Nicolas Flamand

Affiliations

Centre de recherche de l'Institut universitaire de cardiologie et de pneumologie de Québec (IUCPQ), Université Laval, Québec, QC, Canada.
Département de médecine, Faculté de Médecine, Université Laval, Québec, QC, Canada.
Canada Research Excellence Chair in the Microbiome-Endocannabinoidome Axis in Metabolic Health (CERC-MEND), Université Laval, Québec, QC, Canada.

Publications (34)

Dietary fatty acid intake and gut microbiota determine circulating endocannabinoidome signaling beyond the effect of body fat.

Scientific reports

Avec: Sophie Castonguay-Paradis , Sébastien Lacroix , Gabrielle Rochefort , Lydiane Parent , Julie Perron , Cyril Martin , Benoît Lamarche , Frédéric Raymond , Nicolas Flamand , Vincenzo Di Marzo , Alain Veilleux

Intestinal epithelial N-acylphosphatidylethanolamine phospholipase D links dietary fat to metabolic adaptations in obesity and steatosis.

Nature communications

Avec: Amandine Everard , Hubert Plovier , Marialetizia Rastelli , Matthias Van Hul , Alice de Wouters d'Oplinter , Lucie Geurts , Céline Druart , Sylvie Robine , Nathalie M Delzenne , Giulio G Muccioli , Willem M de Vos , Serge Luquet , Nicolas Flamand , Vincenzo Di Marzo , Patrice D Cani

Alterations of brain endocannabinoidome signaling in germ-free mice.

Biochimica et biophysica acta. Molecular and cell biology of lipids

Avec: Claudia Manca , Melissa Shen , Besma Boubertakh , Cyril Martin , Nicolas Flamand , Cristoforo Silvestri , Vincenzo Di Marzo

[Extracellular molecules controlling the contraction of airway smooth muscle and their potential contribution to bronchial hyperresponsiveness].

Revue des maladies respiratoires

Avec: M Gazzola , N Flamand , Y Bossé

Oral Capsaicinoid Administration Alters the Plasma Endocannabinoidome and Fecal Microbiota of Reproductive-Aged Women Living with Overweight and Obesity.

Biomedicines

Avec: Claudia Manca , Sébastien Lacroix , Francine Pérusse , Nicolas Flamand , Yvon Chagnon , Vicky Drapeau , Angelo Tremblay , Vincenzo Di Marzo , Cristoforo Silvestri

Remodeling of the Dermal Extracellular Matrix in a Tissue-Engineered Psoriatic Skin Model by n-3 Polyunsaturated Fatty Acids.

Biomedicines

Avec: Mélissa Simard , Alexe Grenier , Geneviève Rioux , Andréa Tremblay , Isalie Blais , Nicolas Flamand , Roxane Pouliot

Plasma endocannabinoidome and fecal microbiota interplay in people with HIV and subclinical coronary artery disease: Results from the Canadian HIV and Aging Cohort Study.

iScience

Avec: Ralph-Sydney Mboumba Bouassa , Giada Giorgini , Cristoforo Silvestri , Chanté Muller , Nayudu Nallabelli , Yulia Alexandrova , Madeleine Durand , Cécile Tremblay , Mohamed El-Far , Carl Chartrand-Lefebvre , Marc Messier-Peet , Shari Margolese , Nicolas Flamand , Cecilia T Costiniuk , Vincenzo Di Marzo , Mohammad-Ali Jenabian

The human fecal endocannabinoidome mediator profile is mainly defined by the fecal microbiota and diet.

The Journal of clinical endocrinology and metabolism

Avec: Sophie Castonguay-Paradis , Lydiane Parent , Gabrielle St-Arnaud , Julie Perron , Élizabeth Dumais , Nicolas Flamand , Frédéric Raymond , Vincenzo Di Marzo , Alain Veilleux

Impact of selenium on the intestinal microbiome-eCBome axis in the context of diet-related metabolic health in mice.

Frontiers in immunology

Avec: Fredy Alexander Guevara Agudelo , Nadine Leblanc , Isabelle Bourdeau-Julien , Gabrielle St-Arnaud , Sébastien Lacroix , Cyril Martin , Nicolas Flamand , Alain Veilleux , Vincenzo Di Marzo , Frédéric Raymond

Rapid and Concomitant Gut Microbiota and Endocannabinoidome Response to Diet-Induced Obesity in Mice.

mSystems

Avec: Sébastien Lacroix , Florent Pechereau , Nadine Leblanc , Besma Boubertakh , Alain Houde , Cyril Martin , Nicolas Flamand , Cristoforo Silvestri , Frédéric Raymond , Vincenzo Di Marzo , Alain Veilleux

RGS4 promotes allergen- and aspirin-associated airway hyperresponsiveness by inhibiting PGE2 biosynthesis.

The Journal of allergy and clinical immunology

Avec: Gordon S Wong , Jamie L Redes , Nariman Balenga , Morgan McCullough , Nathalie Fuentes , Ameya Gokhale , Cynthia Koziol-White , Joseph A Jude , Laura A Madigan , Eunice C Chan , William H Jester , Sabrina Biardel , Nicolas Flamand , Reynold A Panettieri , Kirk M Druey

Human leukocytes differentially express endocannabinoid-glycerol lipases and hydrolyze 2-arachidonoyl-glycerol and its metabolites from the 15-lipoxygenase and cyclooxygenase pathways.

Journal of leukocyte biology

Avec: Caroline Turcotte , Élizabeth Dumais , Anne-Sophie Archambault , Cyril Martin , Marie-Renée Blanchet , Élyse Bissonnette , Louis-Philippe Boulet , Michel Laviolette , Vincenzo Di Marzo , Nicolas Flamand

Synthesis and molecular targets of N-13-hydroxy-octadienoyl-ethanolamine, a novel endogenous bioactive 15-lipoxygenase-derived metabolite of N-linoleoyl-ethanolamine found in the skin and saliva.

Biochimica et biophysica acta. Molecular and cell biology of lipids

Avec: Francesco Tinto , Anne-Sophie Archambault , Élizabeth Dumais , Volatiana Rakotoarivelo , Magdalena Kostrzewa , Cyril Martin , Pier-Luc Plante , Yves Desjardins , Mélissa Simard , Roxane Pouliot , Luciano De Petrocellis , Alessia Ligresti , Vincenzo Di Marzo , Nicolas Flamand

Expression and Functions of the CB

Frontiers in pharmacology

Avec: Mélissa Simard , Volatiana Rakotoarivelo , Vincenzo Di Marzo , Nicolas Flamand

Formation, Signaling and Occurrence of Specialized Pro-Resolving Lipid Mediators-What is the Evidence so far?

Frontiers in pharmacology

Avec: Nils Helge Schebb , Hartmut Kühn , Astrid S Kahnt , Katharina M Rund , Valerie B O'Donnell , Nicolas Flamand , Marc Peters-Golden , Per-Johan Jakobsson , Karsten H Weylandt , Nadine Rohwer , Robert C Murphy , Gerd Geisslinger , Garret A FitzGerald , Julien Hanson , Claes Dahlgren , Mohamad Wessam Alnouri , Stefan Offermanns , Dieter Steinhilber

Human and Mouse Eosinophils Differ in Their Ability to Biosynthesize Eicosanoids, Docosanoids, the Endocannabinoid 2-Arachidonoyl-glycerol and Its Congeners.

Cells

Avec: Anne-Sophie Archambault , Julyanne Brassard , Émilie Bernatchez , Cyril Martin , Vincenzo Di Marzo , Michel Laviolette , Louis-Philippe Boulet , Marie-Renée Blanchet , Nicolas Flamand

Cytokines and Lipid Mediators of Inflammation in Lungs of SARS-CoV-2 Infected Mice.

Frontiers in immunology

Avec: Isabelle Dubuc , Julien Prunier , Émile Lacasse , Annie Gravel , Florian Puhm , Isabelle Allaeys , Anne-Sophie Archambault , Leslie Gudimard , Rosaria Villano , Arnaud Droit , Nicolas Flamand , Éric Boilard , Louis Flamand

The diet rapidly and differentially affects the gut microbiota and host lipid mediators in a healthy population.

Microbiome

Avec: Isabelle Bourdeau-Julien , Sophie Castonguay-Paradis , Gabrielle Rochefort , Julie Perron , Benoît Lamarche , Nicolas Flamand , Vincenzo Di Marzo , Alain Veilleux , Frédéric Raymond

A Lipidomics- and Transcriptomics-Based Analysis of the Intestine of Genetically Obese (

Cells

Avec: Francesco Suriano , Claudia Manca , Nicolas Flamand , Matthias Van Hul , Nathalie M Delzenne , Cristoforo Silvestri , Patrice D Cani , Vincenzo Di Marzo

The human milk endocannabinoidome and neonatal growth in gestational diabetes.

Frontiers in endocrinology

Avec: Alice Fradet , Sophie Castonguay-Paradis , Camille Dugas , Julie Perron , Gabrielle St-Arnaud , Isabelle Marc , Alain Doyen , Nicolas Flamand , Fadil Dahhani , Vincenzo Di Marzo , Alain Veilleux , Julie Robitaille

Hepatic NAPE-PLD Is a Key Regulator of Liver Lipid Metabolism.

Cells

Avec: Charlotte Lefort , Martin Roumain , Matthias Van Hul , Marialetizia Rastelli , Rita Manco , Isabelle Leclercq , Nathalie M Delzenne , Vincenzo Di Marzo , Nicolas Flamand , Serge Luquet , Cristoforo Silvestri , Giulio G Muccioli , Patrice D Cani

LPS induces ALOX5 promoter activation and 5-lipoxygenase expression in human monocytic cells.

Prostaglandins, leukotrienes, and essential fatty acids

Avec: Samuel J Poirier , Luc H Boudreau , Nicolas Flamand , Marc E Surette

Role of the Endocannabinoid System in the Adipose Tissue with Focus on Energy Metabolism.

Cells

Avec: Volatiana Rakotoarivelo , Jyoti Sihag , Nicolas Flamand

Biological action of docosahexaenoic acid in a 3D tissue-engineered psoriatic skin model: Focus on the PPAR signaling pathway.

Biochimica et biophysica acta. Molecular and cell biology of lipids

Avec: Sophie Morin , Mélissa Simard , Nicolas Flamand , Roxane Pouliot

The interaction of secreted phospholipase A2-IIA with the microbiota alters its lipidome and promotes inflammation.

JCI insight

Avec: Etienne Doré , Charles Joly-Beauparlant , Satoshi Morozumi , Alban Mathieu , Tania Lévesque , Isabelle Allaeys , Anne-Claire Duchez , Nathalie Cloutier , Mickaël Leclercq , Antoine Bodein , Christine Payré , Cyril Martin , Agnes Petit-Paitel , Michael H Gelb , Manu Rangachari , Makoto Murakami , Laetitia Davidovic , Nicolas Flamand , Makoto Arita , Gérard Lambeau , Arnaud Droit , Eric Boilard

Biosynthesis of the Novel Endogenous 15-Lipoxygenase Metabolites

Cells

Avec: Anne-Sophie Archambault , Francesco Tinto , Élizabeth Dumais , Volatiana Rakotoarivelo , Magdalena Kostrzewa , Pier-Luc Plante , Cyril Martin , Mélissa Simard , Cristoforo Silvestri , Roxane Pouliot , Michel Laviolette , Louis-Philippe Boulet , Rosa Maria Vitale , Alessia Ligresti , Vincenzo Di Marzo , Nicolas Flamand

Biosynthesis and metabolism of endocannabinoids and their congeners from the monoacylglycerol and N-acyl-ethanolamine families.

Biochemical pharmacology

Avec: Mélissa Simard , Anne-Sophie Archambault , Jean-Philippe C Lavoie , Élizabeth Dumais , Vincenzo Di Marzo , Nicolas Flamand

Probiotic interventions promote metabolic health in high fat-fed hamsters in association with gut microbiota and endocannabinoidome alterations.

Beneficial microbes

Avec: S Lacroix , N Leblanc , A Abolghasemi , S Paris-Robidas , C Martin , M Frappier , N Flamand , C Silvestri , F Raymond , M Millette , V Di Marzo , A Veilleux

Altered endocannabinoidome bioactive lipid levels accompany reduced DNBS-induced colonic inflammation in germ-free mice.

Lipids in health and disease

Avec: Tommaso Venneri , Giada Giorgini , Nadine Leblanc , Nicolas Flamand , Francesca Borrelli , Cristoforo Silvestri , Vincenzo Di Marzo

Dietary food patterns as determinants of the gut microbiome-endocannabinoidome axis in humans.

Scientific reports

Avec: Sophie Castonguay-Paradis , Julie Perron , Nicolas Flamand , Benoît Lamarche , Frédéric Raymond , Vincenzo Di Marzo , Alain Veilleux

Association of low-density neutrophils with lung function and disease progression in adult cystic fibrosis.

Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society

Avec: Andréa Murru , Nathalie Vadeboncoeur , Andrée-Anne Therrien , Lise Coderre , Myriam Vaillancourt , Marie-Michèle Labrecque , Yves Berthiaume , Guillaume Bouvet , Damien Adam , Emmanuelle Brochiero , Sylvie Lesage , Nicolas Flamand , Lara Bilodeau , Maria J Fernandes

Comparing Transgenic Production to Supplementation of ω-3 PUFA Reveals Distinct But Overlapping Mechanisms Underlying Protection Against Metabolic and Hepatic Disorders.

Function (Oxford, England)

Avec: Noëmie Daniel , Mélanie Le Barz , Patricia L Mitchell , Thibault V Varin , Isabelle Bourdeau Julien , Dominique Farabos , Geneviève Pilon , Josée Gauthier , Carole Garofalo , Jing X Kang , Jocelyn Trottier , Olivier Barbier , Denis Roy , Benoit Chassaing , Emile Levy , Frédéric Raymond , Antonin Lamaziere , Nicolas Flamand , Cristoforo Silvestri , Christian Jobin , Vincenzo Di Marzo , André Marette

The Impact of the CB

Molecules (Basel, Switzerland)

Avec: Volatiana Rakotoarivelo , Thomas Z Mayer , Mélissa Simard , Nicolas Flamand , Vincenzo Di Marzo

Lipopolysaccharide impacts murine CD103

European journal of immunology

Avec: Julyanne Brassard , Catherine Maheux , Anick Langlois , Emilie Bernatchez , David Marsolais , Nicolas Flamand , Marie-Renee Blanchet

Réseau de co-auteurs

Vincenzo Di Marzo 22 collaborations

Cyril Martin 9 collaborations

Cristoforo Silvestri 9 collaborations

Frédéric Raymond 7 collaborations

Alain Veilleux 7 collaborations

Mélissa Simard 7 collaborations

Anne-Sophie Archambault 6 collaborations

Sophie Castonguay-Paradis 5 collaborations

Julie Perron 5 collaborations

Élizabeth Dumais 5 collaborations

Volatiana Rakotoarivelo 5 collaborations

Sébastien Lacroix 4 collaborations

Roxane Pouliot 4 collaborations

Benoît Lamarche 3 collaborations

Matthias Van Hul 3 collaborations

Nathalie M Delzenne 3 collaborations

Patrice D Cani 3 collaborations

Claudia Manca 3 collaborations

Gabrielle St-Arnaud 3 collaborations

Nadine Leblanc 3 collaborations

Louis-Philippe Boulet 3 collaborations

Michel Laviolette 3 collaborations

Gabrielle Rochefort 2 collaborations

Lydiane Parent 2 collaborations

Marialetizia Rastelli 2 collaborations

Giulio G Muccioli 2 collaborations

Serge Luquet 2 collaborations

Besma Boubertakh 2 collaborations

N Flamand 2 collaborations

Giada Giorgini 2 collaborations

Isabelle Bourdeau-Julien 2 collaborations

Marie-Renée Blanchet 2 collaborations

Francesco Tinto 2 collaborations

Magdalena Kostrzewa 2 collaborations

Pier-Luc Plante 2 collaborations

Alessia Ligresti 2 collaborations

Julyanne Brassard 2 collaborations

Isabelle Allaeys 2 collaborations

Arnaud Droit 2 collaborations

Amandine Everard 1 collaboration

Hubert Plovier 1 collaboration

Alice de Wouters d'Oplinter 1 collaboration

Lucie Geurts 1 collaboration

Céline Druart 1 collaboration

Sylvie Robine 1 collaboration

Willem M de Vos 1 collaboration

Melissa Shen 1 collaboration

M Gazzola 1 collaboration

Y Bossé 1 collaboration

Francine Pérusse 1 collaboration

Yvon Chagnon 1 collaboration

Vicky Drapeau 1 collaboration

Angelo Tremblay 1 collaboration

Alexe Grenier 1 collaboration

Geneviève Rioux 1 collaboration

Andréa Tremblay 1 collaboration

Isalie Blais 1 collaboration

Ralph-Sydney Mboumba Bouassa 1 collaboration

Chanté Muller 1 collaboration

Nayudu Nallabelli 1 collaboration

Yulia Alexandrova 1 collaboration

Madeleine Durand 1 collaboration

Cécile Tremblay 1 collaboration

Mohamed El-Far 1 collaboration

Carl Chartrand-Lefebvre 1 collaboration

Marc Messier-Peet 1 collaboration

Shari Margolese 1 collaboration

Cecilia T Costiniuk 1 collaboration

Mohammad-Ali Jenabian 1 collaboration

Fredy Alexander Guevara Agudelo 1 collaboration

Florent Pechereau 1 collaboration

Alain Houde 1 collaboration

Gordon S Wong 1 collaboration

Jamie L Redes 1 collaboration

Nariman Balenga 1 collaboration

Morgan McCullough 1 collaboration

Nathalie Fuentes 1 collaboration

Ameya Gokhale 1 collaboration

Cynthia Koziol-White 1 collaboration

Joseph A Jude 1 collaboration

Laura A Madigan 1 collaboration

Eunice C Chan 1 collaboration

William H Jester 1 collaboration

Sabrina Biardel 1 collaboration

Reynold A Panettieri 1 collaboration

Kirk M Druey 1 collaboration

Caroline Turcotte 1 collaboration

Élyse Bissonnette 1 collaboration

Yves Desjardins 1 collaboration

Luciano De Petrocellis 1 collaboration

Nils Helge Schebb 1 collaboration

Hartmut Kühn 1 collaboration

Astrid S Kahnt 1 collaboration

Katharina M Rund 1 collaboration

Valerie B O'Donnell 1 collaboration

Marc Peters-Golden 1 collaboration

Per-Johan Jakobsson 1 collaboration

Karsten H Weylandt 1 collaboration

Nadine Rohwer 1 collaboration

Robert C Murphy 1 collaboration

Gerd Geisslinger 1 collaboration

Garret A FitzGerald 1 collaboration

Julien Hanson 1 collaboration

Claes Dahlgren 1 collaboration

Mohamad Wessam Alnouri 1 collaboration

Stefan Offermanns 1 collaboration

Dieter Steinhilber 1 collaboration

Émilie Bernatchez 1 collaboration

Isabelle Dubuc 1 collaboration

Julien Prunier 1 collaboration

Émile Lacasse 1 collaboration

Annie Gravel 1 collaboration

Florian Puhm 1 collaboration

Leslie Gudimard 1 collaboration

Rosaria Villano 1 collaboration

Éric Boilard 1 collaboration

Louis Flamand 1 collaboration

Francesco Suriano 1 collaboration

Alice Fradet 1 collaboration

Camille Dugas 1 collaboration

Isabelle Marc 1 collaboration

Alain Doyen 1 collaboration

Fadil Dahhani 1 collaboration

Julie Robitaille 1 collaboration

Charlotte Lefort 1 collaboration

Martin Roumain 1 collaboration

Rita Manco 1 collaboration

Isabelle Leclercq 1 collaboration

Samuel J Poirier 1 collaboration

Luc H Boudreau 1 collaboration

Marc E Surette 1 collaboration

Jyoti Sihag 1 collaboration

Sophie Morin 1 collaboration

Etienne Doré 1 collaboration

Charles Joly-Beauparlant 1 collaboration

Satoshi Morozumi 1 collaboration

Alban Mathieu 1 collaboration

Tania Lévesque 1 collaboration

Anne-Claire Duchez 1 collaboration

Nathalie Cloutier 1 collaboration

Mickaël Leclercq 1 collaboration

Antoine Bodein 1 collaboration

Christine Payré 1 collaboration

Agnes Petit-Paitel 1 collaboration

Michael H Gelb 1 collaboration

Manu Rangachari 1 collaboration

Makoto Murakami 1 collaboration

Laetitia Davidovic 1 collaboration

Makoto Arita 1 collaboration

Gérard Lambeau 1 collaboration

Eric Boilard 1 collaboration

Rosa Maria Vitale 1 collaboration

Jean-Philippe C Lavoie 1 collaboration

S Lacroix 1 collaboration

N Leblanc 1 collaboration

A Abolghasemi 1 collaboration

S Paris-Robidas 1 collaboration

C Martin 1 collaboration

M Frappier 1 collaboration

C Silvestri 1 collaboration

F Raymond 1 collaboration

M Millette 1 collaboration

V Di Marzo 1 collaboration

A Veilleux 1 collaboration

Tommaso Venneri 1 collaboration

Francesca Borrelli 1 collaboration

Andréa Murru 1 collaboration

Nathalie Vadeboncoeur 1 collaboration

Andrée-Anne Therrien 1 collaboration

Lise Coderre 1 collaboration

Myriam Vaillancourt 1 collaboration

Marie-Michèle Labrecque 1 collaboration

Yves Berthiaume 1 collaboration

Guillaume Bouvet 1 collaboration

Damien Adam 1 collaboration

Emmanuelle Brochiero 1 collaboration

Sylvie Lesage 1 collaboration

Lara Bilodeau 1 collaboration

Maria J Fernandes 1 collaboration

Noëmie Daniel 1 collaboration

Mélanie Le Barz 1 collaboration

Patricia L Mitchell 1 collaboration

Thibault V Varin 1 collaboration

Isabelle Bourdeau Julien 1 collaboration

Dominique Farabos 1 collaboration

Geneviève Pilon 1 collaboration

Josée Gauthier 1 collaboration

Carole Garofalo 1 collaboration

Jing X Kang 1 collaboration

Jocelyn Trottier 1 collaboration

Olivier Barbier 1 collaboration

Denis Roy 1 collaboration

Benoit Chassaing 1 collaboration

Emile Levy 1 collaboration

Antonin Lamaziere 1 collaboration

Christian Jobin 1 collaboration

André Marette 1 collaboration

Thomas Z Mayer 1 collaboration

Catherine Maheux 1 collaboration

Anick Langlois 1 collaboration

Emilie Bernatchez 1 collaboration

David Marsolais 1 collaboration

Marie-Renee Blanchet 1 collaboration