Lorraine J Gudas

Affiliations

Department of Pharmacology, Weill Cornell Medical College, New York, NY, USA.

Publications (41)

Inhibition of UBE2L6 attenuates ISGylation and impedes ATRA-induced differentiation of leukemic cells.

Molecular oncology

Avec: Nina Orfali , Deborah Shan-Krauer , Tracey R O'Donovan , Nigel P Mongan , Lorraine J Gudas , Mary R Cahill , Mario P Tschan , Sharon L McKenna

Modification of stem cell states by alcohol and acetaldehyde.

Chemico-biological interactions

Avec: Ryan N Serio , Lorraine J Gudas

Different Effects of Knockouts in ALDH2 and ACSS2 on Embryonic Stem Cell Differentiation.

Alcoholism, clinical and experimental research

Avec: Ryan N Serio , Changyuan Lu , Steven S Gross , Lorraine J Gudas

Fenretinide Improves Intestinal Barrier Function and Mitigates Alcohol Liver Disease.

Frontiers in pharmacology

Avec: Xiao-Han Tang , Marta Melis , Karen Mai , Lorraine J Gudas , Steven E Trasino

Pancreatic Ductal Adenocarcinoma: New Insights into the Actions of Vitamin A.

Oncology research and treatment

Avec: Eduardo Mere Del Aguila , Xiao-Han Tang , Lorraine J Gudas

Retinoid metabolism: new insights.

Journal of molecular endocrinology

Avec: Lorraine J Gudas

NDUFA4L2 reduces mitochondrial respiration resulting in defective lysosomal trafficking in clear cell renal cell carcinoma.

Cancer biology & therapy

Avec: Jaclyn M Kubala , Kristian B Laursen , Ryan Schreiner , Ryan M Williams , Johannes C van der Mijn , Michael J Crowley , Nigel P Mongan , David M Nanus , Daniel A Heller , Lorraine J Gudas

Combined Metabolomics and Genome-Wide Transcriptomics Analyses Show Multiple HIF1α-Induced Changes in Lipid Metabolism in Early Stage Clear Cell Renal Cell Carcinoma.

Translational oncology

Avec: Johannes C van der Mijn , Leiping Fu , Francesca Khani , Tuo Zhang , Ana M Molina , Christopher E Barbieri , Qiuying Chen , Steven S Gross , Lorraine J Gudas , David M Nanus

Doxycycline-induced exogenous Bmi-1 expression enhances tumor formation in a murine model of oral squamous cell carcinoma.

Cancer biology & therapy

Avec: Jocelin M Kalish , Xiao-Han Tang , Theresa Scognamiglio , Tuo Zhang , Lorraine J Gudas

The genomic landscape of metastatic clear cell renal cell carcinoma after systemic therapy.

Molecular oncology

Avec: Johannes C van der Mijn , Kenneth W Eng , Pooja Chandra , Evan Fernandez , Sinan Ramazanoglu , Alexandros Sigaras , Clara Oromendia , Lorraine J Gudas , Scott T Tagawa , David M Nanus , Bishoy F Faltas , Himisha Beltran , Cora N Sternberg , Olivier Elemento , Andrea Sboner , Juan Miguel Mosquera , Ana M Molina

EZH2 knockout in oral cavity basal epithelia causes more invasive squamous cell carcinomas.

Carcinogenesis

Avec: Jorge Baquero , Xiao-Han Tang , Theresa Scognamiglio , Lorraine J Gudas

The transcription factor bmi1 increases hypoxic signaling in oral cavity epithelia.

Biochimica et biophysica acta. Molecular basis of disease

Avec: Jorge Baquero , Xiao-Han Tang , Annalisa Ferrotta , Tuo Zhang , Krysta M DiKun , Lorraine J Gudas

Exploring anti-androgen therapies in hormone dependent prostate cancer and new therapeutic routes for castration resistant prostate cancer.

Frontiers in endocrinology

Avec: Anna E Harris , Veronika M Metzler , Jennifer Lothion-Roy , Dhruvika Varun , Corinne L Woodcock , Daisy B Haigh , Chantelle Endeley , Maria Haque , Michael S Toss , Mansour Alsaleem , Jenny L Persson , Lorraine J Gudas , Emad Rakha , Brian D Robinson , Francesca Khani , Laura M Martin , Jenna E Moyer , Juliette Brownlie , Srinivasan Madhusudan , Cinzia Allegrucci , Victoria H James , Catrin S Rutland , Rupert G Fray , Atara Ntekim , Simone de Brot , Nigel P Mongan , Jennie N Jeyapalan

Effects of AM80 compared to AC261066 in a high fat diet mouse model of liver disease.

PloS one

Avec: Marta Melis , Xiao-Han Tang , Steven E Trasino , Viral M Patel , Daniel J Stummer , Jose Jessurun , Lorraine J Gudas

Ethanol promotes differentiation of embryonic stem cells through retinoic acid receptor-γ.

The Journal of biological chemistry

Avec: Ryan N Serio , Kristian B Laursen , Alison M Urvalek , Steven S Gross , Lorraine J Gudas

A retinoic acid receptor β2 agonist attenuates transcriptome and metabolome changes underlying nonalcohol-associated fatty liver disease.

The Journal of biological chemistry

Avec: Xiao-Han Tang , Marta Melis , Changyuan Lu , Andrew Rappa , Tuo Zhang , Jose Jessurun , Steven S Gross , Lorraine J Gudas

Mitochondrial Ndufa4l2 Enhances Deposition of Lipids and Expression of Ca9 in the TRACK Model of Early Clear Cell Renal Cell Carcinoma.

Frontiers in oncology

Avec: Kristian B Laursen , Qiuying Chen , Francesca Khani , Nabeel Attarwala , Steve S Gross , Lukas Dow , David M Nanus , Lorraine J Gudas

The Effect of Ethanol Consumption on Composition and Morphology of Femur Cortical Bone in Wild-Type and ALDH2*2-Homozygous Mice.

Calcified tissue international

Avec: Andrey V Malkovskiy , Lauren D Van Wassenhove , Yury Goltsev , Kwame Osei-Sarfo , Che-Hong Chen , Bradley Efron , Lorraine J Gudas , Daria Mochly-Rosen , Jayakumar Rajadas

Synthetic Retinoids Beyond Cancer Therapy.

Annual review of pharmacology and toxicology

Avec: Lorraine J Gudas

Vitamin A and retinoid signaling in the kidneys.

Pharmacology & therapeutics

Avec: Krysta M DiKun , Lorraine J Gudas

Novel genetically engineered mouse models for clear cell renal cell carcinoma.

Scientific reports

Avec: Johannes C van der Mijn , Kristian B Laursen , Leiping Fu , Francesca Khani , Lukas E Dow , Dawid G Nowak , Qiuying Chen , Steven S Gross , David M Nanus , Lorraine J Gudas

All-trans retinoic acid (ATRA)-induced TFEB expression is required for myeloid differentiation in acute promyelocytic leukemia (APL).

European journal of haematology

Avec: Nina Orfali , Tracey R O'Donovan , Mary R Cahill , Dalyia Benjamin , David M Nanus , Sharon L McKenna , Lorraine J Gudas , Nigel P Mongan

Lentiviral-Mediated shRNA Approaches: Applications in Cellular Differentiation and Autophagy.

Methods in molecular biology (Clifton, N.J.)

Avec: Nina Orfali , Jennie N Jeyapalan , Corinne L Woodcock , Tracey R O'Donovan , Dalyia Benjamin , Mary Cahill , Sharon McKenna , Lorraine J Gudas , Nigel P Mongan

NCI 6896: a phase I trial of vorinostat (SAHA) and isotretinoin (13-cis retinoic acid) in the treatment of patients with advanced renal cell carcinoma.

Investigational new drugs

Avec: Ana M Molina , Johannes C van der Mijn , Paul Christos , John Wright , Charlene Thomas , Janice P Dutcher , David M Nanus , Scott T Tagawa , Lorraine J Gudas

A retinoic acid receptor β2 agonist protects against alcohol liver disease and modulates hepatic expression of canonical retinoid metabolism genes.

BioFactors (Oxford, England)

Avec: Marta Melis , Xiao-Han Tang , Nabeel Attarwala , Qiuying Chen , Carlos Prishker , Lihui Qin , Steven S Gross , Lorraine J Gudas , Steven E Trasino

Fenretinide Reduces Intestinal Mucin-2-Positive Goblet Cells in Chronic Alcohol Abuse.

Pharmacology

Avec: Marta Melis , Xiao-Han Tang , Karen Mai , Lorraine J Gudas , Steven E Trasino

Retinoic acid receptor α activity in proximal tubules prevents kidney injury and fibrosis.

Proceedings of the National Academy of Sciences of the United States of America

Avec: Krysta M DiKun , Xiao-Han Tang , Leiping Fu , Mary E Choi , Changyuan Lu , Lorraine J Gudas

The METTL3 RNA Methyltransferase Regulates Transcriptional Networks in Prostate Cancer.

Cancers

Avec: Daisy B Haigh , Corinne L Woodcock , Jennifer Lothion-Roy , Anna E Harris , Veronika M Metzler , Jenny L Persson , Brian D Robinson , Francesca Khani , Mansour Alsaleem , Atara Ntekim , Srinivasan Madhusudan , Melissa B Davis , Kristian B Laursen , Lorraine J Gudas , Catrin S Rutland , Michael S Toss , Nathan Archer , Zsuzsanna Bodi , Emad A Rakha , Rupert G Fray , Jennie N Jeyapalan , Nigel P Mongan

The KDM5B and KDM1A lysine demethylases cooperate in regulating androgen receptor expression and signalling in prostate cancer.

Frontiers in cell and developmental biology

Avec: Veronika M Metzler , Simone de Brot , Daisy B Haigh , Corinne L Woodcock , Jennifer Lothion-Roy , Anna E Harris , Emeli M Nilsson , Atara Ntekim , Jenny L Persson , Brian D Robinson , Francesca Khani , Kristian B Laursen , Lorraine J Gudas , Michael S Toss , Srinivasan Madhusudan , Emad Rakha , David M Heery , Catrin S Rutland , Nigel P Mongan , Jennie N Jeyapalan

Validation of risk factors for recurrence of renal cell carcinoma: Results from a large single-institution series.

PloS one

Avec: Johannes C van der Mijn , Bashir Al Hussein Al Awamlh , Aleem Islam Khan , Lina Posada-Calderon , Clara Oromendia , Jonathan Fainberg , Mark Alshak , Rahmi Elahjji , Hudson Pierce , Benjamin Taylor , Lorraine J Gudas , David M Nanus , Ana M Molina , Joseph Del Pizzo , Douglas S Scherr

Mutations in long-lived epithelial stem cells and their clonal progeny in pre-malignant lesions and in oral squamous cell carcinoma.

Carcinogenesis

Avec: Marta Melis , Tuo Zhang , Theresa Scognamiglio , Lorraine J Gudas

Retinoids induce antagonism between FOXO3A and FOXM1 transcription factors in human oral squamous cell carcinoma (OSCC) cells.

PloS one

Avec: Kwame Osei-Sarfo , Lorraine J Gudas

Kidney-Targeted Redox Scavenger Therapy Prevents Cisplatin-Induced Acute Kidney Injury.

Frontiers in pharmacology

Avec: Ryan M Williams , Janki Shah , Elizabeth Mercer , Helen S Tian , Vanessa Thompson , Justin M Cheung , Madeline Dorso , Jaclyn M Kubala , Lorraine J Gudas , Elisa de Stanchina , Edgar A Jaimes , Daniel A Heller

A Retinoic Acid Receptor

The Journal of pharmacology and experimental therapeutics

Avec: Xiao-Han Tang , Jessica Gambardella , Stanislovas Jankauskas , Xujun Wang , Gaetano Santulli , Lorraine J Gudas , Roberto Levi

Retinoids in the Pathogenesis and Treatment of Liver Diseases.

Nutrients

Avec: Marta Melis , Xiao-Han Tang , Steven E Trasino , Lorraine J Gudas

Transcriptional and metabolic remodeling in clear cell renal cell carcinoma caused by ATF4 activation and the integrated stress response (ISR).

Molecular carcinogenesis

Avec: Johannes C van der Mijn , Qiuying Chen , Kristian B Laursen , Francesca Khani , Xiaofei Wang , Princesca Dorsaint , Andrea Sboner , Steven S Gross , David M Nanus , Lorraine J Gudas

All-

Frontiers in oncology

Avec: Dalyia N Benjamin , Tracey R O'Donovan , Kristian B Laursen , Nina Orfali , Mary R Cahill , Nigel P Mongan , Lorraine J Gudas , Sharon L McKenna

Clinical and molecular significance of the RNA m

Frontiers in genetics

Avec: Jennifer Lothion-Roy , Daisy B Haigh , Anna E Harris , Veronika M Metzler , Mansour Alsaleem , Michael S Toss , Yousif Kariri , Atara Ntekim , Brian D Robinson , Francesca Khani , Lorraine J Gudas , Cinzia Allegrucci , Victoria H James , Srinivasan Madhusudan , Melissa Mather , Richard D Emes , Nathan Archer , Rupert G Fray , Emad Rakha , Jennie N Jeyapalan , Catrin S Rutland , Nigel P Mongan , Corinne L Woodcock

Transcriptomic analysis predicts the risk of progression of premalignant lesions in human tongue.

Discover. Oncology

Avec: Tuo Zhang , David Kutler , Theresa Scognamiglio , Lorraine J Gudas , Xiao-Han Tang

Retinoic Acid Receptor β Loss in Hepatocytes Increases Steatosis and Elevates the Integrated Stress Response in Alcohol-Associated Liver Disease.

International journal of molecular sciences

Avec: Marta Melis , Steven E Trasino , Xiao-Han Tang , Andrew Rappa , Tuo Zhang , Lihui Qin , Lorraine J Gudas

Epitranscriptomic mechanisms of androgen signalling and prostate cancer.

Neoplasia (New York, N.Y.)

Avec: Rodhan Patke , Anna E Harris , Corinne L Woodcock , Rachel Thompson , Rute Santos , Amber Kumari , Cinzia Allegrucci , Nathan Archer , Lorraine J Gudas , Brian D Robinson , Jenny L Persson , Rupert Fray , Jennie Jeyapalan , Catrin S Rutland , Emad Rakha , Srinivasan Madhusudan , Richard D Emes , Musalwa Muyangwa-Semenova , Mansour Alsaleem , Simone de Brot , William Green , Hari Ratan , Nigel P Mongan , Jennifer Lothion-Roy

Réseau de co-auteurs

Xiao-Han Tang 14 collaborations

Nigel P Mongan 10 collaborations

David M Nanus 9 collaborations

Marta Melis 8 collaborations

Kristian B Laursen 8 collaborations

Francesca Khani 8 collaborations

Steven S Gross 7 collaborations

Johannes C van der Mijn 7 collaborations

Tuo Zhang 7 collaborations

Steven E Trasino 6 collaborations

Corinne L Woodcock 6 collaborations

Qiuying Chen 5 collaborations

Anna E Harris 5 collaborations

Jennifer Lothion-Roy 5 collaborations

Brian D Robinson 5 collaborations

Srinivasan Madhusudan 5 collaborations

Catrin S Rutland 5 collaborations

Jennie N Jeyapalan 5 collaborations

Nina Orfali 4 collaborations

Tracey R O'Donovan 4 collaborations

Ana M Molina 4 collaborations

Theresa Scognamiglio 4 collaborations

Veronika M Metzler 4 collaborations

Daisy B Haigh 4 collaborations

Michael S Toss 4 collaborations

Mansour Alsaleem 4 collaborations

Jenny L Persson 4 collaborations

Emad Rakha 4 collaborations

Atara Ntekim 4 collaborations

Mary R Cahill 3 collaborations

Sharon L McKenna 3 collaborations

Ryan N Serio 3 collaborations

Changyuan Lu 3 collaborations

Leiping Fu 3 collaborations

Krysta M DiKun 3 collaborations

Cinzia Allegrucci 3 collaborations

Rupert G Fray 3 collaborations

Simone de Brot 3 collaborations

Nathan Archer 3 collaborations

Karen Mai 2 collaborations

Jaclyn M Kubala 2 collaborations

Ryan M Williams 2 collaborations

Daniel A Heller 2 collaborations

Clara Oromendia 2 collaborations

Scott T Tagawa 2 collaborations

Andrea Sboner 2 collaborations

Jorge Baquero 2 collaborations

Victoria H James 2 collaborations

Jose Jessurun 2 collaborations

Andrew Rappa 2 collaborations

Nabeel Attarwala 2 collaborations

Kwame Osei-Sarfo 2 collaborations

Dalyia Benjamin 2 collaborations

Lihui Qin 2 collaborations

Richard D Emes 2 collaborations

Deborah Shan-Krauer 1 collaboration

Mario P Tschan 1 collaboration

Eduardo Mere Del Aguila 1 collaboration

Ryan Schreiner 1 collaboration

Michael J Crowley 1 collaboration

Christopher E Barbieri 1 collaboration

Jocelin M Kalish 1 collaboration

Kenneth W Eng 1 collaboration

Pooja Chandra 1 collaboration

Evan Fernandez 1 collaboration

Sinan Ramazanoglu 1 collaboration

Alexandros Sigaras 1 collaboration

Bishoy F Faltas 1 collaboration

Himisha Beltran 1 collaboration

Cora N Sternberg 1 collaboration

Olivier Elemento 1 collaboration

Juan Miguel Mosquera 1 collaboration

Annalisa Ferrotta 1 collaboration

Dhruvika Varun 1 collaboration

Chantelle Endeley 1 collaboration

Maria Haque 1 collaboration

Laura M Martin 1 collaboration

Jenna E Moyer 1 collaboration

Juliette Brownlie 1 collaboration

Viral M Patel 1 collaboration

Daniel J Stummer 1 collaboration

Alison M Urvalek 1 collaboration

Steve S Gross 1 collaboration

Lukas Dow 1 collaboration

Andrey V Malkovskiy 1 collaboration

Lauren D Van Wassenhove 1 collaboration

Yury Goltsev 1 collaboration

Che-Hong Chen 1 collaboration

Bradley Efron 1 collaboration

Daria Mochly-Rosen 1 collaboration

Jayakumar Rajadas 1 collaboration

Lukas E Dow 1 collaboration

Dawid G Nowak 1 collaboration

Mary Cahill 1 collaboration

Sharon McKenna 1 collaboration

Paul Christos 1 collaboration

John Wright 1 collaboration

Charlene Thomas 1 collaboration

Janice P Dutcher 1 collaboration

Carlos Prishker 1 collaboration

Mary E Choi 1 collaboration

Melissa B Davis 1 collaboration

Zsuzsanna Bodi 1 collaboration

Emad A Rakha 1 collaboration

Emeli M Nilsson 1 collaboration

David M Heery 1 collaboration

Bashir Al Hussein Al Awamlh 1 collaboration

Aleem Islam Khan 1 collaboration

Lina Posada-Calderon 1 collaboration

Jonathan Fainberg 1 collaboration

Mark Alshak 1 collaboration

Rahmi Elahjji 1 collaboration

Hudson Pierce 1 collaboration

Benjamin Taylor 1 collaboration

Joseph Del Pizzo 1 collaboration

Douglas S Scherr 1 collaboration

Janki Shah 1 collaboration

Elizabeth Mercer 1 collaboration

Helen S Tian 1 collaboration

Vanessa Thompson 1 collaboration

Justin M Cheung 1 collaboration

Madeline Dorso 1 collaboration

Elisa de Stanchina 1 collaboration

Edgar A Jaimes 1 collaboration

Jessica Gambardella 1 collaboration

Stanislovas Jankauskas 1 collaboration

Xujun Wang 1 collaboration

Gaetano Santulli 1 collaboration

Roberto Levi 1 collaboration

Xiaofei Wang 1 collaboration

Princesca Dorsaint 1 collaboration

Dalyia N Benjamin 1 collaboration

Yousif Kariri 1 collaboration

Melissa Mather 1 collaboration

David Kutler 1 collaboration

Rodhan Patke 1 collaboration

Rachel Thompson 1 collaboration

Rute Santos 1 collaboration

Amber Kumari 1 collaboration

Rupert Fray 1 collaboration

Jennie Jeyapalan 1 collaboration

Musalwa Muyangwa-Semenova 1 collaboration

William Green 1 collaboration

Hari Ratan 1 collaboration