Niamh Lynam-Lennon

Affiliations

Department of Surgery, Trinity Translational Medicine Institute, Trinity St. James's Cancer Institute, St. James's Hospital, Trinity College Dublin, Dublin, Ireland.

Publications (23)

Proteomic signatures of radioresistance: Alteration of inflammation, angiogenesis and metabolism-related factors in radioresistant oesophageal adenocarcinoma.

Cancer treatment and research communications

Avec: Simone Marcone , Amy Buckley , Colm J Ryan , Mark McCabe , Niamh Lynam-Lennon , David Matallanas , Jacintha O Sullivan , Susan Kennedy

PD-1 and TIGIT blockade differentially affect tumour cell survival under hypoxia and glucose deprived conditions in oesophageal adenocarcinoma; implications for overcoming resistance to PD-1 blockade in hypoxic tumours.

Translational oncology

Avec: Maria Davern , Marie-Claire Fitzgerald , Croí E Buckley , Aisling B Heeran , Noel E Donlon , Jason McGrath , Fiona O' Connell , Malvika R Deshpande , Conall Hayes , Jamie MacDonald , Andrew D Sheppard , John V Reynolds , Stephen G Maher , Niamh Lynam-Lennon , Brona Murphy , Joanne Lysaght

Therapeutic Potential of PARP Inhibitors in the Treatment of Gastrointestinal Cancers.

Biomedicines

Avec: Abdullah Alhusaini , Aoife Cannon , Stephen G Maher , John V Reynolds , Niamh Lynam-Lennon

Complement in Tumourigenesis and the Response to Cancer Therapy.

Cancers

Avec: Rebecca M O'Brien , Aoife Cannon , John V Reynolds , Joanne Lysaght , Niamh Lynam-Lennon

Precision Medicine and Novel Therapeutic Strategies in Detection and Treatment of Cancer: Highlights from the 58th IACR Annual Conference.

Cancers

Avec: Sean P Kennedy , Oliver Treacy , Emma H Allott , Alex J Eustace , Niamh Lynam-Lennon , Niamh Buckley , Tracy Robson

The tumour microenvironment of the upper and lower gastrointestinal tract differentially influences dendritic cell maturation.

BMC cancer

Avec: Maria E Morrissey , Róisín Byrne , Celina Nulty , Niamh H McCabe , Niamh Lynam-Lennon , Clare T Butler , Susan Kennedy , Dermot O'Toole , John Larkin , Paul McCormick , Brian Mehigan , Mary-Clare Cathcart , Joanne Lysaght , John V Reynolds , Elizabeth J Ryan , Margaret R Dunne , Jacintha O'Sullivan

Visceral Adipose Tissue Modulates Radiosensitivity in Oesophageal Adenocarcinoma.

International journal of medical sciences

Avec: Ann Marie Mongan , Niamh Lynam-Lennon , Suzanne L Doyle , Rory Casey , Eibhlin Carr , Aoife Cannon , Melissa J Conroy , Graham P Pidgeon , Lorraine Brennan , Joanne Lysaght , John V Reynolds , Jacintha O'Sullivan

Chemotherapy regimens induce inhibitory immune checkpoint protein expression on stem-like and senescent-like oesophageal adenocarcinoma cells.

Translational oncology

Avec: Maria Davern , Noel E Donlon , Andrew Sheppard , Fiona O' Connell , Conall Hayes , Anshul Bhardwaj , Emma Foley , Dermot O' Toole , Niamh Lynam-Lennon , Narayanasamy Ravi , John V Reynolds , Stephen G Maher , Joanne Lysaght

Energy Metabolism Is Altered in Radioresistant Rectal Cancer.

International journal of molecular sciences

Avec: Croí E Buckley , Xiaofei Yin , Sebastian Meltzer , Anne Hansen Ree , Kathrine Røe Redalen , Lorraine Brennan , Jacintha O'Sullivan , Niamh Lynam-Lennon

Targeting hallmarks of cancer to enhance radiosensitivity in gastrointestinal cancers.

Nature reviews. Gastroenterology & hepatology

Avec: Amy M Buckley , Niamh Lynam-Lennon , Hazel O'Neill , Jacintha O'Sullivan

Opposing Immune-Metabolic Signature in Visceral Versus Subcutaneous Adipose Tissue in Patients with Adenocarcinoma of the Oesophagus and the Oesophagogastric Junction.

Metabolites

Avec: Aisling B Heeran , Jessica McCready , Margaret R Dunne , Noel E Donlon , Timothy S Nugent , Anshul Bhardwaj , Kathleen A J Mitchelson , Amy M Buckley , Narayanasamy Ravi , Helen M Roche , John V Reynolds , Niamh Lynam-Lennon , Jacintha O'Sullivan

PD-1 blockade enhances chemotherapy toxicity in oesophageal adenocarcinoma.

Scientific reports

Avec: Maria Davern , Rebecca M O' Brien , Jason McGrath , Noel E Donlon , Ashanty M Melo , Croí E Buckley , Andrew D Sheppard , John V Reynolds , Niamh Lynam-Lennon , Stephen G Maher , Joanne Lysaght

Generation and Characterization of an Isogenic Cell Line Model of Radioresistant Esophageal Adenocarcinoma.

Methods in molecular biology (Clifton, N.J.)

Avec: Aoife Cannon , Stephen G Maher , Niamh Lynam-Lennon

PD-1 blockade attenuates surgery-mediated immunosuppression and boosts Th1 immunity perioperatively in oesophagogastric junctional adenocarcinoma.

Frontiers in immunology

Avec: Maria Davern , Caoimhe Gaughan , Fiona O' Connell , Brendan Moran , Eimear Mylod , Andrew D Sheppard , Sinead Ramjit , Jasmine Yun-Tong Kung , James J Phelan , Matthew G Davey , Eanna J Ryan , Christine Butler , Laura Quinn , Claudine Howard , Emily Tone , Eimear Phoenix , Waqas T Butt , Niamh Lynam-Lennon , Stephen G Maher , Narayanasamy Ravi , Claire L Donohoe , John V Reynolds , Joanne Lysaght , Noel E Donlon

Precision Oncology, Artificial Intelligence, and Novel Therapeutic Advancements in the Diagnosis, Prevention, and Treatment of Cancer: Highlights from the 59th Irish Association for Cancer Research (IACR) Annual Conference.

Cancers

Avec: Seodhna M Lynch , Aisling B Heeran , Caoimbhe Burke , Niamh Lynam-Lennon , Alex J Eustace , Kellie Dean , Tracy Robson , Arman Rahman , Simone Marcone

Pyrazinib (P3), [(E)-2-(2-Pyrazin-2-yl-vinyl)-phenol], a small molecule pyrazine compound enhances radiosensitivity in oesophageal adenocarcinoma.

Cancer letters

Avec: Amy M Buckley , Margaret R Dunne , Niamh Lynam-Lennon , Susan A Kennedy , Aoife Cannon , Alison L Reynolds , Stephen G Maher , John V Reynolds , Breandán N Kennedy , Jacintha O'Sullivan

Radiation-induced Bystander Effect (RIBE) alters mitochondrial metabolism using a human rectal cancer ex vivo explant model.

Translational oncology

Avec: Aisling B Heeran , Helen P Berrigan , Croí E Buckley , Heleena Moni Bottu , Orla Prendiville , Amy M Buckley , Niamh Clarke , Noel E Donlon , Timothy S Nugent , Michael Durand , Cara Dunne , John O Larkin , Brian Mehigan , Paul McCormick , Lorraine Brennan , Niamh Lynam-Lennon , Jacintha O'Sullivan

The Protein Secretome Is Altered in Rectal Cancer Tissue Compared to Normal Rectal Tissue, and Alterations in the Secretome Induce Enhanced Innate Immune Responses.

Cancers

Avec: Aisling B Heeran , Margaret R Dunne , Maria E Morrissey , Croí E Buckley , Niamh Clarke , Aoife Cannon , Noel E Donlon , Timothy S Nugent , Michael Durand , Cara Dunne , John O Larkin , Brian Mehigan , Paul McCormick , Niamh Lynam-Lennon , Jacintha O'Sullivan

Impact of radiotherapy on the immune landscape in oesophageal adenocarcinoma.

World journal of gastroenterology

Avec: Noel E Donlon , Maria Davern , Fiona O'Connell , Andrew Sheppard , Aisling Heeran , Anshul Bhardwaj , Christine Butler , Ravi Narayanasamy , Claire Donohoe , James J Phelan , Niamh Lynam-Lennon , Margaret R Dunne , Stephen Maher , Jacintha O'Sullivan , John V Reynolds , Joanne Lysaght

Thinking inside the box: intracellular roles for complement system proteins come into focus.

British journal of cancer

Avec: Rebecca M O'Brien , Niamh Lynam-Lennon , Monica M Olcina

Metformin is a metabolic modulator and radiosensitiser in rectal cancer.

Frontiers in oncology

Avec: Croí E Buckley , Rebecca M O'Brien , Timothy S Nugent , Noel E Donlon , Fiona O'Connell , John V Reynolds , Adnan Hafeez , Diarmuid S O'Ríordáin , Robert A Hannon , Paul Neary , Reza Kalbassi , Brian J Mehigan , Paul H McCormick , Cara Dunne , Michael E Kelly , John O Larkin , Jacintha O'Sullivan , Niamh Lynam-Lennon

Potential of damage associated molecular patterns in synergising radiation and the immune response in oesophageal cancer.

World journal of gastrointestinal oncology

Avec: Noel E Donlon , Maria Davern , Andrew Sheppard , Fiona O'Connell , Brendan Moran , Timothy S Nugent , Aisling Heeran , James J Phelan , Anshul Bhardwaj , Christine Butler , Narayanasamy Ravi , Claire L Donohoe , Niamh Lynam-Lennon , Stephen Maher , John V Reynolds , Joanne Lysaght

Complement is increased in treatment resistant rectal cancer and modulates radioresistance.

Cancer letters

Avec: Rebecca M O'Brien , Sebastian Meltzer , Croí E Buckley , Aisling B Heeran , Timothy S Nugent , Noel E Donlon , John V Reynolds , Anne Hansen Ree , Kathrine Røe Redalen , Adnan Hafeez , Diarmuid S O'Ríordáin , Robert A Hannon , Paul Neary , Reza Kalbassi , Brian J Mehigan , Paul H McCormick , Cara Dunne , Michael E Kelly , John O Larkin , Jacintha O'Sullivan , Joanne Lysaght , Niamh Lynam-Lennon

Réseau de co-auteurs

John V Reynolds 14 collaborations

Noel E Donlon 11 collaborations

Jacintha O'Sullivan 11 collaborations

Joanne Lysaght 10 collaborations

Croí E Buckley 7 collaborations

Stephen G Maher 7 collaborations

Maria Davern 6 collaborations

Aisling B Heeran 6 collaborations

Aoife Cannon 6 collaborations

Timothy S Nugent 6 collaborations

Margaret R Dunne 5 collaborations

Rebecca M O'Brien 4 collaborations

Anshul Bhardwaj 4 collaborations

Narayanasamy Ravi 4 collaborations

Amy M Buckley 4 collaborations

Cara Dunne 4 collaborations

John O Larkin 4 collaborations

Fiona O' Connell 3 collaborations

Andrew D Sheppard 3 collaborations

Paul McCormick 3 collaborations

Brian Mehigan 3 collaborations

Lorraine Brennan 3 collaborations

Andrew Sheppard 3 collaborations

James J Phelan 3 collaborations

Christine Butler 3 collaborations

Fiona O'Connell 3 collaborations

Simone Marcone 2 collaborations

Susan Kennedy 2 collaborations

Jason McGrath 2 collaborations

Conall Hayes 2 collaborations

Alex J Eustace 2 collaborations

Tracy Robson 2 collaborations

Maria E Morrissey 2 collaborations

Sebastian Meltzer 2 collaborations

Anne Hansen Ree 2 collaborations

Kathrine Røe Redalen 2 collaborations

Brendan Moran 2 collaborations

Claire L Donohoe 2 collaborations

Niamh Clarke 2 collaborations

Michael Durand 2 collaborations

Aisling Heeran 2 collaborations

Stephen Maher 2 collaborations

Adnan Hafeez 2 collaborations

Diarmuid S O'Ríordáin 2 collaborations

Robert A Hannon 2 collaborations

Paul Neary 2 collaborations

Reza Kalbassi 2 collaborations

Brian J Mehigan 2 collaborations

Paul H McCormick 2 collaborations

Michael E Kelly 2 collaborations

Amy Buckley 1 collaboration

Colm J Ryan 1 collaboration

Mark McCabe 1 collaboration

David Matallanas 1 collaboration

Jacintha O Sullivan 1 collaboration

Marie-Claire Fitzgerald 1 collaboration

Malvika R Deshpande 1 collaboration

Jamie MacDonald 1 collaboration

Brona Murphy 1 collaboration

Abdullah Alhusaini 1 collaboration

Sean P Kennedy 1 collaboration

Oliver Treacy 1 collaboration

Emma H Allott 1 collaboration

Niamh Buckley 1 collaboration

Róisín Byrne 1 collaboration

Celina Nulty 1 collaboration

Niamh H McCabe 1 collaboration

Clare T Butler 1 collaboration

Dermot O'Toole 1 collaboration

John Larkin 1 collaboration

Mary-Clare Cathcart 1 collaboration

Elizabeth J Ryan 1 collaboration

Ann Marie Mongan 1 collaboration

Suzanne L Doyle 1 collaboration

Rory Casey 1 collaboration

Eibhlin Carr 1 collaboration

Melissa J Conroy 1 collaboration

Graham P Pidgeon 1 collaboration

Emma Foley 1 collaboration

Dermot O' Toole 1 collaboration

Xiaofei Yin 1 collaboration

Hazel O'Neill 1 collaboration

Jessica McCready 1 collaboration

Kathleen A J Mitchelson 1 collaboration

Helen M Roche 1 collaboration

Rebecca M O' Brien 1 collaboration

Ashanty M Melo 1 collaboration

Caoimhe Gaughan 1 collaboration

Eimear Mylod 1 collaboration

Sinead Ramjit 1 collaboration

Jasmine Yun-Tong Kung 1 collaboration

Matthew G Davey 1 collaboration

Eanna J Ryan 1 collaboration

Laura Quinn 1 collaboration

Claudine Howard 1 collaboration

Emily Tone 1 collaboration

Eimear Phoenix 1 collaboration

Waqas T Butt 1 collaboration

Seodhna M Lynch 1 collaboration

Caoimbhe Burke 1 collaboration

Kellie Dean 1 collaboration

Arman Rahman 1 collaboration

Susan A Kennedy 1 collaboration

Alison L Reynolds 1 collaboration

Breandán N Kennedy 1 collaboration

Helen P Berrigan 1 collaboration

Heleena Moni Bottu 1 collaboration

Orla Prendiville 1 collaboration

Ravi Narayanasamy 1 collaboration

Claire Donohoe 1 collaboration

Monica M Olcina 1 collaboration