Kaoru Funabashi

Affiliations

Discovery and Preclinical Research Division, Taiho Pharmaceutical Co., Ltd., Tsukuba, Ibaraki, Japan.

Publications (9)

TAS6417/CLN-081 Is a Pan-Mutation-Selective EGFR Tyrosine Kinase Inhibitor with a Broad Spectrum of Preclinical Activity against Clinically Relevant

Molecular cancer research : MCR

Avec: Hibiki Udagawa , Shinichi Hasako , Akihiro Ohashi , Rumi Fujioka , Yumi Hakozaki , Mikiko Shibuya , Naomi Abe , Toshiharu Komori , Tomonori Haruma , Miki Terasaka , Ryoto Fujita , Akihiro Hashimoto , Kaoru Funabashi , Hiroyuki Yasuda , Kazutaka Miyadera , Koichi Goto , Daniel B Costa , Susumu S Kobayashi

Structures of human peptidylarginine deiminase type III provide insights into substrate recognition and inhibitor design.

Archives of biochemistry and biophysics

Avec: Kazumasa Funabashi , Mizuki Sawata , Anna Nagai , Megumi Akimoto , Ryutaro Mashimo , Hidenari Takahara , Kenji Kizawa , Paul R Thompson , Kenji Ite , Kenichi Kitanishi , Masaki Unno

Futibatinib Is a Novel Irreversible FGFR 1-4 Inhibitor That Shows Selective Antitumor Activity against FGFR-Deregulated Tumors.

Cancer research

Avec: Hiroshi Sootome , Hidenori Fujita , Kenjiro Ito , Hiroaki Ochiiwa , Yayoi Fujioka , Kimihiro Ito , Akihiro Miura , Takeshi Sagara , Satoru Ito , Hirokazu Ohsawa , Sachie Otsuki , Kaoru Funabashi , Masakazu Yashiro , Kenichi Matsuo , Kazuhiko Yonekura , Hiroshi Hirai

Autocitrullination and Changes in the Activity of Peptidylarginine Deiminase 3 Induced by High Ca

ACS omega

Avec: Mizuki Sawata , Hiroki Shima , Kazutaka Murayama , Toshitaka Matsui , Kazuhiko Igarashi , Kazumasa Funabashi , Kenji Ite , Kenji Kizawa , Hidenari Takahara , Masaki Unno

TAS0728, A Covalent-binding, HER2-selective Kinase Inhibitor Shows Potent Antitumor Activity in Preclinical Models.

Molecular cancer therapeutics

Avec: Hiroki Irie , Kimihiro Ito , Yayoi Fujioka , Kei Oguchi , Akio Fujioka , Akihiro Hashimoto , Hirokazu Ohsawa , Kenji Tanaka , Kaoru Funabashi , Hikari Araki , Yuichi Kawai , Tadashi Shimamura , Renu Wadhwa , Shuichi Ohkubo , Kenichi Matsuo

Discovery of Futibatinib: The First Covalent FGFR Kinase Inhibitor in Clinical Use.

ACS medicinal chemistry letters

Avec: Satoru Ito , Sachie Otsuki , Hirokazu Ohsawa , Atsushi Hirano , Hideki Kazuno , Satoshi Yamashita , Kosuke Egami , Yoshihiro Shibata , Ikuo Yamamiya , Fumiaki Yamashita , Yasuo Kodama , Kaoru Funabashi , Hiromi Kazuno , Toshiharu Komori , Satoshi Suzuki , Hiroshi Sootome , Hiroshi Hirai , Takeshi Sagara

TAS2940, a novel brain-penetrable pan-ERBB inhibitor, for tumors with HER2 and EGFR aberrations.

Cancer science

Avec: Kei Oguchi , Hikari Araki , Shingo Tsuji , Masayuki Nakamura , Akihiro Miura , Kaoru Funabashi , Akiko Osada , Sakiho Tanaka , Takamasa Suzuki , Susumu S Kobayashi , Shinji Mizuarai

Vepafestinib is a pharmacologically advanced RET-selective inhibitor with high CNS penetration and inhibitory activity against RET solvent front mutations.

Nature cancer

Avec: Isao Miyazaki , Igor Odintsov , Keiji Ishida , Allan J W Lui , Masanori Kato , Tatsuya Suzuki , Tom Zhang , Kentaro Wakayama , Renate I Kurth , Ryan Cheng , Hidenori Fujita , Lukas Delasos , Morana Vojnic , Inna Khodos , Yukari Yamada , Kota Ishizawa , Marissa S Mattar , Kaoru Funabashi , Qing Chang , Shuichi Ohkubo , Wakako Yano , Ryuichiro Terada , Claudio Giuliano , Yue Christine Lu , Annalisa Bonifacio , Siddharth Kunte , Monika A Davare , Emily H Cheng , Elisa de Stanchina , Emanuela Lovati , Yoshikazu Iwasawa , Marc Ladanyi , Romel Somwar

Discovery of 3-Ethyl-4-(3-isopropyl-4-(4-(1-methyl-1 H-pyrazol-4-yl)-1 H-imidazol-1-yl)-1 H-pyrazolo[3,4- b]pyridin-1-yl)benzamide (TAS-116) as a Potent, Selective, and Orally Available HSP90 Inhibitor.

Journal of medicinal chemistry

Avec: Takao Uno , Yuichi Kawai , Satoshi Yamashita , Hiromi Oshiumi , Chihoko Yoshimura , Takashi Mizutani , Tatsuya Suzuki , Khoon Tee Chong , Kazuhiko Shigeno , Mitsuru Ohkubo , Yasuo Kodama , Hiromi Muraoka , Kaoru Funabashi , Koichi Takahashi , Shuichi Ohkubo , Makoto Kitade

Réseau de co-auteurs

Hirokazu Ohsawa 3 collaborations

Shuichi Ohkubo 3 collaborations

Toshiharu Komori 2 collaborations

Akihiro Hashimoto 2 collaborations

Susumu S Kobayashi 2 collaborations

Kazumasa Funabashi 2 collaborations

Mizuki Sawata 2 collaborations

Hidenari Takahara 2 collaborations

Kenji Kizawa 2 collaborations

Kenji Ite 2 collaborations

Masaki Unno 2 collaborations

Hiroshi Sootome 2 collaborations

Hidenori Fujita 2 collaborations

Yayoi Fujioka 2 collaborations

Kimihiro Ito 2 collaborations

Akihiro Miura 2 collaborations

Takeshi Sagara 2 collaborations

Satoru Ito 2 collaborations

Sachie Otsuki 2 collaborations

Kenichi Matsuo 2 collaborations

Hiroshi Hirai 2 collaborations

Kei Oguchi 2 collaborations

Hikari Araki 2 collaborations

Yuichi Kawai 2 collaborations

Satoshi Yamashita 2 collaborations

Yasuo Kodama 2 collaborations

Tatsuya Suzuki 2 collaborations

Hibiki Udagawa 1 collaboration

Shinichi Hasako 1 collaboration

Akihiro Ohashi 1 collaboration

Rumi Fujioka 1 collaboration

Yumi Hakozaki 1 collaboration

Mikiko Shibuya 1 collaboration

Naomi Abe 1 collaboration

Tomonori Haruma 1 collaboration

Miki Terasaka 1 collaboration

Ryoto Fujita 1 collaboration

Hiroyuki Yasuda 1 collaboration

Kazutaka Miyadera 1 collaboration

Koichi Goto 1 collaboration

Daniel B Costa 1 collaboration

Anna Nagai 1 collaboration

Megumi Akimoto 1 collaboration

Ryutaro Mashimo 1 collaboration

Paul R Thompson 1 collaboration

Kenichi Kitanishi 1 collaboration

Kenjiro Ito 1 collaboration

Hiroaki Ochiiwa 1 collaboration

Masakazu Yashiro 1 collaboration

Kazuhiko Yonekura 1 collaboration

Hiroki Shima 1 collaboration

Kazutaka Murayama 1 collaboration

Toshitaka Matsui 1 collaboration

Kazuhiko Igarashi 1 collaboration

Hiroki Irie 1 collaboration

Akio Fujioka 1 collaboration

Kenji Tanaka 1 collaboration

Tadashi Shimamura 1 collaboration

Renu Wadhwa 1 collaboration

Atsushi Hirano 1 collaboration

Hideki Kazuno 1 collaboration

Kosuke Egami 1 collaboration

Yoshihiro Shibata 1 collaboration

Ikuo Yamamiya 1 collaboration

Fumiaki Yamashita 1 collaboration

Hiromi Kazuno 1 collaboration

Satoshi Suzuki 1 collaboration

Shingo Tsuji 1 collaboration

Masayuki Nakamura 1 collaboration

Akiko Osada 1 collaboration

Sakiho Tanaka 1 collaboration

Takamasa Suzuki 1 collaboration

Shinji Mizuarai 1 collaboration

Isao Miyazaki 1 collaboration

Igor Odintsov 1 collaboration

Keiji Ishida 1 collaboration

Allan J W Lui 1 collaboration

Masanori Kato 1 collaboration

Tom Zhang 1 collaboration

Kentaro Wakayama 1 collaboration

Renate I Kurth 1 collaboration

Ryan Cheng 1 collaboration

Lukas Delasos 1 collaboration

Morana Vojnic 1 collaboration

Inna Khodos 1 collaboration

Yukari Yamada 1 collaboration

Kota Ishizawa 1 collaboration

Marissa S Mattar 1 collaboration

Qing Chang 1 collaboration

Wakako Yano 1 collaboration

Ryuichiro Terada 1 collaboration

Claudio Giuliano 1 collaboration

Yue Christine Lu 1 collaboration

Annalisa Bonifacio 1 collaboration

Siddharth Kunte 1 collaboration

Monika A Davare 1 collaboration

Emily H Cheng 1 collaboration

Elisa de Stanchina 1 collaboration

Emanuela Lovati 1 collaboration

Yoshikazu Iwasawa 1 collaboration

Marc Ladanyi 1 collaboration

Romel Somwar 1 collaboration

Takao Uno 1 collaboration

Hiromi Oshiumi 1 collaboration

Chihoko Yoshimura 1 collaboration

Takashi Mizutani 1 collaboration

Khoon Tee Chong 1 collaboration

Kazuhiko Shigeno 1 collaboration

Mitsuru Ohkubo 1 collaboration

Hiromi Muraoka 1 collaboration

Koichi Takahashi 1 collaboration

Makoto Kitade 1 collaboration