Peter C Searson

Affiliations

Institute for Nanobiotechnology, Johns Hopkins University, Baltimore, Maryland 21218, United States.
Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland 21218, United States.
Department of Materials Science and Engineering, Johns Hopkins University, Baltimore, Maryland 21218, United States.

Publications (37)

Long-Term Cryopreservation Preserves Blood-Brain Barrier Phenotype of iPSC-Derived Brain Microvascular Endothelial Cells and Three-Dimensional Microvessels.

Molecular pharmaceutics

Avec: Raleigh M Linville , Jackson G DeStefano , Renée F Nerenberg , Gabrielle N Grifno , Robert Ye , Erin Gallagher , Peter C Searson

A peptide for transcellular cargo delivery: Structure-function relationship and mechanism of action.

Journal of controlled release : official journal of the Controlled Release Society

Avec: Alexander Komin , Maxim I Bogorad , Ran Lin , Honggang Cui , Peter C Searson , Kalina Hristova

Visualization of the Dynamics of Invasion and Intravasation of the Bacterium That Causes Lyme Disease in a Tissue Engineered Dermal Microvessel Model.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Avec: Zhaobin Guo , Nan Zhao , Tracy D Chung , Anjan Singh , Ikshu Pandey , Linus Wang , Xinyue Gu , Aisha Ademola , Raleigh M Linville , Utpal Pal , J Stephen Dumler , Peter C Searson

Modeling Substrate Entry into the P-Glycoprotein Efflux Pump at the Blood-Brain Barrier.

Journal of medicinal chemistry

Avec: Christian Jorgensen , Martin B Ulmschneider , Peter C Searson

Wearable Devices for Precision Medicine and Health State Monitoring.

IEEE transactions on bio-medical engineering

Avec: In Cheol Jeong , David Bychkov , Peter C Searson

Assessment of Patient Ambulation Profiles to Predict Hospital Readmission, Discharge Location, and Length of Stay in a Cardiac Surgery Progressive Care Unit.

JAMA network open

Avec: In Cheol Jeong , Ryan Healy , Benjamin Bao , William Xie , Tim Madeira , Marc Sussman , Glenn Whitman , Jennifer Schrack , Nicole Zahradka , Erik Hoyer , Charles Brown , Peter C Searson

Reversible blood-brain barrier opening utilizing the membrane active peptide melittin in vitro and in vivo.

Biomaterials

Avec: Raleigh M Linville , Alexander Komin , Xiaoyan Lan , Jackson G DeStefano , Chengyan Chu , Guanshu Liu , Piotr Walczak , Kalina Hristova , Peter C Searson

Three-dimensional microenvironment regulates gene expression, function, and tight junction dynamics of iPSC-derived blood-brain barrier microvessels.

Fluids and barriers of the CNS

Avec: Raleigh M Linville , Matthew B Sklar , Gabrielle N Grifno , Renée F Nerenberg , Justin Zhou , Robert Ye , Jackson G DeStefano , Zhaobin Guo , Ria Jha , John J Jamieson , Nan Zhao , Peter C Searson

A least-squares-fitting procedure for an efficient preclinical ranking of passive transport across the blood-brain barrier endothelium.

Journal of computer-aided molecular design

Avec: Christian Jorgensen , Evan P Troendle , Jakob P Ulmschneider , Peter C Searson , Martin B Ulmschneider

Three-dimensional induced pluripotent stem-cell models of human brain angiogenesis.

Microvascular research

Avec: Raleigh M Linville , Diego Arevalo , Joanna C Maressa , Nan Zhao , Peter C Searson

Human iPSC-derived blood-brain barrier microvessels: validation of barrier function and endothelial cell behavior.

Biomaterials

Avec: Raleigh M Linville , Jackson G DeStefano , Matt B Sklar , Zinnia Xu , Alanna M Farrell , Max I Bogorad , Chengyan Chu , Piotr Walczak , Linzhao Cheng , Vasiliki Mahairaki , Katharine A Whartenby , Peter A Calabresi , Peter C Searson

Effects of acute and chronic oxidative stress on the blood-brain barrier in 2D and 3D in vitro models.

Fluids and barriers of the CNS

Avec: Tracy D Chung , Raleigh M Linville , Zhaobin Guo , Robert Ye , Ria Jha , Gabrielle N Grifno , Peter C Searson

Hypoxia-induced blood-brain barrier dysfunction is prevented by pericyte-conditioned media via attenuated actomyosin contractility and claudin-5 stabilization.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Avec: John J Jamieson , YingYu Lin , Nicholas Malloy , Daniel Soto , Peter C Searson , Sharon Gerecht

Evaluation of physical health status beyond daily step count using a wearable activity sensor.

NPJ digital medicine

Avec: Zheng Xu , Nicole Zahradka , Seyvonne Ip , Amir Koneshloo , Ryan T Roemmich , Sameep Sehgal , Kristin B Highland , Peter C Searson

Corrigendum: The influence of physiological and pathological perturbations on blood-brain barrier function.

Frontiers in neuroscience

Avec: Nan Zhao , Tracy D Chung , Zhaobin Guo , John J Jamieson , Lily Liang , Raleigh M Linville , Alex F Pessell , Linus Wang , Peter C Searson

Gain-of-function mutations of TRPV4 acting in endothelial cells drive blood-CNS barrier breakdown and motor neuron degeneration in mice.

Science translational medicine

Avec: Jeremy M Sullivan , Anna M Bagnell , Jonathan Alevy , Elvia Mena Avila , Ljubica Mihaljević , Pamela C Saavedra-Rivera , Lingling Kong , Jennifer S Huh , Brett A McCray , William H Aisenberg , Aamir R Zuberi , Laurent Bogdanik , Cathleen M Lutz , Zhaozhu Qiu , Katharina A Quinlan , Peter C Searson , Charlotte J Sumner

A Tissue-Engineered 3D Microvessel Model Reveals the Dynamics of Mosaic Vessel Formation in Breast Cancer.

Cancer research

Avec: Vanesa L Silvestri , Elodie Henriet , Raleigh M Linville , Andrew D Wong , Peter C Searson , Andrew J Ewald

Engineered nanoparticles for systemic siRNA delivery to malignant brain tumours.

Nanoscale

Avec: Johan Karlsson , Yuan Rui , Kristen L Kozielski , Amanda L Placone , Olivia Choi , Stephany Y Tzeng , Jayoung Kim , Jamal J Keyes , Max I Bogorad , Kathleen Gabrielson , Hugo Guerrero-Cazares , Alfredo Quiñones-Hinojosa , Peter C Searson , Jordan J Green

An experimentally validated approach to calculate the blood-brain barrier permeability of small molecules.

Scientific reports

Avec: Yukun Wang , Erin Gallagher , Christian Jorgensen , Evan P Troendle , Dan Hu , Peter C Searson , Martin B Ulmschneider

Next-generation in vitro blood-brain barrier models: benchmarking and improving model accuracy.

Fluids and barriers of the CNS

Avec: Raleigh M Linville , Peter C Searson

Atomistic Model of Solute Transport across the Blood-Brain Barrier.

ACS omega

Avec: Christian Jorgensen , Martin B Ulmschneider , Peter C Searson

Chemotherapeutic Drug Delivery and Quantitative Analysis of Proliferation, Apoptosis, and Migration in a Tissue-Engineered Three-Dimensional Microvessel Model of the Tumor Microenvironment.

ACS biomaterials science & engineering

Avec: Andrew D Wong , Luisa M Russell , Moriah E Katt , Peter C Searson

Human IPSC 3D brain model as a tool to study chemical-induced dopaminergic neuronal toxicity.

Neurobiology of disease

Avec: David Pamies , Daphne Wiersma , Moriah E Katt , Liang Zhao , Johannes Burtscher , Georgina Harris , Lena Smirnova , Peter C Searson , Thomas Hartung , Helena T Hogberg

IgM anti-ACE2 autoantibodies in severe COVID-19 activate complement and perturb vascular endothelial function.

JCI insight

Avec: Livia Casciola-Rosen , David R Thiemann , Felipe Andrade , Maria I Trejo-Zambrano , Elissa K Leonard , Jamie B Spangler , Nicole E Skinner , Justin Bailey , Srinivasan Yegnasubramanian , Rulin Wang , Ajay M Vaghasia , Anuj Gupta , Andrea L Cox , Stuart C Ray , Raleigh M Linville , Zhaobin Guo , Peter C Searson , Carolyn E Machamer , Stephen Desiderio , Lauren M Sauer , Oliver Laeyendecker , Brian T Garibaldi , Li Gao , Mahendra Damarla , Paul M Hassoun , Jody E Hooper , Christopher A Mecoli , Lisa Christopher-Stine , Laura Gutierrez-Alamillo , Qingyuan Yang , David Hines , William A Clarke , Richard E Rothman , Andrew Pekosz , Katherine Zj Fenstermacher , Zitong Wang , Scott L Zeger , Antony Rosen

A tissue-engineered model of the blood-tumor barrier during metastatic breast cancer.

Fluids and barriers of the CNS

Avec: Raleigh M Linville , Joanna Maressa , Zhaobin Guo , Tracy D Chung , Alanna Farrell , Ria Jha , Peter C Searson

Modeling hyperosmotic blood-brain barrier opening within human tissue-engineered in vitro brain microvessels.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism

Avec: Raleigh M Linville , Jackson G DeStefano , Matt B Sklar , Chengyan Chu , Piotr Walczak , Peter C Searson

Optimization of osmotic blood-brain barrier opening to enable intravital microscopy studies on drug delivery in mouse cortex.

Journal of controlled release : official journal of the Controlled Release Society

Avec: Chengyan Chu , Anna Jablonska , Wojciech G Lesniak , Aline M Thomas , Xiaoyan Lan , Raleigh M Linville , Shen Li , Peter C Searson , Guanshu Liu , Monica Pearl , Martin G Pomper , Miroslaw Janowski , Tim Magnus , Piotr Walczak

Two Distinct Types of Sweat Profile in Healthy Subjects While Exercising at Constant Power Output Measured by a Wearable Sweat Sensor.

Scientific reports

Avec: Dong-Hoon Choi , Grant Kitchen , Ji Soo Kim , Yi Li , Kain Kim , In Cheol Jeong , Jane Nguyen , Kerry J Stewart , Scott L Zeger , Peter C Searson

The role of mutations associated with familial neurodegenerative disorders on blood-brain barrier function in an iPSC model.

Fluids and barriers of the CNS

Avec: Moriah E Katt , Lakyn N Mayo , Shannon E Ellis , Vasiliki Mahairaki , Jeffrey D Rothstein , Linzhao Cheng , Peter C Searson

Role of iPSC-derived pericytes on barrier function of iPSC-derived brain microvascular endothelial cells in 2D and 3D.

Fluids and barriers of the CNS

Avec: John J Jamieson , Raleigh M Linville , Yuan Yuan Ding , Sharon Gerecht , Peter C Searson

Tissue-engineered blood-brain barrier models via directed differentiation of human induced pluripotent stem cells.

Scientific reports

Avec: Gabrielle N Grifno , Alanna M Farrell , Raleigh M Linville , Diego Arevalo , Joo Ho Kim , Luo Gu , Peter C Searson

The Dynamic Response of Sweat Chloride to Changes in Exercise Load Measured by a Wearable Sweat Sensor.

Scientific reports

Avec: Dong-Hoon Choi , Grant B Kitchen , Kerry J Stewart , Peter C Searson

Out-of-clinic measurement of sweat chloride using a wearable sensor during low-intensity exercise.

NPJ digital medicine

Avec: Dong-Hoon Choi , Grant B Kitchen , Mark T Jennings , Garry R Cutting , Peter C Searson

Cerebrovascular plasticity: Processes that lead to changes in the architecture of brain microvessels.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism

Avec: Max I Bogorad , Jackson G DeStefano , Raleigh M Linville , Andrew D Wong , Peter C Searson

A Capacitive Sweat Rate Sensor for Continuous and Real-Time Monitoring of Sweat Loss.

ACS sensors

Avec: Dong-Hoon Choi , Mark Gonzales , Grant B Kitchen , Dinh-Tuan Phan , Peter C Searson

Brain microvascular endothelial cell dysfunction in an isogenic juvenile iPSC model of Huntington's disease.

Fluids and barriers of the CNS

Avec: Raleigh M Linville , Renée F Nerenberg , Gabrielle Grifno , Diego Arevalo , Zhaobin Guo , Peter C Searson

The influence of physiological and pathological perturbations on blood-brain barrier function.

Frontiers in neuroscience

Avec: Nan Zhao , Tracy D Chung , Zhaobin Guo , John J Jamieson , Lily Liang , Raleigh M Linville , Alex F Pessell , Linus Wang , Peter C Searson

Réseau de co-auteurs

Raleigh M Linville 19 collaborations

Zhaobin Guo 8 collaborations

Jackson G DeStefano 6 collaborations

Nan Zhao 5 collaborations

Tracy D Chung 5 collaborations

John J Jamieson 5 collaborations

Gabrielle N Grifno 4 collaborations

Christian Jorgensen 4 collaborations

Martin B Ulmschneider 4 collaborations

Chengyan Chu 4 collaborations

Piotr Walczak 4 collaborations

Dong-Hoon Choi 4 collaborations

Renée F Nerenberg 3 collaborations

Robert Ye 3 collaborations

Linus Wang 3 collaborations

In Cheol Jeong 3 collaborations

Ria Jha 3 collaborations

Diego Arevalo 3 collaborations

Max I Bogorad 3 collaborations

Andrew D Wong 3 collaborations

Moriah E Katt 3 collaborations

Grant B Kitchen 3 collaborations

Erin Gallagher 2 collaborations

Alexander Komin 2 collaborations

Kalina Hristova 2 collaborations

Nicole Zahradka 2 collaborations

Xiaoyan Lan 2 collaborations

Guanshu Liu 2 collaborations

Evan P Troendle 2 collaborations

Matt B Sklar 2 collaborations

Alanna M Farrell 2 collaborations

Linzhao Cheng 2 collaborations

Vasiliki Mahairaki 2 collaborations

Sharon Gerecht 2 collaborations

Lily Liang 2 collaborations

Alex F Pessell 2 collaborations

Scott L Zeger 2 collaborations

Kerry J Stewart 2 collaborations

Maxim I Bogorad 1 collaboration

Ran Lin 1 collaboration

Honggang Cui 1 collaboration

Anjan Singh 1 collaboration

Ikshu Pandey 1 collaboration

Xinyue Gu 1 collaboration

Aisha Ademola 1 collaboration

Utpal Pal 1 collaboration

J Stephen Dumler 1 collaboration

David Bychkov 1 collaboration

Ryan Healy 1 collaboration

Benjamin Bao 1 collaboration

William Xie 1 collaboration

Tim Madeira 1 collaboration

Marc Sussman 1 collaboration

Glenn Whitman 1 collaboration

Jennifer Schrack 1 collaboration

Erik Hoyer 1 collaboration

Charles Brown 1 collaboration

Matthew B Sklar 1 collaboration

Justin Zhou 1 collaboration

Jakob P Ulmschneider 1 collaboration

Joanna C Maressa 1 collaboration

Zinnia Xu 1 collaboration

Katharine A Whartenby 1 collaboration

Peter A Calabresi 1 collaboration

YingYu Lin 1 collaboration

Nicholas Malloy 1 collaboration

Daniel Soto 1 collaboration

Zheng Xu 1 collaboration

Seyvonne Ip 1 collaboration

Amir Koneshloo 1 collaboration

Ryan T Roemmich 1 collaboration

Sameep Sehgal 1 collaboration

Kristin B Highland 1 collaboration

Jeremy M Sullivan 1 collaboration

Anna M Bagnell 1 collaboration

Jonathan Alevy 1 collaboration

Elvia Mena Avila 1 collaboration

Ljubica Mihaljević 1 collaboration

Pamela C Saavedra-Rivera 1 collaboration

Lingling Kong 1 collaboration

Jennifer S Huh 1 collaboration

Brett A McCray 1 collaboration

William H Aisenberg 1 collaboration

Aamir R Zuberi 1 collaboration

Laurent Bogdanik 1 collaboration

Cathleen M Lutz 1 collaboration

Zhaozhu Qiu 1 collaboration

Katharina A Quinlan 1 collaboration

Charlotte J Sumner 1 collaboration

Vanesa L Silvestri 1 collaboration

Elodie Henriet 1 collaboration

Andrew J Ewald 1 collaboration

Johan Karlsson 1 collaboration

Yuan Rui 1 collaboration

Kristen L Kozielski 1 collaboration

Amanda L Placone 1 collaboration

Olivia Choi 1 collaboration

Stephany Y Tzeng 1 collaboration

Jayoung Kim 1 collaboration

Jamal J Keyes 1 collaboration

Kathleen Gabrielson 1 collaboration

Hugo Guerrero-Cazares 1 collaboration

Alfredo Quiñones-Hinojosa 1 collaboration

Jordan J Green 1 collaboration

Yukun Wang 1 collaboration

Dan Hu 1 collaboration

Luisa M Russell 1 collaboration

David Pamies 1 collaboration

Daphne Wiersma 1 collaboration

Liang Zhao 1 collaboration

Johannes Burtscher 1 collaboration

Georgina Harris 1 collaboration

Lena Smirnova 1 collaboration

Thomas Hartung 1 collaboration

Helena T Hogberg 1 collaboration

Livia Casciola-Rosen 1 collaboration

David R Thiemann 1 collaboration

Felipe Andrade 1 collaboration

Maria I Trejo-Zambrano 1 collaboration

Elissa K Leonard 1 collaboration

Jamie B Spangler 1 collaboration

Nicole E Skinner 1 collaboration

Justin Bailey 1 collaboration

Srinivasan Yegnasubramanian 1 collaboration

Rulin Wang 1 collaboration

Ajay M Vaghasia 1 collaboration

Anuj Gupta 1 collaboration

Andrea L Cox 1 collaboration

Stuart C Ray 1 collaboration

Carolyn E Machamer 1 collaboration

Stephen Desiderio 1 collaboration

Lauren M Sauer 1 collaboration

Oliver Laeyendecker 1 collaboration

Brian T Garibaldi 1 collaboration

Li Gao 1 collaboration

Mahendra Damarla 1 collaboration

Paul M Hassoun 1 collaboration

Jody E Hooper 1 collaboration

Christopher A Mecoli 1 collaboration

Lisa Christopher-Stine 1 collaboration

Laura Gutierrez-Alamillo 1 collaboration

Qingyuan Yang 1 collaboration

David Hines 1 collaboration

William A Clarke 1 collaboration

Richard E Rothman 1 collaboration

Andrew Pekosz 1 collaboration

Katherine Zj Fenstermacher 1 collaboration

Zitong Wang 1 collaboration

Antony Rosen 1 collaboration

Joanna Maressa 1 collaboration

Alanna Farrell 1 collaboration

Anna Jablonska 1 collaboration

Wojciech G Lesniak 1 collaboration

Aline M Thomas 1 collaboration

Shen Li 1 collaboration

Monica Pearl 1 collaboration

Martin G Pomper 1 collaboration

Miroslaw Janowski 1 collaboration

Tim Magnus 1 collaboration

Grant Kitchen 1 collaboration

Ji Soo Kim 1 collaboration

Yi Li 1 collaboration

Kain Kim 1 collaboration

Jane Nguyen 1 collaboration

Lakyn N Mayo 1 collaboration

Shannon E Ellis 1 collaboration

Jeffrey D Rothstein 1 collaboration

Yuan Yuan Ding 1 collaboration

Joo Ho Kim 1 collaboration

Luo Gu 1 collaboration

Mark T Jennings 1 collaboration

Garry R Cutting 1 collaboration

Mark Gonzales 1 collaboration

Dinh-Tuan Phan 1 collaboration

Gabrielle Grifno 1 collaboration