J M Valpuesta

Affiliations

Department of Macromolecular Structure, Computational Systems Biology Group, Centro Nacional de Biotecnología (CNB-CSIC), Madrid, 28049, Spain. fsmadrid@salud.madrid.org jmv@cnb.csic.es noa.martin@salud.madrid.org.

ORCID: 0000-0001-7468-8053

Publications (22)

Chaperonin Mechanisms: Multiple and (Mis)Understood?

Annual review of biophysics

Avec: Amnon Horovitz , Tali Haviv Reingewertz , Jorge Cuéllar , José María Valpuesta

Structural insights into the ability of nucleoplasmin to assemble and chaperone histone octamers for DNA deposition.

Scientific reports

Avec: Aitor Franco , Rocío Arranz , Noelia Fernández-Rivero , Adrián Velázquez-Campoy , Jaime Martín-Benito , Joan Segura , Adelina Prado , José M Valpuesta , Arturo Muga

Molecular architecture of the Bardet-Biedl syndrome protein 2-7-9 subcomplex.

The Journal of biological chemistry

Avec: W Grant Ludlam , Takuma Aoba , Jorge Cuéllar , M Teresa Bueno-Carrasco , Aman Makaju , James D Moody , Sarah Franklin , José M Valpuesta , Barry M Willardson

Globular Aggregates Stemming from the Self-Assembly of an Amphiphilic

Nanomaterials (Basel, Switzerland)

Avec: Manuel A Martínez , Elisa E Greciano , Jorge Cuéllar , José M Valpuesta , Luis Sánchez

Assisted assembly of bacteriophage T7 core components for genome translocation across the bacterial envelope.

Proceedings of the National Academy of Sciences of the United States of America

Avec: Mar Pérez-Ruiz , Mar Pulido-Cid , Juan Román Luque-Ortega , José María Valpuesta , Ana Cuervo , José L Carrascosa

Nucleus-translocated mitochondrial cytochrome c liberates nucleophosmin-sequestered ARF tumor suppressor by changing nucleolar liquid-liquid phase separation.

Nature structural & molecular biology

Avec: Katiuska González-Arzola , Antonio Díaz-Quintana , Noelia Bernardo-García , Jonathan Martínez-Fábregas , Francisco Rivero-Rodríguez , Miguel Á Casado-Combreras , Carlos A Elena-Real , Alejandro Velázquez-Cruz , Sergio Gil-Caballero , Adrián Velázquez-Campoy , Elzbieta Szulc , María P Gavilán , Isabel Ayala , Rocío Arranz , Rosa M Ríos , Xavier Salvatella , José M Valpuesta , Juan A Hermoso , Miguel A De la Rosa , Irene Díaz-Moreno

The self-association equilibrium of DNAJA2 regulates its interaction with unfolded substrate proteins and with Hsc70.

Nature communications

Avec: Lorea Velasco-Carneros , Jorge Cuéllar , Leire Dublang , César Santiago , Jean-Didier Maréchal , Jaime Martín-Benito , Moisés Maestro , José Ángel Fernández-Higuero , Natalia Orozco , Fernando Moro , José María Valpuesta , Arturo Muga

Truncation-Driven Lateral Association of α-Synuclein Hinders Amyloid Clearance by the Hsp70-Based Disaggregase.

International journal of molecular sciences

Avec: Aitor Franco , Jorge Cuéllar , José Ángel Fernández-Higuero , Igor de la Arada , Natalia Orozco , José M Valpuesta , Adelina Prado , Arturo Muga

Chaperonins: Nanocarriers with Biotechnological Applications.

Nanomaterials (Basel, Switzerland)

Avec: Sergio Pipaón , Marcos Gragera , M Teresa Bueno-Carrasco , Juan García-Bernalt Diego , Miguel Cantero , Jorge Cuéllar , María Rosario Fernández-Fernández , José María Valpuesta

T cell asymmetry and metabolic crosstalk can fine-tune immunological synapses.

Trends in immunology

Avec: Noa Beatriz Martin-Cofreces , Jose Maria Valpuesta , Francisco Sánchez-Madrid

Chaperonin CCT controls extracellular vesicle production and cell metabolism through kinesin dynamics.

Journal of extracellular vesicles

Avec: Amelia Rojas-Gómez , Sara G Dosil , Francisco J Chichón , Nieves Fernández-Gallego , Alessia Ferrarini , Enrique Calvo , Diego Calzada-Fraile , Silvia Requena , Joaquin Otón , Alvaro Serrano , Rocio Tarifa , Montserrat Arroyo , Andrea Sorrentino , Eva Pereiro , Jesus Vázquez , José M Valpuesta , Francisco Sánchez-Madrid , Noa B Martín-Cófreces

Folding for the Immune Synapse: CCT Chaperonin and the Cytoskeleton.

Frontiers in cell and developmental biology

Avec: Noa Beatriz Martín-Cófreces , José María Valpuesta , Francisco Sánchez-Madrid

Arc self-association and formation of virus-like capsids are mediated by an N-terminal helical coil motif.

The FEBS journal

Avec: Maria S Eriksen , Oleksii Nikolaienko , Erik I Hallin , Sverre Grødem , Helene J Bustad , Marte I Flydal , Ian Merski , Tomohisa Hosokawa , Daniela Lascu , Shreeram Akerkar , Jorge Cuéllar , James J Chambers , Rory O'Connell , Gopinath Muruganandam , Remy Loris , Christine Touma , Tambudzai Kanhema , Yasunori Hayashi , Margaret M Stratton , José M Valpuesta , Petri Kursula , Aurora Martinez , Clive R Bramham

The chaperonin CCT controls T cell receptor-driven 3D configuration of centrioles.

Science advances

Avec: N B Martin-Cofreces , F J Chichon , E Calvo , D Torralba , E Bustos-Moran , S G Dosil , A Rojas-Gomez , E Bonzon-Kulichenko , J A Lopez , J Otón , A Sorrentino , J C Zabala , I Vernos , J Vazquez , J M Valpuesta , F Sanchez-Madrid

The cochaperone CHIP marks Hsp70- and Hsp90-bound substrates for degradation through a very flexible mechanism.

Scientific reports

Avec: Lucía Quintana-Gallardo , Jaime Martín-Benito , Miguel Marcilla , Guadalupe Espadas , Eduard Sabidó , José María Valpuesta

Structural mechanism for tyrosine hydroxylase inhibition by dopamine and reactivation by Ser40 phosphorylation.

Nature communications

Avec: María Teresa Bueno-Carrasco , Jorge Cuéllar , Marte I Flydal , César Santiago , Trond-André Kråkenes , Rune Kleppe , José R López-Blanco , Miguel Marcilla , Knut Teigen , Sara Alvira , Pablo Chacón , Aurora Martinez , José M Valpuesta

The Molecular Chaperone CCT Sequesters Gelsolin and Protects it from Cleavage by Caspase-3.

Journal of molecular biology

Avec: Jorge Cuéllar , Josefine Vallin , Andreas Svanström , Moisés Maestro-López , María Teresa Bueno-Carrasco , W Grant Ludlam , Barry M Willardson , José M Valpuesta , Julie Grantham

A Targetable N-Terminal Motif Orchestrates α-Synuclein Oligomer-to-Fibril Conversion.

Journal of the American Chemical Society

Avec: Jaime Santos , Jorge Cuellar , Irantzu Pallarès , Emily J Byrd , Alons Lends , Fernando Moro , Muhammed Bilal Abdul-Shukkoor , Jordi Pujols , Lorea Velasco-Carneros , Frank Sobott , Daniel E Otzen , Antonio N Calabrese , Arturo Muga , Jan Skov Pedersen , Antoine Loquet , Jose María Valpuesta , Sheena E Radford , Salvador Ventura

Engineering protein assemblies with allosteric control via monomer fold-switching.

Nature communications

Avec: Luis A Campos , Rajendra Sharma , Sara Alvira , Federico M Ruiz , Beatriz Ibarra-Molero , Mourad Sadqi , Carlos Alfonso , Germán Rivas , Jose M Sanchez-Ruiz , Antonio Romero Garrido , José M Valpuesta , Victor Muñoz

Elevated levels of Secreted-Frizzled-Related-Protein 1 contribute to Alzheimer's disease pathogenesis.

Nature neuroscience

Avec: Pilar Esteve , Javier Rueda-Carrasco , María Inés Mateo , María Jesús Martin-Bermejo , Jonathan Draffin , Guadalupe Pereyra , África Sandonís , Inmaculada Crespo , Inmaculada Moreno , Ester Aso , Paula Garcia-Esparcia , Estrella Gomez-Tortosa , Alberto Rábano , Juan Fortea , Daniel Alcolea , Alberto Lleo , Michael T Heneka , José M Valpuesta , José A Esteban , Isidro Ferrer , Mercedes Domínguez , Paola Bovolenta

Structural and functional analysis of the role of the chaperonin CCT in mTOR complex assembly.

Nature communications

Avec: Jorge Cuéllar , W Grant Ludlam , Nicole C Tensmeyer , Takuma Aoba , Madhura Dhavale , César Santiago , M Teresa Bueno-Carrasco , Michael J Mann , Rebecca L Plimpton , Aman Makaju , Sarah Franklin , Barry M Willardson , José M Valpuesta

Combining Electron Microscopy (EM) and Cross-Linking Mass Spectrometry (XL-MS) for Structural Characterization of Protein Complexes.

Methods in molecular biology (Clifton, N.J.)

Avec: Lucía Quintana-Gallardo , Moisés Maestro-López , Jaime Martín-Benito , Miguel Marcilla , Daniel Rutz , Johannes Buchner , José M Valpuesta , Jorge Cuéllar

Réseau de co-auteurs

José M Valpuesta 13 collaborations

Jorge Cuéllar 11 collaborations

José María Valpuesta 6 collaborations

Jaime Martín-Benito 4 collaborations

Arturo Muga 4 collaborations

W Grant Ludlam 3 collaborations

M Teresa Bueno-Carrasco 3 collaborations

Barry M Willardson 3 collaborations

César Santiago 3 collaborations

Francisco Sánchez-Madrid 3 collaborations

Miguel Marcilla 3 collaborations

Aitor Franco 2 collaborations

Rocío Arranz 2 collaborations

Adrián Velázquez-Campoy 2 collaborations

Adelina Prado 2 collaborations

Takuma Aoba 2 collaborations

Aman Makaju 2 collaborations

Sarah Franklin 2 collaborations

Lorea Velasco-Carneros 2 collaborations

José Ángel Fernández-Higuero 2 collaborations

Natalia Orozco 2 collaborations

Fernando Moro 2 collaborations

Marte I Flydal 2 collaborations

Aurora Martinez 2 collaborations

Lucía Quintana-Gallardo 2 collaborations

María Teresa Bueno-Carrasco 2 collaborations

Sara Alvira 2 collaborations

Moisés Maestro-López 2 collaborations

Amnon Horovitz 1 collaboration

Tali Haviv Reingewertz 1 collaboration

Noelia Fernández-Rivero 1 collaboration

Joan Segura 1 collaboration

James D Moody 1 collaboration

Manuel A Martínez 1 collaboration

Elisa E Greciano 1 collaboration

Luis Sánchez 1 collaboration

Mar Pérez-Ruiz 1 collaboration

Mar Pulido-Cid 1 collaboration

Juan Román Luque-Ortega 1 collaboration

Ana Cuervo 1 collaboration

José L Carrascosa 1 collaboration

Katiuska González-Arzola 1 collaboration

Antonio Díaz-Quintana 1 collaboration

Noelia Bernardo-García 1 collaboration

Jonathan Martínez-Fábregas 1 collaboration

Francisco Rivero-Rodríguez 1 collaboration

Miguel Á Casado-Combreras 1 collaboration

Carlos A Elena-Real 1 collaboration

Alejandro Velázquez-Cruz 1 collaboration

Sergio Gil-Caballero 1 collaboration

Elzbieta Szulc 1 collaboration

María P Gavilán 1 collaboration

Isabel Ayala 1 collaboration

Rosa M Ríos 1 collaboration

Xavier Salvatella 1 collaboration

Juan A Hermoso 1 collaboration

Miguel A De la Rosa 1 collaboration

Irene Díaz-Moreno 1 collaboration

Leire Dublang 1 collaboration

Jean-Didier Maréchal 1 collaboration

Moisés Maestro 1 collaboration

Igor de la Arada 1 collaboration

Sergio Pipaón 1 collaboration

Marcos Gragera 1 collaboration

Juan García-Bernalt Diego 1 collaboration

Miguel Cantero 1 collaboration

María Rosario Fernández-Fernández 1 collaboration

Noa Beatriz Martin-Cofreces 1 collaboration

Jose Maria Valpuesta 1 collaboration

Amelia Rojas-Gómez 1 collaboration

Sara G Dosil 1 collaboration

Francisco J Chichón 1 collaboration

Nieves Fernández-Gallego 1 collaboration

Alessia Ferrarini 1 collaboration

Enrique Calvo 1 collaboration

Diego Calzada-Fraile 1 collaboration

Silvia Requena 1 collaboration

Joaquin Otón 1 collaboration

Alvaro Serrano 1 collaboration

Rocio Tarifa 1 collaboration

Montserrat Arroyo 1 collaboration

Andrea Sorrentino 1 collaboration

Eva Pereiro 1 collaboration

Jesus Vázquez 1 collaboration

Noa B Martín-Cófreces 1 collaboration

Noa Beatriz Martín-Cófreces 1 collaboration

Maria S Eriksen 1 collaboration

Oleksii Nikolaienko 1 collaboration

Erik I Hallin 1 collaboration

Sverre Grødem 1 collaboration

Helene J Bustad 1 collaboration

Ian Merski 1 collaboration

Tomohisa Hosokawa 1 collaboration

Daniela Lascu 1 collaboration

Shreeram Akerkar 1 collaboration

James J Chambers 1 collaboration

Rory O'Connell 1 collaboration

Gopinath Muruganandam 1 collaboration

Remy Loris 1 collaboration

Christine Touma 1 collaboration

Tambudzai Kanhema 1 collaboration

Yasunori Hayashi 1 collaboration

Margaret M Stratton 1 collaboration

Petri Kursula 1 collaboration

Clive R Bramham 1 collaboration

N B Martin-Cofreces 1 collaboration

F J Chichon 1 collaboration

E Calvo 1 collaboration

D Torralba 1 collaboration

E Bustos-Moran 1 collaboration

S G Dosil 1 collaboration

A Rojas-Gomez 1 collaboration

E Bonzon-Kulichenko 1 collaboration

J A Lopez 1 collaboration

J Otón 1 collaboration

A Sorrentino 1 collaboration

J C Zabala 1 collaboration

I Vernos 1 collaboration

J Vazquez 1 collaboration

F Sanchez-Madrid 1 collaboration

Guadalupe Espadas 1 collaboration

Eduard Sabidó 1 collaboration

Trond-André Kråkenes 1 collaboration

Rune Kleppe 1 collaboration

José R López-Blanco 1 collaboration

Knut Teigen 1 collaboration

Pablo Chacón 1 collaboration

Josefine Vallin 1 collaboration

Andreas Svanström 1 collaboration

Julie Grantham 1 collaboration

Jaime Santos 1 collaboration

Jorge Cuellar 1 collaboration

Irantzu Pallarès 1 collaboration

Emily J Byrd 1 collaboration

Alons Lends 1 collaboration

Muhammed Bilal Abdul-Shukkoor 1 collaboration

Jordi Pujols 1 collaboration

Frank Sobott 1 collaboration

Daniel E Otzen 1 collaboration

Antonio N Calabrese 1 collaboration

Jan Skov Pedersen 1 collaboration

Antoine Loquet 1 collaboration

Jose María Valpuesta 1 collaboration

Sheena E Radford 1 collaboration

Salvador Ventura 1 collaboration

Luis A Campos 1 collaboration

Rajendra Sharma 1 collaboration

Federico M Ruiz 1 collaboration

Beatriz Ibarra-Molero 1 collaboration

Mourad Sadqi 1 collaboration

Carlos Alfonso 1 collaboration

Germán Rivas 1 collaboration

Jose M Sanchez-Ruiz 1 collaboration

Antonio Romero Garrido 1 collaboration

Victor Muñoz 1 collaboration

Pilar Esteve 1 collaboration

Javier Rueda-Carrasco 1 collaboration

María Inés Mateo 1 collaboration

María Jesús Martin-Bermejo 1 collaboration

Jonathan Draffin 1 collaboration

Guadalupe Pereyra 1 collaboration

África Sandonís 1 collaboration

Inmaculada Crespo 1 collaboration

Inmaculada Moreno 1 collaboration

Ester Aso 1 collaboration

Paula Garcia-Esparcia 1 collaboration

Estrella Gomez-Tortosa 1 collaboration

Alberto Rábano 1 collaboration

Juan Fortea 1 collaboration

Daniel Alcolea 1 collaboration

Alberto Lleo 1 collaboration

Michael T Heneka 1 collaboration

José A Esteban 1 collaboration

Isidro Ferrer 1 collaboration

Mercedes Domínguez 1 collaboration

Paola Bovolenta 1 collaboration

Nicole C Tensmeyer 1 collaboration

Madhura Dhavale 1 collaboration

Michael J Mann 1 collaboration

Rebecca L Plimpton 1 collaboration

Daniel Rutz 1 collaboration

Johannes Buchner 1 collaboration