Michael Ardolino

Affiliations

Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States.

Publications (20)

The two-faces of NK cells in oncolytic virotherapy.

Cytokine & growth factor reviews

Avec: M Marotel , M S Hasim , A Hagerman , M Ardolino

Loss of the Ste20-like kinase induces a basal/stem-like phenotype in HER2-positive breast cancers.

Oncogene

Avec: Khalid N Al-Zahrani , John Abou-Hamad , David P Cook , Benjamin R Pryce , Jonathan J Hodgins , Cédrik Labrèche , Pascale Robineau-Charette , Christiano T de Souza , John C Bell , Rebecca C Auer , Michele Ardolino , Barbara C Vanderhyden , Luc A Sabourin

Flattening the COVID-19 Curve With Natural Killer Cell Based Immunotherapies.

Frontiers in immunology

Avec: Marisa Market , Leonard Angka , Andre B Martel , Donald Bastin , Oladunni Olanubi , Gayashan Tennakoon , Dominique M Boucher , Juliana Ng , Michele Ardolino , Rebecca C Auer

Immunotherapy for sarcomas: new frontiers and unveiled opportunities.

Journal for immunotherapy of cancer

Avec: Harsimrat Kaur Birdi , Anna Jirovec , Serena Cortés-Kaplan , Joel Werier , Carolyn Nessim , Jean-Simon Diallo , Michele Ardolino

The dopamine transporter antagonist vanoxerine inhibits G9a and suppresses cancer stem cell functions in colon tumors.

Nature cancer

Avec: Christopher J Bergin , Aïcha Zouggar , Amanda Mendes da Silva , Tanguy Fenouil , Joshua R Haebe , Angelique N Masibag , Gautam Agrawal , Muhammad S Shah , Tamara Sandouka , Mario Tiberi , Rebecca C Auer , Michele Ardolino , Yannick D Benoit

FGL2 promotes tumour growth and attenuates infiltration of activated immune cells in melanoma and ovarian cancer models.

Scientific reports

Avec: Kristianne J C Galpin , Galaxia M Rodriguez , Vincent Maranda , David P Cook , Elizabeth Macdonald , Humaira Murshed , Shan Zhao , Curtis W McCloskey , Andrzej Chruscinski , Gary A Levy , Michele Ardolino , Barbara C Vanderhyden

Sox10-Deficient Drug-Resistant Melanoma Cells Are Refractory to Oncolytic RNA Viruses.

Cells

Avec: John Abou-Hamad , Jonathan J Hodgins , Edward Yakubovich , Barbara C Vanderhyden , Michele Ardolino , Luc A Sabourin

Killers 2.0: NK cell therapies at the forefront of cancer control.

The Journal of clinical investigation

Avec: Jonathan J Hodgins , Sarwat T Khan , Maria M Park , Rebecca C Auer , Michele Ardolino

Discovery of MK-1468: A Potent, Kinome-Selective, Brain-Penetrant Amidoisoquinoline LRRK2 Inhibitor for the Potential Treatment of Parkinson's Disease.

Journal of medicinal chemistry

Avec: Solomon D Kattar , Anmol Gulati , Kaila A Margrey , Mitchell H Keylor , Michael Ardolino , Xin Yan , Rebecca Johnson , Rachel L Palte , Spencer E McMinn , Lisa Nogle , Jing Su , Dong Xiao , Jennifer Piesvaux , Susi Lee , Laxminarayan G Hegde , Janice D Woodhouse , Robert Faltus , Lily Y Moy , Tina Xiong , Paul J Ciaccio , Kara Pearson , Mayankbhai Patel , Karin M Otte , Cheryl E G Leyns , Matthew E Kennedy , David Jonathan Bennett , Erin F DiMauro , Matthew J Fell , Peter H Fuller

CEACAM1 is a direct SOX10 target and inhibits melanoma immune infiltration and stemness.

iScience

Avec: John Abou-Hamad , Jonathan J Hodgins , Christiano T de Souza , Brennan Garland , Cédrik Labrèche , Marie Marotel , Cameron Gibson , Samuel Delisle , Julia Pascoal , Rebecca C Auer , Michele Ardolino , Luc A Sabourin

PD-L1 promotes oncolytic virus infection via a metabolic shift that inhibits the type I IFN pathway.

The Journal of experimental medicine

Avec: Jonathan J Hodgins , John Abou-Hamad , Colin Edward O'Dwyer , Ash Hagerman , Edward Yakubovich , Christiano Tanese de Souza , Marie Marotel , Ariel Buchler , Saleh Fadel , Maria M Park , Claire Fong-McMaster , Mathieu F Crupi , Olivia Joan Makinson , Reem Kurdieh , Reza Rezaei , Harkirat Singh Dhillon , Carolina S Ilkow , John C Bell , Mary-Ellen Harper , Benjamin H Rotstein , Rebecca C Auer , Barbara C Vanderhyden , Luc A Sabourin , Marie-Claude Bourgeois-Daigneault , David P Cook , Michele Ardolino

Muscle-specific deletion of SLK/Stk2 enhances p38 activity and myogenesis in mdx mice.

Biochimica et biophysica acta. Molecular cell research

Avec: Benjamin R Pryce , Cédrik Labrèche , Dounia Hamoudi , John Abou-Hamad , Khalid N Al-Zahrani , Jonathan J Hodgins , Antoine Boulanger-Piette , Sabrina Bossé , Cindy Balog-Alvarez , Jérôme Frénette , Michele Ardolino , Joe N Kornegay , Luc A Sabourin

Synthetic virology approaches to improve the safety and efficacy of oncolytic virus therapies.

Nature communications

Avec: Taha Azad , Reza Rezaei , Ragunath Singaravelu , Adrian Pelin , Stephen Boulton , Julia Petryk , Kemal Alper Onsu , Nikolas T Martin , Victoria Hoskin , Mina Ghahremani , Marie Marotel , Ricardo Marius , Xiaohong He , Mathieu J F Crupi , Huy-Dung Hoang , Abolfazl Nik-Akhtar , Mahsa Ahmadi , Nika Kooshki Zamani , Ashkan Golshani , Tommy Alain , Peter Greer , Michele Ardolino , Bryan C Dickinson , Lee-Hwa Tai , Carolina S Ilkow , John C Bell

Granzyme A and CD160 expression delineates ILC1 with graded functions in the mouse liver.

European journal of immunology

Avec: Chiara Di Censo , Marie Marotel , Irene Mattiola , Lena Müller , Gianluca Scarno , Giuseppe Pietropaolo , Giovanna Peruzzi , Mattia Laffranchi , Julija Mazej , Mohamed Shaad Hasim , Sara Asif , Eleonora Russo , Luana Tomaipitinca , Helena Stabile , Seung-Hwan Lee , Laura Vian , Massimo Gadina , Angela Gismondi , Han-Yu Shih , Yohei Mikami , Cristina Capuano , Giovanni Bernardini , Michael Bonelli , Silvano Sozzani , Andreas Diefenbach , Michele Ardolino , Angela Santoni , Giuseppe Sciumè

When killers become thieves: Trogocytosed PD-1 inhibits NK cells in cancer.

Science advances

Avec: Mohamed S Hasim , Marie Marotel , Jonathan J Hodgins , Elisabetta Vulpis , Olivia J Makinson , Sara Asif , Han-Yu Shih , Amit K Scheer , Olivia MacMillan , Felipe G Alonso , Kelly P Burke , David P Cook , Rui Li , Maria Teresa Petrucci , Angela Santoni , Padraic G Fallon , Arlene H Sharpe , Giuseppe Sciumè , André Veillette , Alessandra Zingoni , Douglas A Gray , Arleigh McCurdy , Michele Ardolino

A New Functional Screening Platform Identifies Colistin Sulfate as an Enhancer of Natural Killer Cell Cytotoxicity.

Cancers

Avec: Serena Cortés-Kaplan , Reem Kurdieh , Mohamed S Hasim , Shelby Kaczmarek , Zaid Taha , Glib Maznyi , Scott McComb , Seung-Hwan Lee , Jean-Simon Diallo , Michele Ardolino

Evaluation of resazurin phenoxazine dye as a highly sensitive cell viability potency assay for natural killer cell-derived extracellular vesicle-based cancer biotherapeutics.

Journal of extracellular biology

Avec: Frederic St-Denis-Bissonnette , Shirley Qiu , Sarah E Cummings , Melanie Kirkby , Yohannes Haile , Sarah Wassmer , Gauri Muradia , Jelica Mehic , Andrew Stalker , Amit Shrestha , Michele Ardolino , Seung-Hwan Lee , Dylan Burger , Lisheng Wang , Jessie R Lavoie

Advancements in CAR-NK therapy: lessons to be learned from CAR-T therapy.

Frontiers in immunology

Avec: Marisa K Kilgour , Donald J Bastin , Seung-Hwan Lee , Michele Ardolino , Scott McComb , Alissa Visram

Targeting CD73 with flavonoids inhibits cancer stem cells and increases lymphocyte infiltration in a triple-negative breast cancer mouse model.

Frontiers in immunology

Avec: Karan Mediratta , Sara El-Sahli , Marie Marotel , Muhammad Z Awan , Melanie Kirkby , Ammar Salkini , Reem Kurdieh , Salman Abdisalam , Amit Shrestha , Chiara Di Censo , Andrew Sulaiman , Sarah McGarry , Jessie R Lavoie , Zhen Liu , Seung-Hwan Lee , Xuguang Li , Giuseppe Sciumè , Vanessa M D'Costa , Michele Ardolino , Lisheng Wang

Discovery and Optimization of N-Heteroaryl Indazole LRRK2 Inhibitors.

Journal of medicinal chemistry

Avec: Kaitlyn M Logan , Will Kaplan , Vladimir Simov , Hua Zhou , Derun Li , Luis Torres , Gregori J Morriello , John J Acton , Barbara Pio , Yi-Heng Chen , Mitchell H Keylor , Rebecca Johnson , Solomon D Kattar , Ryan Chau , Xin Yan , Michael Ardolino , Cayetana Zarate , Karin M Otte , Rachel L Palte , Tina Xiong , Spencer E McMinn , Shishi Lin , Santhosh F Neelamkavil , Ping Liu , Jing Su , Laxminarayan G Hegde , Janice D Woodhouse , Lily Y Moy , Paul J Ciaccio , Jennifer Piesvaux , Matthias Zebisch , Clare Henry , John Barker , Harold B Wood , Matthew E Kennedy , Erin F DiMauro , Matthew J Fell , Peter H Fuller

Réseau de co-auteurs

Michele Ardolino 17 collaborations

Jonathan J Hodgins 7 collaborations

Rebecca C Auer 6 collaborations

Marie Marotel 6 collaborations

John Abou-Hamad 5 collaborations

Luc A Sabourin 5 collaborations

Seung-Hwan Lee 5 collaborations

David P Cook 4 collaborations

Barbara C Vanderhyden 4 collaborations

Cédrik Labrèche 3 collaborations

John C Bell 3 collaborations

Reem Kurdieh 3 collaborations

Giuseppe Sciumè 3 collaborations

Khalid N Al-Zahrani 2 collaborations

Benjamin R Pryce 2 collaborations

Christiano T de Souza 2 collaborations

Serena Cortés-Kaplan 2 collaborations

Jean-Simon Diallo 2 collaborations

Edward Yakubovich 2 collaborations

Maria M Park 2 collaborations

Solomon D Kattar 2 collaborations

Mitchell H Keylor 2 collaborations

Xin Yan 2 collaborations

Rebecca Johnson 2 collaborations

Rachel L Palte 2 collaborations

Spencer E McMinn 2 collaborations

Jing Su 2 collaborations

Jennifer Piesvaux 2 collaborations

Laxminarayan G Hegde 2 collaborations

Janice D Woodhouse 2 collaborations

Lily Y Moy 2 collaborations

Tina Xiong 2 collaborations

Paul J Ciaccio 2 collaborations

Karin M Otte 2 collaborations

Matthew E Kennedy 2 collaborations

Erin F DiMauro 2 collaborations

Matthew J Fell 2 collaborations

Peter H Fuller 2 collaborations

Reza Rezaei 2 collaborations

Carolina S Ilkow 2 collaborations

Chiara Di Censo 2 collaborations

Sara Asif 2 collaborations

Han-Yu Shih 2 collaborations

Angela Santoni 2 collaborations

Mohamed S Hasim 2 collaborations

Scott McComb 2 collaborations

Melanie Kirkby 2 collaborations

Amit Shrestha 2 collaborations

Lisheng Wang 2 collaborations

Jessie R Lavoie 2 collaborations

M Marotel 1 collaboration

M S Hasim 1 collaboration

A Hagerman 1 collaboration

M Ardolino 1 collaboration

Pascale Robineau-Charette 1 collaboration

Marisa Market 1 collaboration

Leonard Angka 1 collaboration

Andre B Martel 1 collaboration

Donald Bastin 1 collaboration

Oladunni Olanubi 1 collaboration

Gayashan Tennakoon 1 collaboration

Dominique M Boucher 1 collaboration

Juliana Ng 1 collaboration

Harsimrat Kaur Birdi 1 collaboration

Anna Jirovec 1 collaboration

Joel Werier 1 collaboration

Carolyn Nessim 1 collaboration

Christopher J Bergin 1 collaboration

Aïcha Zouggar 1 collaboration

Amanda Mendes da Silva 1 collaboration

Tanguy Fenouil 1 collaboration

Joshua R Haebe 1 collaboration

Angelique N Masibag 1 collaboration

Gautam Agrawal 1 collaboration

Muhammad S Shah 1 collaboration

Tamara Sandouka 1 collaboration

Mario Tiberi 1 collaboration

Yannick D Benoit 1 collaboration

Kristianne J C Galpin 1 collaboration

Galaxia M Rodriguez 1 collaboration

Vincent Maranda 1 collaboration

Elizabeth Macdonald 1 collaboration

Humaira Murshed 1 collaboration

Shan Zhao 1 collaboration

Curtis W McCloskey 1 collaboration

Andrzej Chruscinski 1 collaboration

Gary A Levy 1 collaboration

Sarwat T Khan 1 collaboration

Anmol Gulati 1 collaboration

Kaila A Margrey 1 collaboration

Lisa Nogle 1 collaboration

Dong Xiao 1 collaboration

Susi Lee 1 collaboration

Robert Faltus 1 collaboration

Kara Pearson 1 collaboration

Mayankbhai Patel 1 collaboration

Cheryl E G Leyns 1 collaboration

David Jonathan Bennett 1 collaboration

Brennan Garland 1 collaboration

Cameron Gibson 1 collaboration

Samuel Delisle 1 collaboration

Julia Pascoal 1 collaboration

Colin Edward O'Dwyer 1 collaboration

Ash Hagerman 1 collaboration

Christiano Tanese de Souza 1 collaboration

Ariel Buchler 1 collaboration

Saleh Fadel 1 collaboration

Claire Fong-McMaster 1 collaboration

Mathieu F Crupi 1 collaboration

Olivia Joan Makinson 1 collaboration

Harkirat Singh Dhillon 1 collaboration

Mary-Ellen Harper 1 collaboration

Benjamin H Rotstein 1 collaboration

Marie-Claude Bourgeois-Daigneault 1 collaboration

Dounia Hamoudi 1 collaboration

Antoine Boulanger-Piette 1 collaboration

Sabrina Bossé 1 collaboration

Cindy Balog-Alvarez 1 collaboration

Jérôme Frénette 1 collaboration

Joe N Kornegay 1 collaboration

Taha Azad 1 collaboration

Ragunath Singaravelu 1 collaboration

Adrian Pelin 1 collaboration

Stephen Boulton 1 collaboration

Julia Petryk 1 collaboration

Kemal Alper Onsu 1 collaboration

Nikolas T Martin 1 collaboration

Victoria Hoskin 1 collaboration

Mina Ghahremani 1 collaboration

Ricardo Marius 1 collaboration

Xiaohong He 1 collaboration

Mathieu J F Crupi 1 collaboration

Huy-Dung Hoang 1 collaboration

Abolfazl Nik-Akhtar 1 collaboration

Mahsa Ahmadi 1 collaboration

Nika Kooshki Zamani 1 collaboration

Ashkan Golshani 1 collaboration

Tommy Alain 1 collaboration

Peter Greer 1 collaboration

Bryan C Dickinson 1 collaboration

Lee-Hwa Tai 1 collaboration

Irene Mattiola 1 collaboration

Lena Müller 1 collaboration

Gianluca Scarno 1 collaboration

Giuseppe Pietropaolo 1 collaboration

Giovanna Peruzzi 1 collaboration

Mattia Laffranchi 1 collaboration

Julija Mazej 1 collaboration

Mohamed Shaad Hasim 1 collaboration

Eleonora Russo 1 collaboration

Luana Tomaipitinca 1 collaboration

Helena Stabile 1 collaboration

Laura Vian 1 collaboration

Massimo Gadina 1 collaboration

Angela Gismondi 1 collaboration

Yohei Mikami 1 collaboration

Cristina Capuano 1 collaboration

Giovanni Bernardini 1 collaboration

Michael Bonelli 1 collaboration

Silvano Sozzani 1 collaboration

Andreas Diefenbach 1 collaboration

Elisabetta Vulpis 1 collaboration

Olivia J Makinson 1 collaboration

Amit K Scheer 1 collaboration

Olivia MacMillan 1 collaboration

Felipe G Alonso 1 collaboration

Kelly P Burke 1 collaboration

Rui Li 1 collaboration

Maria Teresa Petrucci 1 collaboration

Padraic G Fallon 1 collaboration

Arlene H Sharpe 1 collaboration

André Veillette 1 collaboration

Alessandra Zingoni 1 collaboration

Douglas A Gray 1 collaboration

Arleigh McCurdy 1 collaboration

Shelby Kaczmarek 1 collaboration

Zaid Taha 1 collaboration

Glib Maznyi 1 collaboration

Frederic St-Denis-Bissonnette 1 collaboration

Shirley Qiu 1 collaboration

Sarah E Cummings 1 collaboration

Yohannes Haile 1 collaboration

Sarah Wassmer 1 collaboration

Gauri Muradia 1 collaboration

Jelica Mehic 1 collaboration

Andrew Stalker 1 collaboration

Dylan Burger 1 collaboration

Marisa K Kilgour 1 collaboration

Donald J Bastin 1 collaboration

Alissa Visram 1 collaboration

Karan Mediratta 1 collaboration

Sara El-Sahli 1 collaboration

Muhammad Z Awan 1 collaboration

Ammar Salkini 1 collaboration

Salman Abdisalam 1 collaboration

Andrew Sulaiman 1 collaboration

Sarah McGarry 1 collaboration

Zhen Liu 1 collaboration

Xuguang Li 1 collaboration

Vanessa M D'Costa 1 collaboration

Kaitlyn M Logan 1 collaboration

Will Kaplan 1 collaboration

Vladimir Simov 1 collaboration

Hua Zhou 1 collaboration

Derun Li 1 collaboration

Luis Torres 1 collaboration

Gregori J Morriello 1 collaboration

John J Acton 1 collaboration

Barbara Pio 1 collaboration

Yi-Heng Chen 1 collaboration

Ryan Chau 1 collaboration

Cayetana Zarate 1 collaboration

Shishi Lin 1 collaboration

Santhosh F Neelamkavil 1 collaboration

Ping Liu 1 collaboration

Matthias Zebisch 1 collaboration

Clare Henry 1 collaboration

John Barker 1 collaboration

Harold B Wood 1 collaboration