Mark I Avigan

Affiliations

US Food and Drug Administration, Silver Spring, MD, USA.

Publications (15)

Consensus Guidelines: Best Practices for Detection, Assessment and Management of Suspected Acute Drug-Induced Liver Injury During Clinical Trials in Adults with Chronic Viral Hepatitis and Adults with Cirrhosis Secondary to Hepatitis B, C and Nonalcoholic Steatohepatitis.

Drug safety

Avec: William R Treem , Melissa Palmer , Isabelle Lonjon-Domanec , Daniel Seekins , Lara Dimick-Santos , Mark I Avigan , John F Marcinak , Ajit Dash , Arie Regev , Eric Maller , Meenal Patwardhan , James H Lewis , Don C Rockey , Adrian M Di Bisceglie , James W Freston , Raul J Andrade , Naga Chalasani

Next-Generation DILI Biomarkers: Prioritization of Biomarkers for Qualification and Best Practices for Biospecimen Collection in Drug Development.

Clinical pharmacology and therapeutics

Avec: Sharin E Roth , Mark I Avigan , David Bourdet , David Brott , Rachel Church , Ajit Dash , Douglas Keller , Philip Sherratt , Paul B Watkins , Lucas Westcott-Baker , Silvia Lentini , Michael Merz , Lila Ramaiah , Shashi K Ramaiah , Ann Marie Stanley , John Marcinak

Liver safety assessment in clinical trials of new agents for chronic hepatitis B.

Journal of viral hepatitis

Avec: Robert J Fontana , Mark I Avigan , Harry L A Janssen , Arie Regev , Poonam Mishra , Anuj Gaggar , Nathaniel Brown , Cynthia Wat , Patricia Mendez , Ryan T Anderson , Bruce Given , Veronica Miller , Maria Beumont

A preclinical model of severe NASH-like liver injury by chronic administration of a high-fat and high-sucrose diet in mice.

Toxicology and applied pharmacology

Avec: Rose A Willett , Volodymyr P Tryndyak , Jennifer M Hughes Hanks , Lana Elkins , Suresh K Nagumalli , Mark I Avigan , Sharon A Ross , Gonçalo Gamboa da Costa , Frederick A Beland , Ivan Rusyn , Igor P Pogribny

Liver biopsy for assessment of suspected drug-induced liver injury in metabolic dysfunction-associated steatohepatitis clinical trials: Expert consensus from the Liver Forum.

Alimentary pharmacology & therapeutics

Avec: Melissa Palmer , David E Kleiner , Zachary Goodman , Elizabeth Brunt , Mark I Avigan , Arie Regev , Paul H Hayashi , James H Lewis , Ruby Mehta , Stephen A Harrison , Massimo Siciliano , Charles A McWherter , Raj Vuppalanchi , Cynthia Behling , Veronica Miller , Naga Chalasani , Arun J Sanyal

An Evaluation of Postmarketing Reports of Serious Idiosyncratic Liver Injury Associated with Ulipristal Acetate for the Treatment of Uterine Fibroids.

Drug safety

Avec: Sarah Kang , Allen Brinker , S Christopher Jones , Lara Dimick-Santos , Mark I Avigan

Lipidomic profiling of the hepatic esterified fatty acid composition in diet-induced nonalcoholic fatty liver disease in genetically diverse Collaborative Cross mice.

The Journal of nutritional biochemistry

Avec: Suresh K Nagumalli , Rose A Willett , Aline de Conti , Volodymyr P Tryndyak , Mark I Avigan , Gonçalo Gamboa da Costa , Frederick A Beland , Ivan Rusyn , Igor P Pogribny

Effect of an obesogenic high-fat and high-sucrose diet on hepatic gene expression signatures in male Collaborative Cross mice.

American journal of physiology. Gastrointestinal and liver physiology

Avec: Volodymyr P Tryndyak , Rose A Willett , Suresh K Nagumalli , Dan Li , Mark I Avigan , Frederick A Beland , Ivan Rusyn , Igor P Pogribny

Best practices for detection, assessment and management of suspected immune-mediated liver injury caused by immune checkpoint inhibitors during drug development.

Journal of autoimmunity

Avec: Arie Regev , Mark I Avigan , Alexandre Kiazand , John M Vierling , James H Lewis , Stephanie O Omokaro , Adrian M Di Bisceglie , Robert J Fontana , Herbert L Bonkovsky , James W Freston , Jack P Uetrecht , Ethan D Miller , Nonko D Pehlivanov , Syed Asif Haque , Melanie J Harrison , Gerd A Kullak-Ublick , Hewei Li , Niti N Patel , Meenal Patwardhan , Karen D Price , Paul B Watkins , Naga P Chalasani

Consensus guidelines: best practices for detection, assessment and management of suspected acute drug-induced liver injury occurring during clinical trials in adults with chronic cholestatic liver disease.

Alimentary pharmacology & therapeutics

Avec: Melissa Palmer , Arie Regev , Keith Lindor , Mark I Avigan , Lara Dimick-Santos , William Treem , John F Marcinak , James H Lewis , Frank A Anania , Daniel Seekins , Benjamin L Shneider , Naga Chalasani

Deciphering the Dynamic Complexities of the Liver Microenvironment - Toward a Better Understanding of Immune-Mediated liver Injury Caused by Immune Checkpoint Inhibitors (ILICI).

The AAPS journal

Avec: Tao Wang , Matthew M Yeh , Mark I Avigan , Lorraine Pelosof , Gerald M Feldman

Drug-Induced Liver Injury in the Elderly: Consensus Statements and Recommendations from the IQ-DILI Initiative.

Drug safety

Avec: Eric B Cohen , Meenal Patwardhan , Ritu Raheja , David H Alpers , Raul J Andrade , Mark I Avigan , James H Lewis , Don C Rockey , Francis Chui , Alexandru M Iacob , Camila C Linardi , Arie Regev , Jesse Shick , M Isabel Lucena

Characterization of the variability in the extent of nonalcoholic fatty liver induced by a high-fat diet in the genetically diverse Collaborative Cross mouse model.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Avec: Aline de Conti , Volodymyr Tryndyak , Rose A Willett , Barbara Borowa-Mazgaj , Anna Watson , Ralph Patton , Sangeeta Khare , Levan Muskhelishvili , Greg R Olson , Mark I Avigan , Carl E Cerniglia , Sharon A Ross , Arun J Sanyal , Frederick A Beland , Ivan Rusyn , Igor P Pogribny

Consensus: guidelines: best practices for detection, assessment and management of suspected acute drug-induced liver injury during clinical trials in patients with nonalcoholic steatohepatitis.

Alimentary pharmacology & therapeutics

Avec: Arie Regev , Melissa Palmer , Mark I Avigan , Lara Dimick-Santos , William R Treem , John F Marcinak , Daniel Seekins , Gopal Krishna , Frank A Anania , James W Freston , James H Lewis , Arun J Sanyal , Naga Chalasani

Non-alcoholic fatty liver disease-associated DNA methylation and gene expression alterations in the livers of Collaborative Cross mice fed an obesogenic high-fat and high-sucrose diet.

Epigenetics

Avec: Volodymyr P Tryndyak , Rose A Willett , Mark I Avigan , Arun J Sanyal , Frederick A Beland , Ivan Rusyn , Igor P Pogribny

Réseau de co-auteurs

Arie Regev 7 collaborations

James H Lewis 6 collaborations

Rose A Willett 5 collaborations

Frederick A Beland 5 collaborations

Ivan Rusyn 5 collaborations

Igor P Pogribny 5 collaborations

Melissa Palmer 4 collaborations

Lara Dimick-Santos 4 collaborations

Naga Chalasani 4 collaborations

Volodymyr P Tryndyak 4 collaborations

Arun J Sanyal 4 collaborations

Daniel Seekins 3 collaborations

John F Marcinak 3 collaborations

Meenal Patwardhan 3 collaborations

James W Freston 3 collaborations

Suresh K Nagumalli 3 collaborations

William R Treem 2 collaborations

Ajit Dash 2 collaborations

Don C Rockey 2 collaborations

Adrian M Di Bisceglie 2 collaborations

Raul J Andrade 2 collaborations

Paul B Watkins 2 collaborations

Robert J Fontana 2 collaborations

Veronica Miller 2 collaborations

Sharon A Ross 2 collaborations

Gonçalo Gamboa da Costa 2 collaborations

Aline de Conti 2 collaborations

Frank A Anania 2 collaborations

Isabelle Lonjon-Domanec 1 collaboration

Eric Maller 1 collaboration

Sharin E Roth 1 collaboration

David Bourdet 1 collaboration

David Brott 1 collaboration

Rachel Church 1 collaboration

Douglas Keller 1 collaboration

Philip Sherratt 1 collaboration

Lucas Westcott-Baker 1 collaboration

Silvia Lentini 1 collaboration

Michael Merz 1 collaboration

Lila Ramaiah 1 collaboration

Shashi K Ramaiah 1 collaboration

Ann Marie Stanley 1 collaboration

John Marcinak 1 collaboration

Harry L A Janssen 1 collaboration

Poonam Mishra 1 collaboration

Anuj Gaggar 1 collaboration

Nathaniel Brown 1 collaboration

Cynthia Wat 1 collaboration

Patricia Mendez 1 collaboration

Ryan T Anderson 1 collaboration

Bruce Given 1 collaboration

Maria Beumont 1 collaboration

Jennifer M Hughes Hanks 1 collaboration

Lana Elkins 1 collaboration

David E Kleiner 1 collaboration

Zachary Goodman 1 collaboration

Elizabeth Brunt 1 collaboration

Paul H Hayashi 1 collaboration

Ruby Mehta 1 collaboration

Stephen A Harrison 1 collaboration

Massimo Siciliano 1 collaboration

Charles A McWherter 1 collaboration

Raj Vuppalanchi 1 collaboration

Cynthia Behling 1 collaboration

Sarah Kang 1 collaboration

Allen Brinker 1 collaboration

S Christopher Jones 1 collaboration

Dan Li 1 collaboration

Alexandre Kiazand 1 collaboration

John M Vierling 1 collaboration

Stephanie O Omokaro 1 collaboration

Herbert L Bonkovsky 1 collaboration

Jack P Uetrecht 1 collaboration

Ethan D Miller 1 collaboration

Nonko D Pehlivanov 1 collaboration

Syed Asif Haque 1 collaboration

Melanie J Harrison 1 collaboration

Gerd A Kullak-Ublick 1 collaboration

Hewei Li 1 collaboration

Niti N Patel 1 collaboration

Karen D Price 1 collaboration

Naga P Chalasani 1 collaboration

Keith Lindor 1 collaboration

William Treem 1 collaboration

Benjamin L Shneider 1 collaboration

Tao Wang 1 collaboration

Matthew M Yeh 1 collaboration

Lorraine Pelosof 1 collaboration

Gerald M Feldman 1 collaboration

Eric B Cohen 1 collaboration

Ritu Raheja 1 collaboration

David H Alpers 1 collaboration

Francis Chui 1 collaboration

Alexandru M Iacob 1 collaboration

Camila C Linardi 1 collaboration

Jesse Shick 1 collaboration

M Isabel Lucena 1 collaboration

Volodymyr Tryndyak 1 collaboration

Barbara Borowa-Mazgaj 1 collaboration

Anna Watson 1 collaboration

Ralph Patton 1 collaboration

Sangeeta Khare 1 collaboration

Levan Muskhelishvili 1 collaboration

Greg R Olson 1 collaboration

Carl E Cerniglia 1 collaboration

Gopal Krishna 1 collaboration