John P O'Bryan

Affiliations

Department of Cell and Molecular Pharmacology and Experimental Therapeutics, Hollings Cancer Center, Medical University of South Carolina, Charleston, SC 29425, United States of America; Ralph H. Johnson VA Medical Center, Charleston, SC 29401, United States of America. Electronic address: obryanjo@musc.edu.

Publications (13)

Therapeutic targeting of RAS: New hope for drugging the "undruggable".

Biochimica et biophysica acta. Molecular cell research

Avec: Imran Khan , J Matthew Rhett , John P O'Bryan

Identification of the nucleotide-free state as a therapeutic vulnerability for inhibition of selected oncogenic RAS mutants.

Cell reports

Avec: Imran Khan , Akiko Koide , Mariyam Zuberi , Gayatri Ketavarapu , Eric Denbaum , Kai Wen Teng , J Matthew Rhett , Russell Spencer-Smith , G Aaron Hobbs , Ernest Ramsay Camp , Shohei Koide , John P O'Bryan

Ceramide synthase 6 impacts T-cell allogeneic response and graft-versus-host disease through regulating N-RAS/ERK pathway.

Leukemia

Avec: M Hanief Sofi , Linlu Tian , Steven Schutt , Imran Khan , Hee-Jin Choi , Yongxia Wu , David Bastian , Taylor Ticer , Mohamed Faisal Kassir , Firdevs Cansu Atilgan , Jisun Kim , Xiaohui Sui , Aleksandra Zivkovic , Shikhar Mehrotra , John P O'Bryan , Holger Stark , Paul J Martin , Besim Ogretmen , Xue-Zhong Yu

Inhibition of RAS-driven signaling and tumorigenesis with a pan-RAS monobody targeting the Switch I/II pocket.

Proceedings of the National Academy of Sciences of the United States of America

Avec: Lauren Wallon , Imran Khan , Kai Wen Teng , Akiko Koide , Mariyam Zuberi , Jianping Li , Gayatri Ketavarapu , Nathaniel J Traaseth , John P O'Bryan , Shohei Koide

Mutations in the α4-α5 allosteric lobe of RAS do not significantly impair RAS signaling or self-association.

The Journal of biological chemistry

Avec: Michael Whaby , Lauren Wallon , Megan Mazzei , Imran Khan , Kai Wen Teng , Shohei Koide , John P O'Bryan

HSP70-mediated mitochondrial dynamics and autophagy represent a novel vulnerability in pancreatic cancer.

Cell death and differentiation

Avec: Giulia D S Ferretti , Colleen E Quaas , Irene Bertolini , Alessandro Zuccotti , Ozge Saatci , Jennifer A Kashatus , Salma Sharmin , David Y Lu , Adi Narayana Reddy Poli , Abigail F Quesnelle , Jezabel Rodriguez-Blanco , Aguirre A de Cubas , G Aaron Hobbs , Qin Liu , John P O'Bryan , Joseph M Salvino , David F Kashatus , Ozgur Sahin , Thibaut Barnoud

The P-type ATPase transporter ATP7A promotes angiogenesis by limiting autophagic degradation of VEGFR2.

Nature communications

Avec: Dipankar Ash , Varadarajan Sudhahar , Seock-Won Youn , Mustafa Nazir Okur , Archita Das , John P O'Bryan , Maggie McMenamin , Yali Hou , Jack H Kaplan , Tohru Fukai , Masuko Ushio-Fukai

Probing RAS Function with Monobodies.

Methods in molecular biology (Clifton, N.J.)

Avec: Imran Khan , John P O'Bryan

Targeting the α4-α5 interface of RAS results in multiple levels of inhibition.

Small GTPases

Avec: Russell Spencer-Smith , Lie Li , Sheela Prasad , Akiko Koide , Shohei Koide , John P O'Bryan

Direct inhibition of RAS: Quest for the Holy Grail?

Seminars in cancer biology

Avec: Russell Spencer-Smith , John P O'Bryan

Targeting the α4-α5 dimerization interface of K-RAS inhibits tumor formation in vivo.

Oncogene

Avec: Imran Khan , Russell Spencer-Smith , John P O'Bryan

Inhibition of RAS: proven and potential vulnerabilities.

Biochemical Society transactions

Avec: Mariyam Zuberi , Imran Khan , John P O'Bryan

Selective and noncovalent targeting of RAS mutants for inhibition and degradation.

Nature communications

Avec: Kai Wen Teng , Steven T Tsai , Takamitsu Hattori , Carmine Fedele , Akiko Koide , Chao Yang , Xuben Hou , Yingkai Zhang , Benjamin G Neel , John P O'Bryan , Shohei Koide

Réseau de co-auteurs

Imran Khan 8 collaborations

Shohei Koide 5 collaborations

Akiko Koide 4 collaborations

Kai Wen Teng 4 collaborations

Russell Spencer-Smith 4 collaborations

Mariyam Zuberi 3 collaborations

J Matthew Rhett 2 collaborations

Gayatri Ketavarapu 2 collaborations

G Aaron Hobbs 2 collaborations

Lauren Wallon 2 collaborations

Eric Denbaum 1 collaboration

Ernest Ramsay Camp 1 collaboration

M Hanief Sofi 1 collaboration

Linlu Tian 1 collaboration

Steven Schutt 1 collaboration

Hee-Jin Choi 1 collaboration

Yongxia Wu 1 collaboration

David Bastian 1 collaboration

Taylor Ticer 1 collaboration

Mohamed Faisal Kassir 1 collaboration

Firdevs Cansu Atilgan 1 collaboration

Jisun Kim 1 collaboration

Xiaohui Sui 1 collaboration

Aleksandra Zivkovic 1 collaboration

Shikhar Mehrotra 1 collaboration

Holger Stark 1 collaboration

Paul J Martin 1 collaboration

Besim Ogretmen 1 collaboration

Xue-Zhong Yu 1 collaboration

Jianping Li 1 collaboration

Nathaniel J Traaseth 1 collaboration

Michael Whaby 1 collaboration

Megan Mazzei 1 collaboration

Giulia D S Ferretti 1 collaboration

Colleen E Quaas 1 collaboration

Irene Bertolini 1 collaboration

Alessandro Zuccotti 1 collaboration

Ozge Saatci 1 collaboration

Jennifer A Kashatus 1 collaboration

Salma Sharmin 1 collaboration

David Y Lu 1 collaboration

Adi Narayana Reddy Poli 1 collaboration

Abigail F Quesnelle 1 collaboration

Jezabel Rodriguez-Blanco 1 collaboration

Aguirre A de Cubas 1 collaboration

Qin Liu 1 collaboration

Joseph M Salvino 1 collaboration

David F Kashatus 1 collaboration

Ozgur Sahin 1 collaboration

Thibaut Barnoud 1 collaboration

Dipankar Ash 1 collaboration

Varadarajan Sudhahar 1 collaboration

Seock-Won Youn 1 collaboration

Mustafa Nazir Okur 1 collaboration

Archita Das 1 collaboration

Maggie McMenamin 1 collaboration

Yali Hou 1 collaboration

Jack H Kaplan 1 collaboration

Tohru Fukai 1 collaboration

Masuko Ushio-Fukai 1 collaboration

Lie Li 1 collaboration

Sheela Prasad 1 collaboration

Steven T Tsai 1 collaboration

Takamitsu Hattori 1 collaboration

Carmine Fedele 1 collaboration

Chao Yang 1 collaboration

Xuben Hou 1 collaboration

Yingkai Zhang 1 collaboration

Benjamin G Neel 1 collaboration