Kostyantyn Krysan

Affiliations

Department of Medicine, University of California, Los Angeles, Los Angeles, California.

Publications (20)

Resolving the Spatial and Cellular Architecture of Lung Adenocarcinoma by Multiregion Single-Cell Sequencing.

Cancer discovery

Avec: Ansam Sinjab , Guangchun Han , Warapen Treekitkarnmongkol , Kieko Hara , Patrick M Brennan , Minghao Dang , Dapeng Hao , Ruiping Wang , Enyu Dai , Hitoshi Dejima , Jiexin Zhang , Elena Bogatenkova , Beatriz Sanchez-Espiridion , Kyle Chang , Danielle R Little , Samer Bazzi , Linh M Tran , Kostyantyn Krysan , Carmen Behrens , Dzifa Y Duose , Edwin R Parra , Maria Gabriela Raso , Luisa M Solis , Junya Fukuoka , Jianjun Zhang , Boris Sepesi , Tina Cascone , Lauren Averett Byers , Don L Gibbons , Jichao Chen , Seyed Javad Moghaddam , Edwin J Ostrin , Daniel Rosen , John V Heymach , Paul Scheet , Steven M Dubinett , Junya Fujimoto , Ignacio I Wistuba , Christopher S Stevenson , Avrum Spira , Linghua Wang , Humam Kadara

Single-stranded pre-methylated 5mC adapters uncover the methylation profile of plasma ultrashort Single-stranded cell-free DNA.

Nucleic acids research

Avec: Jordan C Cheng , Neeti Swarup , Marco Morselli , Wei-Lun Huang , Mohammad Aziz , Christa Caggiano , Misagh Kordi , Abhijit A Patel , David Chia , Yong Kim , Feng Li , Fang Wei , Noah Zaitlen , Kostyantyn Krysan , Steve Dubinett , Matteo Pellegrini , David T W Wong

Noninvasive lung cancer subtype classification using tumor-derived signatures and cfDNA methylome.

Cancer research communications

Avec: Shuo Li , Wenyuan Li , Bin Liu , Kostyantyn Krysan , Steven M Dubinett

Author Correction: Chronic IL-1β-induced inflammation regulates epithelial-to-mesenchymal transition memory phenotypes via epigenetic modifications in non-small cell lung cancer.

Scientific reports

Avec: Rui Li , Stephanie L Ong , Linh M Tran , Zhe Jing , Bin Liu , Stacy J Park , Zi Ling Huang , Tonya C Walser , Eileen L Heinrich , Gina Lee , Ramin Salehi-Rad , William P Crosson , Paul C Pagano , Manash K Paul , Shili Xu , Harvey Herschman , Kostyantyn Krysan , Steven Dubinett

The Immune Contexture Associates with the Genomic Landscape in Lung Adenomatous Premalignancy.

Cancer research

Avec: Kostyantyn Krysan , Linh M Tran , Brandon S Grimes , Gregory A Fishbein , Atsuko Seki , Brian K Gardner , Tonya C Walser , Ramin Salehi-Rad , Jane Yanagawa , Jay M Lee , Sherven Sharma , Denise R Aberle , Arum E Spira , David A Elashoff , William D Wallace , Michael C Fishbein , Steven M Dubinett

Inhibition of Granulocytic Myeloid-Derived Suppressor Cells Overcomes Resistance to Immune Checkpoint Inhibition in LKB1-Deficient Non-Small Cell Lung Cancer.

Cancer research

Avec: Rui Li , Ramin Salehi-Rad , William Crosson , Milica Momcilovic , Raymond J Lim , Stephanie L Ong , Zi Ling Huang , Tianhao Zhang , Jensen Abascal , Camelia Dumitras , Zhe Jing , Stacy J Park , Kostyantyn Krysan , David B Shackelford , Linh M Tran , Bin Liu , Steven M Dubinett

Comprehensive tissue deconvolution of cell-free DNA by deep learning for disease diagnosis and monitoring.

Proceedings of the National Academy of Sciences of the United States of America

Avec: Shuo Li , Weihua Zeng , Xiaohui Ni , Qiao Liu , Wenyuan Li , Mary L Stackpole , Yonggang Zhou , Arjan Gower , Kostyantyn Krysan , Preeti Ahuja , David S Lu , Steven S Raman , William Hsu , Denise R Aberle , Clara E Magyar , Samuel W French , Steven-Huy B Han , Edward B Garon , Vatche G Agopian , Wing Hung Wong , Steven M Dubinett , Xianghong Jasmine Zhou

Chronic IL-1β-induced inflammation regulates epithelial-to-mesenchymal transition memory phenotypes via epigenetic modifications in non-small cell lung cancer.

Scientific reports

Molecular subtyping reveals immune alterations associated with progression of bronchial premalignant lesions.

Nature communications

Avec: Jennifer E Beane , Sarah A Mazzilli , Joshua D Campbell , Grant Duclos , Kostyantyn Krysan , Christopher Moy , Catalina Perdomo , Michael Schaffer , Gang Liu , Sherry Zhang , Hanqiao Liu , Jessica Vick , Samjot S Dhillon , Suso J Platero , Steven M Dubinett , Christopher Stevenson , Mary E Reid , Marc E Lenburg , Avrum E Spira

Organoids Model Transcriptional Hallmarks of Oncogenic KRAS Activation in Lung Epithelial Progenitor Cells.

Cell stem cell

Avec: Antonella F M Dost , Aaron L Moye , Marall Vedaie , Linh M Tran , Eileen Fung , Dar Heinze , Carlos Villacorta-Martin , Jessie Huang , Ryan Hekman , Julian H Kwan , Benjamin C Blum , Sharon M Louie , Samuel P Rowbotham , Julio Sainz de Aja , Mary E Piper , Preetida J Bhetariya , Roderick T Bronson , Andrew Emili , Gustavo Mostoslavsky , Gregory A Fishbein , William D Wallace , Kostyantyn Krysan , Steven M Dubinett , Jane Yanagawa , Darrell N Kotton , Carla F Kim

Early Diagnosis and Screening for Lung Cancer.

Cold Spring Harbor perspectives in medicine

Avec: Humam Kadara , Linh M Tran , Bin Liu , Anil Vachani , Shuo Li , Ansam Sinjab , Xianghong J Zhou , Steven M Dubinett , Kostyantyn Krysan

CCL21-DC in situ vaccination in murine NSCLC overcomes resistance to immunotherapy and generates systemic tumor-specific immunity.

Journal for immunotherapy of cancer

Avec: Ramin Salehi-Rad , Raymond J Lim , Yushen Du , Linh M Tran , Rui Li , Stephanie L Ong , Zi Ling Huang , Camelia Dumitras , Tianhao Zhang , Stacy J Park , William Crosson , Bitta Kahangi , Jensen Abascal , Christopher Seet , Michael Oh , Maryam Shabihkhani , Manash Paul , Kostyantyn Krysan , Aaron E Lisberg , Edward B Garon , Bin Liu , Steven M Dubinett

CXCL9/10-engineered dendritic cells promote T cell activation and enhance immune checkpoint blockade for lung cancer.

Cell reports. Medicine

Avec: Raymond J Lim , Ramin Salehi-Rad , Linh M Tran , Michael S Oh , Camelia Dumitras , William P Crosson , Rui Li , Tejas S Patel , Samantha Man , Cara E Yean , Jensen Abascal , ZiLing Huang , Stephanie L Ong , Kostyantyn Krysan , Steven M Dubinett , Bin Liu

FRA1 contributes to MEK-ERK pathway-dependent PD-L1 upregulation by KRAS mutation in premalignant human bronchial epithelial cells.

American journal of translational research

Avec: Mi-Heon Lee , Jane Yanagawa , Linh Tran , Tonya C Walser , Bharti Bisht , Eileen Fung , Stacy J Park , Gang Zeng , Kostyantyn Krysan , William D Wallace , Manash K Paul , Luc Girard , Boning Gao , John D Minna , Steven M Dubinett , Jay M Lee

Response and recurrence correlates in individuals treated with neoadjuvant anti-PD-1 therapy for resectable oral cavity squamous cell carcinoma.

Cell reports. Medicine

Avec: Sixue Liu , Hannah M Knochelmann , Shirley H Lomeli , Aayoung Hong , Mary Richardson , Zhentao Yang , Raymond J Lim , Yan Wang , Camelia Dumitras , Kostyantyn Krysan , Cynthia Timmers , Martin J Romeo , Carsten Krieg , Elizabeth C O'Quinn , Joshua D Horton , Steve M Dubinett , Chrystal M Paulos , David M Neskey , Roger S Lo

Novel Kras-mutant murine models of non-small cell lung cancer possessing co-occurring oncogenic mutations and increased tumor mutational burden.

Cancer immunology, immunotherapy : CII

Avec: Ramin Salehi-Rad , Rui Li , Linh M Tran , Raymond J Lim , Jensen Abascal , Milica Momcilovic , Stacy J Park , Stephanie L Ong , Maryam Shabihkhani , Zi Ling Huang , Manash Paul , David B Shackelford , Kostyantyn Krysan , Bin Liu , Steven M Dubinett

Immunosurveillance and Regression in the Context of Squamous Pulmonary Premalignancy.

Cancer discovery

Avec: Kostyantyn Krysan , Linh M Tran , Steven M Dubinett

Lung Cancer and Immunity Markers.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology

Avec: Raymond J Lim , Bin Liu , Kostyantyn Krysan , Steven M Dubinett

The Liquid Biopsy Consortium: Challenges and opportunities for early cancer detection and monitoring.

Cell reports. Medicine

Avec: Syeda Maheen Batool , Anudeep Yekula , Prerna Khanna , Tiffaney Hsia , Austin S Gamblin , Emil Ekanayake , Ana K Escobedo , Dong Gil You , Cesar M Castro , Hyungsoon Im , Tugba Kilic , Michelle Andrea Garlin , Johan Skog , Daniela M Dinulescu , Jonathan Dudley , Nishant Agrawal , Jordan Cheng , Fereidoun Abtin , Denise R Aberle , David Chia , David Elashoff , Tristan Grognan , Kostyantyn Krysan , Scott S Oh , Charles Strom , Michael Tu , Fang Wei , Rena R Xian , Steven J Skates , David Y Zhang , Thi Trinh , Mark Watson , Rebecca Aft , Siddarth Rawal , Ashutosh Agarwal , Susan B Kesmodel , Changhuei Yang , Cheng Shen , Fred H Hochberg , David T W Wong , Abhijit A Patel , Nickolas Papadopoulos , Chetan Bettegowda , Richard J Cote , Sudhir Srivastava , Hakho Lee , Bob S Carter , Leonora Balaj

Single-Cell Characterization of Pulmonary Nodules Implicates Suppression of Immunosurveillance across Early Stages of Lung Adenocarcinoma.

Cancer research

Avec: Jane Yanagawa , Linh M Tran , Ramin Salehi-Rad , Raymond J Lim , Camelia Dumitras , Eileen Fung , William D Wallace , Ashley E Prosper , Gregory Fishbein , Conor Shea , Rui Hong , Bitta Kahangi , John J Deng , Adam C Gower , Bin Liu , Joshua D Campbell , Sarah A Mazzilli , Jennifer E Beane , Humam Kadara , Marc E Lenburg , Avrum E Spira , Denise R Aberle , Kostyantyn Krysan , Steven M Dubinett

Réseau de co-auteurs

Steven M Dubinett 15 collaborations

Linh M Tran 12 collaborations

Bin Liu 10 collaborations

Ramin Salehi-Rad 8 collaborations

Raymond J Lim 7 collaborations

Rui Li 6 collaborations

Stephanie L Ong 6 collaborations

Stacy J Park 6 collaborations

Zi Ling Huang 5 collaborations

Camelia Dumitras 5 collaborations

Tonya C Walser 4 collaborations

Jane Yanagawa 4 collaborations

Denise R Aberle 4 collaborations

William D Wallace 4 collaborations

Jensen Abascal 4 collaborations

Humam Kadara 3 collaborations

Shuo Li 3 collaborations

Zhe Jing 3 collaborations

William P Crosson 3 collaborations

Manash K Paul 3 collaborations

Eileen Fung 3 collaborations

Ansam Sinjab 2 collaborations

Abhijit A Patel 2 collaborations

David Chia 2 collaborations

Fang Wei 2 collaborations

David T W Wong 2 collaborations

Wenyuan Li 2 collaborations

Eileen L Heinrich 2 collaborations

Gina Lee 2 collaborations

Paul C Pagano 2 collaborations

Shili Xu 2 collaborations

Harvey Herschman 2 collaborations

Steven Dubinett 2 collaborations

Gregory A Fishbein 2 collaborations

Jay M Lee 2 collaborations

William Crosson 2 collaborations

Milica Momcilovic 2 collaborations

Tianhao Zhang 2 collaborations

David B Shackelford 2 collaborations

Edward B Garon 2 collaborations

Jennifer E Beane 2 collaborations

Sarah A Mazzilli 2 collaborations

Joshua D Campbell 2 collaborations

Marc E Lenburg 2 collaborations

Avrum E Spira 2 collaborations

Bitta Kahangi 2 collaborations

Maryam Shabihkhani 2 collaborations

Manash Paul 2 collaborations

Guangchun Han 1 collaboration

Warapen Treekitkarnmongkol 1 collaboration

Kieko Hara 1 collaboration

Patrick M Brennan 1 collaboration

Minghao Dang 1 collaboration

Dapeng Hao 1 collaboration

Ruiping Wang 1 collaboration

Enyu Dai 1 collaboration

Hitoshi Dejima 1 collaboration

Jiexin Zhang 1 collaboration

Elena Bogatenkova 1 collaboration

Beatriz Sanchez-Espiridion 1 collaboration

Kyle Chang 1 collaboration

Danielle R Little 1 collaboration

Samer Bazzi 1 collaboration

Carmen Behrens 1 collaboration

Dzifa Y Duose 1 collaboration

Edwin R Parra 1 collaboration

Maria Gabriela Raso 1 collaboration

Luisa M Solis 1 collaboration

Junya Fukuoka 1 collaboration

Jianjun Zhang 1 collaboration

Boris Sepesi 1 collaboration

Tina Cascone 1 collaboration

Lauren Averett Byers 1 collaboration

Don L Gibbons 1 collaboration

Jichao Chen 1 collaboration

Seyed Javad Moghaddam 1 collaboration

Edwin J Ostrin 1 collaboration

Daniel Rosen 1 collaboration

John V Heymach 1 collaboration

Paul Scheet 1 collaboration

Junya Fujimoto 1 collaboration

Ignacio I Wistuba 1 collaboration

Christopher S Stevenson 1 collaboration

Avrum Spira 1 collaboration

Linghua Wang 1 collaboration

Jordan C Cheng 1 collaboration

Neeti Swarup 1 collaboration

Marco Morselli 1 collaboration

Wei-Lun Huang 1 collaboration

Mohammad Aziz 1 collaboration

Christa Caggiano 1 collaboration

Misagh Kordi 1 collaboration

Yong Kim 1 collaboration

Feng Li 1 collaboration

Noah Zaitlen 1 collaboration

Steve Dubinett 1 collaboration

Matteo Pellegrini 1 collaboration

Brandon S Grimes 1 collaboration

Atsuko Seki 1 collaboration

Brian K Gardner 1 collaboration

Sherven Sharma 1 collaboration

Arum E Spira 1 collaboration

David A Elashoff 1 collaboration

Michael C Fishbein 1 collaboration

Weihua Zeng 1 collaboration

Xiaohui Ni 1 collaboration

Qiao Liu 1 collaboration

Mary L Stackpole 1 collaboration

Yonggang Zhou 1 collaboration

Arjan Gower 1 collaboration

Preeti Ahuja 1 collaboration

David S Lu 1 collaboration

Steven S Raman 1 collaboration

William Hsu 1 collaboration

Clara E Magyar 1 collaboration

Samuel W French 1 collaboration

Steven-Huy B Han 1 collaboration

Vatche G Agopian 1 collaboration

Wing Hung Wong 1 collaboration

Xianghong Jasmine Zhou 1 collaboration

Grant Duclos 1 collaboration

Christopher Moy 1 collaboration

Catalina Perdomo 1 collaboration

Michael Schaffer 1 collaboration

Gang Liu 1 collaboration

Sherry Zhang 1 collaboration

Hanqiao Liu 1 collaboration

Jessica Vick 1 collaboration

Samjot S Dhillon 1 collaboration

Suso J Platero 1 collaboration

Christopher Stevenson 1 collaboration

Mary E Reid 1 collaboration

Antonella F M Dost 1 collaboration

Aaron L Moye 1 collaboration

Marall Vedaie 1 collaboration

Dar Heinze 1 collaboration

Carlos Villacorta-Martin 1 collaboration

Jessie Huang 1 collaboration

Ryan Hekman 1 collaboration

Julian H Kwan 1 collaboration

Benjamin C Blum 1 collaboration

Sharon M Louie 1 collaboration

Samuel P Rowbotham 1 collaboration

Julio Sainz de Aja 1 collaboration

Mary E Piper 1 collaboration

Preetida J Bhetariya 1 collaboration

Roderick T Bronson 1 collaboration

Andrew Emili 1 collaboration

Gustavo Mostoslavsky 1 collaboration

Darrell N Kotton 1 collaboration

Carla F Kim 1 collaboration

Anil Vachani 1 collaboration

Xianghong J Zhou 1 collaboration

Yushen Du 1 collaboration

Christopher Seet 1 collaboration

Michael Oh 1 collaboration

Aaron E Lisberg 1 collaboration

Michael S Oh 1 collaboration

Tejas S Patel 1 collaboration

Samantha Man 1 collaboration

Cara E Yean 1 collaboration

ZiLing Huang 1 collaboration

Mi-Heon Lee 1 collaboration

Linh Tran 1 collaboration

Bharti Bisht 1 collaboration

Gang Zeng 1 collaboration

Luc Girard 1 collaboration

Boning Gao 1 collaboration

John D Minna 1 collaboration

Sixue Liu 1 collaboration

Hannah M Knochelmann 1 collaboration

Shirley H Lomeli 1 collaboration

Aayoung Hong 1 collaboration

Mary Richardson 1 collaboration

Zhentao Yang 1 collaboration

Yan Wang 1 collaboration

Cynthia Timmers 1 collaboration

Martin J Romeo 1 collaboration

Carsten Krieg 1 collaboration

Elizabeth C O'Quinn 1 collaboration

Joshua D Horton 1 collaboration

Steve M Dubinett 1 collaboration

Chrystal M Paulos 1 collaboration

David M Neskey 1 collaboration

Roger S Lo 1 collaboration

Syeda Maheen Batool 1 collaboration

Anudeep Yekula 1 collaboration

Prerna Khanna 1 collaboration

Tiffaney Hsia 1 collaboration

Austin S Gamblin 1 collaboration

Emil Ekanayake 1 collaboration

Ana K Escobedo 1 collaboration

Dong Gil You 1 collaboration

Cesar M Castro 1 collaboration

Hyungsoon Im 1 collaboration

Tugba Kilic 1 collaboration

Michelle Andrea Garlin 1 collaboration

Johan Skog 1 collaboration

Daniela M Dinulescu 1 collaboration

Jonathan Dudley 1 collaboration

Nishant Agrawal 1 collaboration

Jordan Cheng 1 collaboration

Fereidoun Abtin 1 collaboration

David Elashoff 1 collaboration

Tristan Grognan 1 collaboration

Scott S Oh 1 collaboration

Charles Strom 1 collaboration

Michael Tu 1 collaboration

Rena R Xian 1 collaboration

Steven J Skates 1 collaboration

David Y Zhang 1 collaboration

Thi Trinh 1 collaboration

Mark Watson 1 collaboration

Rebecca Aft 1 collaboration

Siddarth Rawal 1 collaboration

Ashutosh Agarwal 1 collaboration

Susan B Kesmodel 1 collaboration

Changhuei Yang 1 collaboration

Cheng Shen 1 collaboration

Fred H Hochberg 1 collaboration

Nickolas Papadopoulos 1 collaboration

Chetan Bettegowda 1 collaboration

Richard J Cote 1 collaboration

Sudhir Srivastava 1 collaboration

Hakho Lee 1 collaboration

Bob S Carter 1 collaboration

Leonora Balaj 1 collaboration

Ashley E Prosper 1 collaboration

Gregory Fishbein 1 collaboration

Conor Shea 1 collaboration

Rui Hong 1 collaboration

John J Deng 1 collaboration

Adam C Gower 1 collaboration