Patricia S Steeg

Affiliations

Women's Malignancies Branch, Center for Cancer Research and Natural Products Branch, Developmental Therapeutics Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, National Institutes of Health, Frederick, MD, USA.

Publications (22)

Antibody-drug conjugates for cancer.

Lancet (London, England)

Avec: Cindy H Chau , Patricia S Steeg , William D Figg

Tumour exosomal CEMIP protein promotes cancer cell colonization in brain metastasis.

Nature cell biology

Avec: Gonçalo Rodrigues , Ayuko Hoshino , Candia M Kenific , Irina R Matei , Loïc Steiner , Daniela Freitas , Han Sang Kim , Peter R Oxley , Ilana Scandariato , Irene Casanova-Salas , Jinxiang Dai , Chaitanya R Badwe , Brunilde Gril , Milica Tešić Mark , Brian D Dill , Henrik Molina , Haiying Zhang , Alberto Benito-Martin , Linda Bojmar , Yonathan Ararso , Katharine Offer , Quincey LaPlant , Weston Buehring , Huajuan Wang , Xinran Jiang , Tyler M Lu , Yuan Liu , Joshua K Sabari , Sandra J Shin , Navneet Narula , Paula S Ginter , Vinagolu K Rajasekhar , John H Healey , Etienne Meylan , Bruno Costa-Silva , Shizhen Emily Wang , Shahin Rafii , Nasser Khaled Altorki , Charles M Rudin , David R Jones , Patricia S Steeg , Héctor Peinado , Cyrus M Ghajar , Jacqueline Bromberg , Maria de Sousa , David Pisapia , David Lyden

MEDI3039, a novel highly potent tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) receptor 2 agonist, causes regression of orthotopic tumors and inhibits outgrowth of metastatic triple-negative breast cancer.

Breast cancer research : BCR

Avec: Yoshimi Endo Greer , Samuel F Gilbert , Brunilde Gril , Rajesh Narwal , Danielle L Peacock Brooks , David A Tice , Patricia S Steeg , Stanley Lipkowitz

Identification and Characterization of Cancer Cells That Initiate Metastases to the Brain and Other Organs.

Molecular cancer research : MCR

Avec: Anna S Berghoff , Yunxiang Liao , Matthia A Karreman , Ayseguel Ilhan-Mutlu , Katharina Gunkel , Martin R Sprick , Christian Eisen , Tobias Kessler , Matthias Osswald , Susanne Wünsche , Manuel Feinauer , Brunhilde Gril , Frederic Marmé , Laura L Michel , Zuszanna Bago-Horvath , Felix Sahm , Natalia Becker , Michael O Breckwoldt , Gergely Solecki , Miriam Gömmel , Lulu Huang , Petra Rübmann , Carina M Thome , Miriam Ratliff , Andreas Trumpp , Patricia S Steeg , Matthias Preusser , Wolfgang Wick , Frank Winkler

Endocytosis: a pivotal pathway for regulating metastasis.

British journal of cancer

Avec: Imran Khan , Patricia S Steeg

Distinct uptake and elimination profiles for trastuzumab, human IgG and biocytin-TMR in experimental HER2+ brain metastases of breast cancer.

Neuro-oncology

Avec: Vanesa L Silvestri , Andy D Tran , Monika Chung , Natalie Chung , Brunilde Gril , Christina Robinson , Simone Difilippantonio , Debbie Wei , Michael J Kruhlak , Cody J Peer , W Douglas Figg , Imran Khan , Patricia S Steeg

Estradiol induces BDNF/TrkB signaling in triple-negative breast cancer to promote brain metastases.

Oncogene

Avec: Maria J Contreras-Zárate , Nicole L Day , D Ryan Ormond , Virginia F Borges , Stuart Tobet , Brunilde Gril , Patricia S Steeg , Diana M Cittelly

A framework for the development of effective anti-metastatic agents.

Nature reviews. Clinical oncology

Avec: Robin L Anderson , Theo Balasas , Juliana Callaghan , R Charles Coombes , Jeff Evans , Jacqueline A Hall , Sally Kinrade , David Jones , Paul S Jones , Rob Jones , John F Marshall , Maria Beatrice Panico , Jacqui A Shaw , Patricia S Steeg , Mark Sullivan , Warwick Tong , Andrew D Westwell , James W A Ritchie , Auteur inconnu

Brain Metastasis Cell Lines Panel: A Public Resource of Organotropic Cell Lines.

Cancer research

Avec: Manuel Valiente , Amanda E D Van Swearingen , Carey K Anders , Amos Bairoch , Adrienne Boire , Paula D Bos , Diana M Cittelly , Neta Erez , Gino B Ferraro , Dai Fukumura , Brunilde Gril , Meenhard Herlyn , Sheri L Holmen , Rakesh K Jain , Johanna A Joyce , Mihaela Lorger , Joan Massague , Josh Neman , Nicola R Sibson , Patricia S Steeg , Frits Thorsen , Leonie S Young , Damir Varešlija , Adina Vultur , Frances Weis-Garcia , Frank Winkler

National Cancer Institute Collaborative Workshop on Shaping the Landscape of Brain Metastases Research: challenges and recommended priorities.

The Lancet. Oncology

Avec: Michelle M Kim , Minesh P Mehta , DeeDee K Smart , Patricia S Steeg , Julie A Hong , Michael G Espey , Pataje G Prasanna , Laura Crandon , Christine Hodgdon , Niki Kozak , Terri S Armstrong , Aki Morikawa , Nicole Willmarth , Kirk Tanner , Adrienne Boire , Melanie Hayden Gephart , Kim A Margolin , Jona Hattangadi-Gluth , Hussein Tawbi , Daniel M Trifiletti , Caroline Chung , Upal Basu-Roy , Robyn Burns , Isabella C Glitza Oliva , Ayal A Aizer , Carey K Anders , Joanne Davis , Manmeet S Ahluwalia , Veronica Chiang , Jing Li , Rupesh Kotecha , Silvia C Formenti , Benjamin M Ellingson , Vinai Gondi , Paul W Sperduto , Jill S Barnholtz-Sloan , Jordi Rodon , Eudocia Q Lee , Mustafa Khasraw , Debra Nana Yeboa , Priscilla K Brastianos , Evanthia Galanis , C Norman Coleman , Mansoor M Ahmed

The murine metastatic microenvironment of experimental brain metastases of breast cancer differs by host age in vivo: a proteomic study.

Clinical & experimental metastasis

Avec: Allison L Hunt , Imran Khan , Alex M L Wu , Sasha C Makohon-Moore , Brian L Hood , Kelly A Conrads , Tamara Abulez , Jonathan Ogata , Dave Mitchell , Glenn Gist , Julie Oliver , Debbie Wei , Monika A Chung , Samiur Rahman , Nicholas W Bateman , Wei Zhang , Thomas P Conrads , Patricia S Steeg

Aging and CNS Myeloid Cell Depletion Attenuate Breast Cancer Brain Metastasis.

Clinical cancer research : an official journal of the American Association for Cancer Research

Avec: Alex Man Lai Wu , Selamawit Gossa , Ramakrishna Samala , Monika A Chung , Brunilde Gril , Howard H Yang , Helen R Thorsheim , Andy D Tran , Debbie Wei , Esra Taner , Kristine Isanogle , Yuan Yang , Emma L Dolan , Christina Robinson , Simone Difilippantonio , Maxwell P Lee , Imran Khan , Quentin R Smith , Dorian B McGavern , Lalage M Wakefield , Patricia S Steeg

Brain metastases.

Nature reviews. Disease primers

Avec: Achal Singh Achrol , Robert C Rennert , Carey Anders , Riccardo Soffietti , Manmeet S Ahluwalia , Lakshmi Nayak , Solange Peters , Nils D Arvold , Griffith R Harsh , Patricia S Steeg , Steven D Chang

The blood-tumour barrier in cancer biology and therapy.

Nature reviews. Clinical oncology

Avec: Patricia S Steeg

Metastasis suppressor NME1 in exosomes or liposomes conveys motility and migration inhibition in breast cancer model systems.

Clinical & experimental metastasis

Avec: Imran Khan , Brunilde Gril , Ayuko Hoshino , Howard H Yang , Maxwell P Lee , Simone Difilippantonio , David C Lyden , Patricia S Steeg

HER2 antibody-drug conjugate controls growth of breast cancer brain metastases in hematogenous xenograft models, with heterogeneous blood-tumor barrier penetration unlinked to a passive marker.

Neuro-oncology

Avec: Brunilde Gril , Debbie Wei , Alexandra S Zimmer , Christina Robinson , Imran Khan , Simone Difilippantonio , Michael G Overstreet , Patricia S Steeg

Temozolomide in secondary prevention of HER2-positive breast cancer brain metastases.

Future oncology (London, England)

Avec: Alexandra S Zimmer , Seth M Steinberg , Dee Dee Smart , Mark R Gilbert , Terri S Armstrong , Eric Burton , Nicole Houston , Nadia Biassou , Brunilde Gril , Priscilla K Brastianos , Scott Carter , David Lyden , Stanley Lipkowitz , Patricia S Steeg

Resistance to the CHK1 inhibitor prexasertib involves functionally distinct CHK1 activities in BRCA wild-type ovarian cancer.

Oncogene

Avec: Jayakumar Nair , Tzu-Ting Huang , Junko Murai , Brittany Haynes , Patricia S Steeg , Yves Pommier , Jung-Min Lee

Metastasis Suppressors NME1 and NME2 Promote Dynamin 2 Oligomerization and Regulate Tumor Cell Endocytosis, Motility, and Metastasis.

Cancer research

Avec: Imran Khan , Brunilde Gril , Patricia S Steeg

A perspective on the metastasis suppressor field.

Cancer metastasis reviews

Avec: Imran Khan , Patricia S Steeg

Phase I Study and Cell-Free DNA Analysis of T-DM1 and Metronomic Temozolomide for Secondary Prevention of HER2-Positive Breast Cancer Brain Metastases.

Clinical cancer research : an official journal of the American Association for Cancer Research

Avec: Sarah Jenkins , Wei Zhang , Seth M Steinberg , Darryl Nousome , Nicole Houston , Xiaolin Wu , Terri S Armstrong , Eric Burton , Dee Dee Smart , Ritu Shah , Cody J Peer , Brett Mozarsky , Oluwatobi Arisa , William D Figg , Tito R Mendoza , Elizabeth Vera , Priscilla Brastianos , Scott Carter , Mark R Gilbert , Carey K Anders , Roisín M Connolly , Carol Tweed , Karen L Smith , Imran Khan , Stanley Lipkowitz , Patricia S Steeg , Alexandra S Zimmer

Comparison of Three Transcytotic Pathways for Distribution to Brain Metastases of Breast Cancer.

Molecular cancer therapeutics

Avec: Imran Khan , Brunilde Gril , Anurag N Paranjape , Christina M Robinson , Simone Difilippantonio , Wojciech Biernat , Michał Bieńkowski , Rafał Pęksa , Renata Duchnowska , Jacek Jassem , Priscilla K Brastianos , Philippe Metellus , Emilie Bialecki , Carolyn C Woodroofe , Haitao Wu , Rolf E Swenson , Patricia S Steeg

Réseau de co-auteurs

Brunilde Gril 11 collaborations

Imran Khan 10 collaborations

Simone Difilippantonio 5 collaborations

Debbie Wei 4 collaborations

Stanley Lipkowitz 3 collaborations

Christina Robinson 3 collaborations

Carey K Anders 3 collaborations

Terri S Armstrong 3 collaborations

Priscilla K Brastianos 3 collaborations

Alexandra S Zimmer 3 collaborations

William D Figg 2 collaborations

Ayuko Hoshino 2 collaborations

David Lyden 2 collaborations

Frank Winkler 2 collaborations

Andy D Tran 2 collaborations

Cody J Peer 2 collaborations

Diana M Cittelly 2 collaborations

Adrienne Boire 2 collaborations

Manmeet S Ahluwalia 2 collaborations

Monika A Chung 2 collaborations

Wei Zhang 2 collaborations

Howard H Yang 2 collaborations

Maxwell P Lee 2 collaborations

Seth M Steinberg 2 collaborations

Dee Dee Smart 2 collaborations

Mark R Gilbert 2 collaborations

Eric Burton 2 collaborations

Nicole Houston 2 collaborations

Scott Carter 2 collaborations

Cindy H Chau 1 collaboration

Gonçalo Rodrigues 1 collaboration

Candia M Kenific 1 collaboration

Irina R Matei 1 collaboration

Loïc Steiner 1 collaboration

Daniela Freitas 1 collaboration

Han Sang Kim 1 collaboration

Peter R Oxley 1 collaboration

Ilana Scandariato 1 collaboration

Irene Casanova-Salas 1 collaboration

Jinxiang Dai 1 collaboration

Chaitanya R Badwe 1 collaboration

Milica Tešić Mark 1 collaboration

Brian D Dill 1 collaboration

Henrik Molina 1 collaboration

Haiying Zhang 1 collaboration

Alberto Benito-Martin 1 collaboration

Linda Bojmar 1 collaboration

Yonathan Ararso 1 collaboration

Katharine Offer 1 collaboration

Quincey LaPlant 1 collaboration

Weston Buehring 1 collaboration

Huajuan Wang 1 collaboration

Xinran Jiang 1 collaboration

Tyler M Lu 1 collaboration

Yuan Liu 1 collaboration

Joshua K Sabari 1 collaboration

Sandra J Shin 1 collaboration

Navneet Narula 1 collaboration

Paula S Ginter 1 collaboration

Vinagolu K Rajasekhar 1 collaboration

John H Healey 1 collaboration

Etienne Meylan 1 collaboration

Bruno Costa-Silva 1 collaboration

Shizhen Emily Wang 1 collaboration

Shahin Rafii 1 collaboration

Nasser Khaled Altorki 1 collaboration

Charles M Rudin 1 collaboration

David R Jones 1 collaboration

Héctor Peinado 1 collaboration

Cyrus M Ghajar 1 collaboration

Jacqueline Bromberg 1 collaboration

Maria de Sousa 1 collaboration

David Pisapia 1 collaboration

Yoshimi Endo Greer 1 collaboration

Samuel F Gilbert 1 collaboration

Rajesh Narwal 1 collaboration

Danielle L Peacock Brooks 1 collaboration

David A Tice 1 collaboration

Anna S Berghoff 1 collaboration

Yunxiang Liao 1 collaboration

Matthia A Karreman 1 collaboration

Ayseguel Ilhan-Mutlu 1 collaboration

Katharina Gunkel 1 collaboration

Martin R Sprick 1 collaboration

Christian Eisen 1 collaboration

Tobias Kessler 1 collaboration

Matthias Osswald 1 collaboration

Susanne Wünsche 1 collaboration

Manuel Feinauer 1 collaboration

Brunhilde Gril 1 collaboration

Frederic Marmé 1 collaboration

Laura L Michel 1 collaboration

Zuszanna Bago-Horvath 1 collaboration

Felix Sahm 1 collaboration

Natalia Becker 1 collaboration

Michael O Breckwoldt 1 collaboration

Gergely Solecki 1 collaboration

Miriam Gömmel 1 collaboration

Lulu Huang 1 collaboration

Petra Rübmann 1 collaboration

Carina M Thome 1 collaboration

Miriam Ratliff 1 collaboration

Andreas Trumpp 1 collaboration

Matthias Preusser 1 collaboration

Wolfgang Wick 1 collaboration

Vanesa L Silvestri 1 collaboration

Monika Chung 1 collaboration

Natalie Chung 1 collaboration

Michael J Kruhlak 1 collaboration

W Douglas Figg 1 collaboration

Maria J Contreras-Zárate 1 collaboration

Nicole L Day 1 collaboration

D Ryan Ormond 1 collaboration

Virginia F Borges 1 collaboration

Stuart Tobet 1 collaboration

Robin L Anderson 1 collaboration

Theo Balasas 1 collaboration

Juliana Callaghan 1 collaboration

R Charles Coombes 1 collaboration

Jeff Evans 1 collaboration

Jacqueline A Hall 1 collaboration

Sally Kinrade 1 collaboration

David Jones 1 collaboration

Paul S Jones 1 collaboration

Rob Jones 1 collaboration

John F Marshall 1 collaboration

Maria Beatrice Panico 1 collaboration

Jacqui A Shaw 1 collaboration

Mark Sullivan 1 collaboration

Warwick Tong 1 collaboration

Andrew D Westwell 1 collaboration

James W A Ritchie 1 collaboration

None None 1 collaboration

Manuel Valiente 1 collaboration

Amanda E D Van Swearingen 1 collaboration

Amos Bairoch 1 collaboration

Paula D Bos 1 collaboration

Neta Erez 1 collaboration

Gino B Ferraro 1 collaboration

Dai Fukumura 1 collaboration

Meenhard Herlyn 1 collaboration

Sheri L Holmen 1 collaboration

Rakesh K Jain 1 collaboration

Johanna A Joyce 1 collaboration

Mihaela Lorger 1 collaboration

Joan Massague 1 collaboration

Josh Neman 1 collaboration

Nicola R Sibson 1 collaboration

Frits Thorsen 1 collaboration

Leonie S Young 1 collaboration

Damir Varešlija 1 collaboration

Adina Vultur 1 collaboration

Frances Weis-Garcia 1 collaboration

Michelle M Kim 1 collaboration

Minesh P Mehta 1 collaboration

DeeDee K Smart 1 collaboration

Julie A Hong 1 collaboration

Michael G Espey 1 collaboration

Pataje G Prasanna 1 collaboration

Laura Crandon 1 collaboration

Christine Hodgdon 1 collaboration

Niki Kozak 1 collaboration

Aki Morikawa 1 collaboration

Nicole Willmarth 1 collaboration

Kirk Tanner 1 collaboration

Melanie Hayden Gephart 1 collaboration

Kim A Margolin 1 collaboration

Jona Hattangadi-Gluth 1 collaboration

Hussein Tawbi 1 collaboration

Daniel M Trifiletti 1 collaboration

Caroline Chung 1 collaboration

Upal Basu-Roy 1 collaboration

Robyn Burns 1 collaboration

Isabella C Glitza Oliva 1 collaboration

Ayal A Aizer 1 collaboration

Joanne Davis 1 collaboration

Veronica Chiang 1 collaboration

Jing Li 1 collaboration

Rupesh Kotecha 1 collaboration

Silvia C Formenti 1 collaboration

Benjamin M Ellingson 1 collaboration

Vinai Gondi 1 collaboration

Paul W Sperduto 1 collaboration

Jill S Barnholtz-Sloan 1 collaboration

Jordi Rodon 1 collaboration

Eudocia Q Lee 1 collaboration

Mustafa Khasraw 1 collaboration

Debra Nana Yeboa 1 collaboration

Evanthia Galanis 1 collaboration

C Norman Coleman 1 collaboration

Mansoor M Ahmed 1 collaboration

Allison L Hunt 1 collaboration

Alex M L Wu 1 collaboration

Sasha C Makohon-Moore 1 collaboration

Brian L Hood 1 collaboration

Kelly A Conrads 1 collaboration

Tamara Abulez 1 collaboration

Jonathan Ogata 1 collaboration

Dave Mitchell 1 collaboration

Glenn Gist 1 collaboration

Julie Oliver 1 collaboration

Samiur Rahman 1 collaboration

Nicholas W Bateman 1 collaboration

Thomas P Conrads 1 collaboration

Alex Man Lai Wu 1 collaboration

Selamawit Gossa 1 collaboration

Ramakrishna Samala 1 collaboration

Helen R Thorsheim 1 collaboration

Esra Taner 1 collaboration

Kristine Isanogle 1 collaboration

Yuan Yang 1 collaboration

Emma L Dolan 1 collaboration

Quentin R Smith 1 collaboration

Dorian B McGavern 1 collaboration

Lalage M Wakefield 1 collaboration

Achal Singh Achrol 1 collaboration

Robert C Rennert 1 collaboration

Carey Anders 1 collaboration

Riccardo Soffietti 1 collaboration

Lakshmi Nayak 1 collaboration

Solange Peters 1 collaboration

Nils D Arvold 1 collaboration

Griffith R Harsh 1 collaboration

Steven D Chang 1 collaboration

David C Lyden 1 collaboration

Michael G Overstreet 1 collaboration

Nadia Biassou 1 collaboration

Jayakumar Nair 1 collaboration

Tzu-Ting Huang 1 collaboration

Junko Murai 1 collaboration

Brittany Haynes 1 collaboration

Yves Pommier 1 collaboration

Jung-Min Lee 1 collaboration

Sarah Jenkins 1 collaboration

Darryl Nousome 1 collaboration

Xiaolin Wu 1 collaboration

Ritu Shah 1 collaboration

Brett Mozarsky 1 collaboration

Oluwatobi Arisa 1 collaboration

Tito R Mendoza 1 collaboration

Elizabeth Vera 1 collaboration

Priscilla Brastianos 1 collaboration

Roisín M Connolly 1 collaboration

Carol Tweed 1 collaboration

Karen L Smith 1 collaboration

Anurag N Paranjape 1 collaboration

Christina M Robinson 1 collaboration

Wojciech Biernat 1 collaboration

Michał Bieńkowski 1 collaboration

Rafał Pęksa 1 collaboration

Renata Duchnowska 1 collaboration

Jacek Jassem 1 collaboration

Philippe Metellus 1 collaboration

Emilie Bialecki 1 collaboration

Carolyn C Woodroofe 1 collaboration

Haitao Wu 1 collaboration

Rolf E Swenson 1 collaboration