Izhtak Nissim

Affiliations

Division of Genetics and Metabolism, Children's Hospital of Philadelphia, Philadelphia, PA.
Department of Pediatrics, Biochemistry and Biophysics, University of Pennsylvania, Philadelphia, PA.

Publications (11)

Regulation of nuclear epigenome by mitochondrial DNA heteroplasmy.

Proceedings of the National Academy of Sciences of the United States of America

Avec: Piotr K Kopinski , Kevin A Janssen , Patrick M Schaefer , Sophie Trefely , Caroline E Perry , Prasanth Potluri , Jesus A Tintos-Hernandez , Larry N Singh , Kelly R Karch , Sydney L Campbell , Mary T Doan , Helen Jiang , Itzhak Nissim , Eiko Nakamaru-Ogiso , Kathryn E Wellen , Nathaniel W Snyder , Benjamin A Garcia , Douglas C Wallace

Decreased serotonin transporter activity in the mitral valve contributes to progression of degenerative mitral regurgitation.

Science translational medicine

Avec: Estibaliz Castillero , Emmett Fitzpatrick , Samuel J Keeney , Alex M D'Angelo , Benjamin B Pressly , Michael T Simpson , Mangesh Kurade , W Clinton Erwin , Vivian Moreno , Chiara Camillo , Halley J Shukla , Vaishali V Inamdar , Arbi Aghali , Juan B Grau , Elisa Salvati , Itzhak Nissim , Lubica Rauova , Mark A Oyama , Stanley J Stachelek , Chase Brown , Abba M Krieger , Robert J Levy , Giovanni Ferrari

Orally Administered Alpha Lipoic Acid as a Treatment for Geographic Atrophy: A Randomized Clinical Trial.

Ophthalmology. Retina

Avec: Benjamin J Kim , Allan Hunter , Alexander J Brucker , Paul Hahn , Karen Gehrs , Apurva Patel , Albert O Edwards , Yafeng Li , Rahul N Khurana , Itzhak Nissim , Ebenezer Daniel , Juan Grunwald , Gui-Shuang Ying , Maxwell Pistilli , Maureen G Maguire , Joshua L Dunaief

Donor cell engineering with GSK3 inhibitor-loaded nanoparticles enhances engraftment after in utero transplantation.

Blood

Avec: Stavros P Loukogeorgakis , Camila G Fachin , Andre I B S Dias , Haiying Li , Li Tang , Aimee G Kim , Jesse D Vrecenak , John D Stratigis , Nicholas J Ahn , Ilana Nissim , Izhtak Nissim , Antonio F Moron , Jose L Martins , William H Peranteau , Paolo De Coppi , Darrell J Irvine , Alan W Flake

Malic Enzyme Couples Mitochondria with Aerobic Glycolysis in Osteoblasts.

Cell reports

Avec: Wen-Chih Lee , Xing Ji , Itzhak Nissim , Fanxin Long

BitterDB: taste ligands and receptors database in 2019.

Nucleic acids research

Avec: Ayana Dagan-Wiener , Antonella Di Pizio , Ido Nissim , Malkeet S Bahia , Nitzan Dubovski , Eitan Margulis , Masha Y Niv

Gene therapy for guanidinoacetate methyltransferase deficiency restores cerebral and myocardial creatine while resolving behavioral abnormalities.

Molecular therapy. Methods & clinical development

Avec: Suhail Khoja , Jenna Lambert , Matthew Nitzahn , Adam Eliav , YuChen Zhang , Mikayla Tamboline , Colleen T Le , Eram Nasser , Yunfeng Li , Puja Patel , Irina Zhuravka , Lindsay M Lueptow , Ilona Tkachyova , Shili Xu , Itzhak Nissim , Andreas Schulze , Gerald S Lipshutz

Metabolic Enzyme DLST Promotes Tumor Aggression and Reveals a Vulnerability to OXPHOS Inhibition in High-Risk Neuroblastoma.

Cancer research

Avec: Nicole M Anderson , Xiaodan Qin , Jennifer M Finan , Andrew Lam , Jacob Athoe , Rindert Missiaen , Nicolas Skuli , Annie Kennedy , Amandeep S Saini , Ting Tao , Shizhen Zhu , Itzhak Nissim , A Thomas Look , Guoliang Qing , M Celeste Simon , Hui Feng

Fructose-1,6-Bisphosphatase 2 Inhibits Sarcoma Progression by Restraining Mitochondrial Biogenesis.

Cell metabolism

Avec: Peiwei Huangyang , Fuming Li , Pearl Lee , Itzhak Nissim , Aalim M Weljie , Anthony Mancuso , Bo Li , Brian Keith , Sam S Yoon , M Celeste Simon

Intermittent lipid nanoparticle mRNA administration prevents cortical dysmyelination associated with arginase deficiency.

Molecular therapy. Nucleic acids

Avec: Suhail Khoja , Xiao-Bo Liu , Brian Truong , Matthew Nitzahn , Jenna Lambert , Adam Eliav , Eram Nasser , Emma Randolph , Kristine E Burke , Rebecca White , Xuling Zhu , Paolo G V Martini , Itzhak Nissim , Stephen D Cederbaum , Gerald S Lipshutz

Targeting glutamine metabolism slows soft tissue sarcoma growth.

Nature communications

Avec: Pearl Lee , Dania Malik , Nicholas Perkons , Peiwei Huangyang , Sanika Khare , Seth Rhoades , Yao-Yu Gong , Michelle Burrows , Jennifer M Finan , Itzhak Nissim , Terence P F Gade , Aalim M Weljie , M Celeste Simon

Réseau de co-auteurs

Itzhak Nissim 9 collaborations

M Celeste Simon 3 collaborations

Suhail Khoja 2 collaborations

Jenna Lambert 2 collaborations

Matthew Nitzahn 2 collaborations

Adam Eliav 2 collaborations

Eram Nasser 2 collaborations

Gerald S Lipshutz 2 collaborations

Jennifer M Finan 2 collaborations

Peiwei Huangyang 2 collaborations

Pearl Lee 2 collaborations

Aalim M Weljie 2 collaborations

Piotr K Kopinski 1 collaboration

Kevin A Janssen 1 collaboration

Patrick M Schaefer 1 collaboration

Sophie Trefely 1 collaboration

Caroline E Perry 1 collaboration

Prasanth Potluri 1 collaboration

Jesus A Tintos-Hernandez 1 collaboration

Larry N Singh 1 collaboration

Kelly R Karch 1 collaboration

Sydney L Campbell 1 collaboration

Mary T Doan 1 collaboration

Helen Jiang 1 collaboration

Eiko Nakamaru-Ogiso 1 collaboration

Kathryn E Wellen 1 collaboration

Nathaniel W Snyder 1 collaboration

Benjamin A Garcia 1 collaboration

Douglas C Wallace 1 collaboration

Estibaliz Castillero 1 collaboration

Emmett Fitzpatrick 1 collaboration

Samuel J Keeney 1 collaboration

Alex M D'Angelo 1 collaboration

Benjamin B Pressly 1 collaboration

Michael T Simpson 1 collaboration

Mangesh Kurade 1 collaboration

W Clinton Erwin 1 collaboration

Vivian Moreno 1 collaboration

Chiara Camillo 1 collaboration

Halley J Shukla 1 collaboration

Vaishali V Inamdar 1 collaboration

Arbi Aghali 1 collaboration

Juan B Grau 1 collaboration

Elisa Salvati 1 collaboration

Lubica Rauova 1 collaboration

Mark A Oyama 1 collaboration

Stanley J Stachelek 1 collaboration

Chase Brown 1 collaboration

Abba M Krieger 1 collaboration

Robert J Levy 1 collaboration

Giovanni Ferrari 1 collaboration

Benjamin J Kim 1 collaboration

Allan Hunter 1 collaboration

Alexander J Brucker 1 collaboration

Paul Hahn 1 collaboration

Karen Gehrs 1 collaboration

Apurva Patel 1 collaboration

Albert O Edwards 1 collaboration

Yafeng Li 1 collaboration

Rahul N Khurana 1 collaboration

Ebenezer Daniel 1 collaboration

Juan Grunwald 1 collaboration

Gui-Shuang Ying 1 collaboration

Maxwell Pistilli 1 collaboration

Maureen G Maguire 1 collaboration

Joshua L Dunaief 1 collaboration

Stavros P Loukogeorgakis 1 collaboration

Camila G Fachin 1 collaboration

Andre I B S Dias 1 collaboration

Haiying Li 1 collaboration

Li Tang 1 collaboration

Aimee G Kim 1 collaboration

Jesse D Vrecenak 1 collaboration

John D Stratigis 1 collaboration

Nicholas J Ahn 1 collaboration

Ilana Nissim 1 collaboration

Antonio F Moron 1 collaboration

Jose L Martins 1 collaboration

William H Peranteau 1 collaboration

Paolo De Coppi 1 collaboration

Darrell J Irvine 1 collaboration

Alan W Flake 1 collaboration

Wen-Chih Lee 1 collaboration

Xing Ji 1 collaboration

Fanxin Long 1 collaboration

Ayana Dagan-Wiener 1 collaboration

Antonella Di Pizio 1 collaboration

Ido Nissim 1 collaboration

Malkeet S Bahia 1 collaboration

Nitzan Dubovski 1 collaboration

Eitan Margulis 1 collaboration

Masha Y Niv 1 collaboration

YuChen Zhang 1 collaboration

Mikayla Tamboline 1 collaboration

Colleen T Le 1 collaboration

Yunfeng Li 1 collaboration

Puja Patel 1 collaboration

Irina Zhuravka 1 collaboration

Lindsay M Lueptow 1 collaboration

Ilona Tkachyova 1 collaboration

Shili Xu 1 collaboration

Andreas Schulze 1 collaboration

Nicole M Anderson 1 collaboration

Xiaodan Qin 1 collaboration

Andrew Lam 1 collaboration

Jacob Athoe 1 collaboration

Rindert Missiaen 1 collaboration

Nicolas Skuli 1 collaboration

Annie Kennedy 1 collaboration

Amandeep S Saini 1 collaboration

Ting Tao 1 collaboration

Shizhen Zhu 1 collaboration

A Thomas Look 1 collaboration

Guoliang Qing 1 collaboration

Hui Feng 1 collaboration

Fuming Li 1 collaboration

Anthony Mancuso 1 collaboration

Bo Li 1 collaboration

Brian Keith 1 collaboration

Sam S Yoon 1 collaboration

Xiao-Bo Liu 1 collaboration

Brian Truong 1 collaboration

Emma Randolph 1 collaboration

Kristine E Burke 1 collaboration

Rebecca White 1 collaboration

Xuling Zhu 1 collaboration

Paolo G V Martini 1 collaboration

Stephen D Cederbaum 1 collaboration

Dania Malik 1 collaboration

Nicholas Perkons 1 collaboration

Sanika Khare 1 collaboration

Seth Rhoades 1 collaboration

Yao-Yu Gong 1 collaboration

Michelle Burrows 1 collaboration

Terence P F Gade 1 collaboration