Oliver T Fackler

Publications (25)

A Recurrent Neural Network for Particle Tracking in Microscopy Images Using Future Information, Track Hypotheses, and Multiple Detections.

IEEE transactions on image processing : a publication of the IEEE Signal Processing Society

Avec: Roman Spilger , Andrea Imle , Ji-Young Lee , Barbara Muller , Oliver T Fackler , Ralf Bartenschlager , Karl Rohr

FAMoS: A Flexible and dynamic Algorithm for Model Selection to analyse complex systems dynamics.

PLoS computational biology

Avec: Michael Gabel , Tobias Hohl , Andrea Imle , Oliver T Fackler , Frederik Graw

T cell receptor-triggered nuclear actin network formation drives CD4

Science immunology

Avec: N Tsopoulidis , S Kaw , V Laketa , S Kutscheidt , C Baarlink , B Stolp , R Grosse , O T Fackler

The antiviral activity of rodent and lagomorph SERINC3 and SERINC5 is counteracted by known viral antagonists.

The Journal of general virology

Avec: Patrícia de Sousa-Pereira , Joana Abrantes , Stefan Bauernfried , Virginia Pierini , Pedro José Esteves , Oliver T Keppler , Massimo Pizzato , Veit Hornung , Oliver T Fackler , Hanna-Mari Baldauf

Ex vivo and in vivo suppression of SARS-CoV-2 with combinatorial AAV/RNAi expression vectors.

Molecular therapy : the journal of the American Society of Gene Therapy

Avec: Jonas Becker , Megan Lynn Stanifer , Sarah Rebecca Leist , Bettina Stolp , Olena Maiakovska , Ande West , Ellen Wiedtke , Kathleen Börner , Ali Ghanem , Ina Ambiel , Longping Victor Tse , Oliver Till Fackler , Ralph Steven Baric , Steeve Boulant , Dirk Grimm

SERINC5 Can Enhance Proinflammatory Cytokine Production by Primary Human Myeloid Cells in Response to Challenge with HIV-1 Particles.

Journal of virology

Avec: Virginia Pierini , Lara Gallucci , Christina M Stürzel , Frank Kirchhoff , Oliver T Fackler

Receptor transfer between immune cells by autoantibody-enhanced, CD32-driven trogocytosis is hijacked by HIV-1 to infect resting CD4 T cells.

Cell reports. Medicine

Avec: Manuel Albanese , Hong-Ru Chen , Madeleine Gapp , Maximilian Muenchhoff , Hsiu-Hui Yang , David Peterhoff , Katja Hoffmann , Qianhao Xiao , Adrian Ruhle , Ina Ambiel , Stephanie Schneider , Ernesto Mejías-Pérez , Marcel Stern , Paul R Wratil , Katharina Hofmann , Laura Amann , Linda Jocham , Thimo Fuchs , Alessandro F Ulivi , Simon Besson-Girard , Simon Weidlich , Jochen Schneider , Christoph D Spinner , Kathrin Sutter , Ulf Dittmer , Andreas Humpe , Philipp Baumeister , Andreas Wieser , Simon Rothenfusser , Johannes Bogner , Julia Roider , Percy Knolle , Hartmut Hengel , Ralf Wagner , Vibor Laketa , Oliver T Fackler , Oliver T Keppler

ARPC5 isoforms and their regulation by calcium-calmodulin-N-WASP drive distinct Arp2/3-dependent actin remodeling events in CD4 T cells.

eLife

Avec: Lopamudra Sadhu , Nikolaos Tsopoulidis , Md Hasanuzzaman , Vibor Laketa , Michael Way , Oliver T Fackler

The Ebola virus VP40 matrix layer undergoes endosomal disassembly essential for membrane fusion.

The EMBO journal

Avec: Sophie L Winter , Gonen Golani , Fabio Lolicato , Melina Vallbracht , Keerthihan Thiyagarajah , Samy Sid Ahmed , Christian Lüchtenborg , Oliver T Fackler , Britta Brügger , Thomas Hoenen , Walter Nickel , Ulrich S Schwarz , Petr Chlanda

Experimental and computational analyses reveal that environmental restrictions shape HIV-1 spread in 3D cultures.

Nature communications

Avec: Andrea Imle , Peter Kumberger , Nikolas D Schnellbächer , Jana Fehr , Paola Carrillo-Bustamante , Janez Ales , Philip Schmidt , Christian Ritter , William J Godinez , Barbara Müller , Karl Rohr , Fred A Hamprecht , Ulrich S Schwarz , Frederik Graw , Oliver T Fackler

Rapid, efficient and activation-neutral gene editing of polyclonal primary human resting CD4

Nature methods

Avec: Manuel Albanese , Adrian Ruhle , Jennifer Mittermaier , Ernesto Mejías-Pérez , Madeleine Gapp , Andreas Linder , Niklas A Schmacke , Katharina Hofmann , Alexandru A Hennrich , David N Levy , Andreas Humpe , Karl-Klaus Conzelmann , Veit Hornung , Oliver T Fackler , Oliver T Keppler

Contact-dependent inhibition of HIV-1 replication in

Cell reports. Medicine

Avec: Tatjana Reif , Gerhard Dyckhoff , Ralph Hohenberger , Carl-Christian Kolbe , Henning Gruell , Florian Klein , Eicke Latz , Bettina Stolp , Oliver T Fackler

SERINC5 Is an Unconventional HIV Restriction Factor That Is Upregulated during Myeloid Cell Differentiation.

Journal of innate immunity

Avec: Ariane Zutz , Christian Schölz , Stephanie Schneider , Virginia Pierini , Maximilian Münchhoff , Kathrin Sutter , Georg Wittmann , Ulf Dittmer , Rika Draenert , Johannes R Bogner , Oliver T Fackler , Oliver T Keppler

GPCR-induced calcium transients trigger nuclear actin assembly for chromatin dynamics.

Nature communications

Avec: Ying Wang , Alice Sherrard , Bing Zhao , Michael Melak , Jonathan Trautwein , Eva-Maria Kleinschnitz , Nikolaos Tsopoulidis , Oliver T Fackler , Carsten Schwan , Robert Grosse

A Conserved Acidic Residue in the C-Terminal Flexible Loop of HIV-1 Nef Contributes to the Activity of SERINC5 and CD4 Downregulation.

Viruses

Avec: Claudia Firrito , Cinzia Bertelli , Annachiara Rosa , Ajit Chande , Swetha Ananth , Hannah van Dijk , Oliver T Fackler , Charlotte Stoneham , Rajendra Singh , John Guatelli , Massimo Pizzato

Tissue-like environments shape functional interactions of HIV-1 with immature dendritic cells.

EMBO reports

Avec: Lara Gallucci , Tobias Abele , Raffaele Fronza , Bettina Stolp , Vibor Laketa , Samy Sid Ahmed , Annica Flemming , Barbara Müller , Kerstin Göpfrich , Oliver T Fackler

ProDOL: a general method to determine the degree of labeling for staining optimization and molecular counting.

Nature methods

Avec: Stanimir Asenov Tashev , Jonas Euchner , Klaus Yserentant , Siegfried Hänselmann , Felix Hild , Wioleta Chmielewicz , Johan Hummert , Florian Schwörer , Nikolaos Tsopoulidis , Stefan Germer , Zoe Saßmannshausen , Oliver T Fackler , Ursula Klingmüller , Dirk-Peter Herten

HIV-1 infection of CD4 T cells impairs antigen-specific B cell function.

The EMBO journal

Avec: Sheetal Kaw , Swetha Ananth , Nikolaos Tsopoulidis , Katharina Morath , Bahar M Coban , Ralph Hohenberger , Olcay C Bulut , Florian Klein , Bettina Stolp , Oliver T Fackler

Environmental Restrictions: A New Concept Governing HIV-1 Spread Emerging from Integrated Experimental-Computational Analysis of Tissue-Like 3D Cultures.

Cells

Avec: Samy Sid Ahmed , Nils Bundgaard , Frederik Graw , Oliver T Fackler

Temporal control of the integrated stress response by a stochastic molecular switch.

Science advances

Avec: Philipp Klein , Stefan M Kallenberger , Hanna Roth , Karsten Roth , Thi Bach Nga Ly-Hartig , Vera Magg , Janez Aleš , Soheil Rastgou Talemi , Yu Qiang , Steffen Wolf , Olga Oleksiuk , Roma Kurilov , Barbara Di Ventura , Ralf Bartenschlager , Roland Eils , Karl Rohr , Fred A Hamprecht , Thomas Höfer , Oliver T Fackler , Georg Stoecklin , Alessia Ruggieri

SARS-CoV-2 variants of concern display enhanced intrinsic pathogenic properties and expanded organ tropism in mouse models.

Cell reports

Avec: Bettina Stolp , Marcel Stern , Ina Ambiel , Katharina Hofmann , Katharina Morath , Lara Gallucci , Mirko Cortese , Ralf Bartenschlager , Alessia Ruggieri , Frederik Graw , Martina Rudelius , Oliver Till Keppler , Oliver Till Fackler

VisuStatR: visualizing motility and morphology statistics on images in R.

Bioinformatics (Oxford, England)

Avec: Christoph Harmel , Samy Sid Ahmed , Robin Koch , Jana Tünnermann , Tania Distler , Andrea Imle , Luca Giorgetti , Emanuel Bahn , Oliver T Fackler , Frederik Graw

Bottom-up synthetic immunology.

Nature nanotechnology

Avec: Kerstin Göpfrich , Michael Platten , Friedrich Frischknecht , Oliver T Fackler

Genomic profiling of HIV-1 integration in microglia cells links viral integration to the topologically associated domains.

Cell reports

Avec: Mona Rheinberger , Ana Luisa Costa , Martin Kampmann , Dunja Glavas , Iart Luca Shytaj , Sheetal Sreeram , Carlotta Penzo , Nadine Tibroni , Yoelvis Garcia-Mesa , Konstantin Leskov , Oliver T Fackler , Kristian Vlahovicek , Jonathan Karn , Bojana Lucic , Carl Herrmann , Marina Lusic

Activation-neutral gene editing of tonsillar CD4 T cells for functional studies in human ex vivo tonsil cultures.

Cell reports methods

Avec: Katharina Morath , Lopamudra Sadhu , Gerhard Dyckhoff , Madeleine Gapp , Oliver T Keppler , Oliver T Fackler

Réseau de co-auteurs

Frederik Graw 5 collaborations

Oliver T Keppler 5 collaborations

Bettina Stolp 5 collaborations

Andrea Imle 4 collaborations

Nikolaos Tsopoulidis 4 collaborations

Samy Sid Ahmed 4 collaborations

Ralf Bartenschlager 3 collaborations

Karl Rohr 3 collaborations

Virginia Pierini 3 collaborations

Ina Ambiel 3 collaborations

Lara Gallucci 3 collaborations

Madeleine Gapp 3 collaborations

Katharina Hofmann 3 collaborations

Vibor Laketa 3 collaborations

Katharina Morath 3 collaborations

Massimo Pizzato 2 collaborations

Veit Hornung 2 collaborations

Oliver Till Fackler 2 collaborations

Manuel Albanese 2 collaborations

Adrian Ruhle 2 collaborations

Stephanie Schneider 2 collaborations

Ernesto Mejías-Pérez 2 collaborations

Marcel Stern 2 collaborations

Kathrin Sutter 2 collaborations

Ulf Dittmer 2 collaborations

Andreas Humpe 2 collaborations

Lopamudra Sadhu 2 collaborations

Ulrich S Schwarz 2 collaborations

Barbara Müller 2 collaborations

Fred A Hamprecht 2 collaborations

Gerhard Dyckhoff 2 collaborations

Ralph Hohenberger 2 collaborations

Florian Klein 2 collaborations

Swetha Ananth 2 collaborations

Kerstin Göpfrich 2 collaborations

Alessia Ruggieri 2 collaborations

Roman Spilger 1 collaboration

Ji-Young Lee 1 collaboration

Barbara Muller 1 collaboration

Michael Gabel 1 collaboration

Tobias Hohl 1 collaboration

N Tsopoulidis 1 collaboration

S Kaw 1 collaboration

V Laketa 1 collaboration

S Kutscheidt 1 collaboration

C Baarlink 1 collaboration

B Stolp 1 collaboration

R Grosse 1 collaboration

O T Fackler 1 collaboration

Patrícia de Sousa-Pereira 1 collaboration

Joana Abrantes 1 collaboration

Stefan Bauernfried 1 collaboration

Pedro José Esteves 1 collaboration

Hanna-Mari Baldauf 1 collaboration

Jonas Becker 1 collaboration

Megan Lynn Stanifer 1 collaboration

Sarah Rebecca Leist 1 collaboration

Olena Maiakovska 1 collaboration

Ande West 1 collaboration

Ellen Wiedtke 1 collaboration

Kathleen Börner 1 collaboration

Ali Ghanem 1 collaboration

Longping Victor Tse 1 collaboration

Ralph Steven Baric 1 collaboration

Steeve Boulant 1 collaboration

Dirk Grimm 1 collaboration

Christina M Stürzel 1 collaboration

Frank Kirchhoff 1 collaboration

Hong-Ru Chen 1 collaboration

Maximilian Muenchhoff 1 collaboration

Hsiu-Hui Yang 1 collaboration

David Peterhoff 1 collaboration

Katja Hoffmann 1 collaboration

Qianhao Xiao 1 collaboration

Paul R Wratil 1 collaboration

Laura Amann 1 collaboration

Linda Jocham 1 collaboration

Thimo Fuchs 1 collaboration

Alessandro F Ulivi 1 collaboration

Simon Besson-Girard 1 collaboration

Simon Weidlich 1 collaboration

Jochen Schneider 1 collaboration

Christoph D Spinner 1 collaboration

Philipp Baumeister 1 collaboration

Andreas Wieser 1 collaboration

Simon Rothenfusser 1 collaboration

Johannes Bogner 1 collaboration

Julia Roider 1 collaboration

Percy Knolle 1 collaboration

Hartmut Hengel 1 collaboration

Ralf Wagner 1 collaboration

Md Hasanuzzaman 1 collaboration

Michael Way 1 collaboration

Sophie L Winter 1 collaboration

Gonen Golani 1 collaboration

Fabio Lolicato 1 collaboration

Melina Vallbracht 1 collaboration

Keerthihan Thiyagarajah 1 collaboration

Christian Lüchtenborg 1 collaboration

Britta Brügger 1 collaboration

Thomas Hoenen 1 collaboration

Walter Nickel 1 collaboration

Petr Chlanda 1 collaboration

Peter Kumberger 1 collaboration

Nikolas D Schnellbächer 1 collaboration

Jana Fehr 1 collaboration

Paola Carrillo-Bustamante 1 collaboration

Janez Ales 1 collaboration

Philip Schmidt 1 collaboration

Christian Ritter 1 collaboration

William J Godinez 1 collaboration

Jennifer Mittermaier 1 collaboration

Andreas Linder 1 collaboration

Niklas A Schmacke 1 collaboration

Alexandru A Hennrich 1 collaboration

David N Levy 1 collaboration

Karl-Klaus Conzelmann 1 collaboration

Tatjana Reif 1 collaboration

Carl-Christian Kolbe 1 collaboration

Henning Gruell 1 collaboration

Eicke Latz 1 collaboration

Ariane Zutz 1 collaboration

Christian Schölz 1 collaboration

Maximilian Münchhoff 1 collaboration

Georg Wittmann 1 collaboration

Rika Draenert 1 collaboration

Johannes R Bogner 1 collaboration

Ying Wang 1 collaboration

Alice Sherrard 1 collaboration

Bing Zhao 1 collaboration

Michael Melak 1 collaboration

Jonathan Trautwein 1 collaboration

Eva-Maria Kleinschnitz 1 collaboration

Carsten Schwan 1 collaboration

Robert Grosse 1 collaboration

Claudia Firrito 1 collaboration

Cinzia Bertelli 1 collaboration

Annachiara Rosa 1 collaboration

Ajit Chande 1 collaboration

Hannah van Dijk 1 collaboration

Charlotte Stoneham 1 collaboration

Rajendra Singh 1 collaboration

John Guatelli 1 collaboration

Tobias Abele 1 collaboration

Raffaele Fronza 1 collaboration

Annica Flemming 1 collaboration

Stanimir Asenov Tashev 1 collaboration

Jonas Euchner 1 collaboration

Klaus Yserentant 1 collaboration

Siegfried Hänselmann 1 collaboration

Felix Hild 1 collaboration

Wioleta Chmielewicz 1 collaboration

Johan Hummert 1 collaboration

Florian Schwörer 1 collaboration

Stefan Germer 1 collaboration

Zoe Saßmannshausen 1 collaboration

Ursula Klingmüller 1 collaboration

Dirk-Peter Herten 1 collaboration

Sheetal Kaw 1 collaboration

Bahar M Coban 1 collaboration

Olcay C Bulut 1 collaboration

Nils Bundgaard 1 collaboration

Philipp Klein 1 collaboration

Stefan M Kallenberger 1 collaboration

Hanna Roth 1 collaboration

Karsten Roth 1 collaboration

Thi Bach Nga Ly-Hartig 1 collaboration

Vera Magg 1 collaboration

Janez Aleš 1 collaboration

Soheil Rastgou Talemi 1 collaboration

Yu Qiang 1 collaboration

Steffen Wolf 1 collaboration

Olga Oleksiuk 1 collaboration

Roma Kurilov 1 collaboration

Barbara Di Ventura 1 collaboration

Roland Eils 1 collaboration

Thomas Höfer 1 collaboration

Georg Stoecklin 1 collaboration

Mirko Cortese 1 collaboration

Martina Rudelius 1 collaboration

Oliver Till Keppler 1 collaboration

Christoph Harmel 1 collaboration

Robin Koch 1 collaboration

Jana Tünnermann 1 collaboration

Tania Distler 1 collaboration

Luca Giorgetti 1 collaboration

Emanuel Bahn 1 collaboration

Michael Platten 1 collaboration

Friedrich Frischknecht 1 collaboration

Mona Rheinberger 1 collaboration

Ana Luisa Costa 1 collaboration

Martin Kampmann 1 collaboration

Dunja Glavas 1 collaboration

Iart Luca Shytaj 1 collaboration

Sheetal Sreeram 1 collaboration

Carlotta Penzo 1 collaboration

Nadine Tibroni 1 collaboration

Yoelvis Garcia-Mesa 1 collaboration

Konstantin Leskov 1 collaboration

Kristian Vlahovicek 1 collaboration

Jonathan Karn 1 collaboration

Bojana Lucic 1 collaboration

Carl Herrmann 1 collaboration

Marina Lusic 1 collaboration