Priyadarshini Jaishankar

Affiliations

Department of Pharmaceutical Chemistry and Small Molecule Discovery Center, University of California San Francisco, CA 94143, USA.

Publications (13)

Zebrafish studies identify serotonin receptors mediating antiepileptic activity in Dravet syndrome.

Brain communications

Avec: Aliesha L Griffin , Priyadarshini Jaishankar , Jean-Marc Grandjean , Steven H Olson , Adam R Renslo , Scott C Baraban

Expanding Automated Multiconformer Ligand Modeling to Macrocycles and Fragments.

bioRxiv : the preprint server for biology

Avec: Jessica Flowers , Nathaniel Echols , Galen Correy , Priya Jaishankar , Takaya Togo , Adam R Renslo , Henry van den Bedem , James S Fraser , Stephanie A Wankowicz

Activation of Caspase-6 Is Promoted by a Mutant Huntingtin Fragment and Blocked by an Allosteric Inhibitor Compound.

Cell chemical biology

Avec: Dagmar E Ehrnhoefer , Niels H Skotte , Jeanette Reinshagen , Xiaofan Qiu , Björn Windshügel , Priyadarshini Jaishankar , Safia Ladha , Olga Petina , Mehdi Khankischpur , Yen T N Nguyen , Nicholas S Caron , Adelia Razeto , Matthias Meyer Zu Rheda , Yu Deng , Khuong T Huynh , Ilka Wittig , Philip Gribbon , Adam R Renslo , Detlef Geffken , Sheraz Gul , Michael R Hayden

Heteroaryl Phosphonates as Noncovalent Inhibitors of Both Serine- and Metallocarbapenemases.

Journal of medicinal chemistry

Avec: Orville A Pemberton , Priyadarshini Jaishankar , Afroza Akhtar , Jessie L Adams , Lindsey N Shaw , Adam R Renslo , Yu Chen

Structure-Based Optimization of Covalent, Small-Molecule Stabilizers of the 14-3-3σ/ERα Protein-Protein Interaction from Nonselective Fragments.

Journal of the American Chemical Society

Avec: Markella Konstantinidou , Emira J Visser , Edmee Vandenboorn , Sheng Chen , Priyadarshini Jaishankar , Maurits Overmans , Shubhankar Dutta , R Jeffrey Neitz , Adam R Renslo , Christian Ottmann , Luc Brunsveld , Michelle R Arkin

Engaging a Non-catalytic Cysteine Residue Drives Potent and Selective Inhibition of Caspase-6.

Journal of the American Chemical Society

Avec: Kurt S Van Horn , Dongju Wang , Daniel Medina-Cleghorn , Peter S Lee , Clifford Bryant , Chad Altobelli , Priyadarshini Jaishankar , Kevin K Leung , Raymond A Ng , Andrew J Ambrose , Yinyan Tang , Michelle R Arkin , Adam R Renslo

From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking.

Angewandte Chemie (International ed. in English)

Avec: Emira J Visser , Priyadarshini Jaishankar , Eline Sijbesma , Marloes A M Pennings , Edmee M F Vandenboorn , Xavier Guillory , R Jeffrey Neitz , John Morrow , Shubhankar Dutta , Adam R Renslo , Luc Brunsveld , Michelle R Arkin , Christian Ottmann

Synthesis and In Vivo Profiling of Desymmetrized Antimalarial Trioxolanes with Diverse Carbamate Side Chains.

ACS medicinal chemistry letters

Avec: Matthew T Klope , Juan A Tapia Cardona , Jun Chen , Ryan L Gonciarz , Ke Cheng , Priyadarshini Jaishankar , Julie Kim , Jenny Legac , Philip J Rosenthal , Adam R Renslo

Cyanopyrrolidine Inhibitors of Ubiquitin Specific Protease 7 Mediate Desulfhydration of the Active-Site Cysteine.

ACS chemical biology

Avec: Charlene Bashore , Priyadarshini Jaishankar , Nicholas J Skelton , Jakob Fuhrmann , Brian R Hearn , Peter S Liu , Adam R Renslo , Erin C Dueber

Active-Site Druggability of Carbapenemases and Broad-Spectrum Inhibitor Discovery.

ACS infectious diseases

Avec: Nicholas J Torelli , Afroza Akhtar , Kyle DeFrees , Priyadarshini Jaishankar , Orville A Pemberton , Xiujun Zhang , Cody Johnson , Adam R Renslo , Yu Chen

Inhibiting a dynamic viral protease by targeting a non-catalytic cysteine.

Cell chemical biology

Avec: Kaitlin R Hulce , Priyadarshini Jaishankar , Gregory M Lee , Markus-Frederik Bohn , Emily J Connelly , Kristin Wucherer , Chayanid Ongpipattanakul , Regan F Volk , Shih-Wei Chuo , Michelle R Arkin , Adam R Renslo , Charles S Craik

The Mac1 ADP-ribosylhydrolase is a Therapeutic Target for SARS-CoV-2.

bioRxiv : the preprint server for biology

Avec: Rahul K Suryawanshi , Priyadarshini Jaishankar , Galen J Correy , Moira M Rachman , Patrick C O'Leary , Taha Y Taha , Francisco J Zapatero-Belinchón , Maria McCavitt-Malvido , Yagmur U Doruk , Maisie G V Stevens , Morgan E Diolati , Manasi P Jogalekar , Alicia L Richards , Mauricio Montano , Julia Rosecrans , Michael Matthay , Takaya Togo , Ryan L Gonciarz , Saumya Gopalkrishnan , R Jeffrey Neitz , Nevan J Krogan , Danielle L Swaney , Brian K Shoichet , Melanie Ott , Adam R Renslo , Alan Ashworth , James S Fraser

Extensive exploration of structure activity relationships for the SARS-CoV-2 macrodomain from shape-based fragment merging and active learning.

bioRxiv : the preprint server for biology

Avec: Galen J Correy , Moira Rachman , Takaya Togo , Stefan Gahbauer , Yagmur U Doruk , Maisie Stevens , Priyadarshini Jaishankar , Brian Kelley , Brian Goldman , Molly Schmidt , Trevor Kramer , Alan Ashworth , Patrick Riley , Brian K Shoichet , Adam R Renslo , W Patrick Walters , James S Fraser

Réseau de co-auteurs

Adam R Renslo 13 collaborations

Michelle R Arkin 4 collaborations

Takaya Togo 3 collaborations

James S Fraser 3 collaborations

R Jeffrey Neitz 3 collaborations

Orville A Pemberton 2 collaborations

Afroza Akhtar 2 collaborations

Yu Chen 2 collaborations

Emira J Visser 2 collaborations

Shubhankar Dutta 2 collaborations

Christian Ottmann 2 collaborations

Luc Brunsveld 2 collaborations

Ryan L Gonciarz 2 collaborations

Galen J Correy 2 collaborations

Yagmur U Doruk 2 collaborations

Brian K Shoichet 2 collaborations

Alan Ashworth 2 collaborations

Aliesha L Griffin 1 collaboration

Jean-Marc Grandjean 1 collaboration

Steven H Olson 1 collaboration

Scott C Baraban 1 collaboration

Jessica Flowers 1 collaboration

Nathaniel Echols 1 collaboration

Galen Correy 1 collaboration

Priya Jaishankar 1 collaboration

Henry van den Bedem 1 collaboration

Stephanie A Wankowicz 1 collaboration

Dagmar E Ehrnhoefer 1 collaboration

Niels H Skotte 1 collaboration

Jeanette Reinshagen 1 collaboration

Xiaofan Qiu 1 collaboration

Björn Windshügel 1 collaboration

Safia Ladha 1 collaboration

Olga Petina 1 collaboration

Mehdi Khankischpur 1 collaboration

Yen T N Nguyen 1 collaboration

Nicholas S Caron 1 collaboration

Adelia Razeto 1 collaboration

Matthias Meyer Zu Rheda 1 collaboration

Yu Deng 1 collaboration

Khuong T Huynh 1 collaboration

Ilka Wittig 1 collaboration

Philip Gribbon 1 collaboration

Detlef Geffken 1 collaboration

Sheraz Gul 1 collaboration

Michael R Hayden 1 collaboration

Jessie L Adams 1 collaboration

Lindsey N Shaw 1 collaboration

Markella Konstantinidou 1 collaboration

Edmee Vandenboorn 1 collaboration

Sheng Chen 1 collaboration

Maurits Overmans 1 collaboration

Kurt S Van Horn 1 collaboration

Dongju Wang 1 collaboration

Daniel Medina-Cleghorn 1 collaboration

Peter S Lee 1 collaboration

Clifford Bryant 1 collaboration

Chad Altobelli 1 collaboration

Kevin K Leung 1 collaboration

Raymond A Ng 1 collaboration

Andrew J Ambrose 1 collaboration

Yinyan Tang 1 collaboration

Eline Sijbesma 1 collaboration

Marloes A M Pennings 1 collaboration

Edmee M F Vandenboorn 1 collaboration

Xavier Guillory 1 collaboration

John Morrow 1 collaboration

Matthew T Klope 1 collaboration

Juan A Tapia Cardona 1 collaboration

Jun Chen 1 collaboration

Ke Cheng 1 collaboration

Julie Kim 1 collaboration

Jenny Legac 1 collaboration

Philip J Rosenthal 1 collaboration

Charlene Bashore 1 collaboration

Nicholas J Skelton 1 collaboration

Jakob Fuhrmann 1 collaboration

Brian R Hearn 1 collaboration

Peter S Liu 1 collaboration

Erin C Dueber 1 collaboration

Nicholas J Torelli 1 collaboration

Kyle DeFrees 1 collaboration

Xiujun Zhang 1 collaboration

Cody Johnson 1 collaboration

Kaitlin R Hulce 1 collaboration

Gregory M Lee 1 collaboration

Markus-Frederik Bohn 1 collaboration

Emily J Connelly 1 collaboration

Kristin Wucherer 1 collaboration

Chayanid Ongpipattanakul 1 collaboration

Regan F Volk 1 collaboration

Shih-Wei Chuo 1 collaboration

Charles S Craik 1 collaboration

Rahul K Suryawanshi 1 collaboration

Moira M Rachman 1 collaboration

Patrick C O'Leary 1 collaboration

Taha Y Taha 1 collaboration

Francisco J Zapatero-Belinchón 1 collaboration

Maria McCavitt-Malvido 1 collaboration

Maisie G V Stevens 1 collaboration

Morgan E Diolati 1 collaboration

Manasi P Jogalekar 1 collaboration

Alicia L Richards 1 collaboration

Mauricio Montano 1 collaboration

Julia Rosecrans 1 collaboration

Michael Matthay 1 collaboration

Saumya Gopalkrishnan 1 collaboration

Nevan J Krogan 1 collaboration

Danielle L Swaney 1 collaboration

Melanie Ott 1 collaboration

Moira Rachman 1 collaboration

Stefan Gahbauer 1 collaboration

Maisie Stevens 1 collaboration

Brian Kelley 1 collaboration

Brian Goldman 1 collaboration

Molly Schmidt 1 collaboration

Trevor Kramer 1 collaboration

Patrick Riley 1 collaboration

W Patrick Walters 1 collaboration