Namandje N Bumpus

Affiliations

Division of Clinical Pharmacology, Department of Medicine, the Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Department of Pharmacology and Molecular Sciences, the Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

Publications (30)

Twelfth-Position Deuteration of Nevirapine Reduces 12-Hydroxy-Nevirapine Formation and Nevirapine-Induced Hepatocyte Death.

Journal of medicinal chemistry

Avec: Carley J S Heck , Herana Kamal Seneviratne , Namandjé N Bumpus

Transgender women on oral HIV pre-exposure prophylaxis have significantly lower tenofovir and emtricitabine concentrations when also taking oestrogen when compared to cisgender men.

Journal of the International AIDS Society

Avec: Eugenie Shieh , Mark A Marzinke , Edward J Fuchs , Allyson Hamlin , Rahul Bakshi , Wutyi Aung , Jennifer Breakey , Tonia Poteat , Todd Brown , Namandjé N Bumpus , Craig W Hendrix

Genetic variation of kinases and activation of nucleotide analog reverse transcriptase inhibitor tenofovir.

Pharmacogenomics

Avec: Allyson N Hamlin , Joseph Tillotson , Namandjé N Bumpus

Efavirenz and Efavirenz-like Compounds Activate Human, Murine, and Macaque Hepatic IRE1

Molecular pharmacology

Avec: Carley J S Heck , Allyson N Hamlin , Namandjé N Bumpus

Metabolism of Long-Acting Rilpivirine After Intramuscular Injection: HIV Prevention Trials Network Study 076 (HPTN 076).

AIDS research and human retroviruses

Avec: Herana Kamal Seneviratne , Joseph Tillotson , Julie M Lade , Linda-Gail Bekker , Sue Li , Subash Pathak , Jessica Justman , Nyaradzo Mgodi , Shobha Swaminathan , Nirupama Sista , Jennifer Farrior , Paul Richardson , Craig W Hendrix , Namandje N Bumpus

Interaction of Depot Medroxyprogesterone Acetate and Tenofovir Disoproxil Fumarate/Emtricitabine on Peripheral Blood Mononuclear Cells and Cervical Tissue Susceptibility to HIV Infection and Pharmacokinetics.

Journal of acquired immune deficiency syndromes (1999)

Avec: Jenell S Coleman , Clarissa P Diniz , Edward J Fuchs , Mark A Marzinke , Wutyi Aung , Rahul P Bakshi , Homayoon Farzadegan , Jay H Bream , Tricia L Nilles , Sherry Hudson , Namandjé N Bumpus , George J Schwartz , Michael A Rosenblum , James F Rooney , Craig W Hendrix

Tenofovir Activation Is Diminished in the Brain and Liver of Creatine Kinase Brain-Type Knockout Mice.

ACS pharmacology & translational science

Avec: Colten D Eberhard , Eric P Mosher , Namandjé N Bumpus , Benjamin C Orsburn

Biotransformation and bioactivation reactions - 2018 literature highlights.

Drug metabolism reviews

Avec: S Cyrus Khojasteh , Namandjé N Bumpus , James P Driscoll , Grover P Miller , Kaushik Mitra , Ivonne M C M Rietjens , Donglu Zhang

A mevalonate bypass system facilitates elucidation of plastid biology in malaria parasites.

PLoS pathogens

Avec: Russell P Swift , Krithika Rajaram , Hans B Liu , Amanda Dziedzic , Anne E Jedlicka , Aleah D Roberts , Krista A Matthews , Hugo Jhun , Namandje N Bumpus , Shivendra G Tewari , Anders Wallqvist , Sean T Prigge

Spatial Distribution Profiles of Emtricitabine, Tenofovir, Efavirenz, and Rilpivirine in Murine Tissues Following

ACS pharmacology & translational science

Avec: Herana Kamal Seneviratne , Allyson N Hamlin , Carley J S Heck , Namandjé N Bumpus

Naturally Occurring Mutations to Muscle-Type Creatine Kinase Impact Its Canonical and Pharmacological Activities in a Substrate-Dependent Manner In Vitro.

Molecular pharmacology

Avec: Eric P Mosher , Colten D Eberhard , Namandjé N Bumpus

Tenofovir Douche as HIV Pre-Exposure Prophylaxis for Receptive Anal Intercourse: Safety, Acceptability, Pharmacokinetics, & Pharmacodynamics (DREAM 01).

The Journal of infectious diseases

Avec: Ethel D Weld , Ian McGowan , Peter Anton , Edward J Fuchs , Ken Ho , Alex Carballo-Dieguez , Lisa C Rohan , Rebecca Giguere , Rhonda Brand , Stacey Edick , Rahul P Bakshi , Teresa Parsons , Madhuri Manohar , Aaron Seigel , Jared Engstrom , Julie Elliott , Cindy Jacobson , Christina Bagia , Lin Wang , Amer Al-Khouja , Douglas J Hartman , Namandje N Bumpus , Hans M L Spiegel , Mark A Marzinke , Craig W Hendrix

Biotransformation of Efavirenz and Proteomic Analysis of Cytochrome P450s and UDP-Glucuronosyltransferases in Mouse, Macaque, and Human Brain-Derived In Vitro Systems.

Drug metabolism and disposition: the biological fate of chemicals

Avec: Abigail M Wheeler , Benjamin C Orsburn , Namandjé N Bumpus

Human brain sialoglycan ligand for CD33, a microglial inhibitory Siglec implicated in Alzheimer's disease.

The Journal of biological chemistry

Avec: Anabel Gonzalez-Gil , Ryan N Porell , Steve M Fernandes , Eila Maenpaa , T August Li , Tong Li , Philip C Wong , Kazuhiro Aoki , Michael Tiemeyer , Zaikuan J Yu , Benjamin C Orsburn , Namandjé N Bumpus , Russell T Matthews , Ronald L Schnaar

Human Cyclophilin B Nuclease Activity Revealed via Nucleic Acid-Based Electrochemical Sensors.

Angewandte Chemie (International ed. in English)

Avec: Vincent Clark , Kelly Waters , Ben Orsburn , Namandjé N Bumpus , Nandini Kundu , Jonathan T Sczepanski , Partha Ray , Netzahualcóyotl Arroyo-Currás

Achieving a Deeper Understanding of Drug Metabolism and Responses Using Single-Cell Technologies.

Drug metabolism and disposition: the biological fate of chemicals

Avec: Abigail M Wheeler , Colten D Eberhard , Eric P Mosher , Yuting Yuan , Hannah N Wilkins , Herana Kamal Seneviratne , Benjamin C Orsburn , Namandjé N Bumpus

The SAGA HAT module is tethered by its SWIRM domain and modulates activity of the SAGA DUB module.

Biochimica et biophysica acta. Gene regulatory mechanisms

Avec: Sara T Haile , Sanim Rahman , James K Fields , Benjamin C Orsburn , Namandjé N Bumpus , Cynthia Wolberger

Identification of Novel UGT1A1 Variants Including UGT1A1 454C>A through the Genotyping of Healthy Participants of the HPTN 077 Study.

ACS pharmacology & translational science

Avec: Herana Kamal Seneviratne , Allyson N Hamlin , Sue Li , Beatriz Grinsztejn , Halima Dawood , Albert Y Liu , Irene Kuo , Mina C Hosseinipour , Ravindre Panchia , Leslie Cottle , Gordon Chau , Adeola Adeyeye , Alex R Rinehart , Marybeth McCauley , Joseph S Eron , Myron S Cohen , Raphael J Landovitz , Craig W Hendrix , Namandjé N Bumpus

Drug Concentration Asymmetry in Tissues and Plasma for Small Molecule-Related Therapeutic Modalities.

Drug metabolism and disposition: the biological fate of chemicals

Avec: Donglu Zhang , Cornelis E C A Hop , Gabriela Patilea-Vrana , Gautham Gampa , Herana Kamal Seneviratne , Jashvant D Unadkat , Jane R Kenny , Karthik Nagapudi , Li Di , Lian Zhou , Mark Zak , Matthew R Wright , Namandjé N Bumpus , Richard Zang , Xingrong Liu , Yurong Lai , S Cyrus Khojasteh

Antiretroviral drug concentrations in brain tissue of adult decedents.

AIDS (London, England)

Avec: Micol Ferrara , Namandjé N Bumpus , Qing Ma , Ronald J Ellis , Virawudh Soontornniyomkij , Jerel A Fields , Ajay Bharti , Cristian L Achim , David J Moore , Scott L Letendre

Pharmacogenomics of Antiretroviral Drug Metabolism and Transport.

Annual review of pharmacology and toxicology

Avec: Zaikuan J Yu , Eric P Mosher , Namandjé N Bumpus

Control of topoisomerase II activity and chemotherapeutic inhibition by TCA cycle metabolites.

Cell chemical biology

Avec: Joyce H Lee , Eric P Mosher , Young-Sam Lee , Namandjé N Bumpus , James M Berger

Progesterone receptor membrane component 1 (PGRMC1) binds and stabilizes cytochromes P450 through a heme-independent mechanism.

The Journal of biological chemistry

Avec: Meredith R McGuire , Debaditya Mukhopadhyay , Stephanie L Myers , Eric P Mosher , Rita T Brookheart , Kai Kammers , Alfica Sehgal , Ebru S Selen , Michael J Wolfgang , Namandjé N Bumpus , Peter J Espenshade

Correction to "Identification of Novel UGT1A1 Variants Including UGT1A1 454C>A through the Genotyping of Healthy Participants of the HPTN 077 Study".

ACS pharmacology & translational science

Avec: Herana Kamal Seneviratne , Allyson N Hamlin , Sue Li , Beatriz Grinsztejn , Halima Dawood , Albert Y Liu , Irene Kuo , Mina C Hosseinipour , Ravindre Panchia , Leslie Cottle , Gordon Chau , Adeola Adeyeye , Alex R Rinehart , Marybeth McCauley , Joseph J Eron , Myron S Cohen , Raphael J Landovitz , Craig W Hendrix , Namandjé N Bumpus

Atp7b-dependent choroid plexus dysfunction causes transient copper deficit and metabolic changes in the developing mouse brain.

PLoS genetics

Avec: Clorissa L Washington-Hughes , Shubhrajit Roy , Herana Kamal Seneviratne , Senthilkumar S Karuppagounder , Yulemni Morel , Jace W Jones , Alex Zak , Tong Xiao , Tatiana N Boronina , Robert N Cole , Namandjé N Bumpus , Christopher J Chang , Ted M Dawson , Svetlana Lutsenko

Tenofovir Plasma Concentration from Preexposure Prophylaxis at the Time of Potential HIV Exposure: a Population Pharmacokinetic Modeling and Simulation Study Involving Serodiscordant Couples in East Africa.

Antimicrobial agents and chemotherapy

Avec: Surulivelrajan Mallayasamy , Ayyappa Chaturvedula , Michael J Fossler , Mark Sale , Vineet Goti , Namandje N Bumpus , Mark A Marzinke , Craig W Hendrix , Jessica E Haberer , Auteur inconnu

Population Pharmacokinetics and Pharmacodynamics of Disulfiram on Inducing Latent HIV-1 Transcription in a Phase IIb Trial.

Clinical pharmacology and therapeutics

Avec: Sulggi A Lee , Julian H Elliott , James McMahon , Wendy Hartogenesis , Namandje N Bumpus , Jeffrey D Lifson , Robert J Gorelick , Peter Bacchetti , Steven G Deeks , Sharon R Lewin , Radojka M Savic

A Mechanistic In Vivo/Ex Vivo Pharmacokinetic-Pharmacodynamic Model of Tenofovir for HIV Prevention.

CPT: pharmacometrics & systems pharmacology

Avec: Priya Jayachandran , Maria Garcia-Cremades , Katarina Vučićević , Namandjé N Bumpus , Peter Anton , Craig Hendrix , Radojka Savić

Tenofovir Activation is Diminished in the Brain and Liver of Creatine Kinase Brain-Type Knockout Mice.

bioRxiv : the preprint server for biology

Avec: Colten D Eberhard , Eric P Mosher , Namandjé N Bumpus , Benjamin C Orsburn

Insights into protein post-translational modification landscapes of individual human cells by trapped ion mobility time-of-flight mass spectrometry.

Nature communications

Avec: Benjamin C Orsburn , Yuting Yuan , Namandjé N Bumpus

Réseau de co-auteurs

Namandjé N Bumpus 25 collaborations

Herana Kamal Seneviratne 8 collaborations

Craig W Hendrix 7 collaborations

Eric P Mosher 7 collaborations

Benjamin C Orsburn 7 collaborations

Allyson N Hamlin 5 collaborations

Mark A Marzinke 4 collaborations

Colten D Eberhard 4 collaborations

Carley J S Heck 3 collaborations

Edward J Fuchs 3 collaborations

Sue Li 3 collaborations

Wutyi Aung 2 collaborations

Joseph Tillotson 2 collaborations

Rahul P Bakshi 2 collaborations

S Cyrus Khojasteh 2 collaborations

Donglu Zhang 2 collaborations

Peter Anton 2 collaborations

Abigail M Wheeler 2 collaborations

Zaikuan J Yu 2 collaborations

Yuting Yuan 2 collaborations

Beatriz Grinsztejn 2 collaborations

Halima Dawood 2 collaborations

Albert Y Liu 2 collaborations

Irene Kuo 2 collaborations

Mina C Hosseinipour 2 collaborations

Ravindre Panchia 2 collaborations

Leslie Cottle 2 collaborations

Gordon Chau 2 collaborations

Adeola Adeyeye 2 collaborations

Alex R Rinehart 2 collaborations

Marybeth McCauley 2 collaborations

Myron S Cohen 2 collaborations

Raphael J Landovitz 2 collaborations

Eugenie Shieh 1 collaboration

Allyson Hamlin 1 collaboration

Rahul Bakshi 1 collaboration

Jennifer Breakey 1 collaboration

Tonia Poteat 1 collaboration

Todd Brown 1 collaboration

Julie M Lade 1 collaboration

Linda-Gail Bekker 1 collaboration

Subash Pathak 1 collaboration

Jessica Justman 1 collaboration

Nyaradzo Mgodi 1 collaboration

Shobha Swaminathan 1 collaboration

Nirupama Sista 1 collaboration

Jennifer Farrior 1 collaboration

Paul Richardson 1 collaboration

Jenell S Coleman 1 collaboration

Clarissa P Diniz 1 collaboration

Homayoon Farzadegan 1 collaboration

Jay H Bream 1 collaboration

Tricia L Nilles 1 collaboration

Sherry Hudson 1 collaboration

George J Schwartz 1 collaboration

Michael A Rosenblum 1 collaboration

James F Rooney 1 collaboration

James P Driscoll 1 collaboration

Grover P Miller 1 collaboration

Kaushik Mitra 1 collaboration

Ivonne M C M Rietjens 1 collaboration

Russell P Swift 1 collaboration

Krithika Rajaram 1 collaboration

Hans B Liu 1 collaboration

Amanda Dziedzic 1 collaboration

Anne E Jedlicka 1 collaboration

Aleah D Roberts 1 collaboration

Krista A Matthews 1 collaboration

Hugo Jhun 1 collaboration

Shivendra G Tewari 1 collaboration

Anders Wallqvist 1 collaboration

Sean T Prigge 1 collaboration

Ethel D Weld 1 collaboration

Ian McGowan 1 collaboration

Ken Ho 1 collaboration

Alex Carballo-Dieguez 1 collaboration

Lisa C Rohan 1 collaboration

Rebecca Giguere 1 collaboration

Rhonda Brand 1 collaboration

Stacey Edick 1 collaboration

Teresa Parsons 1 collaboration

Madhuri Manohar 1 collaboration

Aaron Seigel 1 collaboration

Jared Engstrom 1 collaboration

Julie Elliott 1 collaboration

Cindy Jacobson 1 collaboration

Christina Bagia 1 collaboration

Lin Wang 1 collaboration

Amer Al-Khouja 1 collaboration

Douglas J Hartman 1 collaboration

Hans M L Spiegel 1 collaboration

Anabel Gonzalez-Gil 1 collaboration

Ryan N Porell 1 collaboration

Steve M Fernandes 1 collaboration

Eila Maenpaa 1 collaboration

T August Li 1 collaboration

Tong Li 1 collaboration

Philip C Wong 1 collaboration

Kazuhiro Aoki 1 collaboration

Michael Tiemeyer 1 collaboration

Russell T Matthews 1 collaboration

Ronald L Schnaar 1 collaboration

Vincent Clark 1 collaboration

Kelly Waters 1 collaboration

Ben Orsburn 1 collaboration

Nandini Kundu 1 collaboration

Jonathan T Sczepanski 1 collaboration

Partha Ray 1 collaboration

Netzahualcóyotl Arroyo-Currás 1 collaboration

Hannah N Wilkins 1 collaboration

Sara T Haile 1 collaboration

Sanim Rahman 1 collaboration

James K Fields 1 collaboration

Cynthia Wolberger 1 collaboration

Joseph S Eron 1 collaboration

Cornelis E C A Hop 1 collaboration

Gabriela Patilea-Vrana 1 collaboration

Gautham Gampa 1 collaboration

Jashvant D Unadkat 1 collaboration

Jane R Kenny 1 collaboration

Karthik Nagapudi 1 collaboration

Li Di 1 collaboration

Lian Zhou 1 collaboration

Mark Zak 1 collaboration

Matthew R Wright 1 collaboration

Richard Zang 1 collaboration

Xingrong Liu 1 collaboration

Yurong Lai 1 collaboration

Micol Ferrara 1 collaboration

Qing Ma 1 collaboration

Ronald J Ellis 1 collaboration

Virawudh Soontornniyomkij 1 collaboration

Jerel A Fields 1 collaboration

Ajay Bharti 1 collaboration

Cristian L Achim 1 collaboration

David J Moore 1 collaboration

Scott L Letendre 1 collaboration

Joyce H Lee 1 collaboration

Young-Sam Lee 1 collaboration

James M Berger 1 collaboration

Meredith R McGuire 1 collaboration

Debaditya Mukhopadhyay 1 collaboration

Stephanie L Myers 1 collaboration

Rita T Brookheart 1 collaboration

Kai Kammers 1 collaboration

Alfica Sehgal 1 collaboration

Ebru S Selen 1 collaboration

Michael J Wolfgang 1 collaboration

Peter J Espenshade 1 collaboration

Joseph J Eron 1 collaboration

Clorissa L Washington-Hughes 1 collaboration

Shubhrajit Roy 1 collaboration

Senthilkumar S Karuppagounder 1 collaboration

Yulemni Morel 1 collaboration

Jace W Jones 1 collaboration

Alex Zak 1 collaboration

Tong Xiao 1 collaboration

Tatiana N Boronina 1 collaboration

Robert N Cole 1 collaboration

Christopher J Chang 1 collaboration

Ted M Dawson 1 collaboration

Svetlana Lutsenko 1 collaboration

Surulivelrajan Mallayasamy 1 collaboration

Ayyappa Chaturvedula 1 collaboration

Michael J Fossler 1 collaboration

Mark Sale 1 collaboration

Vineet Goti 1 collaboration

Jessica E Haberer 1 collaboration

None None 1 collaboration

Sulggi A Lee 1 collaboration

Julian H Elliott 1 collaboration

James McMahon 1 collaboration

Wendy Hartogenesis 1 collaboration

Jeffrey D Lifson 1 collaboration

Robert J Gorelick 1 collaboration

Peter Bacchetti 1 collaboration

Steven G Deeks 1 collaboration

Sharon R Lewin 1 collaboration

Radojka M Savic 1 collaboration

Priya Jayachandran 1 collaboration

Maria Garcia-Cremades 1 collaboration

Katarina Vučićević 1 collaboration

Craig Hendrix 1 collaboration

Radojka Savić 1 collaboration