Manfred Jücker

Affiliations

Center for Experimental Medicine, Institute of Biochemistry and Signal Transduction, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Publications (38)

Activation of CD44/PAK1/AKT signaling promotes resistance to FGFR1 inhibition in squamous-cell lung cancer.

NPJ precision oncology

Avec: Omar Elakad , Björn Häupl , Vera Labitzky , Sha Yao , Stefan Küffer , Alexander von Hammerstein-Equord , Bernhard C Danner , Manfred Jücker , Henning Urlaub , Tobias Lange , Philipp Ströbel , Thomas Oellerich , Hanibal Bohnenberger

Activated Src kinases downstream of BCR-ABL and Flt3 induces proteasomal degradation of SHIP1 by phosphorylation of tyrosine 1021.

Biochimica et biophysica acta. Molecular cell research

Avec: Patrick Ehm , Bettina Bettin , Manfred Jücker

Targeted hyperactivation of AKT through inhibition of ectopic expressed SHIP1 induces cell death in colon carcinoma cells and derived metastases.

Cellular signalling

Avec: Patrick A H Ehm , Michael Linnebacher , Andreas Block , Christoph Rehbach , Manfred Jücker

Generating Patient-Derived HCC Cell Lines Suitable for Predictive In Vitro and In Vivo Drug Screening by Orthotopic Transplantation.

Cells

Avec: Lisa Staffeldt , Gregor Mattert , Kristoffer Riecken , Götz Rövenstrunk , Anika Volkmar , Asmus Heumann , Mohamed Moustafa , Manfred Jücker , Boris Fehse , Udo Schumacher , Stefan Lüth , Janine Kah

Ikaros sets the threshold for negative B-cell selection by regulation of the signaling strength of the AKT pathway.

Cell communication and signaling : CCS

Avec: Patrick A H Ehm , Stefan Horn , Konstantin Hoffer , Malte Kriegs , Michael Horn , Susanne Giehler , Marcus Nalaskowski , Christoph Rehbach , Martin A Horstmann , Manfred Jücker

Characterization of circulating breast cancer cells with tumorigenic and metastatic capacity.

EMBO molecular medicine

Avec: Claudia Koch , Andra Kuske , Simon A Joosse , Gökhan Yigit , George Sflomos , Sonja Thaler , Daniel J Smit , Stefan Werner , Kerstin Borgmann , Sebastian Gärtner , Parinaz Mossahebi Mohammadi , Laura Battista , Laure Cayrefourcq , Janine Altmüller , Gabriela Salinas-Riester , Kaamini Raithatha , Arne Zibat , Yvonne Goy , Leonie Ott , Kai Bartkowiak , Tuan Zea Tan , Qing Zhou , Michael R Speicher , Volkmar Müller , Tobias M Gorges , Manfred Jücker , Jean-Paul Thiery , Cathrin Brisken , Sabine Riethdorf , Catherine Alix-Panabières , Klaus Pantel

Modeling Spontaneous Bone Metastasis Formation of Solid Human Tumor Xenografts in Mice.

Cancers

Avec: Vera Labitzky , Anke Baranowsky , Hanna Maar , Sandra Hanika , Sarah Starzonek , Ann-Kristin Ahlers , Katrin Stübke , Eva J Koziolek , Markus Heine , Paula Schäfer , Sabine Windhorst , Manfred Jücker , Kristoffer Riecken , Michael Amling , Thorsten Schinke , Udo Schumacher , Ursula Valentiner , Tobias Lange

Distinct functions of AKT isoforms in breast cancer: a comprehensive review.

Cell communication and signaling : CCS

Avec: Nico Hinz , Manfred Jücker

AKT1 and PTEN show the highest affinities among phosphoinositide binding proteins for the second messengers PtdIns(3,4,5)P

Biochemical and biophysical research communications

Avec: Nina Nelson , Adelia Razeto , Alessia Gilardi , Mira Grättinger , Johannes Kirchmair , Manfred Jücker

Truncated O-GalNAc glycans impact on fundamental signaling pathways in pancreatic cancer.

Glycobiology

Avec: Bianca T Hofmann , Aeint-Steffen Picksak , Marcel Kwiatkowski , Katharina Grupp , Manfred Jücker , Kai Bachmann , Baris Mercanoglu , Jakob R Izbicki , Christoph Kahlert , Maximilian Bockhorn , Cenap Güngör , Florian Ewald , Gerrit Wolters-Eisfeld

Targeted PI3K/AKT-hyperactivation induces cell death in chronic lymphocytic leukemia.

Nature communications

Avec: Veronika Ecker , Martina Stumpf , Lisa Brandmeier , Tanja Neumayer , Lisa Pfeuffer , Thomas Engleitner , Ingo Ringshausen , Nina Nelson , Manfred Jücker , Stefan Wanninger , Thorsten Zenz , Clemens Wendtner , Katrin Manske , Katja Steiger , Roland Rad , Markus Müschen , Jürgen Ruland , Maike Buchner

SHIP1 Is Present but Strongly Downregulated in T-ALL, and after Restoration Suppresses Leukemia Growth in a T-ALL Xenotransplantation Mouse Model.

Cells

Avec: Patrick Ehm , Ruth Rietow , Wiebke Wegner , Lara Bußmann , Malte Kriegs , Kevin Dierck , Stefan Horn , Thomas Streichert , Martin Horstmann , Manfred Jücker

Impact of AKT1 on cell invasion and radiosensitivity in a triple negative breast cancer cell line developing brain metastasis.

Frontiers in oncology

Avec: Joanna Kempska , Leticia Oliveira-Ferrer , Astrid Grottke , Minyue Qi , Malik Alawi , Felix Meyer , Kerstin Borgmann , Fabienne Hamester , Kathrin Eylmann , Maila Rossberg , Daniel J Smit , Manfred Jücker , Elena Laakmann , Isabell Witzel , Barbara Schmalfeldt , Volkmar Müller , Karen Legler

Analysis of the FLVR motif of SHIP1 and its importance for the protein stability of SH2 containing signaling proteins.

Cellular signalling

Avec: Patrick A H Ehm , Fabiola Lange , Carolin Hentschel , Anneke Jepsen , Madeleine Glück , Nina Nelson , Bettina Bettin , Christina de Bruyn Kops , Johannes Kirchmair , Marcus Nalaskowski , Manfred Jücker

PI3K/AKT/mTOR signaling as a molecular target in head and neck cancer.

Biochemical pharmacology

Avec: Franziska E Marquard , Manfred Jücker

Characterization of the substrate specificity of the inositol 5-phosphatase SHIP1.

Biochemical and biophysical research communications

Avec: Nina Nelson , Torsten Wundenberg , Hongying Lin , Christoph Rehbach , Stefan Horn , Sabine Windhorst , Manfred Jücker

Ectopic Expression of Hematopoietic SHIP1 in Human Colorectal Cancer.

Biomedicines

Avec: Matthias Schaks , Kristina Allgoewer , Nina Nelson , Patrick Ehm , Asmus Heumann , Florian Ewald , Udo Schumacher , Ronald Simon , Guido Sauter , Manfred Jücker

Knockdown of AKT3 Activates HER2 and DDR Kinases in Bone-Seeking Breast Cancer Cells, Promotes Metastasis In Vivo and Attenuates the TGFβ/CTGF Axis.

Cells

Avec: Nico Hinz , Anke Baranowsky , Michael Horn , Malte Kriegs , Freya Sibbertsen , Daniel J Smit , Philippe Clezardin , Tobias Lange , Thorsten Schinke , Manfred Jücker

JAK2-V617F is a negative regulation factor of SHIP1 protein and thus influences the AKT signaling pathway in patients with Myeloproliferative neoplasm (MPN).

The international journal of biochemistry & cell biology

Avec: Madeleine Glück , Lina Dally , Manfred Jücker , Patrick Ehm

All Three AKT Isoforms Can Upregulate Oxygen Metabolism and Lactate Production in Human Hepatocellular Carcinoma Cell Lines.

International journal of molecular sciences

Avec: Ling-Yu Tian , Daniel J Smit , Nadezhda V Popova , Stefan Horn , Lis Noelia Velasquez , Samuel Huber , Manfred Jücker

K-Ras(V12) differentially affects the three Akt isoforms in lung and pancreatic carcinoma cells and upregulates E-cadherin and NCAM via Akt3.

Cell communication and signaling : CCS

Avec: Rebekka Geißert , Angela Lammert , Stefanie Wirth , Rabea Hönig , Dirk Lohfink , Monika Unger , Denis Pek , Konstantin Schlüter , Theresa Scheftschik , Daniel J Smit , Manfred Jücker , Andre Menke , Klaudia Giehl

Circulating tumor cells as a promising target for individualized drug susceptibility tests in cancer therapy.

Biochemical pharmacology

Avec: Daniel J Smit , Klaus Pantel , Manfred Jücker

AKT in Bone Metastasis of Solid Tumors: A Comprehensive Review.

Cancers

Avec: Nico Hinz , Manfred Jücker

Differential regulation of extracellular matrix proteins in three recurrent liver metastases of a single patient with colorectal cancer.

Clinical & experimental metastasis

Avec: Hannah Voß , Marcus Wurlitzer , Daniel J Smit , Florian Ewald , Malik Alawi , Michael Spohn , Daniela Indenbirken , Maryam Omidi , Kerstin David , Hartmut Juhl , Ronald Simon , Guido Sauter , Lutz Fischer , Jakob R Izbicki , Mark P Molloy , Björn Nashan , Hartmut Schlüter , Manfred Jücker

Combined Targeting of AKT and mTOR Inhibits Proliferation of Human NF1-Associated Malignant Peripheral Nerve Sheath Tumour Cells In Vitro but not in a Xenograft Mouse Model In Vivo.

International journal of molecular sciences

Avec: Alexander Schulte , Florian Ewald , Melanie Spyra , Daniel J Smit , Wei Jiang , Johannes Salamon , Manfred Jücker , Victor-Felix Mautner

High Sensitivity of Circulating Tumor Cells Derived from a Colorectal Cancer Patient for Dual Inhibition with AKT and mTOR Inhibitors.

Cells

Avec: Daniel J Smit , Laure Cayrefourcq , Marie-Therese Haider , Nico Hinz , Klaus Pantel , Catherine Alix-Panabières , Manfred Jücker

The Functional Role of Extracellular Matrix Proteins in Cancer.

Cancers

Avec: Nadezhda V Popova , Manfred Jücker

Investigation of the function of the PI3-Kinase / AKT signaling pathway for leukemogenesis and therapy of acute childhood lymphoblastic leukemia (ALL).

Cellular signalling

Avec: Patrick Ehm , Astrid Grottke , Bettina Bettin , Manfred Jücker

The Role of PI3K/AKT/mTOR Signaling in Hepatocellular Carcinoma Metabolism.

International journal of molecular sciences

Avec: Ling-Yu Tian , Daniel J Smit , Manfred Jücker

The Role of mTOR Signaling as a Therapeutic Target in Cancer.

International journal of molecular sciences

Avec: Nadezhda V Popova , Manfred Jücker

Combined Targeting of AKT and mTOR Synergistically Inhibits Formation of Primary Colorectal Carcinoma Tumouroids

Anticancer research

Avec: Dominik Nörz , Christina S Mullins , Daniel J Smit , Michael Linnebacher , Grith Hagel , Alp Mirdogan , Jacqueline Siekiera , Patrick Ehm , Jakob R Izbicki , Andreas Block , Ole Thastrup , Manfred Jücker

Combined Targeting of AKT and mTOR Inhibits Tumor Formation of EpCAM

Cancers

Avec: Mohamed Moustafa , Katarzyna-Krystyna Dähling , Armin Günther , Leonie Riebandt , Daniel J Smit , Kristoffer Riecken , Carina Schröder , Ruimeng Zhuang , Till Krech , Malte Kriegs , Boris Fehse , Jakob R Izbicki , Lutz Fischer , Björn Nashan , Jun Li , Manfred Jücker

AKT Isoforms as a Target in Cancer and Immunotherapy.

Current topics in microbiology and immunology

Avec: Daniel J Smit , Manfred Jücker

Reduced expression and activity of patient-derived SHIP1 phosphatase domain mutants.

Cellular signalling

Avec: Patrick Ehm , Nina Nelson , Susanne Giehler , Matthias Schaks , Bettina Bettin , Johannes Kirchmair , Manfred Jücker

Tumor cell integrin β4 and tumor stroma E-/P-selectin cooperatively regulate tumor growth in vivo.

Journal of hematology & oncology

Avec: Sandra Genduso , Vera Freytag , Daniela Schetler , Lennart Kirchner , Alina Schiecke , Hanna Maar , Daniel Wicklein , Florian Gebauer , Katharina Bröker , Christine Stürken , Karin Milde-Langosch , Leticia Oliveira-Ferrer , Franz L Ricklefs , Florian Ewald , Gerrit Wolters-Eisfeld , Kristoffer Riecken , Ludmilla Unrau , Linda Krause , Hanibal Bohnenberger , Anne Offermann , Sven Perner , Susanne Sebens , Katrin Lamszus , Linda Diehl , Stefan Linder , Manfred Jücker , Udo Schumacher , Tobias Lange

The Functional Roles of the Src Homology 2 Domain-Containing Inositol 5-Phosphatases SHIP1 and SHIP2 in the Pathogenesis of Human Diseases.

International journal of molecular sciences

Avec: Spike Murphy Müller , Manfred Jücker

Functional characterization of PI3K C2 domain mutations detected in breast cancer circulating tumor cells and metastatic cells.

Cellular signalling

Avec: Daniel J Smit , Helena Brauer , Stefan Horn , Gökhan Yigit , Marie-Therese Haider , Vivian Pogenberg , Udo Schumacher , Klaus Pantel , Manfred Jücker

Analysis of the Plasticity of Circulating Tumor Cells Reveals Differentially Regulated Kinases During the Suspension-to-Adherent Transition.

Cancer medicine

Avec: Daniel J Smit , Konstantin Hoffer , Bettina Bettin , Malte Kriegs , Laure Cayrefourcq , Udo Schumacher , Klaus Pantel , Catherine Alix-Panabières , Manfred Jücker

Réseau de co-auteurs

Daniel J Smit 15 collaborations

Patrick Ehm 7 collaborations

Udo Schumacher 6 collaborations

Nina Nelson 6 collaborations

Bettina Bettin 5 collaborations

Stefan Horn 5 collaborations

Malte Kriegs 5 collaborations

Klaus Pantel 5 collaborations

Florian Ewald 5 collaborations

Tobias Lange 4 collaborations

Kristoffer Riecken 4 collaborations

Nico Hinz 4 collaborations

Jakob R Izbicki 4 collaborations

Patrick A H Ehm 3 collaborations

Christoph Rehbach 3 collaborations

Laure Cayrefourcq 3 collaborations

Catherine Alix-Panabières 3 collaborations

Johannes Kirchmair 3 collaborations

Nadezhda V Popova 3 collaborations

Vera Labitzky 2 collaborations

Hanibal Bohnenberger 2 collaborations

Michael Linnebacher 2 collaborations

Andreas Block 2 collaborations

Asmus Heumann 2 collaborations

Mohamed Moustafa 2 collaborations

Boris Fehse 2 collaborations

Konstantin Hoffer 2 collaborations

Michael Horn 2 collaborations

Susanne Giehler 2 collaborations

Marcus Nalaskowski 2 collaborations

Gökhan Yigit 2 collaborations

Kerstin Borgmann 2 collaborations

Volkmar Müller 2 collaborations

Anke Baranowsky 2 collaborations

Hanna Maar 2 collaborations

Sabine Windhorst 2 collaborations

Thorsten Schinke 2 collaborations

Gerrit Wolters-Eisfeld 2 collaborations

Leticia Oliveira-Ferrer 2 collaborations

Astrid Grottke 2 collaborations

Malik Alawi 2 collaborations

Madeleine Glück 2 collaborations

Matthias Schaks 2 collaborations

Ronald Simon 2 collaborations

Guido Sauter 2 collaborations

Ling-Yu Tian 2 collaborations

Lutz Fischer 2 collaborations

Björn Nashan 2 collaborations

Marie-Therese Haider 2 collaborations

Omar Elakad 1 collaboration

Björn Häupl 1 collaboration

Sha Yao 1 collaboration

Stefan Küffer 1 collaboration

Alexander von Hammerstein-Equord 1 collaboration

Bernhard C Danner 1 collaboration

Henning Urlaub 1 collaboration

Philipp Ströbel 1 collaboration

Thomas Oellerich 1 collaboration

Lisa Staffeldt 1 collaboration

Gregor Mattert 1 collaboration

Götz Rövenstrunk 1 collaboration

Anika Volkmar 1 collaboration

Stefan Lüth 1 collaboration

Janine Kah 1 collaboration

Martin A Horstmann 1 collaboration

Claudia Koch 1 collaboration

Andra Kuske 1 collaboration

Simon A Joosse 1 collaboration

George Sflomos 1 collaboration

Sonja Thaler 1 collaboration

Stefan Werner 1 collaboration

Sebastian Gärtner 1 collaboration

Parinaz Mossahebi Mohammadi 1 collaboration

Laura Battista 1 collaboration

Janine Altmüller 1 collaboration

Gabriela Salinas-Riester 1 collaboration

Kaamini Raithatha 1 collaboration

Arne Zibat 1 collaboration

Yvonne Goy 1 collaboration

Leonie Ott 1 collaboration

Kai Bartkowiak 1 collaboration

Tuan Zea Tan 1 collaboration

Qing Zhou 1 collaboration

Michael R Speicher 1 collaboration

Tobias M Gorges 1 collaboration

Jean-Paul Thiery 1 collaboration

Cathrin Brisken 1 collaboration

Sabine Riethdorf 1 collaboration

Sandra Hanika 1 collaboration

Sarah Starzonek 1 collaboration

Ann-Kristin Ahlers 1 collaboration

Katrin Stübke 1 collaboration

Eva J Koziolek 1 collaboration

Markus Heine 1 collaboration

Paula Schäfer 1 collaboration

Michael Amling 1 collaboration

Ursula Valentiner 1 collaboration

Adelia Razeto 1 collaboration

Alessia Gilardi 1 collaboration

Mira Grättinger 1 collaboration

Bianca T Hofmann 1 collaboration

Aeint-Steffen Picksak 1 collaboration

Marcel Kwiatkowski 1 collaboration

Katharina Grupp 1 collaboration

Kai Bachmann 1 collaboration

Baris Mercanoglu 1 collaboration

Christoph Kahlert 1 collaboration

Maximilian Bockhorn 1 collaboration

Cenap Güngör 1 collaboration

Veronika Ecker 1 collaboration

Martina Stumpf 1 collaboration

Lisa Brandmeier 1 collaboration

Tanja Neumayer 1 collaboration

Lisa Pfeuffer 1 collaboration

Thomas Engleitner 1 collaboration

Ingo Ringshausen 1 collaboration

Stefan Wanninger 1 collaboration

Thorsten Zenz 1 collaboration

Clemens Wendtner 1 collaboration

Katrin Manske 1 collaboration

Katja Steiger 1 collaboration

Roland Rad 1 collaboration

Markus Müschen 1 collaboration

Jürgen Ruland 1 collaboration

Maike Buchner 1 collaboration

Ruth Rietow 1 collaboration

Wiebke Wegner 1 collaboration

Lara Bußmann 1 collaboration

Kevin Dierck 1 collaboration

Thomas Streichert 1 collaboration

Martin Horstmann 1 collaboration

Joanna Kempska 1 collaboration

Minyue Qi 1 collaboration

Felix Meyer 1 collaboration

Fabienne Hamester 1 collaboration

Kathrin Eylmann 1 collaboration

Maila Rossberg 1 collaboration

Elena Laakmann 1 collaboration

Isabell Witzel 1 collaboration

Barbara Schmalfeldt 1 collaboration

Karen Legler 1 collaboration

Fabiola Lange 1 collaboration

Carolin Hentschel 1 collaboration

Anneke Jepsen 1 collaboration

Christina de Bruyn Kops 1 collaboration

Franziska E Marquard 1 collaboration

Torsten Wundenberg 1 collaboration

Hongying Lin 1 collaboration

Kristina Allgoewer 1 collaboration

Freya Sibbertsen 1 collaboration

Philippe Clezardin 1 collaboration

Lina Dally 1 collaboration

Lis Noelia Velasquez 1 collaboration

Samuel Huber 1 collaboration

Rebekka Geißert 1 collaboration

Angela Lammert 1 collaboration

Stefanie Wirth 1 collaboration

Rabea Hönig 1 collaboration

Dirk Lohfink 1 collaboration

Monika Unger 1 collaboration

Denis Pek 1 collaboration

Konstantin Schlüter 1 collaboration

Theresa Scheftschik 1 collaboration

Andre Menke 1 collaboration

Klaudia Giehl 1 collaboration

Hannah Voß 1 collaboration

Marcus Wurlitzer 1 collaboration

Michael Spohn 1 collaboration

Daniela Indenbirken 1 collaboration

Maryam Omidi 1 collaboration

Kerstin David 1 collaboration

Hartmut Juhl 1 collaboration

Mark P Molloy 1 collaboration

Hartmut Schlüter 1 collaboration

Alexander Schulte 1 collaboration

Melanie Spyra 1 collaboration

Wei Jiang 1 collaboration

Johannes Salamon 1 collaboration

Victor-Felix Mautner 1 collaboration

Dominik Nörz 1 collaboration

Christina S Mullins 1 collaboration

Grith Hagel 1 collaboration

Alp Mirdogan 1 collaboration

Jacqueline Siekiera 1 collaboration

Ole Thastrup 1 collaboration

Katarzyna-Krystyna Dähling 1 collaboration

Armin Günther 1 collaboration

Leonie Riebandt 1 collaboration

Carina Schröder 1 collaboration

Ruimeng Zhuang 1 collaboration

Till Krech 1 collaboration

Jun Li 1 collaboration

Sandra Genduso 1 collaboration

Vera Freytag 1 collaboration

Daniela Schetler 1 collaboration

Lennart Kirchner 1 collaboration

Alina Schiecke 1 collaboration

Daniel Wicklein 1 collaboration

Florian Gebauer 1 collaboration

Katharina Bröker 1 collaboration

Christine Stürken 1 collaboration

Karin Milde-Langosch 1 collaboration

Franz L Ricklefs 1 collaboration

Ludmilla Unrau 1 collaboration

Linda Krause 1 collaboration

Anne Offermann 1 collaboration

Sven Perner 1 collaboration

Susanne Sebens 1 collaboration

Katrin Lamszus 1 collaboration

Linda Diehl 1 collaboration

Stefan Linder 1 collaboration

Spike Murphy Müller 1 collaboration

Helena Brauer 1 collaboration

Vivian Pogenberg 1 collaboration