Martin Empting

Affiliations

Department of Drug Design and Optimization (DDOP), Helmholtz-Institute for Pharmaceutical Research Saarland (HIPS)-Helmholtz Centre for Infection Research (HZI), Saarbrücken, Germany.
Department of Pharmacy, Saarland University, Saarbrücken, Germany.
German Centre for Infection Research (DZIF), Saarbrücken, Germany.

Publications (31)

Tracheal brush cells release acetylcholine in response to bitter tastants for paracrine and autocrine signaling.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Avec: Monika I Hollenhorst , Innokentij Jurastow , Rajender Nandigama , Silke Appenzeller , Lei Li , Jörg Vogel , Stephanie Wiederhold , Mike Althaus , Martin Empting , Janine Altmüller , Anna K H Hirsch , Veit Flockerzi , Brendan J Canning , Antoine-Emmanuel Saliba , Gabriela Krasteva-Christ

First Small-Molecule Inhibitors Targeting the RNA-Binding Protein IGF2BP2/IMP2 for Cancer Therapy.

ACS chemical biology

Avec: Charlotte Dahlem , Ali Abuhaliema , Sonja M Kessler , Tarek Kröhler , Ben G E Zoller , Shilpee Chanda , Yingwen Wu , Simon Both , Fabian Müller , Konstantin Lepikhov , Susanne H Kirsch , Stephan Laggai , Rolf Müller , Martin Empting , Alexandra K Kiemer

Respiratory Syncytial Virus Two-Step Infection Screen Reveals Inhibitors of Early and Late Life Cycle Stages.

Antimicrobial agents and chemotherapy

Avec: Svenja M Sake , Christina Kosch , Sebastian Blockus , Sibylle Haid , Antonia P Gunesch , Xiaoyu Zhang , Martina Friesland , Sofie B Trummer , Christina Grethe , Anne Kühnel , Jessica Rückert , W Paul Duprex , Jiabin Huang , Marie-Anne Rameix-Welti , Martin Empting , Nicole Fischer , Anna K H Hirsch , Thomas F Schulz , Thomas Pietschmann

Fragment-Based Discovery of a Qualified Hit Targeting the Latency-Associated Nuclear Antigen of the Oncogenic Kaposi's Sarcoma-Associated Herpesvirus/Human Herpesvirus 8.

Journal of medicinal chemistry

Avec: Philine Kirsch , Valentin Jakob , Kevin Oberhausen , Saskia C Stein , Ivano Cucarro , Thomas F Schulz , Martin Empting

KSHV-specific antivirals targeting the protein-DNA interaction of the latency-associated nuclear antigen.

Future medicinal chemistry

Avec: Aylin Berwanger , Martin Empting

Divergent synthesis and biological evaluation of 2-(trifluoromethyl)pyridines as virulence-attenuating inverse agonists targeting PqsR.

European journal of medicinal chemistry

Avec: Christian Schütz , Amir Hodzic , Mostafa Hamed , Ahmed S Abdelsamie , Andreas M Kany , Maximilian Bauer , Teresa Röhrig , Stefan Schmelz , Andrea Scrima , Wulf Blankenfeldt , Martin Empting

Nanoparticles in liposomes: a platform for increased antibiotic selectivity in multidrug resistant bacteria in respiratory tract infections.

Drug delivery and translational research

Avec: Nathalie E Fakhoury , Samar Mansour , Mohammad Abdel-Halim , Mostafa M Hamed , Martin Empting , Annette Boese , Brigitta Loretz , Claus-Michael Lehr , Salma N Tammam

Discovery of Novel Latency-Associated Nuclear Antigen Inhibitors as Antiviral Agents Against Kaposi's Sarcoma-Associated Herpesvirus.

ACS chemical biology

Avec: Philine Kirsch , Valentin Jakob , Walid A M Elgaher , Christine Walt , Kevin Oberhausen , Thomas F Schulz , Martin Empting

Synthesis of New Cyclomarin Derivatives and Their Biological Evaluation towards Mycobacterium Tuberculosis and Plasmodium Falciparum.

Chemistry (Weinheim an der Bergstrasse, Germany)

Avec: Alexander Kiefer , Chantal D Bader , Jana Held , Anna Esser , Jan Rybniker , Martin Empting , Rolf Müller , Uli Kazmaier

Phage display-based discovery of cyclic peptides against the broad spectrum bacterial anti-virulence target CsrA.

European journal of medicinal chemistry

Avec: Valentin Jakob , Ben G E Zoller , Julia Rinkes , Yingwen Wu , Alexander F Kiefer , Michael Hust , Saskia Polten , Andrew M White , Peta J Harvey , Thomas Durek , David J Craik , Andreas Siebert , Uli Kazmaier , Martin Empting

NMR Experiments Provide Insights into Ligand-Binding to the SARS-CoV-2 Spike Protein Receptor-Binding Domain.

Journal of the American Chemical Society

Avec: Robert Creutznacher , Thorben Maass , Barbora Veselkova , George Ssebyatika , Thomas Krey , Martin Empting , Norbert Tautz , Martin Frank , Knut Kölbel , Charlotte Uetrecht , Thomas Peters

Modeling the Effect of Hydrophobicity on the Passive Permeation of Solutes across a Bacterial Model Membrane.

Journal of chemical information and modeling

Avec: Carla F Sousa , Mohamed A M Kamal , Robert Richter , Kalanika Elamaldeniya , Rolf W Hartmann , Martin Empting , Claus-Michael Lehr , Olga V Kalinina

Disrupting Kaposi's Sarcoma-Associated Herpesvirus (KSHV) Latent Replication with a Small Molecule Inhibitor.

Journal of medicinal chemistry

Avec: Aylin Berwanger , Saskia C Stein , Andreas M Kany , Melissa Gartner , Brigitta Loretz , Claus-Michael Lehr , Anna K H Hirsch , Thomas F Schulz , Martin Empting

Restriction-Free Construction of a Phage-Presented Very Short Macrocyclic Peptide Library.

Methods in molecular biology (Clifton, N.J.)

Avec: Valentin Jakob , Saskia Helmsing , Michael Hust , Martin Empting

Hit evaluation of an α-helical peptide: Ala-scan, truncation and sidechain-to-sidechain macrocyclization of an RNA polymerase Inhibitor.

Biological chemistry

Avec: Ahmed Ashraf Moustafa Kamal , Monica Habib , Joerg Haupenthal , Rolf Wolfgang Hartmann , Martin Empting

Squalenyl Hydrogen Sulfate Nanoparticles for Simultaneous Delivery of Tobramycin and an Alkylquinolone Quorum Sensing Inhibitor Enable the Eradication of P. aeruginosa Biofilm Infections.

Angewandte Chemie (International ed. in English)

Avec: Duy-Khiet Ho , Xabier Murgia , Chiara De Rossi , Rebekka Christmann , Antonio G Hüfner de Mello Martins , Marcus Koch , Anastasia Andreas , Jennifer Herrmann , Rolf Müller , Martin Empting , Rolf W Hartmann , Didier Desmaele , Brigitta Loretz , Patrick Couvreur , Claus-Michael Lehr

Micro-rheological properties of lung homogenates correlate with infection severity in a mouse model of Pseudomonas aeruginosa lung infection.

Scientific reports

Avec: Xabier Murgia , Andreas M Kany , Christian Herr , Duy-Khiet Ho , Chiara De Rossi , Robert Bals , Claus-Michael Lehr , Anna K H Hirsch , Rolf W Hartmann , Martin Empting , Teresa Röhrig

Transferring Microclusters of

ACS infectious diseases

Avec: Justus C Horstmann , Annabelle Laric , Annette Boese , Daniela Yildiz , Teresa Röhrig , Martin Empting , Nicolas Frank , Daniel Krug , Rolf Müller , Nicole Schneider-Daum , Cristiane de Souza Carvalho-Wodarz , Claus-Michael Lehr

Enzyme-Linked Lipid Nanocarriers for Coping Pseudomonal Pulmonary Infection. Would Nanocarriers Complement Biofilm Disruption or Pave Its Road?

International journal of nanomedicine

Avec: Noha Nafee , Dina M Gaber , Alaa Abouelfetouh , Mustafa Alseqely , Martin Empting , Marc Schneider

Drug repurposing screen identifies lonafarnib as respiratory syncytial virus fusion protein inhibitor.

Nature communications

Avec: Svenja M Sake , Xiaoyu Zhang , Manoj Kumar Rajak , Melanie Urbanek-Quaing , Arnaud Carpentier , Antonia P Gunesch , Christina Grethe , Alina Matthaei , Jessica Rückert , Marie Galloux , Thibaut Larcher , Ronan Le Goffic , Fortune Hontonnou , Arnab K Chatterjee , Kristen Johnson , Kaycie Morwood , Katharina Rox , Walid A M Elgaher , Jiabin Huang , Martin Wetzke , Gesine Hansen , Nicole Fischer , Jean-Francois Eléouët , Marie-Anne Rameix-Welti , Anna K H Hirsch , Elisabeth Herold , Martin Empting , Chris Lauber , Thomas F Schulz , Thomas Krey , Sibylle Haid , Thomas Pietschmann

Towards Translation of PqsR Inverse Agonists: From In Vitro Efficacy Optimization to In Vivo Proof-of-Principle.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Avec: Mostafa M Hamed , Ahmed S Abdelsamie , Katharina Rox , Christian Schütz , Andreas M Kany , Teresa Röhrig , Stefan Schmelz , Wulf Blankenfeldt , Alejandro Arce-Rodriguez , José Manuel Borrero-de Acuña , Dieter Jahn , Jessica Rademacher , Felix C Ringshausen , Nina Cramer , Burkhard Tümmler , Anna K H Hirsch , Rolf W Hartmann , Martin Empting

Flexible Fragment Growing Boosts Potency of Quorum-Sensing Inhibitors against Pseudomonas aeruginosa Virulence.

ChemMedChem

Avec: Michael Zender , Florian Witzgall , Alexander Kiefer , Benjamin Kirsch , Christine K Maurer , Andreas M Kany , Ningna Xu , Stefan Schmelz , Carsten Börger , Wulf Blankenfeldt , Martin Empting

Concepts and Core Principles of Fragment-Based Drug Design.

Molecules (Basel, Switzerland)

Avec: Philine Kirsch , Alwin M Hartman , Anna K H Hirsch , Martin Empting

Hit-to-lead optimization of a latency-associated nuclear antigen inhibitor against Kaposi's sarcoma-associated herpesvirus infections.

European journal of medicinal chemistry

Avec: Philine Kirsch , Saskia C Stein , Aylin Berwanger , Julia Rinkes , Valentin Jakob , Thomas F Schulz , Martin Empting

A New PqsR Inverse Agonist Potentiates Tobramycin Efficacy to Eradicate Pseudomonas aeruginosa Biofilms.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Avec: Christian Schütz , Duy-Khiet Ho , Mostafa Mohamed Hamed , Ahmed Saad Abdelsamie , Teresa Röhrig , Christian Herr , Andreas Martin Kany , Katharina Rox , Stefan Schmelz , Lorenz Siebenbürger , Marius Wirth , Carsten Börger , Samir Yahiaoui , Robert Bals , Andrea Scrima , Wulf Blankenfeldt , Justus Constantin Horstmann , Rebekka Christmann , Xabier Murgia , Marcus Koch , Aylin Berwanger , Brigitta Loretz , Anna Katharina Herta Hirsch , Rolf Wolfgang Hartmann , Claus-Michael Lehr , Martin Empting

Towards the sustainable discovery and development of new antibiotics.

Nature reviews. Chemistry

Avec: Marcus Miethke , Marco Pieroni , Tilmann Weber , Mark Brönstrup , Peter Hammann , Ludovic Halby , Paola B Arimondo , Philippe Glaser , Bertrand Aigle , Helge B Bode , Rui Moreira , Yanyan Li , Andriy Luzhetskyy , Marnix H Medema , Jean-Luc Pernodet , Marc Stadler , José Rubén Tormo , Olga Genilloud , Andrew W Truman , Kira J Weissman , Eriko Takano , Stefano Sabatini , Evi Stegmann , Heike Brötz-Oesterhelt , Wolfgang Wohlleben , Myriam Seemann , Martin Empting , Anna K H Hirsch , Brigitta Loretz , Claus-Michael Lehr , Alexander Titz , Jennifer Herrmann , Timo Jaeger , Silke Alt , Thomas Hesterkamp , Mathias Winterhalter , Andrea Schiefer , Kenneth Pfarr , Achim Hoerauf , Heather Graz , Michael Graz , Mika Lindvall , Savithri Ramurthy , Anders Karlén , Maarten van Dongen , Hrvoje Petkovic , Andreas Keller , Frédéric Peyrane , Stefano Donadio , Laurent Fraisse , Laura J V Piddock , Ian H Gilbert , Heinz E Moser , Rolf Müller

Thioxothiazolo[3,4-a]quinazoline derivatives inhibit the human cytomegalovirus alkaline nuclease.

Antiviral research

Avec: Tianyu Zhang , Theodore I Potgieter , Erik Kosche , Jessica Rückert , Eleonore Ostermann , Thomas Schulz , Martin Empting , Wolfram Brune

Discovery and optimization of thiazole-based quorum sensing inhibitors as potent blockers of Pseudomonas aeruginosa pathogenicity.

European journal of medicinal chemistry

Avec: Ahmed S Abdelsamie , Mostafa M Hamed , Christian Schütz , Teresa Röhrig , Andreas M Kany , Stefan Schmelz , Wulf Blankenfeldt , Anna K H Hirsch , Rolf W Hartmann , Martin Empting

Towards the sustainable discovery and development of new antibiotics.

Nature reviews. Chemistry

Establishment of an In Bacterio Assay for the Assessment of Carbon Storage Regulator A (CsrA) Inhibitors.

Chembiochem : a European journal of chemical biology

Avec: Yingwen Wu , Ben G E Zoller , Mohamed Ashraf Mostafa Kamal , Sven-Kevin Hotop , Claus-Michael Lehr , Mark Brönstrup , Petra Dersch , Martin Empting

Gene Editing and Small Molecule Inhibitors of the RNA Binding Protein IGF2BP2/IMP2 Show its Potential as an Anti-Cancer Drug Target.

Frontiers in bioscience (Landmark edition)

Avec: Shilpee Chanda , Konstantin Lepikhov , Charlotte Dahlem , Hanna S Schymik , Jessica Hoppstädter , An-Kristin Geber , Konrad Wagner , Sonja M Kessler , Martin Empting , Alexandra K Kiemer

Réseau de co-auteurs

Anna K H Hirsch 10 collaborations

Claus-Michael Lehr 10 collaborations

Rolf Müller 6 collaborations

Thomas F Schulz 6 collaborations

Andreas M Kany 6 collaborations

Teresa Röhrig 6 collaborations

Brigitta Loretz 6 collaborations

Valentin Jakob 5 collaborations

Stefan Schmelz 5 collaborations

Wulf Blankenfeldt 5 collaborations

Rolf W Hartmann 5 collaborations

Philine Kirsch 4 collaborations

Aylin Berwanger 4 collaborations

Christian Schütz 4 collaborations

Ben G E Zoller 3 collaborations

Yingwen Wu 3 collaborations

Jessica Rückert 3 collaborations

Saskia C Stein 3 collaborations

Ahmed S Abdelsamie 3 collaborations

Mostafa M Hamed 3 collaborations

Duy-Khiet Ho 3 collaborations

Xabier Murgia 3 collaborations

Jennifer Herrmann 3 collaborations

Katharina Rox 3 collaborations

Mark Brönstrup 3 collaborations

Charlotte Dahlem 2 collaborations

Sonja M Kessler 2 collaborations

Shilpee Chanda 2 collaborations

Konstantin Lepikhov 2 collaborations

Alexandra K Kiemer 2 collaborations

Svenja M Sake 2 collaborations

Sibylle Haid 2 collaborations

Antonia P Gunesch 2 collaborations

Xiaoyu Zhang 2 collaborations

Christina Grethe 2 collaborations

Jiabin Huang 2 collaborations

Marie-Anne Rameix-Welti 2 collaborations

Nicole Fischer 2 collaborations

Thomas Pietschmann 2 collaborations

Kevin Oberhausen 2 collaborations

Andrea Scrima 2 collaborations

Annette Boese 2 collaborations

Walid A M Elgaher 2 collaborations

Alexander Kiefer 2 collaborations

Uli Kazmaier 2 collaborations

Julia Rinkes 2 collaborations

Michael Hust 2 collaborations

Thomas Krey 2 collaborations

Rolf Wolfgang Hartmann 2 collaborations

Chiara De Rossi 2 collaborations

Rebekka Christmann 2 collaborations

Marcus Koch 2 collaborations

Christian Herr 2 collaborations

Robert Bals 2 collaborations

Carsten Börger 2 collaborations

Marcus Miethke 2 collaborations

Marco Pieroni 2 collaborations

Tilmann Weber 2 collaborations

Peter Hammann 2 collaborations

Ludovic Halby 2 collaborations

Paola B Arimondo 2 collaborations

Philippe Glaser 2 collaborations

Bertrand Aigle 2 collaborations

Helge B Bode 2 collaborations

Rui Moreira 2 collaborations

Yanyan Li 2 collaborations

Andriy Luzhetskyy 2 collaborations

Marnix H Medema 2 collaborations

Jean-Luc Pernodet 2 collaborations

Marc Stadler 2 collaborations

José Rubén Tormo 2 collaborations

Olga Genilloud 2 collaborations

Andrew W Truman 2 collaborations

Kira J Weissman 2 collaborations

Eriko Takano 2 collaborations

Stefano Sabatini 2 collaborations

Evi Stegmann 2 collaborations

Heike Brötz-Oesterhelt 2 collaborations

Wolfgang Wohlleben 2 collaborations

Myriam Seemann 2 collaborations

Alexander Titz 2 collaborations

Timo Jaeger 2 collaborations

Silke Alt 2 collaborations

Thomas Hesterkamp 2 collaborations

Mathias Winterhalter 2 collaborations

Andrea Schiefer 2 collaborations

Kenneth Pfarr 2 collaborations

Achim Hoerauf 2 collaborations

Heather Graz 2 collaborations

Michael Graz 2 collaborations

Mika Lindvall 2 collaborations

Savithri Ramurthy 2 collaborations

Anders Karlén 2 collaborations

Maarten van Dongen 2 collaborations

Hrvoje Petkovic 2 collaborations

Andreas Keller 2 collaborations

Frédéric Peyrane 2 collaborations

Stefano Donadio 2 collaborations

Laurent Fraisse 2 collaborations

Laura J V Piddock 2 collaborations

Ian H Gilbert 2 collaborations

Heinz E Moser 2 collaborations

Monika I Hollenhorst 1 collaboration

Innokentij Jurastow 1 collaboration

Rajender Nandigama 1 collaboration

Silke Appenzeller 1 collaboration

Lei Li 1 collaboration

Jörg Vogel 1 collaboration

Stephanie Wiederhold 1 collaboration

Mike Althaus 1 collaboration

Janine Altmüller 1 collaboration

Veit Flockerzi 1 collaboration

Brendan J Canning 1 collaboration

Antoine-Emmanuel Saliba 1 collaboration

Gabriela Krasteva-Christ 1 collaboration

Ali Abuhaliema 1 collaboration

Tarek Kröhler 1 collaboration

Simon Both 1 collaboration

Fabian Müller 1 collaboration

Susanne H Kirsch 1 collaboration

Stephan Laggai 1 collaboration

Christina Kosch 1 collaboration

Sebastian Blockus 1 collaboration

Martina Friesland 1 collaboration

Sofie B Trummer 1 collaboration

Anne Kühnel 1 collaboration

W Paul Duprex 1 collaboration

Ivano Cucarro 1 collaboration

Amir Hodzic 1 collaboration

Mostafa Hamed 1 collaboration

Maximilian Bauer 1 collaboration

Nathalie E Fakhoury 1 collaboration

Samar Mansour 1 collaboration

Mohammad Abdel-Halim 1 collaboration

Salma N Tammam 1 collaboration

Christine Walt 1 collaboration

Chantal D Bader 1 collaboration

Jana Held 1 collaboration

Anna Esser 1 collaboration

Jan Rybniker 1 collaboration

Alexander F Kiefer 1 collaboration

Saskia Polten 1 collaboration

Andrew M White 1 collaboration

Peta J Harvey 1 collaboration

Thomas Durek 1 collaboration

David J Craik 1 collaboration

Andreas Siebert 1 collaboration

Robert Creutznacher 1 collaboration

Thorben Maass 1 collaboration

Barbora Veselkova 1 collaboration

George Ssebyatika 1 collaboration

Norbert Tautz 1 collaboration

Martin Frank 1 collaboration

Knut Kölbel 1 collaboration

Charlotte Uetrecht 1 collaboration

Thomas Peters 1 collaboration

Carla F Sousa 1 collaboration

Mohamed A M Kamal 1 collaboration

Robert Richter 1 collaboration

Kalanika Elamaldeniya 1 collaboration

Olga V Kalinina 1 collaboration

Melissa Gartner 1 collaboration

Saskia Helmsing 1 collaboration

Ahmed Ashraf Moustafa Kamal 1 collaboration

Monica Habib 1 collaboration

Joerg Haupenthal 1 collaboration

Antonio G Hüfner de Mello Martins 1 collaboration

Anastasia Andreas 1 collaboration

Didier Desmaele 1 collaboration

Patrick Couvreur 1 collaboration

Justus C Horstmann 1 collaboration

Annabelle Laric 1 collaboration

Daniela Yildiz 1 collaboration

Nicolas Frank 1 collaboration

Daniel Krug 1 collaboration

Nicole Schneider-Daum 1 collaboration

Cristiane de Souza Carvalho-Wodarz 1 collaboration

Noha Nafee 1 collaboration

Dina M Gaber 1 collaboration

Alaa Abouelfetouh 1 collaboration

Mustafa Alseqely 1 collaboration

Marc Schneider 1 collaboration

Manoj Kumar Rajak 1 collaboration

Melanie Urbanek-Quaing 1 collaboration

Arnaud Carpentier 1 collaboration

Alina Matthaei 1 collaboration

Marie Galloux 1 collaboration

Thibaut Larcher 1 collaboration

Ronan Le Goffic 1 collaboration

Fortune Hontonnou 1 collaboration

Arnab K Chatterjee 1 collaboration

Kristen Johnson 1 collaboration

Kaycie Morwood 1 collaboration

Martin Wetzke 1 collaboration

Gesine Hansen 1 collaboration

Jean-Francois Eléouët 1 collaboration

Elisabeth Herold 1 collaboration

Chris Lauber 1 collaboration

Alejandro Arce-Rodriguez 1 collaboration

José Manuel Borrero-de Acuña 1 collaboration

Dieter Jahn 1 collaboration

Jessica Rademacher 1 collaboration

Felix C Ringshausen 1 collaboration

Nina Cramer 1 collaboration

Burkhard Tümmler 1 collaboration

Michael Zender 1 collaboration

Florian Witzgall 1 collaboration

Benjamin Kirsch 1 collaboration

Christine K Maurer 1 collaboration

Ningna Xu 1 collaboration

Alwin M Hartman 1 collaboration

Mostafa Mohamed Hamed 1 collaboration

Ahmed Saad Abdelsamie 1 collaboration

Andreas Martin Kany 1 collaboration

Lorenz Siebenbürger 1 collaboration

Marius Wirth 1 collaboration

Samir Yahiaoui 1 collaboration

Justus Constantin Horstmann 1 collaboration

Anna Katharina Herta Hirsch 1 collaboration

Tianyu Zhang 1 collaboration

Theodore I Potgieter 1 collaboration

Erik Kosche 1 collaboration

Eleonore Ostermann 1 collaboration

Thomas Schulz 1 collaboration

Wolfram Brune 1 collaboration

Mohamed Ashraf Mostafa Kamal 1 collaboration

Sven-Kevin Hotop 1 collaboration

Petra Dersch 1 collaboration

Hanna S Schymik 1 collaboration

Jessica Hoppstädter 1 collaboration

An-Kristin Geber 1 collaboration

Konrad Wagner 1 collaboration