Malcolm D Walkinshaw

Affiliations

Institute of Quantitative Biology, Biochemistry and Biotechnology, University of Edinburgh, King's Buildings, Edinburgh EH9 3BF, UK.

Publications (13)

Pyruvate Kinase Regulates the Pentose-Phosphate Pathway in Response to Hypoxia in Mycobacterium tuberculosis.

Journal of molecular biology

Avec: Wenhe Zhong , Jingjing Guo , Liang Cui , Yok Hian Chionh , Kuohan Li , Abbas El Sahili , Qixu Cai , Meng Yuan , Paul A M Michels , Linda A Fothergill-Gilmore , Malcolm D Walkinshaw , Yuguang Mu , Julien Lescar , Peter C Dedon

Structural and kinetic characterization of Trypanosoma congolense pyruvate kinase.

Molecular and biochemical parasitology

Avec: Joar Esteban Pinto Torres , Meng Yuan , Julie Goossens , Wim Versées , Guy Caljon , Paul A Michels , Malcolm D Walkinshaw , Stefan Magez , Yann G-J Sterckx

A computationally designed binding mode flip leads to a novel class of potent tri-vector cyclophilin inhibitors.

Chemical science

Avec: Alessio De Simone , Charis Georgiou , Harris Ioannidis , Arun A Gupta , Jordi Juárez-Jiménez , Dahlia Doughty-Shenton , Elizabeth A Blackburn , Martin A Wear , Jonathan P Richards , Paul N Barlow , Neil Carragher , Malcolm D Walkinshaw , Alison N Hulme , Julien Michel

Kinetic and structural studies of Trypanosoma and Leishmania phosphofructokinases show evolutionary divergence and identify AMP as a switch regulating glycolysis versus gluconeogenesis.

The FEBS journal

Avec: Peter M Fernandes , James Kinkead , Iain W McNae , Monserrat Vásquez-Valdivieso , Martin A Wear , Paul A M Michels , Malcolm D Walkinshaw

Pyruvate kinase from Plasmodium falciparum: Structural and kinetic insights into the allosteric mechanism.

Biochemical and biophysical research communications

Avec: Wenhe Zhong , Kuohan Li , Qixu Cai , Jingjing Guo , Meng Yuan , Yee Hwa Wong , Malcolm D Walkinshaw , Linda A Fothergill-Gilmore , Paul A M Michels , Peter C Dedon , Julien Lescar

Biochemical and transcript level differences between the three human phosphofructokinases show optimisation of each isoform for specific metabolic niches.

The Biochemical journal

Avec: Peter M Fernandes , James Kinkead , Iain McNae , Paul A M Michels , Malcolm D Walkinshaw

Fast acting allosteric phosphofructokinase inhibitors block trypanosome glycolysis and cure acute African trypanosomiasis in mice.

Nature communications

Avec: Iain W McNae , James Kinkead , Divya Malik , Li-Hsuan Yen , Martin K Walker , Chris Swain , Scott P Webster , Nick Gray , Peter M Fernandes , Elmarie Myburgh , Elizabeth A Blackburn , Ryan Ritchie , Carol Austin , Martin A Wear , Adrian J Highton , Andrew J Keats , Antonio Vong , Jacqueline Dornan , Jeremy C Mottram , Paul A M Michels , Simon Pettit , Malcolm D Walkinshaw

Dynamic design: manipulation of millisecond timescale motions on the energy landscape of cyclophilin A.

Chemical science

Avec: Jordi Juárez-Jiménez , Arun A Gupta , Gogulan Karunanithy , Antonia S J S Mey , Charis Georgiou , Harris Ioannidis , Alessio De Simone , Paul N Barlow , Alison N Hulme , Malcolm D Walkinshaw , Andrew J Baldwin , Julien Michel

Peripheral blood immune cell profiling of acute corneal transplant rejection.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons

Avec: Jesper Hjortdal , Matthew D Griffin , Marion Cadoux , W John Armitage , Max Bylesjo , Peadar Mac Gabhann , Conor C Murphy , Uwe Pleyer , Derek Tole , Bertrand Vabres , Malcolm D Walkinshaw , Pierre-Antoine Gourraud , Matilde Karakachoff , Sophie Brouard , Nicolas Degauque

The kinetic characteristics of human and trypanosomatid phosphofructokinases for the reverse reaction.

The Biochemical journal

Avec: Peter M Fernandes , James Kinkead , Iain W McNae , Frédéric Bringaud , Paul A M Michels , Malcolm D Walkinshaw

Oligopeptide Signaling through TbGPR89 Drives Trypanosome Quorum Sensing.

Cell

Avec: Federico Rojas , Eleanor Silvester , Julie Young , Rachel Milne , Mabel Tettey , Douglas R Houston , Malcolm D Walkinshaw , Irene Pérez-Pi , Manfred Auer , Helen Denton , Terry K Smith , Joanne Thompson , Keith R Matthews

The unusual kinetics of lactate dehydrogenase of Schistosoma mansoni and their role in the rapid metabolic switch after penetration of the mammalian host.

International journal for parasitology

Avec: Michiel L Bexkens , Olivier M F Martin , Jos M van den Heuvel , Marion G J Schmitz , Bas Teusink , Barbara M Bakker , Jaap J van Hellemond , Jurgen R Haanstra , Malcolm D Walkinshaw , Aloysius G M Tielens

Metabolic insights into phosphofructokinase inhibition in bloodstream-form trypanosomes.

Frontiers in cellular and infection microbiology

Avec: Zandile Nare , Tessa Moses , Karl Burgess , Achim Schnaufer , Malcolm D Walkinshaw , Paul A M Michels

Réseau de co-auteurs

Paul A M Michels 7 collaborations

Peter M Fernandes 4 collaborations

James Kinkead 4 collaborations

Meng Yuan 3 collaborations

Martin A Wear 3 collaborations

Iain W McNae 3 collaborations

Wenhe Zhong 2 collaborations

Jingjing Guo 2 collaborations

Kuohan Li 2 collaborations

Qixu Cai 2 collaborations

Linda A Fothergill-Gilmore 2 collaborations

Julien Lescar 2 collaborations

Peter C Dedon 2 collaborations

Alessio De Simone 2 collaborations

Charis Georgiou 2 collaborations

Harris Ioannidis 2 collaborations

Arun A Gupta 2 collaborations

Jordi Juárez-Jiménez 2 collaborations

Elizabeth A Blackburn 2 collaborations

Paul N Barlow 2 collaborations

Alison N Hulme 2 collaborations

Julien Michel 2 collaborations

Liang Cui 1 collaboration

Yok Hian Chionh 1 collaboration

Abbas El Sahili 1 collaboration

Yuguang Mu 1 collaboration

Joar Esteban Pinto Torres 1 collaboration

Julie Goossens 1 collaboration

Wim Versées 1 collaboration

Guy Caljon 1 collaboration

Paul A Michels 1 collaboration

Stefan Magez 1 collaboration

Yann G-J Sterckx 1 collaboration

Dahlia Doughty-Shenton 1 collaboration

Jonathan P Richards 1 collaboration

Neil Carragher 1 collaboration

Monserrat Vásquez-Valdivieso 1 collaboration

Yee Hwa Wong 1 collaboration

Iain McNae 1 collaboration

Divya Malik 1 collaboration

Li-Hsuan Yen 1 collaboration

Martin K Walker 1 collaboration

Chris Swain 1 collaboration

Scott P Webster 1 collaboration

Nick Gray 1 collaboration

Elmarie Myburgh 1 collaboration

Ryan Ritchie 1 collaboration

Carol Austin 1 collaboration

Adrian J Highton 1 collaboration

Andrew J Keats 1 collaboration

Antonio Vong 1 collaboration

Jacqueline Dornan 1 collaboration

Jeremy C Mottram 1 collaboration

Simon Pettit 1 collaboration

Gogulan Karunanithy 1 collaboration

Antonia S J S Mey 1 collaboration

Andrew J Baldwin 1 collaboration

Jesper Hjortdal 1 collaboration

Matthew D Griffin 1 collaboration

Marion Cadoux 1 collaboration

W John Armitage 1 collaboration

Max Bylesjo 1 collaboration

Peadar Mac Gabhann 1 collaboration

Conor C Murphy 1 collaboration

Uwe Pleyer 1 collaboration

Derek Tole 1 collaboration

Bertrand Vabres 1 collaboration

Pierre-Antoine Gourraud 1 collaboration

Matilde Karakachoff 1 collaboration

Sophie Brouard 1 collaboration

Nicolas Degauque 1 collaboration

Frédéric Bringaud 1 collaboration

Federico Rojas 1 collaboration

Eleanor Silvester 1 collaboration

Julie Young 1 collaboration

Rachel Milne 1 collaboration

Mabel Tettey 1 collaboration

Douglas R Houston 1 collaboration

Irene Pérez-Pi 1 collaboration

Manfred Auer 1 collaboration

Helen Denton 1 collaboration

Terry K Smith 1 collaboration

Joanne Thompson 1 collaboration

Keith R Matthews 1 collaboration

Michiel L Bexkens 1 collaboration

Olivier M F Martin 1 collaboration

Jos M van den Heuvel 1 collaboration

Marion G J Schmitz 1 collaboration

Bas Teusink 1 collaboration

Barbara M Bakker 1 collaboration

Jaap J van Hellemond 1 collaboration

Jurgen R Haanstra 1 collaboration

Aloysius G M Tielens 1 collaboration

Zandile Nare 1 collaboration

Tessa Moses 1 collaboration

Karl Burgess 1 collaboration

Achim Schnaufer 1 collaboration