Ivan Scandale

Affiliations

Drugs for Neglected Diseases Initiative, Geneva, Switzerland.

Publications (23)

Generation and evaluation of protease inhibitor-resistant SARS-CoV-2 strains.

Antiviral research

Avec: Hawa Sophia Bouzidi , Jean-Sélim Driouich , Raphaëlle Klitting , Ornéllie Bernadin , Géraldine Piorkowski , Rayane Amaral , Laurent Fraisse , Charles E Mowbray , Ivan Scandale , Fanny Escudié , Eric Chatelain , Xavier de Lamballerie , Antoine Nougairède , Franck Touret

Animal models of Chagas disease and their translational value to drug development.

Expert opinion on drug discovery

Avec: Eric Chatelain , Ivan Scandale

Drug development for the treatment of onchocerciasis: Population pharmacokinetic and adverse events modeling of emodepside.

PLoS neglected tropical diseases

Avec: Frauke Assmus , Richard M Hoglund , Frédéric Monnot , Sabine Specht , Ivan Scandale , Joel Tarning

Filarial nematode phenotypic screening cascade to identify compounds with anti-parasitic activity for drug discovery optimization.

International journal for parasitology. Drugs and drug resistance

Avec: Natalie Hawryluk , Li Zhiru , Clotilde Carlow , Suzanne Gokool , Simon Townson , Tamara Kreiss , Agnieszka Chojnowski , Monika Prorok , John Siekierka , Alexandra Ehrens , Marianne Koschel , Nathaly Lhermitte-Vallarino , Coralie Martin , Achim Hoerauf , Geraldine Hernandez , Stacie Canan , Vikram Khetani , Jerome Zeldis , Sabine Specht , Marc P Hübner , Ivan Scandale

Discovery of Substituted Di(pyridin-2-yl)-1,2,4-thiadiazol-5-amines as Novel Macrofilaricidal Compounds for the Treatment of Human Filarial Infections.

Journal of medicinal chemistry

Avec: Natalie Hawryluk , Dale Robinson , Yixing Shen , Graham Kyne , Matthew Bedore , Sanjay Menon , Stacie Canan , Thomas von Geldern , Simon Townson , Suzanne Gokool , Alexandra Ehrens , Marianne Koschel , Nathaly Lhermitte-Vallarino , Coralie Martin , Achim Hoerauf , Geraldine Hernandez , Deepak Dalvie , Sabine Specht , Marc Peter Hübner , Ivan Scandale

Comparing in vivo bioluminescence imaging and the Multi-Cruzi immunoassay platform to develop improved Chagas disease diagnostic procedures and biomarkers for monitoring parasitological cure.

PLoS neglected tropical diseases

Avec: Amanda Fortes Francisco , Ursula Saade , Shiromani Jayawardhana , Hans Pottel , Ivan Scandale , Eric Chatelain , Peter Liehl , John M Kelly , Maan Zrein

Evaluation of emodepside in laboratory models of human intestinal nematode and schistosome infections.

Parasites & vectors

Avec: Tanja Karpstein , Valérian Pasche , Cécile Häberli , Ivan Scandale , Anna Neodo , Jennifer Keiser

Development of emodepside as a possible adulticidal treatment for human onchocerciasis-The fruit of a successful industrial-academic collaboration.

PLoS pathogens

Avec: Jürgen Krücken , Lindy Holden-Dye , Jennifer Keiser , Roger K Prichard , Simon Townson , Benjamin L Makepeace , Marc P Hübner , Steffen R Hahnel , Ivan Scandale , Achim Harder , Daniel Kulke

Bioluminescence imaging reveals enhanced SARS-CoV-2 clearance in mice with combinatorial regimens.

iScience

Avec: Irfan Ullah , Fanny Escudie , Ivan Scandale , Zoela Gilani , Gabrielle Gendron-Lepage , Fleur Gaudette , Charles Mowbray , Laurent Fraisse , Renée Bazin , Andrés Finzi , Walther Mothes , Priti Kumar , Eric Chatelain , Pradeep D Uchil

Combinatorial Regimens Augment Drug Monotherapy for SARS-CoV-2 Clearance in Mice.

bioRxiv : the preprint server for biology

Further preclinical characterization of molnupiravir against SARS-CoV-2: Antiviral activity determinants and viral genome alteration patterns.

Heliyon

Avec: Paul-Rémi Petit , Franck Touret , Jean-Sélim Driouich , Maxime Cochin , Léa Luciani , Ornéllie Bernadin , Caroline Laprie , Géraldine Piorkowski , Laurent Fraisse , Peter Sjö , Charles E Mowbray , Fanny Escudié , Ivan Scandale , Eric Chatelain , Xavier de Lamballerie , Caroline Solas , Antoine Nougairède

Onchocerciasis drug development: from preclinical models to humans.

Parasitology research

Avec: Adela Ngwewondo , Ivan Scandale , Sabine Specht

The oral protease inhibitor (PF-07321332) protects Syrian hamsters against infection with SARS-CoV-2 variants of concern.

Nature communications

Avec: Rana Abdelnabi , Caroline S Foo , Dirk Jochmans , Laura Vangeel , Steven De Jonghe , Patrick Augustijns , Raf Mols , Birgit Weynand , Thanaporn Wattanakul , Richard M Hoglund , Joel Tarning , Charles E Mowbray , Peter Sjö , Fanny Escudié , Ivan Scandale , Eric Chatelain , Johan Neyts

Lack of antiviral activity of probenecid in vitro and in Syrian golden hamsters.

The Journal of antimicrobial chemotherapy

Avec: Helen J Box , Joanne Sharp , Shaun H Pennington , Edyta Kijak , Lee Tatham , Claire H Caygill , Rose C Lopeman , Laura N Jeffreys , Joanne Herriott , Megan Neary , Anthony Valentijn , Henry Pertinez , Paul Curley , Usman Arshad , Rajith K R Rajoli , Dirk Jochmans , Laura Vangeel , Johan Neyts , Eric Chatelain , Fanny Escudié , Ivan Scandale , Steve Rannard , James P Stewart , Giancarlo A Biagini , Andrew Owen

A guide for the generation of repositories of clinical samples for research on Chagas disease.

PLoS neglected tropical diseases

Avec: Nieves Martínez-Peinado , Juan Carlos Gabaldón-Figueira , Roberto Rodrigues Ferreira , María Carmen Thomas , Manuel Carlos López , Tania Cremonini Araújo-Jorge , Belkisyolé Alarcón de Noya , Soledad Berón , Janine Ramsey , Irene Losada Galván , Alejandro Gabriel Schijman , Adriana González Martínez , Andrés Mariano Ruiz , Gimena Rojas , Roberto Magalhães Saraiva , Oscar Noya-González , Andrea Gómez , Rosa A Maldonado , Jimmy Pinto , Faustino Torrico , Ivan Scandale , Fernán Agüero , María-Jesús Pinazo , Joaquim Gascón , Alejandro Marcel Hasslocher-Moreno , Julio Alonso-Padilla , Auteur inconnu

Oxfendazole mediates macrofilaricidal efficacy against the filarial nematode Litomosoides sigmodontis in vivo and inhibits Onchocerca spec. motility in vitro.

PLoS neglected tropical diseases

Avec: Marc P Hübner , Coralie Martin , Sabine Specht , Marianne Koschel , Bettina Dubben , Stefan J Frohberger , Alexandra Ehrens , Martina Fendler , Dominique Struever , Edward Mitre , Nathaly Vallarino-Lhermitte , Suzanne Gokool , Sara Lustigman , Manfred Schneider , Simon Townson , Achim Hoerauf , Ivan Scandale

Evaluation of the in vitro susceptibility of various filarial nematodes to emodepside.

International journal for parasitology. Drugs and drug resistance

Avec: Marc P Hübner , Simon Townson , Suzanne Gokool , Senyo Tagboto , Mary J Maclean , Guilherme G Verocai , Adrian J Wolstenholme , Stefan J Frohberger , Achim Hoerauf , Sabine Specht , Ivan Scandale , Achim Harder , Martin Glenschek-Sieberth , Steffen R Hahnel , Daniel Kulke

Preclinical and Clinical Characteristics of the Trichuricidal Drug Oxantel Pamoate and Clinical Development Plans: A Review.

Drugs

Avec: Marta S Palmeirim , Sabine Specht , Ivan Scandale , Irene Gander-Meisterernst , Monika Chabicovsky , Jennifer Keiser

Onchocerciasis Drug Discovery: In Vitro Evaluation of FDA-Approved Drugs against

Pharmaceutics

Avec: Suzanne Gokool , Simon Townson , Andrew Freeman , Jadzia Siemienski-Kleyn , Jakub Zubrzycki , Senyo Tagboto , Marc P Hübner , Ivan Scandale

Pre-clinical evaluation of antiviral activity of nitazoxanide against SARS-CoV-2.

EBioMedicine

Avec: Jean-Sélim Driouich , Maxime Cochin , Franck Touret , Paul-Rémi Petit , Magali Gilles , Grégory Moureau , Karine Barthélémy , Caroline Laprie , Thanaporn Wattanakul , Palang Chotsiri , Richard M Hoglund , Joel Tarning , Laurent Fraisse , Peter Sjö , Charles E Mowbray , Fanny Escudié , Ivan Scandale , Eric Chatelain , Xavier de Lamballerie , Caroline Solas , Antoine Nougairède

Need for a Standardized Translational Drug Development Platform: Lessons Learned from the Repurposing of Drugs for COVID-19.

Microorganisms

Avec: Frauke Assmus , Jean-Sélim Driouich , Rana Abdelnabi , Laura Vangeel , Franck Touret , Ayorinde Adehin , Palang Chotsiri , Maxime Cochin , Caroline S Foo , Dirk Jochmans , Seungtaek Kim , Léa Luciani , Grégory Moureau , Soonju Park , Paul-Rémi Pétit , David Shum , Thanaporn Wattanakul , Birgit Weynand , Laurent Fraisse , Jean-Robert Ioset , Charles E Mowbray , Andrew Owen , Richard M Hoglund , Joel Tarning , Xavier de Lamballerie , Antoine Nougairède , Johan Neyts , Peter Sjö , Fanny Escudié , Ivan Scandale , Eric Chatelain

A pharmacometric approach to evaluate drugs for potential repurposing as COVID-19 therapeutics.

Expert review of clinical pharmacology

Avec: Thanaporn Wattanakul , Palang Chotsiri , Ivan Scandale , Richard M Hoglund , Joel Tarning

State-of-the-Art in the Drug Discovery Pathway for Chagas Disease: A Framework for Drug Development and Target Validation.

Research and reports in tropical medicine

Avec: Juan Carlos Gabaldón-Figueira , Nieves Martinez-Peinado , Elisa Escabia , Albert Ros-Lucas , Eric Chatelain , Ivan Scandale , Joaquim Gascon , María-Jesús Pinazo , Julio Alonso-Padilla

Réseau de co-auteurs

Eric Chatelain 11 collaborations

Sabine Specht 7 collaborations

Laurent Fraisse 6 collaborations

Fanny Escudié 6 collaborations

Simon Townson 6 collaborations

Charles E Mowbray 5 collaborations

Richard M Hoglund 5 collaborations

Joel Tarning 5 collaborations

Suzanne Gokool 5 collaborations

Marc P Hübner 5 collaborations

Jean-Sélim Driouich 4 collaborations

Xavier de Lamballerie 4 collaborations

Antoine Nougairède 4 collaborations

Franck Touret 4 collaborations

Achim Hoerauf 4 collaborations

Peter Sjö 4 collaborations

Thanaporn Wattanakul 4 collaborations

Alexandra Ehrens 3 collaborations

Marianne Koschel 3 collaborations

Coralie Martin 3 collaborations

Jennifer Keiser 3 collaborations

Maxime Cochin 3 collaborations

Dirk Jochmans 3 collaborations

Laura Vangeel 3 collaborations

Johan Neyts 3 collaborations

Palang Chotsiri 3 collaborations

Ornéllie Bernadin 2 collaborations

Géraldine Piorkowski 2 collaborations

Frauke Assmus 2 collaborations

Natalie Hawryluk 2 collaborations

Nathaly Lhermitte-Vallarino 2 collaborations

Geraldine Hernandez 2 collaborations

Stacie Canan 2 collaborations

Steffen R Hahnel 2 collaborations

Achim Harder 2 collaborations

Daniel Kulke 2 collaborations

Irfan Ullah 2 collaborations

Fanny Escudie 2 collaborations

Zoela Gilani 2 collaborations

Gabrielle Gendron-Lepage 2 collaborations

Fleur Gaudette 2 collaborations

Charles Mowbray 2 collaborations

Renée Bazin 2 collaborations

Andrés Finzi 2 collaborations

Walther Mothes 2 collaborations

Priti Kumar 2 collaborations

Pradeep D Uchil 2 collaborations

Paul-Rémi Petit 2 collaborations

Léa Luciani 2 collaborations

Caroline Laprie 2 collaborations

Caroline Solas 2 collaborations

Rana Abdelnabi 2 collaborations

Caroline S Foo 2 collaborations

Birgit Weynand 2 collaborations

Andrew Owen 2 collaborations

Juan Carlos Gabaldón-Figueira 2 collaborations

María-Jesús Pinazo 2 collaborations

Julio Alonso-Padilla 2 collaborations

Stefan J Frohberger 2 collaborations

Senyo Tagboto 2 collaborations

Grégory Moureau 2 collaborations

Hawa Sophia Bouzidi 1 collaboration

Raphaëlle Klitting 1 collaboration

Rayane Amaral 1 collaboration

Frédéric Monnot 1 collaboration

Li Zhiru 1 collaboration

Clotilde Carlow 1 collaboration

Tamara Kreiss 1 collaboration

Agnieszka Chojnowski 1 collaboration

Monika Prorok 1 collaboration

John Siekierka 1 collaboration

Vikram Khetani 1 collaboration

Jerome Zeldis 1 collaboration

Dale Robinson 1 collaboration

Yixing Shen 1 collaboration

Graham Kyne 1 collaboration

Matthew Bedore 1 collaboration

Sanjay Menon 1 collaboration

Thomas von Geldern 1 collaboration

Deepak Dalvie 1 collaboration

Marc Peter Hübner 1 collaboration

Amanda Fortes Francisco 1 collaboration

Ursula Saade 1 collaboration

Shiromani Jayawardhana 1 collaboration

Hans Pottel 1 collaboration

Peter Liehl 1 collaboration

John M Kelly 1 collaboration

Maan Zrein 1 collaboration

Tanja Karpstein 1 collaboration

Valérian Pasche 1 collaboration

Cécile Häberli 1 collaboration

Anna Neodo 1 collaboration

Jürgen Krücken 1 collaboration

Lindy Holden-Dye 1 collaboration

Roger K Prichard 1 collaboration

Benjamin L Makepeace 1 collaboration

Adela Ngwewondo 1 collaboration

Steven De Jonghe 1 collaboration

Patrick Augustijns 1 collaboration

Raf Mols 1 collaboration

Helen J Box 1 collaboration

Joanne Sharp 1 collaboration

Shaun H Pennington 1 collaboration

Edyta Kijak 1 collaboration

Lee Tatham 1 collaboration

Claire H Caygill 1 collaboration

Rose C Lopeman 1 collaboration

Laura N Jeffreys 1 collaboration

Joanne Herriott 1 collaboration

Megan Neary 1 collaboration

Anthony Valentijn 1 collaboration

Henry Pertinez 1 collaboration

Paul Curley 1 collaboration

Usman Arshad 1 collaboration

Rajith K R Rajoli 1 collaboration

Steve Rannard 1 collaboration

James P Stewart 1 collaboration

Giancarlo A Biagini 1 collaboration

Nieves Martínez-Peinado 1 collaboration

Roberto Rodrigues Ferreira 1 collaboration

María Carmen Thomas 1 collaboration

Manuel Carlos López 1 collaboration

Tania Cremonini Araújo-Jorge 1 collaboration

Belkisyolé Alarcón de Noya 1 collaboration

Soledad Berón 1 collaboration

Janine Ramsey 1 collaboration

Irene Losada Galván 1 collaboration

Alejandro Gabriel Schijman 1 collaboration

Adriana González Martínez 1 collaboration

Andrés Mariano Ruiz 1 collaboration

Gimena Rojas 1 collaboration

Roberto Magalhães Saraiva 1 collaboration

Oscar Noya-González 1 collaboration

Andrea Gómez 1 collaboration

Rosa A Maldonado 1 collaboration

Jimmy Pinto 1 collaboration

Faustino Torrico 1 collaboration

Fernán Agüero 1 collaboration

Joaquim Gascón 1 collaboration

Alejandro Marcel Hasslocher-Moreno 1 collaboration

None None 1 collaboration

Bettina Dubben 1 collaboration

Martina Fendler 1 collaboration

Dominique Struever 1 collaboration

Edward Mitre 1 collaboration

Nathaly Vallarino-Lhermitte 1 collaboration

Sara Lustigman 1 collaboration

Manfred Schneider 1 collaboration

Mary J Maclean 1 collaboration

Guilherme G Verocai 1 collaboration

Adrian J Wolstenholme 1 collaboration

Martin Glenschek-Sieberth 1 collaboration

Marta S Palmeirim 1 collaboration

Irene Gander-Meisterernst 1 collaboration

Monika Chabicovsky 1 collaboration

Andrew Freeman 1 collaboration

Jadzia Siemienski-Kleyn 1 collaboration

Jakub Zubrzycki 1 collaboration

Magali Gilles 1 collaboration

Karine Barthélémy 1 collaboration

Ayorinde Adehin 1 collaboration

Seungtaek Kim 1 collaboration

Soonju Park 1 collaboration

Paul-Rémi Pétit 1 collaboration

David Shum 1 collaboration

Jean-Robert Ioset 1 collaboration

Nieves Martinez-Peinado 1 collaboration

Elisa Escabia 1 collaboration

Albert Ros-Lucas 1 collaboration

Joaquim Gascon 1 collaboration