Martin W LaFleur

Affiliations

Department of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA; Evergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women's Hospital, Boston, MA 02115, USA.

Publications (20)

Obesity Shapes Metabolism in the Tumor Microenvironment to Suppress Anti-Tumor Immunity.

Cell

Avec: Alison E Ringel , Jefte M Drijvers , Gregory J Baker , Alessia Catozzi , Juan C García-Cañaveras , Brandon M Gassaway , Brian C Miller , Vikram R Juneja , Thao H Nguyen , Shakchhi Joshi , Cong-Hui Yao , Haejin Yoon , Peter T Sage , Martin W LaFleur , Justin D Trombley , Connor A Jacobson , Zoltan Maliga , Steven P Gygi , Peter K Sorger , Joshua D Rabinowitz , Arlene H Sharpe , Marcia C Haigis

CRISPR Screens to Identify Regulators of Tumor Immunity.

Annual review of cancer biology

Avec: Martin W LaFleur , Arlene H Sharpe

Author Correction: Subsets of exhausted CD8

Nature immunology

Avec: Brian C Miller , Debattama R Sen , Rose Al Abosy , Kevin Bi , Yamini V Virkud , Martin W LaFleur , Kathleen B Yates , Ana Lako , Kristen Felt , Girish S Naik , Michael Manos , Evisa Gjini , Juhi R Kuchroo , Jeffrey J Ishizuka , Jenna L Collier , Gabriel K Griffin , Seth Maleri , Dawn E Comstock , Sarah A Weiss , Flavian D Brown , Arpit Panda , Margaret D Zimmer , Robert T Manguso , F Stephen Hodi , Scott J Rodig , Arlene H Sharpe , W Nicholas Haining

T Cell Activation Depends on Extracellular Alanine.

Cell reports

Avec: Noga Ron-Harel , Jonathan M Ghergurovich , Giulia Notarangelo , Martin W LaFleur , Yoshiki Tsubosaka , Arlene H Sharpe , Joshua D Rabinowitz , Marcia C Haigis

Batf-mediated epigenetic control of effector CD8

Science immunology

Avec: Hsiao-Wei Tsao , James Kaminski , Makoto Kurachi , R Anthony Barnitz , Michael A DiIorio , Martin W LaFleur , Wataru Ise , Tomohiro Kurosaki , E John Wherry , W Nicholas Haining , Nir Yosef

Formate Supplementation Enhances Antitumor CD8+ T-cell Fitness and Efficacy of PD-1 Blockade.

Cancer discovery

Avec: Jared H Rowe , Ilaria Elia , Osmaan Shahid , Emily F Gaudiano , Natalia E Sifnugel , Sheila Johnson , Amy G Reynolds , Megan E Fung , Shakchhi Joshi , Martin W LaFleur , Joon Seok Park , Kristen E Pauken , Joshua D Rabinowitz , Gordon J Freeman , Marcia C Haigis , Arlene H Sharpe

Epigenetic tuning of PD-1 expression improves exhausted T cell function and viral control.

Nature immunology

Avec: Sarah A Weiss , Amy Y Huang , Megan E Fung , Daniela Martinez , Alex C Y Chen , Thomas J LaSalle , Brian C Miller , Christopher D Scharer , Mudra Hegde , Thao H Nguyen , Jared H Rowe , Jossef F Osborn , Dillon G Patterson , Natalia Sifnugel , C Mei-An Nolan , Richard A Davidson , Marc A Schwartz , Alexander P R Bally , Dennis K Neeld , Martin W LaFleur , Jeremy M Boss , John G Doench , W Nicholas Haining , Arlene H Sharpe , Debattama R Sen

Neuropeptide signalling orchestrates T cell differentiation.

Nature

Avec: Yu Hou , Linyu Sun , Martin W LaFleur , Linglin Huang , Conner Lambden , Pratiksha I Thakore , Kathryn Geiger-Schuller , Kimitoshi Kimura , Longjun Yan , Yue Zang , Ruihan Tang , Jingwen Shi , Rocky Barilla , Liwen Deng , Ayshwarya Subramanian , Antonia Wallrapp , Hee Sun Choi , Yoon-Chul Kye , Orr Ashenberg , Geoffrey Schiebinger , John G Doench , Isaac M Chiu , Aviv Regev , Arlene H Sharpe , Vijay K Kuchroo

Pharmacologic Screening Identifies Metabolic Vulnerabilities of CD8

Cancer immunology research

Avec: Jefte M Drijvers , Jacob E Gillis , Tara Muijlwijk , Thao H Nguyen , Emily F Gaudiano , Isaac S Harris , Martin W LaFleur , Alison E Ringel , Cong-Hui Yao , Kiran Kurmi , Vikram R Juneja , Justin D Trombley , Marcia C Haigis , Arlene H Sharpe

Framework for in vivo T cell screens.

The Journal of experimental medicine

Avec: Lauren E Milling , Samuel C Markson , Qin Tjokrosurjo , Nicole M Derosia , Ivy S L Streeter , Grant H Hickok , Ashlyn M Lemmen , Thao H Nguyen , Priyamvada Prathima , William Fithian , Marc A Schwartz , Nir Hacohen , John G Doench , Martin W LaFleur , Arlene H Sharpe

Targeting PD-L2-RGMb overcomes microbiome-related immunotherapy resistance.

Nature

Avec: Joon Seok Park , Francesca S Gazzaniga , Meng Wu , Amalia K Luthens , Jacob Gillis , Wen Zheng , Martin W LaFleur , Sarah B Johnson , Golnaz Morad , Elizabeth M Park , Yifan Zhou , Stephanie S Watowich , Jennifer A Wargo , Gordon J Freeman , Dennis L Kasper , Arlene H Sharpe

In Vivo CRISPR Screening Reveals CHD7 as a Positive Regulator of Short-lived Effector Cells.

Journal of immunology (Baltimore, Md. : 1950)

Avec: Martin W LaFleur , Jasmin M D'Andrea , Dillon G Patterson , Ivy S L Streeter , Matthew A Coxe , Jossef F Osborn , Lauren E Milling , Qin Tjokrosurjo , Jacob E Gillis , Thao H Nguyen , Marc A Schwartz , Nir Hacohen , John G Doench , Arlene H Sharpe

Subsets of exhausted CD8

Nature immunology

PTPN2 regulates the generation of exhausted CD8

Nature immunology

Avec: Martin W LaFleur , Thao H Nguyen , Matthew A Coxe , Brian C Miller , Kathleen B Yates , Jacob E Gillis , Debattama R Sen , Emily F Gaudiano , Rose Al Abosy , Gordon J Freeman , W Nicholas Haining , Arlene H Sharpe

Fibroblastic reticular cells enhance T cell metabolism and survival via epigenetic remodeling.

Nature immunology

Avec: Flavian D Brown , Debattama R Sen , Martin W LaFleur , Jernej Godec , Veronika Lukacs-Kornek , Frank A Schildberg , Hye-Jung Kim , Kathleen B Yates , Stéphane J H Ricoult , Kevin Bi , Justin D Trombley , Varun N Kapoor , Illana A Stanley , Viviana Cremasco , Nika N Danial , Brendan D Manning , Arlene H Sharpe , W Nicholas Haining , Shannon J Turley

Epitope spreading toward wild-type melanocyte-lineage antigens rescues suboptimal immune checkpoint blockade responses.

Science translational medicine

Avec: Jennifer A Lo , Masayoshi Kawakubo , Vikram R Juneja , Mack Y Su , Tal H Erlich , Martin W LaFleur , Lajos V Kemeny , Mamunur Rashid , Mohsen Malehmir , S Alireza Rabi , Rumya Raghavan , Jennifer Allouche , Gyulnara Kasumova , Dennie T Frederick , Kristen E Pauken , Qing Yu Weng , Marcelo Pereira da Silva , Yu Xu , Anita A J van der Sande , Whitney Silkworth , Elisabeth Roider , Edward P Browne , David J Lieb , Belinda Wang , Levi A Garraway , Catherine J Wu , Keith T Flaherty , Constance E Brinckerhoff , David W Mullins , David J Adams , Nir Hacohen , Mai P Hoang , Genevieve M Boland , Gordon J Freeman , Arlene H Sharpe , Dieter Manstein , David E Fisher

X-CHIME enables combinatorial, inducible, lineage-specific and sequential knockout of genes in the immune system.

Nature immunology

Avec: Martin W LaFleur , Ashlyn M Lemmen , Ivy S L Streeter , Thao H Nguyen , Lauren E Milling , Nicole M Derosia , Zachary M Hoffman , Jacob E Gillis , Qin Tjokrosurjo , Samuel C Markson , Amy Y Huang , Praju V Anekal , Paula Montero Llopis , W Nicholas Haining , John G Doench , Arlene H Sharpe

Immuno-PET identifies the myeloid compartment as a key contributor to the outcome of the antitumor response under PD-1 blockade.

Proceedings of the National Academy of Sciences of the United States of America

Avec: Mohammad Rashidian , Martin W LaFleur , Vincent L Verschoor , Anushka Dongre , Yun Zhang , Thao H Nguyen , Stephen Kolifrath , Amir R Aref , Christie J Lau , Cloud P Paweletz , Xia Bu , Gordon J Freeman , M Inmaculada Barrasa , Robert A Weinberg , Arlene H Sharpe , Hidde L Ploegh

A CRISPR-Cas9 delivery system for in vivo screening of genes in the immune system.

Nature communications

Avec: Martin W LaFleur , Thao H Nguyen , Matthew A Coxe , Kathleen B Yates , Justin D Trombley , Sarah A Weiss , Flavian D Brown , Jacob E Gillis , Daniel J Coxe , John G Doench , W Nicholas Haining , Arlene H Sharpe

Control of gasdermin D oligomerization and pyroptosis by the Ragulator-Rag-mTORC1 pathway.

Cell

Avec: Charles L Evavold , Iva Hafner-Bratkovič , Pascal Devant , Jasmin M D'Andrea , Elsy M Ngwa , Elvira Boršić , John G Doench , Martin W LaFleur , Arlene H Sharpe , Jay R Thiagarajah , Jonathan C Kagan

Réseau de co-auteurs

Arlene H Sharpe 19 collaborations

Thao H Nguyen 9 collaborations

W Nicholas Haining 8 collaborations

John G Doench 7 collaborations

Brian C Miller 5 collaborations

Debattama R Sen 5 collaborations

Kathleen B Yates 5 collaborations

Gordon J Freeman 5 collaborations

Jacob E Gillis 5 collaborations

Justin D Trombley 4 collaborations

Marcia C Haigis 4 collaborations

Sarah A Weiss 4 collaborations

Flavian D Brown 4 collaborations

Vikram R Juneja 3 collaborations

Joshua D Rabinowitz 3 collaborations

Rose Al Abosy 3 collaborations

Kevin Bi 3 collaborations

Emily F Gaudiano 3 collaborations

Marc A Schwartz 3 collaborations

Lauren E Milling 3 collaborations

Qin Tjokrosurjo 3 collaborations

Ivy S L Streeter 3 collaborations

Nir Hacohen 3 collaborations

Matthew A Coxe 3 collaborations

Alison E Ringel 2 collaborations

Jefte M Drijvers 2 collaborations

Shakchhi Joshi 2 collaborations

Cong-Hui Yao 2 collaborations

Yamini V Virkud 2 collaborations

Ana Lako 2 collaborations

Kristen Felt 2 collaborations

Girish S Naik 2 collaborations

Michael Manos 2 collaborations

Evisa Gjini 2 collaborations

Juhi R Kuchroo 2 collaborations

Jeffrey J Ishizuka 2 collaborations

Jenna L Collier 2 collaborations

Gabriel K Griffin 2 collaborations

Seth Maleri 2 collaborations

Dawn E Comstock 2 collaborations

Arpit Panda 2 collaborations

Margaret D Zimmer 2 collaborations

Robert T Manguso 2 collaborations

F Stephen Hodi 2 collaborations

Scott J Rodig 2 collaborations

Jared H Rowe 2 collaborations

Megan E Fung 2 collaborations

Joon Seok Park 2 collaborations

Kristen E Pauken 2 collaborations

Amy Y Huang 2 collaborations

Jossef F Osborn 2 collaborations

Dillon G Patterson 2 collaborations

Samuel C Markson 2 collaborations

Nicole M Derosia 2 collaborations

Ashlyn M Lemmen 2 collaborations

Jasmin M D'Andrea 2 collaborations

Gregory J Baker 1 collaboration

Alessia Catozzi 1 collaboration

Juan C García-Cañaveras 1 collaboration

Brandon M Gassaway 1 collaboration

Haejin Yoon 1 collaboration

Peter T Sage 1 collaboration

Connor A Jacobson 1 collaboration

Zoltan Maliga 1 collaboration

Steven P Gygi 1 collaboration

Peter K Sorger 1 collaboration

Noga Ron-Harel 1 collaboration

Jonathan M Ghergurovich 1 collaboration

Giulia Notarangelo 1 collaboration

Yoshiki Tsubosaka 1 collaboration

Hsiao-Wei Tsao 1 collaboration

James Kaminski 1 collaboration

Makoto Kurachi 1 collaboration

R Anthony Barnitz 1 collaboration

Michael A DiIorio 1 collaboration

Wataru Ise 1 collaboration

Tomohiro Kurosaki 1 collaboration

E John Wherry 1 collaboration

Nir Yosef 1 collaboration

Ilaria Elia 1 collaboration

Osmaan Shahid 1 collaboration

Natalia E Sifnugel 1 collaboration

Sheila Johnson 1 collaboration

Amy G Reynolds 1 collaboration

Daniela Martinez 1 collaboration

Alex C Y Chen 1 collaboration

Thomas J LaSalle 1 collaboration

Christopher D Scharer 1 collaboration

Mudra Hegde 1 collaboration

Natalia Sifnugel 1 collaboration

C Mei-An Nolan 1 collaboration

Richard A Davidson 1 collaboration

Alexander P R Bally 1 collaboration

Dennis K Neeld 1 collaboration

Jeremy M Boss 1 collaboration

Yu Hou 1 collaboration

Linyu Sun 1 collaboration

Linglin Huang 1 collaboration

Conner Lambden 1 collaboration

Pratiksha I Thakore 1 collaboration

Kathryn Geiger-Schuller 1 collaboration

Kimitoshi Kimura 1 collaboration

Longjun Yan 1 collaboration

Yue Zang 1 collaboration

Ruihan Tang 1 collaboration

Jingwen Shi 1 collaboration

Rocky Barilla 1 collaboration

Liwen Deng 1 collaboration

Ayshwarya Subramanian 1 collaboration

Antonia Wallrapp 1 collaboration

Hee Sun Choi 1 collaboration

Yoon-Chul Kye 1 collaboration

Orr Ashenberg 1 collaboration

Geoffrey Schiebinger 1 collaboration

Isaac M Chiu 1 collaboration

Aviv Regev 1 collaboration

Vijay K Kuchroo 1 collaboration

Tara Muijlwijk 1 collaboration

Isaac S Harris 1 collaboration

Kiran Kurmi 1 collaboration

Grant H Hickok 1 collaboration

Priyamvada Prathima 1 collaboration

William Fithian 1 collaboration

Francesca S Gazzaniga 1 collaboration

Meng Wu 1 collaboration

Amalia K Luthens 1 collaboration

Jacob Gillis 1 collaboration

Wen Zheng 1 collaboration

Sarah B Johnson 1 collaboration

Golnaz Morad 1 collaboration

Elizabeth M Park 1 collaboration

Yifan Zhou 1 collaboration

Stephanie S Watowich 1 collaboration

Jennifer A Wargo 1 collaboration

Dennis L Kasper 1 collaboration

Jernej Godec 1 collaboration

Veronika Lukacs-Kornek 1 collaboration

Frank A Schildberg 1 collaboration

Hye-Jung Kim 1 collaboration

Stéphane J H Ricoult 1 collaboration

Varun N Kapoor 1 collaboration

Illana A Stanley 1 collaboration

Viviana Cremasco 1 collaboration

Nika N Danial 1 collaboration

Brendan D Manning 1 collaboration

Shannon J Turley 1 collaboration

Jennifer A Lo 1 collaboration

Masayoshi Kawakubo 1 collaboration

Mack Y Su 1 collaboration

Tal H Erlich 1 collaboration

Lajos V Kemeny 1 collaboration

Mamunur Rashid 1 collaboration

Mohsen Malehmir 1 collaboration

S Alireza Rabi 1 collaboration

Rumya Raghavan 1 collaboration

Jennifer Allouche 1 collaboration

Gyulnara Kasumova 1 collaboration

Dennie T Frederick 1 collaboration

Qing Yu Weng 1 collaboration

Marcelo Pereira da Silva 1 collaboration

Yu Xu 1 collaboration

Anita A J van der Sande 1 collaboration

Whitney Silkworth 1 collaboration

Elisabeth Roider 1 collaboration

Edward P Browne 1 collaboration

David J Lieb 1 collaboration

Belinda Wang 1 collaboration

Levi A Garraway 1 collaboration

Catherine J Wu 1 collaboration

Keith T Flaherty 1 collaboration

Constance E Brinckerhoff 1 collaboration

David W Mullins 1 collaboration

David J Adams 1 collaboration

Mai P Hoang 1 collaboration

Genevieve M Boland 1 collaboration

Dieter Manstein 1 collaboration

David E Fisher 1 collaboration

Zachary M Hoffman 1 collaboration

Praju V Anekal 1 collaboration

Paula Montero Llopis 1 collaboration

Mohammad Rashidian 1 collaboration

Vincent L Verschoor 1 collaboration

Anushka Dongre 1 collaboration

Yun Zhang 1 collaboration

Stephen Kolifrath 1 collaboration

Amir R Aref 1 collaboration

Christie J Lau 1 collaboration

Cloud P Paweletz 1 collaboration

Xia Bu 1 collaboration

M Inmaculada Barrasa 1 collaboration

Robert A Weinberg 1 collaboration

Hidde L Ploegh 1 collaboration

Daniel J Coxe 1 collaboration

Charles L Evavold 1 collaboration

Iva Hafner-Bratkovič 1 collaboration

Pascal Devant 1 collaboration

Elsy M Ngwa 1 collaboration

Elvira Boršić 1 collaboration

Jay R Thiagarajah 1 collaboration

Jonathan C Kagan 1 collaboration