Patrick Legembre

Affiliations

INSERM U1262, CRIBL, Université de Limoges, Limoges, France.

Publications (25)

CD95 Structure, Aggregation and Cell Signaling.

Frontiers in cell and developmental biology

Avec: Nicolas Levoin , Mickael Jean , Patrick Legembre

CD95/Fas protects triple negative breast cancer from anti-tumor activity of NK cells.

iScience

Avec: Abdul S Qadir , Jean Philippe Guégan , Christophe Ginestier , Assia Chaibi , Alban Bessede , Emmanuelle Charafe-Jauffret , Manon Macario , Vincent Lavoué , Thibault de la Motte Rouge , Calvin Law , Jacob Vilker , Hongbin Wang , Emily Stroup , Matthew J Schipma , Bryan Bridgeman , Andrea E Murmann , Zhe Ji , Patrick Legembre , Marcus E Peter

CD95 (Fas) and CD95L (FasL)-mediated non-canonical signaling pathways.

Biochimica et biophysica acta. Reviews on cancer

Avec: Layla Haymour , Mickael Jean , Cristian Smulski , Patrick Legembre

Staphylococcus aureus induces DNA damage in host cell.

Scientific reports

Avec: Martine Deplanche , Nassim Mouhali , Minh-Thu Nguyen , Chantal Cauty , Frédéric Ezan , Alan Diot , Lesly Raulin , Stephanie Dutertre , Sophie Langouet , Patrick Legembre , Frederic Taieb , Michael Otto , Frédéric Laurent , Friedrich Götz , Yves Le Loir , Nadia Berkova

An insight into the role of the death receptor CD95 throughout pregnancy: Guardian, facilitator, or foe.

Birth defects research

Avec: Lucas Sagrillo-Fagundes , Josianne Bienvenue-Pariseault , Patrick Legembre , Cathy Vaillancourt

Phospholipase A2 inhibitor and LY6/PLAUR domain-containing protein PINLYP regulates type I interferon innate immunity.

Proceedings of the National Academy of Sciences of the United States of America

Avec: Zhongshun Liu , Congwei Jiang , Zhangmengxue Lei , Sihan Dong , Linlin Kuang , Chenxu Huang , Ying Gao , Mu Liu , Hui Xiao , Patrick Legembre , Jae U Jung , Huaping Liang , Xiaozhen Liang

CD95/Fas suppresses NF-κB activation through recruitment of KPC2 in a CD95L/FasL-independent mechanism.

iScience

Avec: Jean-Philippe Guégan , Justine Pollet , Christophe Ginestier , Emmanuelle Charafe-Jauffret , Marcus E Peter , Patrick Legembre

CD95/Fas and metastatic disease: What does not kill you makes you stronger.

Seminars in cancer biology

Avec: Jean Philippe Guégan , Christophe Ginestier , Emmanuelle Charafe-Jauffret , Thomas Ducret , Jean-François Quignard , Pierre Vacher , Patrick Legembre

Selectins impair regulatory T cell function and contribute to systemic lupus erythematosus pathogenesis.

Science translational medicine

Avec: Marc Scherlinger , Vivien Guillotin , Isabelle Douchet , Pierre Vacher , Andréa Boizard-Moracchini , Jean-Philippe Guegan , Anne Garreau , Nathalie Merillon , Agathe Vermorel , Emmanuel Ribeiro , Irène Machelart , Estibaliz Lazaro , Lionel Couzi , Pierre Duffau , Thomas Barnetche , Jean-Luc Pellegrin , Jean-François Viallard , Maya Saleh , Thierry Schaeverbeke , Patrick Legembre , Marie-Elise Truchetet , Hélène Dumortier , Cécile Contin-Bordes , Vanja Sisirak , Christophe Richez , Patrick Blanco

Keeping Cell Death Alive: An Introduction into the French Cell Death Research Network.

Biomolecules

Avec: Gabriel Ichim , Benjamin Gibert , Sahil Adriouch , Catherine Brenner , Nathalie Davoust , Solange Desagher , David Devos , Svetlana Dokudovskaya , Laurence Dubrez , Jérôme Estaquier , Germain Gillet , Isabelle Guénal , Philippe P Juin , Guido Kroemer , Patrick Legembre , Romain Levayer , Stéphen Manon , Patrick Mehlen , Olivier Meurette , Olivier Micheau , Bernard Mignotte , Florence Nguyen-Khac , Nikolay Popgeorgiev , Jean-Luc Poyet , Muriel Priault , Jean-Ehrland Ricci , Franck B Riquet , Santos A Susin , Magali Suzanne , Pierre Vacher , Ludivine Walter , Bertrand Mollereau

Small molecules that disrupt RAD54-BLM interaction hamper tumor proliferation in colon cancer chemoresistance models.

The Journal of clinical investigation

Avec: Ekjot Kaur , Ritu Agrawal , Rimpy Arun , Vinoth Madhavan , Vivek Srivastava , Dilip Kumar , Pragyan Parimita Rath , Nitin Kumar , Sreekanth Vedagopuram , Nishant Pandey , Swati Priya , Patrick Legembre , Samudrala Gourinath , Avinash Bajaj , Sagar Sengupta

Membrane-bound CD95 ligand modulates CD19-mediated B cell receptor signaling and EBV activation.

Journal of medical virology

Avec: Mu Liu , Chenxu Huang , Xingchen Zhou , Congwei Jiang , Shuai Liu , Ying Gao , Linlin Kuang , Zhangmengxue Lei , Ran Jia , Jin Xu , Patrick Legembre , Xiaozhen Liang

Correction: The Naturally Processed CD95L Elicits a c-Yes/Calcium/PI3K-Driven Cell Migration Pathway.

PLoS biology

Avec: Sébastien Tauzin , Benjamin Chaigne-Delalande , Eric Selva , Nadine Khadra , Sophie Daburon , Cécile Contin-Bordes , Patrick Blanco , Jacques Le Seyec , Thomas Ducret , Laurent Counillon , Jean-François Moreau , Paul Hofman , Pierre Vacher , Patrick Legembre

Probing the side chain tolerance for inhibitors of the CD95/PLCγ1 interaction.

Bioorganic & medicinal chemistry letters

Avec: Ha Thanh Nguyen , Jean-Philippe Guégan , Daniel Best , Pierre van de Weghe , Nicolas Levoin , Patrick Legembre , Mickael Jean

Fas/CD95 Signaling Pathway in Damage-Associated Molecular Pattern (DAMP)-Sensing Receptors.

Cells

Avec: Gael Galli , Pierre Vacher , Bernhard Ryffel , Patrick Blanco , Patrick Legembre

MMP7 cleavage of amino-terminal CD95 death receptor switches signaling toward non-apoptotic pathways.

Cell death & disease

Avec: Shoji F Kenji , Keerthi Kurma , Brigitte Collet , Christelle Oblet , Laure Debure , Carmelo Di Primo , Laëtitia Minder , Franck Vérité , Yannic Danger , Mickael Jean , Aubin Penna , Nicolas Levoin , Patrick Legembre

Correction: The Naturally Processed CD95L Elicits a c-Yes/Calcium/PI3K-Driven Cell Migration Pathway.

PLoS biology

Role of metalloproteases in the CD95 signaling pathways.

Frontiers in immunology

Avec: Laurent Devel , Nicolas Guedeney , Sarah Bregant , Animesh Chowdhury , Mickael Jean , Patrick Legembre

Single bilateral ovarian venous return in uterine transplant: Validation in an orthotopic auto-transplant model in the Yucatan minipig.

Journal of gynecology obstetrics and human reproduction

Avec: Ludivine Dion , Maela Le Lous , Krystel Nyangoh Timoh , Jean Levêque , Alexis Arnaud , Charles Henri-Malbert , Fabrice Foucher , Karim Boudjema , Claude Bendavid , Cécile Vigneau , Patrick Legembre , David Val-Laillet , Vincent Lavoué

Synthesis of peptidomimetics and chemo-biological tools for CD95/PLCγ1 interaction analysis.

Bioorganic & medicinal chemistry letters

Avec: Ha Thanh Nguyen , Jean-Philippe Guégan , Amanda Poissonnier , Florence Jouan , Daniel Best , Pierre van de Weghe , Pierre Vacher , Nicolas Levoin , Patrick Legembre , Mickael Jean

Serum CD95L Level Correlates with Tumor Immune Infiltration and Is a Positive Prognostic Marker for Advanced High-Grade Serous Ovarian Cancer.

Molecular cancer research : MCR

Avec: Thibault De La Motte Rouge , Julien Corné , Aurélie Cauchois , Marie Le Boulch , Clotilde Poupon , Sébastien Henno , Nathalie Rioux-Leclercq , Estelle Le Pabic , Bruno Laviolle , Véronique Catros , Jean Levêque , Alain Fautrel , Matthieu Le Gallo , Patrick Legembre , Vincent Lavoué

Investigation of Phospholipase Cγ1 Interaction with SLP76 Using Molecular Modeling Methods for Identifying Novel Inhibitors.

International journal of molecular sciences

Avec: Neha Tripathi , Iyanar Vetrivel , Stéphane Téletchéa , Mickaël Jean , Patrick Legembre , Adèle D Laurent

Soluble CD95L in cancers and chronic inflammatory disorders, a new therapeutic target?

Biochimica et biophysica acta. Reviews on cancer

Avec: Keerthi Kurma , Andrea Boizard-Moracchini , Gael Galli , Mickael Jean , Pierre Vacher , Patrick Blanco , Patrick Legembre

Ambivalent role of FasL in murine acute graft-versus-host-disease.

Journal of leukocyte biology

Avec: Robin Bernard-Bloch , Eden Lebrault , Xiaofan Li , Aurélien Sutra Del Galy , Arlette Garcia , Christelle Doliger , Véronique Parietti , Patrick Legembre , Gérard Socié , Saoussen Karray

CD95L concatemers highlight different stoichiometries of CD95-mediated apoptotic and nonapoptotic pathways.

European journal of immunology

Avec: Eden Lebrault , Christelle Oblet , Keerthi Kurma , Nicolas Levoin , Robin Jeannet , Mickael Jean , Pierre Vacher , Patrick Legembre

Réseau de co-auteurs

Pierre Vacher 9 collaborations

Mickael Jean 8 collaborations

Nicolas Levoin 5 collaborations

Patrick Blanco 5 collaborations

Christophe Ginestier 3 collaborations

Emmanuelle Charafe-Jauffret 3 collaborations

Vincent Lavoué 3 collaborations

Jean-Philippe Guégan 3 collaborations

Thomas Ducret 3 collaborations

Cécile Contin-Bordes 3 collaborations

Keerthi Kurma 3 collaborations

Jean Philippe Guégan 2 collaborations

Marcus E Peter 2 collaborations

Congwei Jiang 2 collaborations

Zhangmengxue Lei 2 collaborations

Linlin Kuang 2 collaborations

Chenxu Huang 2 collaborations

Ying Gao 2 collaborations

Mu Liu 2 collaborations

Xiaozhen Liang 2 collaborations

Sébastien Tauzin 2 collaborations

Benjamin Chaigne-Delalande 2 collaborations

Eric Selva 2 collaborations

Nadine Khadra 2 collaborations

Sophie Daburon 2 collaborations

Jacques Le Seyec 2 collaborations

Laurent Counillon 2 collaborations

Jean-François Moreau 2 collaborations

Paul Hofman 2 collaborations

Ha Thanh Nguyen 2 collaborations

Daniel Best 2 collaborations

Pierre van de Weghe 2 collaborations

Gael Galli 2 collaborations

Christelle Oblet 2 collaborations

Jean Levêque 2 collaborations

Eden Lebrault 2 collaborations

Abdul S Qadir 1 collaboration

Assia Chaibi 1 collaboration

Alban Bessede 1 collaboration

Manon Macario 1 collaboration

Thibault de la Motte Rouge 1 collaboration

Calvin Law 1 collaboration

Jacob Vilker 1 collaboration

Hongbin Wang 1 collaboration

Emily Stroup 1 collaboration

Matthew J Schipma 1 collaboration

Bryan Bridgeman 1 collaboration

Andrea E Murmann 1 collaboration

Zhe Ji 1 collaboration

Layla Haymour 1 collaboration

Cristian Smulski 1 collaboration

Martine Deplanche 1 collaboration

Nassim Mouhali 1 collaboration

Minh-Thu Nguyen 1 collaboration

Chantal Cauty 1 collaboration

Frédéric Ezan 1 collaboration

Alan Diot 1 collaboration

Lesly Raulin 1 collaboration

Stephanie Dutertre 1 collaboration

Sophie Langouet 1 collaboration

Frederic Taieb 1 collaboration

Michael Otto 1 collaboration

Frédéric Laurent 1 collaboration

Friedrich Götz 1 collaboration

Yves Le Loir 1 collaboration

Nadia Berkova 1 collaboration

Lucas Sagrillo-Fagundes 1 collaboration

Josianne Bienvenue-Pariseault 1 collaboration

Cathy Vaillancourt 1 collaboration

Zhongshun Liu 1 collaboration

Sihan Dong 1 collaboration

Hui Xiao 1 collaboration

Jae U Jung 1 collaboration

Huaping Liang 1 collaboration

Justine Pollet 1 collaboration

Jean-François Quignard 1 collaboration

Marc Scherlinger 1 collaboration

Vivien Guillotin 1 collaboration

Isabelle Douchet 1 collaboration

Andréa Boizard-Moracchini 1 collaboration

Jean-Philippe Guegan 1 collaboration

Anne Garreau 1 collaboration

Nathalie Merillon 1 collaboration

Agathe Vermorel 1 collaboration

Emmanuel Ribeiro 1 collaboration

Irène Machelart 1 collaboration

Estibaliz Lazaro 1 collaboration

Lionel Couzi 1 collaboration

Pierre Duffau 1 collaboration

Thomas Barnetche 1 collaboration

Jean-Luc Pellegrin 1 collaboration

Jean-François Viallard 1 collaboration

Maya Saleh 1 collaboration

Thierry Schaeverbeke 1 collaboration

Marie-Elise Truchetet 1 collaboration

Hélène Dumortier 1 collaboration

Vanja Sisirak 1 collaboration

Christophe Richez 1 collaboration

Gabriel Ichim 1 collaboration

Benjamin Gibert 1 collaboration

Sahil Adriouch 1 collaboration

Catherine Brenner 1 collaboration

Nathalie Davoust 1 collaboration

Solange Desagher 1 collaboration

David Devos 1 collaboration

Svetlana Dokudovskaya 1 collaboration

Laurence Dubrez 1 collaboration

Jérôme Estaquier 1 collaboration

Germain Gillet 1 collaboration

Isabelle Guénal 1 collaboration

Philippe P Juin 1 collaboration

Guido Kroemer 1 collaboration

Romain Levayer 1 collaboration

Stéphen Manon 1 collaboration

Patrick Mehlen 1 collaboration

Olivier Meurette 1 collaboration

Olivier Micheau 1 collaboration

Bernard Mignotte 1 collaboration

Florence Nguyen-Khac 1 collaboration

Nikolay Popgeorgiev 1 collaboration

Jean-Luc Poyet 1 collaboration

Muriel Priault 1 collaboration

Jean-Ehrland Ricci 1 collaboration

Franck B Riquet 1 collaboration

Santos A Susin 1 collaboration

Magali Suzanne 1 collaboration

Ludivine Walter 1 collaboration

Bertrand Mollereau 1 collaboration

Ekjot Kaur 1 collaboration

Ritu Agrawal 1 collaboration

Rimpy Arun 1 collaboration

Vinoth Madhavan 1 collaboration

Vivek Srivastava 1 collaboration

Dilip Kumar 1 collaboration

Pragyan Parimita Rath 1 collaboration

Nitin Kumar 1 collaboration

Sreekanth Vedagopuram 1 collaboration

Nishant Pandey 1 collaboration

Swati Priya 1 collaboration

Samudrala Gourinath 1 collaboration

Avinash Bajaj 1 collaboration

Sagar Sengupta 1 collaboration

Xingchen Zhou 1 collaboration

Shuai Liu 1 collaboration

Ran Jia 1 collaboration

Jin Xu 1 collaboration

Bernhard Ryffel 1 collaboration

Shoji F Kenji 1 collaboration

Brigitte Collet 1 collaboration

Laure Debure 1 collaboration

Carmelo Di Primo 1 collaboration

Laëtitia Minder 1 collaboration

Franck Vérité 1 collaboration

Yannic Danger 1 collaboration

Aubin Penna 1 collaboration

Laurent Devel 1 collaboration

Nicolas Guedeney 1 collaboration

Sarah Bregant 1 collaboration

Animesh Chowdhury 1 collaboration

Ludivine Dion 1 collaboration

Maela Le Lous 1 collaboration

Krystel Nyangoh Timoh 1 collaboration

Alexis Arnaud 1 collaboration

Charles Henri-Malbert 1 collaboration

Fabrice Foucher 1 collaboration

Karim Boudjema 1 collaboration

Claude Bendavid 1 collaboration

Cécile Vigneau 1 collaboration

David Val-Laillet 1 collaboration

Amanda Poissonnier 1 collaboration

Florence Jouan 1 collaboration

Thibault De La Motte Rouge 1 collaboration

Julien Corné 1 collaboration

Aurélie Cauchois 1 collaboration

Marie Le Boulch 1 collaboration

Clotilde Poupon 1 collaboration

Sébastien Henno 1 collaboration

Nathalie Rioux-Leclercq 1 collaboration

Estelle Le Pabic 1 collaboration

Bruno Laviolle 1 collaboration

Véronique Catros 1 collaboration

Alain Fautrel 1 collaboration

Matthieu Le Gallo 1 collaboration

Neha Tripathi 1 collaboration

Iyanar Vetrivel 1 collaboration

Stéphane Téletchéa 1 collaboration

Mickaël Jean 1 collaboration

Adèle D Laurent 1 collaboration

Andrea Boizard-Moracchini 1 collaboration

Robin Bernard-Bloch 1 collaboration

Xiaofan Li 1 collaboration

Aurélien Sutra Del Galy 1 collaboration

Arlette Garcia 1 collaboration

Christelle Doliger 1 collaboration

Véronique Parietti 1 collaboration

Gérard Socié 1 collaboration

Saoussen Karray 1 collaboration

Robin Jeannet 1 collaboration