo , Victor W van Beusechem , Tanja D de Gruijl , Aino Kalervo , Suvi Sorsa , Anna Kanerva , Akseli Hemminki

Oncolytic adenovirus coding for bispecific T cell engager against human MUC-1 potentiates T cell response against solid tumors.

Molecular therapy oncolytics
Avec: Saru Basnet , Joao M Santos , Dafne C A Quixabeira , James H A Clubb , Susanna A M Grönberg-Vähä-Koskela , Victor Arias , Santeri Pakola , Tatiana V Kudling , Camilla Heiniö , Riikka Havunen , Victor Cervera-Carrascon , Suvi Sorsa , Marjukka Anttila , Anna Kanerva , Akseli Hemminki

Effective intravenous delivery of adenovirus armed with TNFα and IL-2 improves anti-PD-1 checkpoint blockade in non-small cell lung cancer.

Oncoimmunology
Avec: Tatiana V Kudling , James H A Clubb , Santeri Pakola , Dafne C A Quixabeira , Iris A K Lähdeniemi , Camilla Heiniö , Victor Arias , Riikka Havunen , Victor Cervera-Carrascon , Joao M Santos , Eva Sutinen , Jari Räsänen , Kristian Borenius , Mikko I Mäyränpää , Eero Aaltonen , Suvi Sorsa , Otto Hemminki , Anna Kanerva , Emmy W Verschuren , Ilkka Ilonen , Akseli Hemminki

Comparison of Clinically Relevant Oncolytic Virus Platforms for Enhancing T Cell Therapy of Solid Tumors.

Molecular therapy oncolytics
Avec: Victor Cervera-Carrascon , Dafne C A Quixabeira , Riikka Havunen , Joao M Santos , Emma Kutvonen , James H A Clubb , Mikko Siurala , Camilla Heiniö , Sadia Zafar , Teija Koivula , Dave Lumen , Marjo Vaha , Arturo Garcia-Horsman , Anu J Airaksinen , Suvi Sorsa , Marjukka Anttila , Veijo Hukkanen , Anna Kanerva , Akseli Hemminki

TNFa and IL2 Encoding Oncolytic Adenovirus Activates Pathogen and Danger-Associated Immunological Signaling.

Cells
Avec: Camilla Heiniö , Riikka Havunen , Joao Santos , Klaas de Lint , Victor Cervera-Carrascon , Anna Kanerva , Akseli Hemminki

Ad5/3 is able to avoid neutralization by binding to erythrocytes and lymphocytes.

Cancer gene therapy
Avec: Sadia Zafar , Dafne Carolina Alves Quixabeira , Tatiana Viktorovna Kudling , Victor Cervera-Carrascon , Joao Manuel Santos , Susanna Grönberg-Vähä-Koskela , Fang Zhao , Pasi Aronen , Camilla Heiniö , Riikka Havunen , Suvi Sorsa , Anna Kanerva , Akseli Hemminki

Local therapy with an engineered oncolytic adenovirus enables antitumor response in non-injected melanoma tumors in mice treated with aPD-1.

Oncoimmunology
Avec: Dafne C A Quixabeira , Victor Cervera-Carrascon , Joao M Santos , James H A Clubb , Tatiana V Kudling , Saru Basnet , Camilla Heiniö , Susanna Grönberg-Vähä-Koskela , Marjukka Anttila , Riikka Havunen , Anna Kanerva , Akseli Hemminki

Local delivery of interleukin 7 with an oncolytic adenovirus activates tumor-infiltrating lymphocytes and causes tumor regression.

Oncoimmunology
Avec: Tatiana V Kudling , James H A Clubb , Dafne C A Quixabeira , Joao M Santos , Riikka Havunen , Alexander Kononov , Camilla Heiniö , Victor Cervera-Carrascon , Santeri Pakola , Saru Basnet , Susanna Grönberg-Vähä-Koskela , Victor Arias , Ivan Gladwyn-Ng , Katri Aro , Leif Bäck , Jari Räsänen , Ilkka Ilonen , Kristian Borenius , Mikko Räsänen , Otto Hemminki , Antti Rannikko , Anna Kanerva , Johanna Tapper , Akseli Hemminki

Modulation of the tumor microenvironment with an oncolytic adenovirus for effective T-cell therapy and checkpoint inhibition.

Methods in enzymology
Avec: João Manuel Santos , Riikka Havunen , Akseli Hemminki

Oncolytic adenoviruses: a game changer approach in the battle between cancer and the immune system.

Expert opinion on biological therapy
Avec: Victor Cervera-Carrascon , Riikka Havunen , Akseli Hemminki

Tumor microenvironment remodeling by an engineered oncolytic adenovirus results in improved outcome from PD-L1 inhibition.

Oncoimmunology
Avec: Victor Cervera-Carrascon , Dafne C A Quixabeira , Joao Manuel Santos , Riikka Havunen , Sadia Zafar , Otto Hemminki , Camilla Heiniö , Eleonora Munaro , Mikko Siurala , Suvi Sorsa , Tuomas Mirtti , Petrus Järvinen , Markus Mildh , Harry Nisen , Antti Rannikko , Marjukka Anttila , Anna Kanerva , Akseli Hemminki

Cytokine-Coding Oncolytic Adenovirus TILT-123 Is Safe, Selective, and Effective as a Single Agent and in Combination with Immune Checkpoint Inhibitor Anti-PD-1.

Cells
Avec: Riikka Havunen , Riikka Kalliokoski , Mikko Siurala , Suvi Sorsa , João M Santos , Victor Cervera-Carrascon , Marjukka Anttila , Akseli Hemminki

Adenovirus Encoding Tumor Necrosis Factor Alpha and Interleukin 2 Induces a Tertiary Lymphoid Structure Signature in Immune Checkpoint Inhibitor Refractory Head and Neck Cancer.

Frontiers in immunology
Avec: James H A Clubb , Tatiana V Kudling , Camilla Heiniö , Saru Basnet , Santeri Pakola , Víctor Cervera Carrascón , João Manuel Santos , Dafne C A Quixabeira , Riikka Havunen , Suvi Sorsa , Vincent Zheng , Tuula Salo , Leif Bäck , Katri Aro , Sanni Tulokas , Venla Loimu , Akseli Hemminki

Effective Combination Immunotherapy with Oncolytic Adenovirus and Anti-PD-1 for Treatment of Human and Murine Ovarian Cancers.

Diseases (Basel, Switzerland)
Avec: Camilla Heiniö , James Clubb , Tatiana Kudling , Dafne Quixabeira , Victor Cervera-Carrascon , Riikka Havunen , Susanna Grönberg-Vähä-Koskela , João Manuel Santos , Johanna Tapper , Anna Kanerva , Akseli Hemminki

Improving the cytotoxic response of tumor-infiltrating lymphocytes towards advanced stage ovarian cancer with an oncolytic adenovirus expressing a human vIL-2 cytokine.

Cancer gene therapy
Avec: D C A Quixabeira , E Jirovec , S Pakola , R Havunen , S Basnet , J M Santos , T V Kudling , J H A Clubb , L Haybout , V Arias , S Grönberg-Vähä-Koskela , V Cervera-Carrascon , A Pasanen , M Anttila , J Tapper , A Kanerva , A Hemminki

Oncolytic adenovirus shapes the ovarian tumor microenvironment for potent tumor-infiltrating lymphocyte tumor reactivity.

Journal for immunotherapy of cancer
Avec: João Manuel Santos , Camilla Heiniö , Victor Cervera-Carrascon , Dafne C A Quixabeira , Mikko Siurala , Riikka Havunen , Ralf Butzow , Sadia Zafar , Tanja de Gruijl , Heini Lassus , Anna Kanerva , Akseli Hemminki

Effect of Genetic Modifications on Physical and Functional Titers of Adenoviral Cancer Gene Therapy Constructs.

Human gene therapy
Avec: Camilla Heiniö , Suvi Sorsa , Mikko Siurala , Susanna Grönberg-Vähä-Koskela , Riikka Havunen , Elina Haavisto , Anniina Koski , Otto Hemminki , Sadia Zafar , Víctor Cervera-Carrascon , Eleonora Munaro , Anna Kanerva , Akseli Hemminki

Oncolytic Adenovirus Type 3 Coding for CD40L Facilitates Dendritic Cell Therapy of Prostate Cancer in Humanized Mice and Patient Samples.

Human gene therapy
Avec: Sadia Zafar , Saru Basnet , Inga-Maria Launonen , Dafne Carolina Alves Quixabeira , Joao Santos , Otto Hemminki , Minna Malmstedt , Victor Cervera-Carrascon , Pasi Aronen , Riikka Kalliokoski , Riikka Havunen , Antti Rannikko , Tuomas Mirtti , Mika Matikainen , Anna Kanerva , Akseli Hemminki

Oncolytic Adenovirus Coding for a Variant Interleukin 2 (vIL-2) Cytokine Re-Programs the Tumor Microenvironment and Confers Enhanced Tumor Control.

Frontiers in immunology
Avec: Dafne C A Quixabeira , Sadia Zafar , Joao M Santos , Victor Cervera-Carrascon , Riikka Havunen , Tatiana V Kudling , Saru Basnet , Marjukka Anttila , Anna Kanerva , Akseli Hemminki

Boosting cytotoxicity of adoptive allogeneic NK cell therapy with an oncolytic adenovirus encoding a human vIL-2 cytokine for the treatment of human ovarian cancer.

Cancer gene therapy
Avec: D C A Quixabeira , S Pakola , E Jirovec , R Havunen , S Basnet , J M Santos , T V Kudling , J H A Clubb , L Haybout , V Arias , S Grönberg-Vähä-Koskela , V Cervera-Carrascon , E Kerkelä , A Pasanen , M Anttila , J Tapper , A Kanerva , A Hemminki

Development of a Syrian hamster anti-PD-L1 monoclonal antibody enables oncolytic adenoviral immunotherapy modelling in an immunocompetent virus replication permissive setting.

Frontiers in immunology
Avec: James H A Clubb , Tatiana V Kudling , Mykhailo Girych , Lyna Haybout , Santeri Pakola , Firas Hamdan , Víctor Cervera-Carrascon , Annabrita Hemmes , Susanna Grönberg-Vähä-Koskela , João Manuel Santos , Dafne C A Quixabeira , Saru Basnet , Camilla Heiniö , Victor Arias , Elise Jirovec , Shreyas Kaptan , Riikka Havunen , Suvi Sorsa , Abdullah Erikat , Joel Schwartz , Marjukka Anttila , Katri Aro , Tapani Viitala , Ilpo Vattulainen , Vincenzo Cerullo , Anna Kanerva , Akseli Hemminki

An oncolytic adenovirus coding for a variant interleukin 2 cytokine improves response to chemotherapy through enhancement of effector lymphocyte cytotoxicity, fibroblast compartment modulation and mitotic slippage.

Frontiers in immunology
Avec: Santeri Pakola , Dafne C A Quixabeira , Tatiana V Kudling , James H A Clubb , Susanna Grönberg-Vähä-Koskela , Saru Basnet , Elise Jirovec , Victor Arias , Lyna Haybout , Camilla Heiniö , Joao M Santos , Victor Cervera-Carrascon , Riikka Havunen , Marjukka Anttila , Akseli Hemminki

Safety, efficacy, and biological data of T cell-enabling oncolytic adenovirus TILT-123 in advanced solid cancers from the TUNIMO monotherapy phase I trial.

Clinical cancer research : an official journal of the American Association for Cancer Research
Avec: Santeri A Pakola , Katriina J Peltola , James H A Clubb , Elise Jirovec , Lyna Haybout , Tatiana V Kudling , Tuomo Alanko , Riitta Korpisaari , Susanna Juteau , Marjut Jaakkola , Jorma Sormunen , Jukka Kemppainen , Annabrita Hemmes , Teijo Pellinen , Mirte van der Heijden , Dafne C A Quixabeira , Claudia Kistler , Suvi Sorsa , Riikka Havunen , Joao M Santos , Victor Cervera-Carrascon , Akseli E Hemminki

Réseau de co-auteurs

Akseli Hemminki 21 collaborations
Victor Cervera-Carrascon 18 collaborations
Camilla Heiniö 16 collaborations
Anna Kanerva 16 collaborations
Dafne C A Quixabeira 13 collaborations
Suvi Sorsa 11 collaborations
Sadia Zafar 9 collaborations
Joao M Santos 9 collaborations
James H A Clubb 9 collaborations
Tatiana V Kudling 9 collaborations
Saru Basnet 8 collaborations
Marjukka Anttila 8 collaborations
Santeri Pakola 7 collaborations
Susanna Grönberg-Vähä-Koskela 7 collaborations
Victor Arias 5 collaborations
Otto Hemminki 5 collaborations
Mikko Siurala 5 collaborations
João Manuel Santos 5 collaborations
Joao Santos 3 collaborations
Katri Aro 3 collaborations
Antti Rannikko 3 collaborations
Lyna Haybout 3 collaborations
Elise Jirovec 3 collaborations
Dafne Quixabeira 2 collaborations
James Clubb 2 collaborations
Jari Räsänen 2 collaborations
Kristian Borenius 2 collaborations
Ilkka Ilonen 2 collaborations
Dafne Carolina Alves Quixabeira 2 collaborations
Joao Manuel Santos 2 collaborations
Pasi Aronen 2 collaborations
Leif Bäck 2 collaborations
Johanna Tapper 2 collaborations
Eleonora Munaro 2 collaborations
Tuomas Mirtti 2 collaborations
Riikka Kalliokoski 2 collaborations
D C A Quixabeira 2 collaborations
E Jirovec 2 collaborations
S Pakola 2 collaborations
R Havunen 2 collaborations
S Basnet 2 collaborations
J M Santos 2 collaborations
T V Kudling 2 collaborations
J H A Clubb 2 collaborations
L Haybout 2 collaborations
V Arias 2 collaborations
S Grönberg-Vähä-Koskela 2 collaborations
V Cervera-Carrascon 2 collaborations
A Pasanen 2 collaborations
M Anttila 2 collaborations
J Tapper 2 collaborations
A Kanerva 2 collaborations
A Hemminki 2 collaborations
Víctor Cervera-Carrascon 2 collaborations
Annabrita Hemmes 2 collaborations
Ioanna Milenova 1 collaboration
Jan Verhoeff 1 collaboration
Juan J Garcia-Vallejo 1 collaboration
Victor W van Beusechem 1 collaboration
Tanja D de Gruijl 1 collaboration
Aino Kalervo 1 collaboration
Susanna A M Grönberg-Vähä-Koskela 1 collaboration
Iris A K Lähdeniemi 1 collaboration
Eva Sutinen 1 collaboration
Mikko I Mäyränpää 1 collaboration
Eero Aaltonen 1 collaboration
Emmy W Verschuren 1 collaboration
Emma Kutvonen 1 collaboration
Teija Koivula 1 collaboration
Dave Lumen 1 collaboration
Marjo Vaha 1 collaboration
Arturo Garcia-Horsman 1 collaboration
Anu J Airaksinen 1 collaboration
Veijo Hukkanen 1 collaboration
Klaas de Lint 1 collaboration
Tatiana Viktorovna Kudling 1 collaboration
Fang Zhao 1 collaboration
Alexander Kononov 1 collaboration
Ivan Gladwyn-Ng 1 collaboration
Mikko Räsänen 1 collaboration
Petrus Järvinen 1 collaboration
Markus Mildh 1 collaboration
Harry Nisen 1 collaboration
João M Santos 1 collaboration
Víctor Cervera Carrascón 1 collaboration
Vincent Zheng 1 collaboration
Tuula Salo 1 collaboration
Sanni Tulokas 1 collaboration
Venla Loimu 1 collaboration
Tatiana Kudling 1 collaboration
Ralf Butzow 1 collaboration
Tanja de Gruijl 1 collaboration
Heini Lassus 1 collaboration
Elina Haavisto 1 collaboration
Anniina Koski 1 collaboration
Inga-Maria Launonen 1 collaboration
Minna Malmstedt 1 collaboration
Mika Matikainen 1 collaboration
E Kerkelä 1 collaboration
Mykhailo Girych 1 collaboration
Firas Hamdan 1 collaboration
Shreyas Kaptan 1 collaboration
Abdullah Erikat 1 collaboration
Joel Schwartz 1 collaboration
Tapani Viitala 1 collaboration
Ilpo Vattulainen 1 collaboration
Vincenzo Cerullo 1 collaboration
Santeri A Pakola 1 collaboration
Katriina J Peltola 1 collaboration
Tuomo Alanko 1 collaboration
Riitta Korpisaari 1 collaboration
Susanna Juteau 1 collaboration
Marjut Jaakkola 1 collaboration
Jorma Sormunen 1 collaboration
Jukka Kemppainen 1 collaboration
Teijo Pellinen 1 collaboration
Mirte van der Heijden 1 collaboration
Claudia Kistler 1 collaboration
Akseli E Hemminki 1 collaboration