Jacek Mokrosiński

Affiliations

University of Cambridge Metabolic Research Laboratories and NIHR Cambridge Biomedical Research Centre, Wellcome-MRC Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, CB2 0QQ, UK.

ORCID: 0000-0001-5008-0457

Publications (6)

A rare human variant that disrupts GPR10 signalling causes weight gain in mice.

Nature communications

Avec: Fleur Talbot , Claire H Feetham , Jacek Mokrosiński , Katherine Lawler , Julia M Keogh , Elana Henning , Edson Mendes de Oliveira , Vikram Ayinampudi , Sadia Saeed , Amélie Bonnefond , Mohammed Arslan , Giles S H Yeo , Philippe Froguel , David A Bechtold , Antony Adamson , Neil Humphreys , Inês Barroso , Simon M Luckman , I Sadaf Farooqi

Loss-of-function mutations in the melanocortin 4 receptor in a UK birth cohort.

Nature medicine

Avec: Kaitlin H Wade , Brian Y H Lam , Audrey Melvin , Warren Pan , Laura J Corbin , David A Hughes , Kara Rainbow , Jian-Hua Chen , Katie Duckett , Xiaoming Liu , Jacek Mokrosiński , Alexander Mörseburg , Sam Neaves , Alice Williamson , Chen Zhang , I Sadaf Farooqi , Giles S H Yeo , Nicholas J Timpson , Stephen O'Rahilly

Human MC4R variants affect endocytosis, trafficking and dimerization revealing multiple cellular mechanisms involved in weight regulation.

Cell reports

Avec: Bas Brouwers , Edson Mendes de Oliveira , Maria Marti-Solano , Fabiola B F Monteiro , Suli-Anne Laurin , Julia M Keogh , Elana Henning , Rebecca Bounds , Carole A Daly , Shane Houston , Vikram Ayinampudi , Natalia Wasiluk , David Clarke , Bianca Plouffe , Michel Bouvier , M Madan Babu , I Sadaf Farooqi , Jacek Mokrosiński

Obesity-Associated

The New England journal of medicine

Avec: Edson Mendes de Oliveira , Julia M Keogh , Fleur Talbot , Elana Henning , Rachel Ahmed , Aliki Perdikari , Rebecca Bounds , Natalia Wasiluk , Vikram Ayinampudi , Inês Barroso , Jacek Mokrosiński , Deepthi Jyothish , Sharon Lim , Sanjay Gupta , Melanie Kershaw , Cristina Matei , Praveen Partha , Tabitha Randell , Antoinette McAulay , Louise C Wilson , Tim Cheetham , Elizabeth C Crowne , Peter Clayton , I Sadaf Farooqi

Human Gain-of-Function MC4R Variants Show Signaling Bias and Protect against Obesity.

Cell

Avec: Luca A Lotta , Jacek Mokrosiński , Edson Mendes de Oliveira , Chen Li , Stephen J Sharp , Jian'an Luan , Bas Brouwers , Vikram Ayinampudi , Nicholas Bowker , Nicola Kerrison , Vasileios Kaimakis , Diana Hoult , Isobel D Stewart , Eleanor Wheeler , Felix R Day , John R B Perry , Claudia Langenberg , Nicholas J Wareham , I Sadaf Farooqi

Characterization of genetic variants of GIPR reveals a contribution of β-arrestin to metabolic phenotypes.

Nature metabolism

Avec: Hüsün S Kizilkaya , Kimmie V Sørensen , Jakob S Madsen , Peter Lindquist , Jonathan D Douros , Jette Bork-Jensen , Alessandro Berghella , Peter A Gerlach , Lærke S Gasbjerg , Jacek Mokrosiński , Stephanie A Mowery , Patrick J Knerr , Brian Finan , Jonathan E Campbell , David A D'Alessio , Diego Perez-Tilve , Felix Faas , Signe Mathiasen , Jørgen Rungby , Henrik T Sørensen , Allan Vaag , Jens S Nielsen , Jens-Christian Holm , Jeannet Lauenborg , Peter Damm , Oluf Pedersen , Allan Linneberg , Bolette Hartmann , Jens J Holst , Torben Hansen , Shane C Wright , Volker M Lauschke , Niels Grarup , Alexander S Hauser , Mette M Rosenkilde

Réseau de co-auteurs

I Sadaf Farooqi 5 collaborations

Edson Mendes de Oliveira 4 collaborations

Vikram Ayinampudi 4 collaborations

Julia M Keogh 3 collaborations

Elana Henning 3 collaborations

Fleur Talbot 2 collaborations

Giles S H Yeo 2 collaborations

Inês Barroso 2 collaborations

Bas Brouwers 2 collaborations

Rebecca Bounds 2 collaborations

Natalia Wasiluk 2 collaborations

Claire H Feetham 1 collaboration

Katherine Lawler 1 collaboration

Sadia Saeed 1 collaboration

Amélie Bonnefond 1 collaboration

Mohammed Arslan 1 collaboration

Philippe Froguel 1 collaboration

David A Bechtold 1 collaboration

Antony Adamson 1 collaboration

Neil Humphreys 1 collaboration

Simon M Luckman 1 collaboration

Kaitlin H Wade 1 collaboration

Brian Y H Lam 1 collaboration

Audrey Melvin 1 collaboration

Warren Pan 1 collaboration

Laura J Corbin 1 collaboration

David A Hughes 1 collaboration

Kara Rainbow 1 collaboration

Jian-Hua Chen 1 collaboration

Katie Duckett 1 collaboration

Xiaoming Liu 1 collaboration

Alexander Mörseburg 1 collaboration

Sam Neaves 1 collaboration

Alice Williamson 1 collaboration

Chen Zhang 1 collaboration

Nicholas J Timpson 1 collaboration

Stephen O'Rahilly 1 collaboration

Maria Marti-Solano 1 collaboration

Fabiola B F Monteiro 1 collaboration

Suli-Anne Laurin 1 collaboration

Carole A Daly 1 collaboration

Shane Houston 1 collaboration

David Clarke 1 collaboration

Bianca Plouffe 1 collaboration

Michel Bouvier 1 collaboration

M Madan Babu 1 collaboration

Rachel Ahmed 1 collaboration

Aliki Perdikari 1 collaboration

Deepthi Jyothish 1 collaboration

Sharon Lim 1 collaboration

Sanjay Gupta 1 collaboration

Melanie Kershaw 1 collaboration

Cristina Matei 1 collaboration

Praveen Partha 1 collaboration

Tabitha Randell 1 collaboration

Antoinette McAulay 1 collaboration

Louise C Wilson 1 collaboration

Tim Cheetham 1 collaboration

Elizabeth C Crowne 1 collaboration

Peter Clayton 1 collaboration

Luca A Lotta 1 collaboration

Chen Li 1 collaboration

Stephen J Sharp 1 collaboration

Jian'an Luan 1 collaboration

Nicholas Bowker 1 collaboration

Nicola Kerrison 1 collaboration

Vasileios Kaimakis 1 collaboration

Diana Hoult 1 collaboration

Isobel D Stewart 1 collaboration

Eleanor Wheeler 1 collaboration

Felix R Day 1 collaboration

John R B Perry 1 collaboration

Claudia Langenberg 1 collaboration

Nicholas J Wareham 1 collaboration

Hüsün S Kizilkaya 1 collaboration

Kimmie V Sørensen 1 collaboration

Jakob S Madsen 1 collaboration

Peter Lindquist 1 collaboration

Jonathan D Douros 1 collaboration

Jette Bork-Jensen 1 collaboration

Alessandro Berghella 1 collaboration

Peter A Gerlach 1 collaboration

Lærke S Gasbjerg 1 collaboration

Stephanie A Mowery 1 collaboration

Patrick J Knerr 1 collaboration

Brian Finan 1 collaboration

Jonathan E Campbell 1 collaboration

David A D'Alessio 1 collaboration

Diego Perez-Tilve 1 collaboration

Felix Faas 1 collaboration

Signe Mathiasen 1 collaboration

Jørgen Rungby 1 collaboration

Henrik T Sørensen 1 collaboration

Allan Vaag 1 collaboration

Jens S Nielsen 1 collaboration

Jens-Christian Holm 1 collaboration

Jeannet Lauenborg 1 collaboration

Peter Damm 1 collaboration

Oluf Pedersen 1 collaboration

Allan Linneberg 1 collaboration

Bolette Hartmann 1 collaboration

Jens J Holst 1 collaboration

Torben Hansen 1 collaboration

Shane C Wright 1 collaboration

Volker M Lauschke 1 collaboration

Niels Grarup 1 collaboration

Alexander S Hauser 1 collaboration

Mette M Rosenkilde 1 collaboration