Keith W Caldecott

Affiliations

Genome Damage and Stability Centre, University of Sussex, Falmer, Brighton BN1 9RQ, UK; Department of Genome Dynamics, Institute of Molecular Genetics of the Czech Academy of Sciences, 142 20 Prague, 4, Czech Republic.

Publications (33)

Topoisomerase II-Induced Chromosome Breakage and Translocation Is Determined by Chromosome Architecture and Transcriptional Activity.

Molecular cell

Avec: Andres Canela , Yaakov Maman , Shar-Yin N Huang , Gordana Wutz , Wen Tang , Guido Zagnoli-Vieira , Elsa Callen , Nancy Wong , Amanda Day , Jan-Michael Peters , Keith W Caldecott , Yves Pommier , André Nussenzweig

Parp1 hyperactivity couples DNA breaks to aberrant neuronal calcium signalling and lethal seizures.

EMBO reports

Avec: Emilia Komulainen , Jack Badman , Stephanie Rey , Stuart Rulten , Limei Ju , Kate Fennell , Ilona Kalasova , Kristyna Ilievova , Peter J McKinnon , Hana Hanzlikova , Kevin Staras , Keith W Caldecott

DNA single-strand break repair and human genetic disease.

Trends in cell biology

Avec: Keith W Caldecott

Causes and consequences of DNA single-strand breaks.

Trends in biochemical sciences

Avec: Keith W Caldecott

Unrepaired base excision repair intermediates in template DNA strands trigger replication fork collapse and PARP inhibitor sensitivity.

The EMBO journal

Avec: Almudena Serrano-Benitez , Sophie E Wells , Lylah Drummond-Clarke , Lilian C Russo , John Christopher Thomas , Giovanna A Leal , Mark Farrow , James Michael Edgerton , Shankar Balasubramanian , Ming Yang , Christian Frezza , Amit Gautam , Jan Brazina , Kamila Burdova , Nicolas C Hoch , Stephen P Jackson , Keith W Caldecott

Pathological mutations in PNKP trigger defects in DNA single-strand break repair but not DNA double-strand break repair.

Nucleic acids research

Avec: Ilona Kalasova , Richard Hailstone , Janin Bublitz , Jovel Bogantes , Winfried Hofmann , Alejandro Leal , Hana Hanzlikova , Keith W Caldecott

Novel PNKP mutations causing defective DNA strand break repair and PARP1 hyperactivity in MCSZ.

Neurology. Genetics

Avec: Ilona Kalasova , Hana Hanzlikova , Neerja Gupta , Yun Li , Janine Altmüller , John J Reynolds , Grant S Stewart , Bernd Wollnik , Gökhan Yigit , Keith W Caldecott

The threat of programmed DNA damage to neuronal genome integrity and plasticity.

Nature genetics

Avec: Keith W Caldecott , Michael E Ward , André Nussenzweig

DNA damage and transcription stress.

Molecular cell

Avec: Larissa Milano , Amit Gautam , Keith W Caldecott

Untangling trapped topoisomerases with tyrosyl-DNA phosphodiesterases.

DNA repair

Avec: Guido Zagnoli-Vieira , Keith W Caldecott

Pathogenic ARH3 mutations result in ADP-ribose chromatin scars during DNA strand break repair.

Nature communications

Avec: Hana Hanzlikova , Evgeniia Prokhorova , Katerina Krejcikova , Zuzana Cihlarova , Ilona Kalasova , Jan Kubovciak , Jana Sachova , Richard Hailstone , Jan Brazina , Shereen Ghosh , Sebahattin Cirak , Joseph G Gleeson , Ivan Ahel , Keith W Caldecott

Homozygous pathogenic variant in

Neurology. Genetics

Avec: Areej Mahjoub , Zuzana Cihlarova , Martine Tétreault , Lauren MacNeil , Neal Sondheimer , Keith W Caldecott , Hana Hanzlikova , Grace Yoon , Auteur inconnu

Perspectives on PARPs in S Phase.

Trends in genetics : TIG

Avec: Hana Hanzlikova , Keith W Caldecott

Deazaflavin Inhibitors of TDP2 with Cellular Activity Can Affect Etoposide Influx and/or Efflux.

ACS chemical biology

Avec: Emilia Komulainen , Lewis Pennicott , Darren Le Grand , Keith W Caldecott

Neuronal enhancers are hotspots for DNA single-strand break repair.

Nature

Avec: Wei Wu , Sarah E Hill , William J Nathan , Jacob Paiano , Elsa Callen , Dongpeng Wang , Kenta Shinoda , Niek van Wietmarschen , Jennifer M Colón-Mercado , Dali Zong , Raffaella De Pace , Han-Yu Shih , Steve Coon , Maia Parsadanian , Raphael Pavani , Hana Hanzlikova , Solji Park , Seol Kyoung Jung , Peter J McHugh , Andres Canela , Chongyi Chen , Rafael Casellas , Keith W Caldecott , Michael E Ward , André Nussenzweig

XRCC1 protects transcription from toxic PARP1 activity during DNA base excision repair.

Nature cell biology

Avec: Marek Adamowicz , Richard Hailstone , Annie A Demin , Emilia Komulainen , Hana Hanzlikova , Jan Brazina , Amit Gautam , Sophie E Wells , Keith W Caldecott

BRAT1 links Integrator and defective RNA processing with neurodegeneration.

Nature communications

Avec: Zuzana Cihlarova , Jan Kubovciak , Margarita Sobol , Katerina Krejcikova , Jana Sachova , Michal Kolar , David Stanek , Cyril Barinka , Grace Yoon , Keith W Caldecott , Hana Hanzlikova

Dispensability of HPF1 for cellular removal of DNA single-strand breaks.

Nucleic acids research

Avec: Kristyna Hrychova , Kamila Burdova , Zuzana Polackova , Despoina Giamaki , Beatrice Valtorta , Jan Brazina , Katerina Krejcikova , Barbora Kuttichova , Keith W Caldecott , Hana Hanzlikova

Mammalian DNA base excision repair: Dancing in the moonlight.

DNA repair

Avec: Keith W Caldecott

XRCC1 protein; Form and function.

DNA repair

Avec: Keith W Caldecott

FUS (fused in sarcoma) is a component of the cellular response to topoisomerase I-induced DNA breakage and transcriptional stress.

Life science alliance

Avec: Maria Isabel Martinez-Macias , Duncan Aq Moore , Ryan L Green , Fernando Gomez-Herreros , Marcel Naumann , Andreas Hermann , Philip Van Damme , Majid Hafezparast , Keith W Caldecott

Effects of TDP2/VPg Unlinkase Activity on Picornavirus Infections Downstream of Virus Translation.

Viruses

Avec: Autumn C Holmes , Guido Zagnoli-Vieira , Keith W Caldecott , Bert L Semler

Characterization of a novel loss-of-function variant in TDP2 in two adult patients with spinocerebellar ataxia autosomal recessive 23 (SCAR23).

Journal of human genetics

Avec: Edoardo Errichiello , Guido Zagnoli-Vieira , Romana Rizzi , Livia Garavelli , Keith W Caldecott , Orsetta Zuffardi

XRCC1 prevents toxic PARP1 trapping during DNA base excision repair.

Molecular cell

Avec: Annie A Demin , Kouji Hirota , Masataka Tsuda , Marek Adamowicz , Richard Hailstone , Jan Brazina , William Gittens , Ilona Kalasova , Zhengping Shao , Shan Zha , Hiroyuki Sasanuma , Hana Hanzlikova , Shunichi Takeda , Keith W Caldecott

Efficient Single-Strand Break Repair Requires Binding to Both Poly(ADP-Ribose) and DNA by the Central BRCT Domain of XRCC1.

Cell reports

Avec: Luis M Polo , Yingqi Xu , Peter Hornyak , Fernando Garces , Zhihong Zeng , Richard Hailstone , Steve J Matthews , Keith W Caldecott , Antony W Oliver , Laurence H Pearl

The SARS-CoV-2 Nsp3 macrodomain reverses PARP9/DTX3L-dependent ADP-ribosylation induced by interferon signaling.

The Journal of biological chemistry

Avec: Lilian Cristina Russo , Rebeka Tomasin , Isaac Araújo Matos , Antonio Carlos Manucci , Sven T Sowa , Katie Dale , Keith W Caldecott , Lari Lehtiö , Deborah Schechtman , Flavia C Meotti , Alexandre Bruni-Cardoso , Nicolas Carlos Hoch

PARP inhibition impedes the maturation of nascent DNA strands during DNA replication.

Nature structural & molecular biology

Avec: Alina Vaitsiankova , Kamila Burdova , Margarita Sobol , Amit Gautam , Oldrich Benada , Hana Hanzlikova , Keith W Caldecott

DNA combing versus DNA spreading and the separation of sister chromatids.

The Journal of cell biology

Avec: Alice Meroni , Sophie E Wells , Carmen Fonseca , Arnab Ray Chaudhuri , Keith W Caldecott , Alessandro Vindigni

DNA Combing

bioRxiv : the preprint server for biology

Avec: Alice Meroni , Sophie E Wells , Carmen Fonseca , Arnab Ray Chaudhuri , Keith W Caldecott , Alessandro Vindigni

Inactivating TDP2 missense mutation in siblings with congenital abnormalities reminiscent of fanconi anemia.

Human genetics

Avec: Guido Zagnoli-Vieira , Jan Brazina , Kris Van Den Bogaert , Wim Huybrechts , Guy Molenaers , Keith W Caldecott , Hilde Van Esch

APE1-dependent base excision repair of DNA photodimers in human cells.

Molecular cell

Avec: Amit Gautam , Heather Fawcett , Kamila Burdova , Jan Brazina , Keith W Caldecott

Novel PNKP mutations associated with reduced DNA single-strand break repair and severe microcephaly, seizures, and developmental delay.

Molecular genetics & genomic medicine

Avec: Ann-Charlotte Thuresson , Jan Brazina , Talia Akram , Julia Albrecht , Niklas Dahl , Cecilia Soussi Zander , Keith W Caldecott

KBM-mediated interactions with KU80 promote cellular resistance to DNA replication stress in CHO cells.

DNA repair

Avec: Sophie E Wells , Keith W Caldecott

Réseau de co-auteurs

Hana Hanzlikova 12 collaborations

Jan Brazina 8 collaborations

Guido Zagnoli-Vieira 5 collaborations

Ilona Kalasova 5 collaborations

Sophie E Wells 5 collaborations

Amit Gautam 5 collaborations

Richard Hailstone 5 collaborations

Kamila Burdova 4 collaborations

André Nussenzweig 3 collaborations

Emilia Komulainen 3 collaborations

Katerina Krejcikova 3 collaborations

Zuzana Cihlarova 3 collaborations

Andres Canela 2 collaborations

Elsa Callen 2 collaborations

Michael E Ward 2 collaborations

Jan Kubovciak 2 collaborations

Jana Sachova 2 collaborations

Grace Yoon 2 collaborations

Marek Adamowicz 2 collaborations

Annie A Demin 2 collaborations

Margarita Sobol 2 collaborations

Alice Meroni 2 collaborations

Carmen Fonseca 2 collaborations

Arnab Ray Chaudhuri 2 collaborations

Alessandro Vindigni 2 collaborations

Yaakov Maman 1 collaboration

Shar-Yin N Huang 1 collaboration

Gordana Wutz 1 collaboration

Wen Tang 1 collaboration

Nancy Wong 1 collaboration

Amanda Day 1 collaboration

Jan-Michael Peters 1 collaboration

Yves Pommier 1 collaboration

Jack Badman 1 collaboration

Stephanie Rey 1 collaboration

Stuart Rulten 1 collaboration

Limei Ju 1 collaboration

Kate Fennell 1 collaboration

Kristyna Ilievova 1 collaboration

Peter J McKinnon 1 collaboration

Kevin Staras 1 collaboration

Almudena Serrano-Benitez 1 collaboration

Lylah Drummond-Clarke 1 collaboration

Lilian C Russo 1 collaboration

John Christopher Thomas 1 collaboration

Giovanna A Leal 1 collaboration

Mark Farrow 1 collaboration

James Michael Edgerton 1 collaboration

Shankar Balasubramanian 1 collaboration

Ming Yang 1 collaboration

Christian Frezza 1 collaboration

Nicolas C Hoch 1 collaboration

Stephen P Jackson 1 collaboration

Janin Bublitz 1 collaboration

Jovel Bogantes 1 collaboration

Winfried Hofmann 1 collaboration

Alejandro Leal 1 collaboration

Neerja Gupta 1 collaboration

Yun Li 1 collaboration

Janine Altmüller 1 collaboration

John J Reynolds 1 collaboration

Grant S Stewart 1 collaboration

Bernd Wollnik 1 collaboration

Gökhan Yigit 1 collaboration

Larissa Milano 1 collaboration

Evgeniia Prokhorova 1 collaboration

Shereen Ghosh 1 collaboration

Sebahattin Cirak 1 collaboration

Joseph G Gleeson 1 collaboration

Ivan Ahel 1 collaboration

Areej Mahjoub 1 collaboration

Martine Tétreault 1 collaboration

Lauren MacNeil 1 collaboration

Neal Sondheimer 1 collaboration

None None 1 collaboration

Lewis Pennicott 1 collaboration

Darren Le Grand 1 collaboration

Wei Wu 1 collaboration

Sarah E Hill 1 collaboration

William J Nathan 1 collaboration

Jacob Paiano 1 collaboration

Dongpeng Wang 1 collaboration

Kenta Shinoda 1 collaboration

Niek van Wietmarschen 1 collaboration

Jennifer M Colón-Mercado 1 collaboration

Dali Zong 1 collaboration

Raffaella De Pace 1 collaboration

Han-Yu Shih 1 collaboration

Steve Coon 1 collaboration

Maia Parsadanian 1 collaboration

Raphael Pavani 1 collaboration

Solji Park 1 collaboration

Seol Kyoung Jung 1 collaboration

Peter J McHugh 1 collaboration

Chongyi Chen 1 collaboration

Rafael Casellas 1 collaboration

Michal Kolar 1 collaboration

David Stanek 1 collaboration

Cyril Barinka 1 collaboration

Kristyna Hrychova 1 collaboration

Zuzana Polackova 1 collaboration

Despoina Giamaki 1 collaboration

Beatrice Valtorta 1 collaboration

Barbora Kuttichova 1 collaboration

Maria Isabel Martinez-Macias 1 collaboration

Duncan Aq Moore 1 collaboration

Ryan L Green 1 collaboration

Fernando Gomez-Herreros 1 collaboration

Marcel Naumann 1 collaboration

Andreas Hermann 1 collaboration

Philip Van Damme 1 collaboration

Majid Hafezparast 1 collaboration

Autumn C Holmes 1 collaboration

Bert L Semler 1 collaboration

Edoardo Errichiello 1 collaboration

Romana Rizzi 1 collaboration

Livia Garavelli 1 collaboration

Orsetta Zuffardi 1 collaboration

Kouji Hirota 1 collaboration

Masataka Tsuda 1 collaboration

William Gittens 1 collaboration

Zhengping Shao 1 collaboration

Shan Zha 1 collaboration

Hiroyuki Sasanuma 1 collaboration

Shunichi Takeda 1 collaboration

Luis M Polo 1 collaboration

Yingqi Xu 1 collaboration

Peter Hornyak 1 collaboration

Fernando Garces 1 collaboration

Zhihong Zeng 1 collaboration

Steve J Matthews 1 collaboration

Antony W Oliver 1 collaboration

Laurence H Pearl 1 collaboration

Lilian Cristina Russo 1 collaboration

Rebeka Tomasin 1 collaboration

Isaac Araújo Matos 1 collaboration

Antonio Carlos Manucci 1 collaboration

Sven T Sowa 1 collaboration

Katie Dale 1 collaboration

Lari Lehtiö 1 collaboration

Deborah Schechtman 1 collaboration

Flavia C Meotti 1 collaboration

Alexandre Bruni-Cardoso 1 collaboration

Nicolas Carlos Hoch 1 collaboration

Alina Vaitsiankova 1 collaboration

Oldrich Benada 1 collaboration

Kris Van Den Bogaert 1 collaboration

Wim Huybrechts 1 collaboration

Guy Molenaers 1 collaboration

Hilde Van Esch 1 collaboration

Heather Fawcett 1 collaboration

Ann-Charlotte Thuresson 1 collaboration

Talia Akram 1 collaboration

Julia Albrecht 1 collaboration

Niklas Dahl 1 collaboration

Cecilia Soussi Zander 1 collaboration