Judith M Gottwein

Affiliations

Faculty of Health and Medical Sciences, Department of Immunology and Microbiology, Copenhagen Hepatitis C Program (CO-HEP), University of Copenhagen, Copenhagen, Denmark.
Department of Infectious Diseases, Hvidovre Hospital, Hvidovre, Denmark.

Publications (24)

Antigenic and immunogenic evaluation of permutations of soluble hepatitis C virus envelope protein E2 and E1 antigens.

PloS one

Avec: Jannick Prentoe , Christoph M Janitzek , Rodrigo Velázquez-Moctezuma , Louise Goksøyr , Rebecca W Olsen , Margherita Fanalista , Elias H Augestad , Susan Thrane , Anne F Pihl , Judith M Gottwein , Adam F Sander , Jens Bukh

Inactivated genotype 1a, 2a and 3a HCV vaccine candidates induced broadly neutralising antibodies in mice.

Gut

Avec: Garazi Pena Alzua , Anne Finne Pihl , Anna Offersgaard , Carlos Rene Duarte Hernandez , Zhe Duan , Shan Feng , Ulrik Fahnøe , Christina Sølund , Nina Weis , Mansun Law , Jannick C Prentoe , Jan Pravsgaard Christensen , Jens Bukh , Judith Margarete Gottwein

Hepatitis C virus RNA is 5'-capped with flavin adenine dinucleotide.

Nature

Avec: Anna V Sherwood , Lizandro R Rivera-Rangel , Line A Ryberg , Helena S Larsen , Klara M Anker , Rui Costa , Cathrine B Vågbø , Eva Jakljevič , Long V Pham , Carlota Fernandez-Antunez , Gabriele Indrisiunaite , Agnieszka Podolska-Charlery , Julius E R Grothen , Nicklas W Langvad , Nicolas Fossat , Anna Offersgaard , Amal Al-Chaer , Louise Nielsen , Anna Kuśnierczyk , Christina Sølund , Nina Weis , Judith M Gottwein , Kenn Holmbeck , Sandro Bottaro , Santseharay Ramirez , Jens Bukh , Troels K H Scheel , Jeppe Vinther

HCV genotype 1-6 NS3 residue 80 substitutions impact protease inhibitor activity and promote viral escape.

Journal of hepatology

Avec: Long V Pham , Sanne Brun Jensen , Ulrik Fahnøe , Martin Schou Pedersen , Qi Tang , Lubna Ghanem , Santseharay Ramirez , Daryl Humes , Stéphanie B N Serre , Kristian Schønning , Jens Bukh , Judith M Gottwein

Hepatitis C Virus Protease Inhibitors Show Differential Efficacy and Interactions with Remdesivir for Treatment of SARS-CoV-2

Antimicrobial agents and chemotherapy

Avec: Karen A Gammeltoft , Yuyong Zhou , Carlos R Duarte Hernandez , Andrea Galli , Anna Offersgaard , Rui Costa , Long V Pham , Ulrik Fahnøe , Shan Feng , Troels K H Scheel , Santseharay Ramirez , Jens Bukh , Judith M Gottwein

In vitro efficacy of artemisinin-based treatments against SARS-CoV-2.

Scientific reports

Avec: Yuyong Zhou , Kerry Gilmore , Santseharay Ramirez , Eva Settels , Karen A Gammeltoft , Long V Pham , Ulrik Fahnøe , Shan Feng , Anna Offersgaard , Jakob Trimpert , Jens Bukh , Klaus Osterrieder , Judith M Gottwein , Peter H Seeberger

Effect of Glycan Shift on Antibodies against Hepatitis C Virus E2 412-425 Epitope Elicited by Chimeric sHBsAg-Based Virus-Like Particles.

Microbiology spectrum

Avec: Anna Czarnota , Anna Offersgaard , Ania Owsianka , Garazi Peña Alzua , Jens Bukh , Judith Margarete Gottwein , Arvind H Patel , Krystyna Bieńkowska-Szewczyk , Katarzyna Grzyb

Toward a vaccine against hepatitis C virus.

Science (New York, N.Y.)

Avec: Anna Offersgaard , Jens Bukh , Judith M Gottwein

Characterization of multi-DAA resistance using a novel hepatitis C virus genotype 3a infectious culture system.

Hepatology (Baltimore, Md.)

Avec: Carlota Fernandez-Antunez , Kuan Wang , Ulrik Fahnøe , Lotte S Mikkelsen , Judith M Gottwein , Jens Bukh , Santseharay Ramirez

An inactivated SARS-CoV-2 vaccine based on a Vero cell culture-adapted high-titer virus confers cross-protection in small animals.

Scientific reports

Avec: Anna Offersgaard , Carlos R Duarte Hernandez , Yuyong Zhou , Zhe Duan , Karen Anbro Gammeltoft , Katrine T Hartmann , Ulrik Fahnøe , Pavel Marichal-Gallardo , Garazi Peña Alzua , Alexander P Underwood , Christina Sølund , Nina Weis , Jesper Hansen Bonde , Jan P Christensen , Gabriel K Pedersen , Henrik Elvang Jensen , Kenn Holmbeck , Jens Bukh , Judith Margarete Gottwein

Specific Antibodies Induced by Immunization with Hepatitis B Virus-Like Particles Carrying Hepatitis C Virus Envelope Glycoprotein 2 Epitopes Show Differential Neutralization Efficiency.

Vaccines

Avec: Anna Czarnota , Anna Offersgaard , Anne Finne Pihl , Jannick Prentoe , Jens Bukh , Judith Margarete Gottwein , Krystyna Bieńkowska-Szewczyk , Katarzyna Grzyb

Substitutions in SARS-CoV-2 Mpro Selected by Protease Inhibitor Boceprevir Confer Resistance to Nirmatrelvir.

Viruses

Avec: Karen Anbro Gammeltoft , Yuyong Zhou , Line Abildgaard Ryberg , Long V Pham , Alekxander Binderup , Carlos Rene Duarte Hernandez , Anna Offersgaard , Ulrik Fahnøe , Günther Herbert Johannes Peters , Santseharay Ramirez , Jens Bukh , Judith Margarete Gottwein

An inactivated SARS-CoV-2 vaccine induced cross-neutralizing persisting antibodies and protected against challenge in small animals.

iScience

Avec: Anna Offersgaard , Carlos Rene Duarte Hernandez , Shan Feng , Pavel Marichal-Gallardo , Kenn Holmbeck , Anne Finne Pihl , Carlota Fernandez-Antunez , Garazi Peña Alzua , Katrine Top Hartmann , Long V Pham , Yuyong Zhou , Karen Anbro Gammeltoft , Ulrik Fahnøe , Uffe Vest Schneider , Gabriel Kristian Pedersen , Henrik Elvang Jensen , Jan Pravsgaard Christensen , Santseharay Ramirez , Jens Bukh , Judith Margarete Gottwein

Evolutionary Pathways to Persistence of Highly Fit and Resistant Hepatitis C Virus Protease Inhibitor Escape Variants.

Hepatology (Baltimore, Md.)

Avec: Sanne Brun Jensen , Ulrik Fahnøe , Long V Pham , Stéphanie Brigitte Nelly Serre , Qi Tang , Lubna Ghanem , Martin Schou Pedersen , Santseharay Ramirez , Daryl Humes , Anne Finne Pihl , Jonathan Filskov , Christina Søhoel Sølund , Julia Dietz , Slim Fourati , Jean-Michel Pawlotsky , Christoph Sarrazin , Nina Weis , Kristian Schønning , Henrik Krarup , Jens Bukh , Judith Margarete Gottwein

Inactivated whole hepatitis C virus vaccine employing a licensed adjuvant elicits cross-genotype neutralizing antibodies in mice.

Journal of hepatology

Avec: Anne Finne Pihl , Shan Feng , Anna Offersgaard , Garazi Peña Alzua , Elias Honerød Augestad , Christian Kjaerulff Mathiesen , Tanja Bertelsen Jensen , Henrik Krarup , Mansun Law , Jannick Prentoe , Jan Pravsgaard Christensen , Jens Bukh , Judith Margarete Gottwein

Efficacy of Ion-Channel Inhibitors Amantadine, Memantine and Rimantadine for the Treatment of SARS-CoV-2 In Vitro.

Viruses

Avec: Yuyong Zhou , Karen A Gammeltoft , Andrea Galli , Anna Offersgaard , Ulrik Fahnøe , Santseharay Ramirez , Jens Bukh , Judith M Gottwein

Identification of novel neutralizing determinants for protection against HCV.

Hepatology (Baltimore, Md.)

Avec: Garazi P Alzua , Anne F Pihl , Anna Offersgaard , Rodrigo Velázquez-Moctezuma , Carlos R Duarte Hernandez , Elias H Augestad , Ulrik Fahnøe , Christian K Mathiesen , Henrik Krarup , Mansun Law , Jannick Prentoe , Jens Bukh , Judith M Gottwein

Nirmatrelvir-resistant SARS-CoV-2 variants with high fitness in an infectious cell culture system.

Science advances

Avec: Yuyong Zhou , Karen Anbro Gammeltoft , Line Abildgaard Ryberg , Long V Pham , Helena Damtoft Tjørnelund , Alekxander Binderup , Carlos Rene Duarte Hernandez , Carlota Fernandez-Antunez , Anna Offersgaard , Ulrik Fahnøe , Günther Herbert Johannes Peters , Santseharay Ramirez , Jens Bukh , Judith Margarete Gottwein

JFH1-based Core-NS2 genotype variants of HCV with genetic stability in vivo and in vitro: Important tools in evaluation of virus neutralization.

Hepatology (Baltimore, Md.)

Avec: Laura Collignon , Kenn Holmbeck , Ashley Just , Lieven Verhoye , Rodrigo Velázquez-Moctezuma , Ulrik Fahnøe , Thomas H R Carlsen , Mansun Law , Jannick Prentoe , Troels K H Scheel , Judith M Gottwein , Philip Meuleman , Jens Bukh

Overcoming Culture Restriction for SARS-CoV-2 in Human Cells Facilitates the Screening of Compounds Inhibiting Viral Replication.

Antimicrobial agents and chemotherapy

Avec: Santseharay Ramirez , Carlota Fernandez-Antunez , Andrea Galli , Alexander Underwood , Long V Pham , Line A Ryberg , Shan Feng , Martin S Pedersen , Lotte S Mikkelsen , Sandrine Belouzard , Jean Dubuisson , Christina Sølund , Nina Weis , Judith M Gottwein , Ulrik Fahnøe , Jens Bukh

Development of a downstream process for the production of an inactivated whole hepatitis C virus vaccine.

Scientific reports

Avec: Keven Lothert , Anna F Offersgaard , Anne F Pihl , Christian K Mathiesen , Tanja B Jensen , Garazi Peña Alzua , Ulrik Fahnøe , Jens Bukh , Judith M Gottwein , Michael W Wolff

SARS-CoV-2 Production in a Scalable High Cell Density Bioreactor.

Vaccines

Avec: Anna Offersgaard , Carlos Rene Duarte Hernandez , Anne Finne Pihl , Rui Costa , Nandini Prabhakar Venkatesan , Xiangliang Lin , Long Van Pham , Shan Feng , Ulrik Fahnøe , Troels Kasper Høyer Scheel , Santseharay Ramirez , Udo Reichl , Jens Bukh , Yvonne Genzel , Judith Margarete Gottwein

High-Titer Hepatitis C Virus Production in a Scalable Single-Use High Cell Density Bioreactor.

Vaccines

Avec: Anna Offersgaard , Carlos Rene Duarte Hernandez , Anne Finne Pihl , Nandini Prabhakar Venkatesan , Henrik Krarup , Xiangliang Lin , Udo Reichl , Jens Bukh , Yvonne Genzel , Judith Margarete Gottwein

Versatile SARS-CoV-2 Reverse-Genetics Systems for the Study of Antiviral Resistance and Replication.

Viruses

Avec: Ulrik Fahnøe , Long V Pham , Carlota Fernandez-Antunez , Rui Costa , Lizandro René Rivera-Rangel , Andrea Galli , Shan Feng , Lotte S Mikkelsen , Judith M Gottwein , Troels K H Scheel , Santseharay Ramirez , Jens Bukh

Réseau de co-auteurs

Jens Bukh 24 collaborations

Ulrik Fahnøe 17 collaborations

Anna Offersgaard 16 collaborations

Santseharay Ramirez 13 collaborations

Judith Margarete Gottwein 11 collaborations

Long V Pham 10 collaborations

Shan Feng 8 collaborations

Anne Finne Pihl 7 collaborations

Yuyong Zhou 7 collaborations

Carlos Rene Duarte Hernandez 6 collaborations

Carlota Fernandez-Antunez 6 collaborations

Jannick Prentoe 5 collaborations

Nina Weis 5 collaborations

Garazi Peña Alzua 5 collaborations

Christina Sølund 4 collaborations

Mansun Law 4 collaborations

Rui Costa 4 collaborations

Kenn Holmbeck 4 collaborations

Troels K H Scheel 4 collaborations

Andrea Galli 4 collaborations

Karen Anbro Gammeltoft 4 collaborations

Henrik Krarup 4 collaborations

Rodrigo Velázquez-Moctezuma 3 collaborations

Anne F Pihl 3 collaborations

Jan Pravsgaard Christensen 3 collaborations

Karen A Gammeltoft 3 collaborations

Carlos R Duarte Hernandez 3 collaborations

Lotte S Mikkelsen 3 collaborations

Elias H Augestad 2 collaborations

Zhe Duan 2 collaborations

Line A Ryberg 2 collaborations

Sanne Brun Jensen 2 collaborations

Martin Schou Pedersen 2 collaborations

Qi Tang 2 collaborations

Lubna Ghanem 2 collaborations

Daryl Humes 2 collaborations

Kristian Schønning 2 collaborations

Anna Czarnota 2 collaborations

Krystyna Bieńkowska-Szewczyk 2 collaborations

Katarzyna Grzyb 2 collaborations

Pavel Marichal-Gallardo 2 collaborations

Henrik Elvang Jensen 2 collaborations

Line Abildgaard Ryberg 2 collaborations

Alekxander Binderup 2 collaborations

Günther Herbert Johannes Peters 2 collaborations

Christian K Mathiesen 2 collaborations

Nandini Prabhakar Venkatesan 2 collaborations

Xiangliang Lin 2 collaborations

Udo Reichl 2 collaborations

Yvonne Genzel 2 collaborations

Christoph M Janitzek 1 collaboration

Louise Goksøyr 1 collaboration

Rebecca W Olsen 1 collaboration

Margherita Fanalista 1 collaboration

Susan Thrane 1 collaboration

Adam F Sander 1 collaboration

Garazi Pena Alzua 1 collaboration

Jannick C Prentoe 1 collaboration

Anna V Sherwood 1 collaboration

Lizandro R Rivera-Rangel 1 collaboration

Helena S Larsen 1 collaboration

Klara M Anker 1 collaboration

Cathrine B Vågbø 1 collaboration

Eva Jakljevič 1 collaboration

Gabriele Indrisiunaite 1 collaboration

Agnieszka Podolska-Charlery 1 collaboration

Julius E R Grothen 1 collaboration

Nicklas W Langvad 1 collaboration

Nicolas Fossat 1 collaboration

Amal Al-Chaer 1 collaboration

Louise Nielsen 1 collaboration

Anna Kuśnierczyk 1 collaboration

Sandro Bottaro 1 collaboration

Jeppe Vinther 1 collaboration

Stéphanie B N Serre 1 collaboration

Kerry Gilmore 1 collaboration

Eva Settels 1 collaboration

Jakob Trimpert 1 collaboration

Klaus Osterrieder 1 collaboration

Peter H Seeberger 1 collaboration

Ania Owsianka 1 collaboration

Arvind H Patel 1 collaboration

Kuan Wang 1 collaboration

Katrine T Hartmann 1 collaboration

Alexander P Underwood 1 collaboration

Jesper Hansen Bonde 1 collaboration

Jan P Christensen 1 collaboration

Gabriel K Pedersen 1 collaboration

Katrine Top Hartmann 1 collaboration

Uffe Vest Schneider 1 collaboration

Gabriel Kristian Pedersen 1 collaboration

Stéphanie Brigitte Nelly Serre 1 collaboration

Jonathan Filskov 1 collaboration

Christina Søhoel Sølund 1 collaboration

Julia Dietz 1 collaboration

Slim Fourati 1 collaboration

Jean-Michel Pawlotsky 1 collaboration

Christoph Sarrazin 1 collaboration

Elias Honerød Augestad 1 collaboration

Christian Kjaerulff Mathiesen 1 collaboration

Tanja Bertelsen Jensen 1 collaboration

Garazi P Alzua 1 collaboration

Helena Damtoft Tjørnelund 1 collaboration

Laura Collignon 1 collaboration

Ashley Just 1 collaboration

Lieven Verhoye 1 collaboration

Thomas H R Carlsen 1 collaboration

Philip Meuleman 1 collaboration

Alexander Underwood 1 collaboration

Martin S Pedersen 1 collaboration

Sandrine Belouzard 1 collaboration

Jean Dubuisson 1 collaboration

Keven Lothert 1 collaboration

Anna F Offersgaard 1 collaboration

Tanja B Jensen 1 collaboration

Michael W Wolff 1 collaboration

Long Van Pham 1 collaboration

Troels Kasper Høyer Scheel 1 collaboration

Lizandro René Rivera-Rangel 1 collaboration