Pavel Janscak

Affiliations

Institute of Molecular Cancer Research, University of Zurich, 8057 Zurich, Switzerland; Institute of Molecular Genetics, Academy of Sciences of the Czech Republic, Videnska 1083, 143 00 Czech Republic.

Publications (13)

Efficient Pre-mRNA Cleavage Prevents Replication-Stress-Associated Genome Instability.

Molecular cell

Avec: Federico Teloni , Jone Michelena , Aleksandra Lezaja , Sinan Kilic , Christina Ambrosi , Shruti Menon , Jana Dobrovolna , Ralph Imhof , Pavel Janscak , Tuncay Baubec , Matthias Altmeyer

Cancer cells use self-inflicted DNA breaks to evade growth limits imposed by genotoxic stress.

Science (New York, N.Y.)

Avec: Brian D Larsen , Jan Benada , Philip Yuk Kwong Yung , Ryan A V Bell , George Pappas , Vaclav Urban , Johanna K Ahlskog , Tia T Kuo , Pavel Janscak , Lynn A Megeney , Simon J Elsässer , Jiri Bartek , Claus S Sørensen

RAD51 Inhibition Induces R-Loop Formation in Early G1 Phase of the Cell Cycle.

International journal of molecular sciences

Avec: Zuzana Nascakova , Barbora Boleslavska , Vaclav Urban , Anna Oravetzova , Edita Vlachova , Pavel Janscak , Jana Dobrovolna

Excessive reactive oxygen species induce transcription-dependent replication stress.

Nature communications

Avec: Martin Andrs , Henriette Stoy , Barbora Boleslavska , Nagaraja Chappidi , Radhakrishnan Kanagaraj , Zuzana Nascakova , Shruti Menon , Satyajeet Rao , Anna Oravetzova , Jana Dobrovolna , Kalpana Surendranath , Massimo Lopes , Pavel Janscak

The importance of nuclear RAGE-Mcm2 axis in diabetes or cancer-associated replication stress.

Nucleic acids research

Avec: Zhe Han , Martin Andrš , Bindhu K Madhavan , Serap Kaymak , Alba Sulaj , Zoltan Kender , Stefan Kopf , Lars Kihm , Rainer Pepperkok , Pavel Janscak , Peter Nawroth , Varun Kumar

RECQ5: A Mysterious Helicase at the Interface of DNA Replication and Transcription.

Genes

Avec: Martin Andrs , Zdenka Hasanova , Anna Oravetzova , Jana Dobrovolna , Pavel Janscak

MutSβ regulates G4-associated telomeric R-loops to maintain telomere integrity in ALT cancer cells.

Cell reports

Avec: Despoina Sakellariou , Sara Thornby Bak , Esin Isik , Sonia I Barroso , Antonio Porro , Andrés Aguilera , Jiri Bartek , Pavel Janscak , Javier Peña-Diaz

Senataxin RNA/DNA helicase promotes replication restart at co-transcriptional R-loops to prevent MUS81-dependent fork degradation.

Nucleic acids research

Avec: Satyajeet Rao , Martin Andrs , Kaustubh Shukla , Esin Isik , Christiane König , Stefan Schneider , Michael Bauer , Vinicio Rosano , Jiri Prokes , Anne Müller , Pavel Janscak

Fork Cleavage-Religation Cycle and Active Transcription Mediate Replication Restart after Fork Stalling at Co-transcriptional R-Loops.

Molecular cell

Avec: Nagaraja Chappidi , Zuzana Nascakova , Barbora Boleslavska , Ralph Zellweger , Esin Isik , Martin Andrs , Shruti Menon , Jana Dobrovolna , Chiara Balbo Pogliano , Joao Matos , Antonio Porro , Massimo Lopes , Pavel Janscak

The ALPK1/TIFA/NF-κB axis links a bacterial carcinogen to R-loop-induced replication stress.

Nature communications

Avec: Michael Bauer , Zuzana Nascakova , Anca-Irina Mihai , Phil F Cheng , Mitchell P Levesque , Simon Lampart , Robert Hurwitz , Lennart Pfannkuch , Jana Dobrovolna , Melanie Jacobs , Sina Bartfeld , Anders Dohlman , Xiling Shen , Alevtina A Gall , Nina R Salama , Antonia Töpfer , Achim Weber , Thomas F Meyer , Pavel Janscak , Anne Müller

DDX17 helicase promotes resolution of R-loop-mediated transcription-replication conflicts in human cells.

Nucleic acids research

Avec: Barbora Boleslavska , Anna Oravetzova , Kaustubh Shukla , Zuzana Nascakova , Oluwakemi Ngozi Ibini , Zdenka Hasanova , Martin Andrs , Radhakrishnan Kanagaraj , Jana Dobrovolna , Pavel Janscak

PPM1D activity promotes the replication stress caused by cyclin E1 overexpression.

Molecular oncology

Avec: Andra S Martinikova , Miroslav Stoyanov , Anna Oravetzova , Yannick P Kok , Shibo Yu , Jana Dobrovolna , Pavel Janscak , Marcel van Vugt , Libor Macurek

MutSβ-MutLβ-FANCJ axis mediates the restart of DNA replication after fork stalling at cotranscriptional G4/R-loops.

Science advances

Avec: Esin Isik , Kaustubh Shukla , Michaela Pospisilova , Christiane König , Martin Andrs , Satyajeet Rao , Vinicio Rosano , Jana Dobrovolna , Lumir Krejci , Pavel Janscak

Réseau de co-auteurs

Jana Dobrovolna 9 collaborations

Martin Andrs 6 collaborations

Zuzana Nascakova 5 collaborations

Anna Oravetzova 5 collaborations

Barbora Boleslavska 4 collaborations

Esin Isik 4 collaborations

Shruti Menon 3 collaborations

Satyajeet Rao 3 collaborations

Kaustubh Shukla 3 collaborations

Vaclav Urban 2 collaborations

Jiri Bartek 2 collaborations

Nagaraja Chappidi 2 collaborations

Radhakrishnan Kanagaraj 2 collaborations

Massimo Lopes 2 collaborations

Zdenka Hasanova 2 collaborations

Antonio Porro 2 collaborations

Christiane König 2 collaborations

Michael Bauer 2 collaborations

Vinicio Rosano 2 collaborations

Anne Müller 2 collaborations

Federico Teloni 1 collaboration

Jone Michelena 1 collaboration

Aleksandra Lezaja 1 collaboration

Sinan Kilic 1 collaboration

Christina Ambrosi 1 collaboration

Ralph Imhof 1 collaboration

Tuncay Baubec 1 collaboration

Matthias Altmeyer 1 collaboration

Brian D Larsen 1 collaboration

Jan Benada 1 collaboration

Philip Yuk Kwong Yung 1 collaboration

Ryan A V Bell 1 collaboration

George Pappas 1 collaboration

Johanna K Ahlskog 1 collaboration

Tia T Kuo 1 collaboration

Lynn A Megeney 1 collaboration

Simon J Elsässer 1 collaboration

Claus S Sørensen 1 collaboration

Edita Vlachova 1 collaboration

Henriette Stoy 1 collaboration

Kalpana Surendranath 1 collaboration

Zhe Han 1 collaboration

Martin Andrš 1 collaboration

Bindhu K Madhavan 1 collaboration

Serap Kaymak 1 collaboration

Alba Sulaj 1 collaboration

Zoltan Kender 1 collaboration

Stefan Kopf 1 collaboration

Lars Kihm 1 collaboration

Rainer Pepperkok 1 collaboration

Peter Nawroth 1 collaboration

Varun Kumar 1 collaboration

Despoina Sakellariou 1 collaboration

Sara Thornby Bak 1 collaboration

Sonia I Barroso 1 collaboration

Andrés Aguilera 1 collaboration

Javier Peña-Diaz 1 collaboration

Stefan Schneider 1 collaboration

Jiri Prokes 1 collaboration

Ralph Zellweger 1 collaboration

Chiara Balbo Pogliano 1 collaboration

Joao Matos 1 collaboration

Anca-Irina Mihai 1 collaboration

Phil F Cheng 1 collaboration

Mitchell P Levesque 1 collaboration

Simon Lampart 1 collaboration

Robert Hurwitz 1 collaboration

Lennart Pfannkuch 1 collaboration

Melanie Jacobs 1 collaboration

Sina Bartfeld 1 collaboration

Anders Dohlman 1 collaboration

Xiling Shen 1 collaboration

Alevtina A Gall 1 collaboration

Nina R Salama 1 collaboration

Antonia Töpfer 1 collaboration

Achim Weber 1 collaboration

Thomas F Meyer 1 collaboration

Oluwakemi Ngozi Ibini 1 collaboration

Andra S Martinikova 1 collaboration

Miroslav Stoyanov 1 collaboration

Yannick P Kok 1 collaboration

Shibo Yu 1 collaboration

Marcel van Vugt 1 collaboration

Libor Macurek 1 collaboration

Michaela Pospisilova 1 collaboration

Lumir Krejci 1 collaboration