Michael Leitges

Affiliations

Memorial University of Newfoundland, St. John's, NL A1C 5S7, Canada.

Publications (17)

Protein Kinase Cι and Wnt/β-Catenin Signaling: Alternative Pathways to Kras/Trp53-Driven Lung Adenocarcinoma.

Cancer cell

Avec: Ning Yin , Yi Liu , Andras Khoor , Xue Wang , E Aubrey Thompson , Michael Leitges , Verline Justilien , Capella Weems , Nicole R Murray , Alan P Fields

Transcriptome Profiling of Mouse Embryonic Fibroblast Spontaneous Immortalization: A Comparative Analysis.

International journal of molecular sciences

Avec: Jocshan Loaiza-Moss , Ursula Braun , Michael Leitges

Addressing the role of PKD3 in the T cell compartment with knockout mice.

Cell communication and signaling : CCS

Avec: Jiří Koutník , Verena Neururer , Thomas Gruber , Sebastian Peer , Natascha Hermann-Kleiter , William J Olson , Verena Labi , Michael Leitges , Gottfried Baier , Kerstin Siegmund

T cell-intrinsic protein kinase D3 is dispensable for the cells' activation.

Frontiers in immunology

Avec: Jiří Koutník , Michael Leitges , Kerstin Siegmund

Dysfunctional EGFR and oxidative stress-induced PKD1 signaling drive formation of DCLK1+ pancreatic stem cells.

iScience

Avec: Alicia K Fleming Martinez , Heike R Döppler , Ligia I Bastea , Brandy Edenfield , Tushar Patel , Michael Leitges , Geou-Yarh Liou , Peter Storz

WNT6/ACC2-induced storage of triacylglycerols in macrophages is exploited by Mycobacterium tuberculosis.

The Journal of clinical investigation

Avec: Julius Brandenburg , Sebastian Marwitz , Simone C Tazoll , Franziska Waldow , Barbara Kalsdorf , Tim Vierbuchen , Thomas Scholzen , Annette Gross , Svenja Goldenbaum , Alexandra Hölscher , Martina Hein , Lara Linnemann , Maja Reimann , Andreas Kispert , Michael Leitges , Jan Rupp , Christoph Lange , Stefan Niemann , Jochen Behrends , Torsten Goldmann , Holger Heine , Ulrich E Schaible , Christoph Hölscher , Dominik Schwudke , Norbert Reiling

Cancers

Avec: Kristin S Inman , Yi Liu , Michele L Scotti Buzhardt , Michael Leitges , Murli Krishna , Howard C Crawford , Alan P Fields , Nicole R Murray

Stromal cell protein kinase C-β inhibition enhances chemosensitivity in B cell malignancies and overcomes drug resistance.

Science translational medicine

Avec: Eugene Park , Jingyu Chen , Andrew Moore , Maurizio Mangolini , Antonella Santoro , Joseph R Boyd , Hilde Schjerven , Veronika Ecker , Maike Buchner , James C Williamson , Paul J Lehner , Luca Gasparoli , Owen Williams , Johannes Bloehdorn , Stephan Stilgenbauer , Michael Leitges , Alexander Egle , Marc Schmidt-Supprian , Seth Frietze , Ingo Ringshausen

Novel mutant mouse line emphasizes the importance of protein kinase C theta for CD4

Cell communication and signaling : CCS

Avec: Kerstin Siegmund , Nikolaus Thuille , Nina Posch , Friedrich Fresser , Michael Leitges , Gottfried Baier

Loss-of-function phenotype of a PKCθ

Cell communication and signaling : CCS

Avec: Nikolaus Thuille , Kerstin Siegmund , Victoria Klepsch , Jacqueline Schörgenhuber , Sarah Danklmaier , Michael Leitges , Gottfried Baier

Control of β-Site Amyloid Precursor Protein-Cleaving Enzyme-1 Expression by Protein Kinase C-λ/ι and Nuclear Factor κ-B.

Current Alzheimer research

Avec: Mini P Sajan , Michael Leitges , Colin Park , David M Diamond , Jin Wu , Barbara C Hansen , Mildred A Duncan , Christopher A Apostolatos , Andre H Apostolatos , Mark Kindy , Robert V Farese

Protein kinase C

Cell reports

Avec: Rajappa S Kenchappa , Yi Liu , Michael G Argenziano , Matei A Banu , Ann C Mladek , Rita West , Amanda Luu , Alfredo Quiñones-Hinojosa , Dolores Hambardzumyan , Verline Justilien , Michael Leitges , Jann N Sarkaria , Peter A Sims , Peter Canoll , Nicole R Murray , Alan P Fields , Steven S Rosenfeld

The kinase PKD3 provides negative feedback on cholesterol and triglyceride synthesis by suppressing insulin signaling.

Science signaling

Avec: Alexander E Mayer , Mona C Löffler , Angel E Loza Valdés , Werner Schmitz , Rabih El-Merahbi , Jonathan Trujillo Viera , Manuela Erk , Thianzhou Zhang , Ursula Braun , Mathias Heikenwalder , Michael Leitges , Almut Schulze , Grzegorz Sumara

Investigations of mouse models during tumorigenesis revealed essential but distinct in vivo functions among the PKC family.

Advances in biological regulation

Avec: Michael Leitges

Protein kinase C-β-dependent changes in the glucose metabolism of bone marrow stromal cells of chronic lymphocytic leukemia.

Stem cells (Dayton, Ohio)

Avec: Franziska von Heydebrand , Maximilian Fuchs , Meik Kunz , Simon Voelkl , Anita N Kremer , Robert A J Oostendorp , Jochen Wilke , Michael Leitges , Alexander Egle , Andreas Mackensen , Gloria Lutzny-Geier

A phosphoproteomic approach reveals that PKD3 controls PKA-mediated glucose and tyrosine metabolism.

Life science alliance

Avec: Angel Loza-Valdes , Alexander E Mayer , Toufic Kassouf , Jonathan Trujillo-Viera , Werner Schmitz , Filip Dziaczkowski , Michael Leitges , Andreas Schlosser , Grzegorz Sumara

T cell-intrinsic PKD3 fine-tunes differentiation into CD8

Immunology

Avec: Jiří Koutník , Sebastian Peer , Dominik Humer , Grzegorz Sumara , Michael Leitges , Gottfried Baier , Kerstin Siegmund

Réseau de co-auteurs

Kerstin Siegmund 5 collaborations

Gottfried Baier 4 collaborations

Yi Liu 3 collaborations

Nicole R Murray 3 collaborations

Alan P Fields 3 collaborations

Jiří Koutník 3 collaborations

Grzegorz Sumara 3 collaborations

Verline Justilien 2 collaborations

Ursula Braun 2 collaborations

Sebastian Peer 2 collaborations

Alexander Egle 2 collaborations

Nikolaus Thuille 2 collaborations

Alexander E Mayer 2 collaborations

Werner Schmitz 2 collaborations

Ning Yin 1 collaboration

Andras Khoor 1 collaboration

Xue Wang 1 collaboration

E Aubrey Thompson 1 collaboration

Capella Weems 1 collaboration

Jocshan Loaiza-Moss 1 collaboration

Verena Neururer 1 collaboration

Thomas Gruber 1 collaboration

Natascha Hermann-Kleiter 1 collaboration

William J Olson 1 collaboration

Verena Labi 1 collaboration

Alicia K Fleming Martinez 1 collaboration

Heike R Döppler 1 collaboration

Ligia I Bastea 1 collaboration

Brandy Edenfield 1 collaboration

Tushar Patel 1 collaboration

Geou-Yarh Liou 1 collaboration

Peter Storz 1 collaboration

Julius Brandenburg 1 collaboration

Sebastian Marwitz 1 collaboration

Simone C Tazoll 1 collaboration

Franziska Waldow 1 collaboration

Barbara Kalsdorf 1 collaboration

Tim Vierbuchen 1 collaboration

Thomas Scholzen 1 collaboration

Annette Gross 1 collaboration

Svenja Goldenbaum 1 collaboration

Alexandra Hölscher 1 collaboration

Martina Hein 1 collaboration

Lara Linnemann 1 collaboration

Maja Reimann 1 collaboration

Andreas Kispert 1 collaboration

Jan Rupp 1 collaboration

Christoph Lange 1 collaboration

Stefan Niemann 1 collaboration

Jochen Behrends 1 collaboration

Torsten Goldmann 1 collaboration

Holger Heine 1 collaboration

Ulrich E Schaible 1 collaboration

Christoph Hölscher 1 collaboration

Dominik Schwudke 1 collaboration

Norbert Reiling 1 collaboration

Kristin S Inman 1 collaboration

Michele L Scotti Buzhardt 1 collaboration

Murli Krishna 1 collaboration

Howard C Crawford 1 collaboration

Eugene Park 1 collaboration

Jingyu Chen 1 collaboration

Andrew Moore 1 collaboration

Maurizio Mangolini 1 collaboration

Antonella Santoro 1 collaboration

Joseph R Boyd 1 collaboration

Hilde Schjerven 1 collaboration

Veronika Ecker 1 collaboration

Maike Buchner 1 collaboration

James C Williamson 1 collaboration

Paul J Lehner 1 collaboration

Luca Gasparoli 1 collaboration

Owen Williams 1 collaboration

Johannes Bloehdorn 1 collaboration

Stephan Stilgenbauer 1 collaboration

Marc Schmidt-Supprian 1 collaboration

Seth Frietze 1 collaboration

Ingo Ringshausen 1 collaboration

Nina Posch 1 collaboration

Friedrich Fresser 1 collaboration

Victoria Klepsch 1 collaboration

Jacqueline Schörgenhuber 1 collaboration

Sarah Danklmaier 1 collaboration

Mini P Sajan 1 collaboration

Colin Park 1 collaboration

David M Diamond 1 collaboration

Jin Wu 1 collaboration

Barbara C Hansen 1 collaboration

Mildred A Duncan 1 collaboration

Christopher A Apostolatos 1 collaboration

Andre H Apostolatos 1 collaboration

Mark Kindy 1 collaboration

Robert V Farese 1 collaboration

Rajappa S Kenchappa 1 collaboration

Michael G Argenziano 1 collaboration

Matei A Banu 1 collaboration

Ann C Mladek 1 collaboration

Rita West 1 collaboration

Amanda Luu 1 collaboration

Alfredo Quiñones-Hinojosa 1 collaboration

Dolores Hambardzumyan 1 collaboration

Jann N Sarkaria 1 collaboration

Peter A Sims 1 collaboration

Peter Canoll 1 collaboration

Steven S Rosenfeld 1 collaboration

Mona C Löffler 1 collaboration

Angel E Loza Valdés 1 collaboration

Rabih El-Merahbi 1 collaboration

Jonathan Trujillo Viera 1 collaboration

Manuela Erk 1 collaboration

Thianzhou Zhang 1 collaboration

Mathias Heikenwalder 1 collaboration

Almut Schulze 1 collaboration

Franziska von Heydebrand 1 collaboration

Maximilian Fuchs 1 collaboration

Meik Kunz 1 collaboration

Simon Voelkl 1 collaboration

Anita N Kremer 1 collaboration

Robert A J Oostendorp 1 collaboration

Jochen Wilke 1 collaboration

Andreas Mackensen 1 collaboration

Gloria Lutzny-Geier 1 collaboration

Angel Loza-Valdes 1 collaboration

Toufic Kassouf 1 collaboration

Jonathan Trujillo-Viera 1 collaboration

Filip Dziaczkowski 1 collaboration

Andreas Schlosser 1 collaboration

Dominik Humer 1 collaboration