Markus A Seeliger

Affiliations

Department of Pharmacological Sciences, Stony Brook University, Stony Brook, New York 11794-8651, United States.

ORCID: 0000-0003-0990-1756

Publications (12)

How ATP-Competitive Inhibitors Allosterically Modulate Tyrosine Kinases That Contain a Src-like Regulatory Architecture.

ACS chemical biology

Avec: Linglan Fang , Jessica Vilas-Boas , Sujata Chakraborty , Zachary E Potter , Ames C Register , Markus A Seeliger , Dustin J Maly

Substrate-selective inhibitors that reprogram the activity of insulin-degrading enzyme.

Nature chemical biology

Avec: Juan Pablo Maianti , Grace A Tan , Amedeo Vetere , Amie J Welsh , Bridget K Wagner , Markus A Seeliger , David R Liu

Validation of an Allosteric Binding Site of Src Kinase Identified by Unbiased Ligand Binding Simulations.

Journal of molecular biology

Avec: Victoria R Mingione , Zachariah H Foda , YiTing Paung , Hannah Philipose , Aziz M Rangwala , Yibing Shan , Markus A Seeliger

Biochemical Studies of Systemic Lupus Erythematosus-Associated Mutations in Nonreceptor Tyrosine Kinases Ack1 and Brk.

Biochemistry

Avec: Yagmur Kan , YiTing Paung , Yunyoung Kim , Markus A Seeliger , W Todd Miller

Lucanthone, a Potential PPT1 Inhibitor, Perturbs Stemness, Reduces Tumor Microtube Formation, and Slows the Growth of Temozolomide-Resistant Gliomas In Vivo.

The Journal of pharmacology and experimental therapeutics

Avec: Daniel P Radin , Sophie Shifman , Ian R Outhwaite , Aryan Sharma , Robert Bases , Markus A Seeliger , Stella E Tsirka

Mutation in Abl kinase with altered drug-binding kinetics indicates a novel mechanism of imatinib resistance.

Proceedings of the National Academy of Sciences of the United States of America

Avec: Agatha Lyczek , Benedict-Tilman Berger , Aziz M Rangwala , YiTing Paung , Jessica Tom , Hannah Philipose , Jiaye Guo , Steven K Albanese , Matthew B Robers , Stefan Knapp , John D Chodera , Markus A Seeliger

Kinases on Double Duty: A Review of UniProtKB Annotated Bifunctionality within the Kinome.

Biomolecules

Avec: Aziz M Rangwala , Victoria R Mingione , George Georghiou , Markus A Seeliger

Discovery and molecular basis of subtype-selective cyclophilin inhibitors.

Nature chemical biology

Avec: Alexander A Peterson , Aziz M Rangwala , Manish K Thakur , Patrick S Ward , Christie Hung , Ian R Outhwaite , Alix I Chan , Dmitry L Usanov , Vamsi K Mootha , Markus A Seeliger , David R Liu

Death by a Thousand Cuts â€" Combining Kinase Inhibitors for Selective Target Inhibition and Rational Polypharmacology.

bioRxiv : the preprint server for biology

Avec: Ian R Outhwaite , Sukrit Singh , Benedict-Tilman Berger , Stefan Knapp , John D Chodera , Markus A Seeliger

Allosteric regulation and inhibition of protein kinases.

Biochemical Society transactions

Avec: Victoria R Mingione , YiTing Paung , Ian R Outhwaite , Markus A Seeliger

Death by a thousand cuts through kinase inhibitor combinations that maximize selectivity and enable rational multitargeting.

eLife

Avec: Ian R Outhwaite , Sukrit Singh , Benedict-Tilman Berger , Stefan Knapp , John D Chodera , Markus A Seeliger

Calculating Protein-Ligand Residence Times through State Predictive Information Bottleneck Based Enhanced Sampling.

Journal of chemical theory and computation

Avec: Suemin Lee , Dedi Wang , Markus A Seeliger , Pratyush Tiwary

Réseau de co-auteurs

Ian R Outhwaite 5 collaborations

YiTing Paung 4 collaborations

Aziz M Rangwala 4 collaborations

Victoria R Mingione 3 collaborations

Benedict-Tilman Berger 3 collaborations

Stefan Knapp 3 collaborations

John D Chodera 3 collaborations

David R Liu 2 collaborations

Hannah Philipose 2 collaborations

Sukrit Singh 2 collaborations

Linglan Fang 1 collaboration

Jessica Vilas-Boas 1 collaboration

Sujata Chakraborty 1 collaboration

Zachary E Potter 1 collaboration

Ames C Register 1 collaboration

Dustin J Maly 1 collaboration

Juan Pablo Maianti 1 collaboration

Grace A Tan 1 collaboration

Amedeo Vetere 1 collaboration

Amie J Welsh 1 collaboration

Bridget K Wagner 1 collaboration

Zachariah H Foda 1 collaboration

Yibing Shan 1 collaboration

Yagmur Kan 1 collaboration

Yunyoung Kim 1 collaboration

W Todd Miller 1 collaboration

Daniel P Radin 1 collaboration

Sophie Shifman 1 collaboration

Aryan Sharma 1 collaboration

Robert Bases 1 collaboration

Stella E Tsirka 1 collaboration

Agatha Lyczek 1 collaboration

Jessica Tom 1 collaboration

Jiaye Guo 1 collaboration

Steven K Albanese 1 collaboration

Matthew B Robers 1 collaboration

George Georghiou 1 collaboration

Alexander A Peterson 1 collaboration

Manish K Thakur 1 collaboration

Patrick S Ward 1 collaboration

Christie Hung 1 collaboration

Alix I Chan 1 collaboration

Dmitry L Usanov 1 collaboration

Vamsi K Mootha 1 collaboration

Suemin Lee 1 collaboration

Dedi Wang 1 collaboration

Pratyush Tiwary 1 collaboration