Michael Sasner

Affiliations

The Jackson Laboratory, Bar Harbor, ME, 04609, USA.

Publications (31)

A novel systems biology approach to evaluate mouse models of late-onset Alzheimer's disease.

Molecular neurodegeneration

Avec: Christoph Preuss , Ravi Pandey , Erin Piazza , Alexander Fine , Asli Uyar , Thanneer Perumal , Dylan Garceau , Kevin P Kotredes , Harriet Williams , Lara M Mangravite , Bruce T Lamb , Adrian L Oblak , Gareth R Howell , Michael Sasner , Benjamin A Logsdon , Auteur inconnu , Gregory W Carter

Model organism development and evaluation for late-onset Alzheimer's disease: MODEL-AD.

Alzheimer's & dementia (New York, N. Y.)

Avec: Adrian L Oblak , Stefania Forner , Paul R Territo , Michael Sasner , Gregory W Carter , Gareth R Howell , Stacey J Sukoff-Rizzo , Benjamin A Logsdon , Lara M Mangravite , Ali Mortazavi , David Baglietto-Vargas , Kim N Green , Grant R MacGregor , Marcelo A Wood , Andrea J Tenner , Frank M LaFerla , Bruce T Lamb , Auteur inconnu , Auteur inconnu

Alzheimer's & dementia (New York, N. Y.)

Avec: Kate E Foley , Cory A Diemler , Amanda A Hewes , Dylan T Garceau , Michael Sasner , Gareth R Howell

Prophylactic evaluation of verubecestat on disease- and symptom-modifying effects in 5XFAD mice.

Alzheimer's & dementia (New York, N. Y.)

Avec: Adrian L Oblak , Zackary A Cope , Sara K Quinney , Ravi S Pandey , Carla Biesdorf , Andi R Masters , Kristen D Onos , Leslie Haynes , Kelly J Keezer , Jill A Meyer , Jonathan S Peters , Scott A Persohn , Amanda A Bedwell , Kierra Eldridge , Rachael Speedy , Gabriela Little , Sean-Paul Williams , Brenda Noarbe , Andre Obenaus , Michael Sasner , Gareth R Howell , Gregory W Carter , Harriet Williams , Bruce T Lamb , Paul R Territo , Stacey J Sukoff Rizzo

In vivo validation of late-onset Alzheimer's disease genetic risk factors.

Alzheimer's & dementia : the journal of the Alzheimer's Association

Avec: Michael Sasner , Christoph Preuss , Ravi S Pandey , Asli Uyar , Dylan Garceau , Kevin P Kotredes , Harriet Williams , Adrian L Oblak , Peter Bor-Chian Lin , Bridget Perkins , Disha Soni , Cindy Ingraham , Audrey Lee-Gosselin , Bruce T Lamb , Gareth R Howell , Gregory W Carter

Corrigendum: Uncovering Disease Mechanisms in a Novel Mouse Model Expressing Humanized APOEε4 and Trem2

Frontiers in aging neuroscience

Avec: Kevin P Kotredes , Adrian Oblak , Ravi S Pandey , Peter Bor-Chian Lin , Dylan Garceau , Harriet Williams , Asli Uyar , Rita O'Rourke , Sarah O'Rourke , Cynthia Ingraham , Daria Bednarczyk , Melisa Belanger , Zackary Cope , Kate E Foley , Benjamin A Logsdon , Lara M Mangravite , Stacey J Sukoff Rizzo , Paul R Territo , Gregory W Carter , Michael Sasner , Bruce T Lamb , Gareth R Howell

Meeting report of the fifth annual workshop on Principles and Techniques for Improving Preclinical to Clinical Translation in Alzheimer's Disease Research.

Alzheimer's & dementia : the journal of the Alzheimer's Association

Avec: Michael Sasner , Kristen D Onos , Paul R Territo , Stacey J Sukoff Rizzo

bioRxiv : the preprint server for biology

Novel App knock-in mouse model shows key features of amyloid pathology and reveals profound metabolic dysregulation of microglia.

Molecular neurodegeneration

Avec: Dan Xia , Steve Lianoglou , Thomas Sandmann , Meredith Calvert , Jung H Suh , Elliot Thomsen , Jason Dugas , Michelle E Pizzo , Sarah L DeVos , Timothy K Earr , Chia-Ching Lin , Sonnet Davis , Connie Ha , Amy Wing-Sze Leung , Hoang Nguyen , Roni Chau , Ernie Yulyaningsih , Isabel Lopez , Hilda Solanoy , Shababa T Masoud , Chun-Chi Liang , Karin Lin , Giuseppe Astarita , Nathalie Khoury , Joy Yu Zuchero , Robert G Thorne , Kevin Shen , Stephanie Miller , Jorge J Palop , Dylan Garceau , Michael Sasner , Jennifer D Whitesell , Julie A Harris , Selina Hummel , Johannes Gnörich , Karin Wind , Lea Kunze , Artem Zatcepin , Matthias Brendel , Michael Willem , Christian Haass , Daniel Barnett , Till S Zimmer , Anna G Orr , Kimberly Scearce-Levie , Joseph W Lewcock , Gilbert Di Paolo , Pascal E Sanchez

The

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism

Avec: Alaina M Reagan , Karen E Christensen , Leah C Graham , Amanda A Bedwell , Kierra Eldridge , Rachael Speedy , Lucas L Figueiredo , Scott C Persohn , Teodoro Bottiglieri , Kwangsik Nho , Michael Sasner , Paul R Territo , Rima Rozen , Gareth R Howell

Decreased glucocerebrosidase activity and substrate accumulation of glycosphingolipids in a novel GBA1 D409V knock-in mouse model.

PloS one

Avec: Nicole K Polinski , Terina N Martinez , Alexander Gorodinsky , Ralph Gareus , Michael Sasner , Mark Herberth , Robert Switzer , Syed O Ahmad , Mali Cosden , Monika Kandebo , Robert E Drolet , Peter D Buckett , Weisong Shan , Yi Chen , Lee J Pellegrino , Gregory D Ellsworth , Leo B Dungan , Warren D Hirst , Sean W Clark , Kuldip D Dave

Comprehensive Evaluation of the 5XFAD Mouse Model for Preclinical Testing Applications: A MODEL-AD Study.

Frontiers in aging neuroscience

Avec: Adrian L Oblak , Peter B Lin , Kevin P Kotredes , Ravi S Pandey , Dylan Garceau , Harriet M Williams , Asli Uyar , Rita O'Rourke , Sarah O'Rourke , Cynthia Ingraham , Daria Bednarczyk , Melisa Belanger , Zackary A Cope , Gabriela J Little , Sean-Paul G Williams , Carl Ash , Adam Bleckert , Tim Ragan , Benjamin A Logsdon , Lara M Mangravite , Stacey J Sukoff Rizzo , Paul R Territo , Gregory W Carter , Gareth R Howell , Michael Sasner , Bruce T Lamb

Pharmacokinetic, pharmacodynamic, and transcriptomic analysis of chronic levetiracetam treatment in 5XFAD mice: A MODEL-AD preclinical testing core study.

Alzheimer's & dementia (New York, N. Y.)

Avec: Kristen D Onos , Sara K Quinney , David R Jones , Andrea R Masters , Ravi Pandey , Kelly J Keezer , Carla Biesdorf , Ingrid F Metzger , Jill A Meyers , Johnathon Peters , Scott C Persohn , Brian P McCarthy , Amanda A Bedwell , Lucas L Figueiredo , Zackary A Cope , Michael Sasner , Gareth R Howell , Harriet M Williams , Adrian L Oblak , Bruce T Lamb , Gregory W Carter , Stacey J Sukoff Rizzo , Paul R Territo

STOP-AD portal: Selecting the optimal pharmaceutical for preclinical drug testing in Alzheimer's disease.

Alzheimer's & dementia : the journal of the Alzheimer's Association

Avec: Sara K Quinney , Kandasamy Murugesh , Adrian Oblak , Kristen D Onos , Mike Sasner , Anna K Greenwood , Kara H Woo , Stacey J Sukoff Rizzo , Paul R Territo

Metabolomics profiling reveals distinct, sex-specific signatures in the serum and brain metabolomes in the mouse models of Alzheimer's disease.

bioRxiv : the preprint server for biology

Avec: Ravi S Pandey , Mattias Arnold , Richa Batra , Jan Krumsiek , Kevin P Kotredes , Dylan Garceau , Harriet Williams , Michael Sasner , Gareth R Howell , Rima Kaddurah-Daouk , Gregory W Carter

Differential splicing of neuronal genes in a Trem2*R47H mouse model mimics alterations associated with Alzheimer's disease.

BMC genomics

Avec: Ravi S Pandey , Kevin P Kotredes , Michael Sasner , Gareth R Howell , Gregory W Carter

The GBA1 D409V mutation exacerbates synuclein pathology to differing extents in two alpha-synuclein models.

Disease models & mechanisms

Avec: Nicole K Polinski , Terina N Martinez , Sylvie Ramboz , Michael Sasner , Mark Herberth , Robert Switzer , Syed O Ahmad , Lee J Pelligrino , Sean W Clark , Jacob N Marcus , Sean M Smith , Kuldip D Dave , Mark A Frasier

Frontiers in aging neuroscience

Avec: Adrian L Oblak , Kevin P Kotredes , Ravi S Pandey , Alaina M Reagan , Cynthia Ingraham , Bridget Perkins , Christopher Lloyd , Deborah Baker , Peter B Lin , Disha M Soni , Andy P Tsai , Scott A Persohn , Amanda A Bedwell , Kierra Eldridge , Rachael Speedy , Jill A Meyer , Johnathan S Peters , Lucas L Figueiredo , Michael Sasner , Paul R Territo , Stacey J Sukoff Rizzo , Gregory W Carter , Bruce T Lamb , Gareth R Howell

Perivascular cells induce microglial phagocytic states and synaptic engulfment via SPP1 in mouse models of Alzheimer's disease.

Nature neuroscience

Avec: Sebastiaan De Schepper , Judy Z Ge , Gerard Crowley , Laís S S Ferreira , Dylan Garceau , Christina E Toomey , Dimitra Sokolova , Javier Rueda-Carrasco , Sun-Hye Shin , Jung-Seok Kim , Thomas Childs , Tammaryn Lashley , Jemima J Burden , Michael Sasner , Carlo Sala Frigerio , Steffen Jung , Soyon Hong

Meeting report of the annual workshop on Principles and Techniques for Improving Preclinical to Clinical Translation in Alzheimer's Disease research.

Alzheimer's & dementia : the journal of the Alzheimer's Association

Avec: Michael Sasner , Paul R Territo , Stacey J Sukoff Rizzo

Gene replacement-Alzheimer's disease (GR-AD): Modeling the genetics of human dementias in mice.

Alzheimer's & dementia : the journal of the Alzheimer's Association

Avec: Kellie Benzow , Kul Karanjeet , Adrian L Oblak , Gregory W Carter , Michael Sasner , Michael D Koob

Characterizing Molecular and Synaptic Signatures in mouse models of Late-Onset Alzheimer's Disease Independent of Amyloid and Tau Pathology.

bioRxiv : the preprint server for biology

Avec: Kevin P Kotredes , Ravi S Pandey , Scott Persohn , Kierra Elderidge , Charles P Burton , Ethan W Miner , Kathryn A Haynes , Diogo Francisco S Santos , Sean-Paul Williams , Nicholas Heaton , Cynthia M Ingraham , Christopher Lloyd , Dylan Garceau , Rita O'Rourke , Sarah Herrick , Claudia Rangel-Barajas , Surendra Maharjan , Nian Wang , Michael Sasner , Bruce T Lamb , Paul R Territo , Stacey J Sukoff Rizzo , Gregory W Carter , Gareth R Howell , Adrian L Oblak

Characterizing molecular and synaptic signatures in mouse models of late-onset Alzheimer's disease independent of amyloid and tau pathology.

Alzheimer's & dementia : the journal of the Alzheimer's Association

Improving preclinical to clinical translation in Alzheimer's disease research.

Alzheimer's & dementia (New York, N. Y.)

Avec: Stacey J Sukoff Rizzo , Andi Masters , Kristen D Onos , Sara Quinney , Michael Sasner , Adrian Oblak , Bruce T Lamb , Paul R Territo , Auteur inconnu

Large-scale discovery of mouse transgenic integration sites reveals frequent structural variation and insertional mutagenesis.

Genome research

Avec: Leslie O Goodwin , Erik Splinter , Tiffany L Davis , Rachel Urban , Hao He , Robert E Braun , Elissa J Chesler , Vivek Kumar , Max van Min , Juliet Ndukum , Vivek M Philip , Laura G Reinholdt , Karen Svenson , Jacqueline K White , Michael Sasner , Cathleen Lutz , Stephen A Murray

Staging Alzheimer's Disease in the Brain and Retina of B6.APP/PS1 Mice by Transcriptional Profiling.

Journal of Alzheimer's disease : JAD

Avec: Sumana R Chintapaludi , Asli Uyar , Harriet M Jackson , Casey J Acklin , Xulong Wang , Michael Sasner , Gregory W Carter , Gareth R Howell

Uncovering Disease Mechanisms in a Novel Mouse Model Expressing Humanized APOEε4 and Trem2*R47H.

Frontiers in aging neuroscience

Avec: Kevin P Kotredes , Adrian Oblak , Ravi S Pandey , Peter Bor-Chian Lin , Dylan Garceau , Harriet Williams , Asli Uyar , Rita O'Rourke , Sarah O'Rourke , Cynthia Ingraham , Daria Bednarycek , Melisa Belanger , Zackary Cope , Kate E Foley , Benjamin A Logsdon , Lara M Mangravite , Stacey J Sukoff Rizzo , Paul R Territo , Gregory W Carter , Michael Sasner , Bruce T Lamb , Gareth R Howell

PIP2 depletion and altered endocytosis caused by expression of Alzheimer's disease-protective variant PLCγ2 R522.

The EMBO journal

Avec: Emily Maguire , Georgina E Menzies , Thomas Phillips , Michael Sasner , Harriet M Williams , Magdalena A Czubala , Neil Evans , Emma L Cope , Rebecca Sims , Gareth R Howell , Emyr Lloyd-Evans , Julie Williams , Nicholas D Allen , Philip R Taylor

Improving mouse models for the study of Alzheimer's disease.

Current topics in developmental biology

Avec: Alaina M Reagan , Kristen D Onos , Sarah E Heuer , Michael Sasner , Gareth R Howell

The

Frontiers in aging neuroscience

Avec: Kate E Foley , Amanda A Hewes , Dylan T Garceau , Kevin P Kotredes , Gregory W Carter , Michael Sasner , Gareth R Howell

Metabolomics profiling reveals distinct, sex-specific signatures in serum and brain metabolomes in mouse models of Alzheimer's disease.

Alzheimer's & dementia : the journal of the Alzheimer's Association

Avec: Ravi S Pandey , Mattias Arnold , Richa Batra , Jan Krumsiek , Kevin P Kotredes , Dylan Garceau , Harriet Williams , Michael Sasner , Gareth R Howell , Rima Kaddurah-Daouk , Gregory W Carter

Réseau de co-auteurs

Gareth R Howell 21 collaborations

Gregory W Carter 18 collaborations

Paul R Territo 14 collaborations

Kevin P Kotredes 13 collaborations

Bruce T Lamb 13 collaborations

Dylan Garceau 12 collaborations

Ravi S Pandey 12 collaborations

Stacey J Sukoff Rizzo 12 collaborations

Adrian L Oblak 11 collaborations

Harriet Williams 8 collaborations

Asli Uyar 7 collaborations

Kristen D Onos 6 collaborations

Lara M Mangravite 5 collaborations

Benjamin A Logsdon 5 collaborations

Rita O'Rourke 5 collaborations

None None 4 collaborations

Kate E Foley 4 collaborations

Amanda A Bedwell 4 collaborations

Peter Bor-Chian Lin 4 collaborations

Adrian Oblak 4 collaborations

Cynthia Ingraham 4 collaborations

Christoph Preuss 3 collaborations

Zackary A Cope 3 collaborations

Sara K Quinney 3 collaborations

Kierra Eldridge 3 collaborations

Rachael Speedy 3 collaborations

Sean-Paul Williams 3 collaborations

Bridget Perkins 3 collaborations

Sarah O'Rourke 3 collaborations

Melisa Belanger 3 collaborations

Alaina M Reagan 3 collaborations

Lucas L Figueiredo 3 collaborations

Harriet M Williams 3 collaborations

Christopher Lloyd 3 collaborations

Ravi Pandey 2 collaborations

Amanda A Hewes 2 collaborations

Dylan T Garceau 2 collaborations

Carla Biesdorf 2 collaborations

Kelly J Keezer 2 collaborations

Jill A Meyer 2 collaborations

Scott A Persohn 2 collaborations

Disha Soni 2 collaborations

Cindy Ingraham 2 collaborations

Audrey Lee-Gosselin 2 collaborations

Daria Bednarczyk 2 collaborations

Zackary Cope 2 collaborations

Scott C Persohn 2 collaborations

Nicole K Polinski 2 collaborations

Terina N Martinez 2 collaborations

Mark Herberth 2 collaborations

Robert Switzer 2 collaborations

Syed O Ahmad 2 collaborations

Sean W Clark 2 collaborations

Kuldip D Dave 2 collaborations

Peter B Lin 2 collaborations

Mattias Arnold 2 collaborations

Richa Batra 2 collaborations

Jan Krumsiek 2 collaborations

Rima Kaddurah-Daouk 2 collaborations

Scott Persohn 2 collaborations

Kierra Elderidge 2 collaborations

Charles P Burton 2 collaborations

Ethan W Miner 2 collaborations

Kathryn A Haynes 2 collaborations

Diogo Francisco S Santos 2 collaborations

Nicholas Heaton 2 collaborations

Cynthia M Ingraham 2 collaborations

Sarah Herrick 2 collaborations

Claudia Rangel-Barajas 2 collaborations

Surendra Maharjan 2 collaborations

Nian Wang 2 collaborations

Erin Piazza 1 collaboration

Alexander Fine 1 collaboration

Thanneer Perumal 1 collaboration

Stefania Forner 1 collaboration

Stacey J Sukoff-Rizzo 1 collaboration

Ali Mortazavi 1 collaboration

David Baglietto-Vargas 1 collaboration

Kim N Green 1 collaboration

Grant R MacGregor 1 collaboration

Marcelo A Wood 1 collaboration

Andrea J Tenner 1 collaboration

Frank M LaFerla 1 collaboration

Cory A Diemler 1 collaboration

Andi R Masters 1 collaboration

Leslie Haynes 1 collaboration

Jonathan S Peters 1 collaboration

Gabriela Little 1 collaboration

Brenda Noarbe 1 collaboration

Andre Obenaus 1 collaboration

Dan Xia 1 collaboration

Steve Lianoglou 1 collaboration

Thomas Sandmann 1 collaboration

Meredith Calvert 1 collaboration

Jung H Suh 1 collaboration

Elliot Thomsen 1 collaboration

Jason Dugas 1 collaboration

Michelle E Pizzo 1 collaboration

Sarah L DeVos 1 collaboration

Timothy K Earr 1 collaboration

Chia-Ching Lin 1 collaboration

Sonnet Davis 1 collaboration

Connie Ha 1 collaboration

Amy Wing-Sze Leung 1 collaboration

Hoang Nguyen 1 collaboration

Roni Chau 1 collaboration

Ernie Yulyaningsih 1 collaboration

Isabel Lopez 1 collaboration

Hilda Solanoy 1 collaboration

Shababa T Masoud 1 collaboration

Chun-Chi Liang 1 collaboration

Karin Lin 1 collaboration

Giuseppe Astarita 1 collaboration

Nathalie Khoury 1 collaboration

Joy Yu Zuchero 1 collaboration

Robert G Thorne 1 collaboration

Kevin Shen 1 collaboration

Stephanie Miller 1 collaboration

Jorge J Palop 1 collaboration

Jennifer D Whitesell 1 collaboration

Julie A Harris 1 collaboration

Selina Hummel 1 collaboration

Johannes Gnörich 1 collaboration

Karin Wind 1 collaboration

Lea Kunze 1 collaboration

Artem Zatcepin 1 collaboration

Matthias Brendel 1 collaboration

Michael Willem 1 collaboration

Christian Haass 1 collaboration

Daniel Barnett 1 collaboration

Till S Zimmer 1 collaboration

Anna G Orr 1 collaboration

Kimberly Scearce-Levie 1 collaboration

Joseph W Lewcock 1 collaboration

Gilbert Di Paolo 1 collaboration

Pascal E Sanchez 1 collaboration

Karen E Christensen 1 collaboration

Leah C Graham 1 collaboration

Teodoro Bottiglieri 1 collaboration

Kwangsik Nho 1 collaboration

Rima Rozen 1 collaboration

Alexander Gorodinsky 1 collaboration

Ralph Gareus 1 collaboration

Mali Cosden 1 collaboration

Monika Kandebo 1 collaboration

Robert E Drolet 1 collaboration

Peter D Buckett 1 collaboration

Weisong Shan 1 collaboration

Yi Chen 1 collaboration

Lee J Pellegrino 1 collaboration

Gregory D Ellsworth 1 collaboration

Leo B Dungan 1 collaboration

Warren D Hirst 1 collaboration

Gabriela J Little 1 collaboration

Sean-Paul G Williams 1 collaboration

Carl Ash 1 collaboration

Adam Bleckert 1 collaboration

Tim Ragan 1 collaboration

David R Jones 1 collaboration

Andrea R Masters 1 collaboration

Ingrid F Metzger 1 collaboration

Jill A Meyers 1 collaboration

Johnathon Peters 1 collaboration

Brian P McCarthy 1 collaboration

Kandasamy Murugesh 1 collaboration

Mike Sasner 1 collaboration

Anna K Greenwood 1 collaboration

Kara H Woo 1 collaboration

Sylvie Ramboz 1 collaboration

Lee J Pelligrino 1 collaboration

Jacob N Marcus 1 collaboration

Sean M Smith 1 collaboration

Mark A Frasier 1 collaboration

Deborah Baker 1 collaboration

Disha M Soni 1 collaboration

Andy P Tsai 1 collaboration

Johnathan S Peters 1 collaboration

Sebastiaan De Schepper 1 collaboration

Judy Z Ge 1 collaboration

Gerard Crowley 1 collaboration

Laís S S Ferreira 1 collaboration

Christina E Toomey 1 collaboration

Dimitra Sokolova 1 collaboration

Javier Rueda-Carrasco 1 collaboration

Sun-Hye Shin 1 collaboration

Jung-Seok Kim 1 collaboration

Thomas Childs 1 collaboration

Tammaryn Lashley 1 collaboration

Jemima J Burden 1 collaboration

Carlo Sala Frigerio 1 collaboration

Steffen Jung 1 collaboration

Soyon Hong 1 collaboration

Kellie Benzow 1 collaboration

Kul Karanjeet 1 collaboration

Michael D Koob 1 collaboration

Andi Masters 1 collaboration

Sara Quinney 1 collaboration

Leslie O Goodwin 1 collaboration

Erik Splinter 1 collaboration

Tiffany L Davis 1 collaboration

Rachel Urban 1 collaboration

Hao He 1 collaboration

Robert E Braun 1 collaboration

Elissa J Chesler 1 collaboration

Vivek Kumar 1 collaboration

Max van Min 1 collaboration

Juliet Ndukum 1 collaboration

Vivek M Philip 1 collaboration

Laura G Reinholdt 1 collaboration

Karen Svenson 1 collaboration

Jacqueline K White 1 collaboration

Cathleen Lutz 1 collaboration

Stephen A Murray 1 collaboration

Sumana R Chintapaludi 1 collaboration

Harriet M Jackson 1 collaboration

Casey J Acklin 1 collaboration

Xulong Wang 1 collaboration

Daria Bednarycek 1 collaboration

Emily Maguire 1 collaboration

Georgina E Menzies 1 collaboration

Thomas Phillips 1 collaboration

Magdalena A Czubala 1 collaboration

Neil Evans 1 collaboration

Emma L Cope 1 collaboration

Rebecca Sims 1 collaboration

Emyr Lloyd-Evans 1 collaboration

Julie Williams 1 collaboration

Nicholas D Allen 1 collaboration

Philip R Taylor 1 collaboration

Sarah E Heuer 1 collaboration