Hiroyuki Tokiwa

Affiliations

Department of Cardiovascular Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan. Electronic address: htokiwa1113@gmail.com.

Publications (22)

Elucidation of Molecular Mechanism of a Selective PPARα Modulator, Pemafibrate, through Combinational Approaches of X-ray Crystallography, Thermodynamic Analysis, and First-Principle Calculations.

International journal of molecular sciences

Avec: Mayu Kawasaki , Akira Kambe , Yuta Yamamoto , Sundaram Arulmozhiraja , Sohei Ito , Yoshimi Nakagawa , Hiroaki Tokiwa , Shogo Nakano , Hitoshi Shimano

Endoplasmic reticulum stress-activated nuclear factor-kappa B signaling pathway induces the upregulation of cardiomyocyte dopamine D1 receptor in heart failure.

Biochemical and biophysical research communications

Avec: Shun Nakamura , Genri Numata , Toshihiro Yamaguchi , Hiroyuki Tokiwa , Yasutomi Higashikuni , Seitaro Nomura , Tetsuo Sasano , Eiki Takimoto , Issei Komuro

A pacing-controlled protocol for frequency-diastolic relations distinguishes diastolic dysfunction specific to a mouse HFpEF model.

American journal of physiology. Heart and circulatory physiology

Avec: Genri Numata , Eiki Takimoto , Taro Kariya , Yusuke Adachi , Hiroyuki Tokiwa , Masayuki Toyoda , Ryo Mafune , Yoshihiro Saito , Shun Nakamura , Kazutaka Ueda , Yuichi Ikeda , Issei Komuro

Development of an Analysis Toolkit, AnalysisFMO, to Visualize Interaction Energies Generated by Fragment Molecular Orbital Calculations.

Journal of chemical information and modeling

Avec: Takaki Tokiwa , Shogo Nakano , Yuta Yamamoto , Takeshi Ishikawa , Sohei Ito , Vladimir Sladek , Kaori Fukuzawa , Yuji Mochizuki , Hiroaki Tokiwa , Fuminori Misaizu , Yasuteru Shigeta

Dual conformation of the ligand induces the partial agonistic activity of retinoid X receptor α (RXRα).

FEBS letters

Avec: Yurina Miyashita , Nobutaka Numoto , Sundaram Arulmozhiraja , Shogo Nakano , Naoya Matsuo , Kanade Shimizu , Osamu Shibahara , Michiko Fujihara , Hiroki Kakuta , Sohei Ito , Teikichi Ikura , Nobutoshi Ito , Hiroaki Tokiwa

Could London Dispersion Force Control Regioselective (2 + 2) Cyclodimerizations of Benzynes? YES: Application to the Synthesis of Helical Biphenylenes.

Journal of the American Chemical Society

Avec: Takashi Ikawa , Yuta Yamamoto , Akito Heguri , Yutaka Fukumoto , Tomonari Murakami , Akira Takagi , Yuto Masuda , Kenzo Yahata , Hiroshi Aoyama , Yasuteru Shigeta , Hiroaki Tokiwa , Shuji Akai

Endothelial estrogen - myocardial cGMP axis critically determines angiogenesis and cardiac performance during pressure-overload.

Cardiovascular research

Avec: Nobuaki Fukuma , Hiroyuki Tokiwa , Genri Numata , Kazutaka Ueda , Pangyen Liu , Miyu Tajima , Yu Otsu , Taro Kariya , Yukio Hiroi , James K Liao , Issei Komuro , Eiki Takimoto

Syntheses of 25-Adamantyl-25-alkyl-2-methylidene-1α,25-dihydroxyvitamin D

Biomolecules

Avec: Kazuki Maekawa , Michiyasu Ishizawa , Takashi Ikawa , Hironao Sajiki , Taro Matsumoto , Hiroaki Tokiwa , Makoto Makishima , Sachiko Yamada

Total Synthesis of Termicalcicolanone A via Organocatalysis and Regioselective Claisen Rearrangement.

Organic letters

Avec: Saki Ito , Taiki Kitamura , Sundaram Arulmozhiraja , Kei Manabe , Hiroaki Tokiwa , Yumiko Suzuki

Sex Differences and Regulatory Actions of Estrogen in Cardiovascular System.

Frontiers in physiology

Avec: Kazutaka Ueda , Nobuaki Fukuma , Yusuke Adachi , Genri Numata , Hiroyuki Tokiwa , Masayuki Toyoda , Akira Otani , Masaki Hashimoto , Pang-Yen Liu , Eiki Takimoto

Computational Analysis Reveals a Critical Point Mutation in the

Molecules (Basel, Switzerland)

Avec: Yuta Yamamoto , Shogo Nakano , Fumio Seki , Yasuteru Shigeta , Sohei Ito , Hiroaki Tokiwa , Makoto Takeda

Disseminated intravascular coagulation as a complication of bursitis: angiogenesis and repetitive bleeding as potential factors for disseminated intravascular coagulation: a case report.

Journal of medical case reports

Avec: Taisuke Hamada , Tasuku Nishihara , Yosuke Mizuno , Teruki Kidani , Hiroki Tokiwa , Naoki Abe , Keisuke Sekiya , Sakiko Kitamura , Yasushi Takasaki , Hiromasa Miura , Toshihiro Yorozuya

PGC-1α-mediated angiogenesis prevents pulmonary hypertension in mice.

JCI insight

Avec: Takayuki Fujiwara , Norifumi Takeda , Hironori Hara , Satoshi Ishii , Genri Numata , Hiroyuki Tokiwa , Manami Katoh , Sonoko Maemura , Takaaki Suzuki , Hiroshi Takiguchi , Tomonobu Yanase , Yoshiaki Kubota , Seitaro Nomura , Masaru Hatano , Kazutaka Ueda , Mutsuo Harada , Haruhiro Toko , Eiki Takimoto , Hiroshi Akazawa , Hiroyuki Morita , Satoshi Nishimura , Issei Komuro

Tie2-Cre-Induced Inactivation of Non-Nuclear Estrogen Receptor-α Signaling Abrogates Estrogen Protection Against Vascular Injury.

JACC. Basic to translational science

Avec: Pang-Yen Liu , Nobuaki Fukuma , Yukio Hiroi , Akiko Kunita , Hiroyuki Tokiwa , Kazutaka Ueda , Taro Kariya , Genri Numata , Yusuke Adachi , Miyu Tajima , Masayuki Toyoda , Yuxin Li , Kensuke Noma , Mutsuo Harada , Haruhiro Toko , Tetsuo Ushiku , Yoshimitsu Kanai , Eiki Takimoto , James K Liao , Issei Komuro

The emerging role of estrogen's non-nuclear signaling in the cardiovascular disease.

Frontiers in cardiovascular medicine

Avec: Hiroyuki Tokiwa , Kazutaka Ueda , Eiki Takimoto

Hepatocyte ELOVL Fatty Acid Elongase 6 Determines Ceramide Acyl-Chain Length and Hepatic Insulin Sensitivity in Mice.

Hepatology (Baltimore, Md.)

Avec: Takashi Matsuzaka , Motoko Kuba , Saori Koyasu , Yuta Yamamoto , Kaori Motomura , Sundaram Arulmozhiraja , Hiroshi Ohno , Rahul Sharma , Takuya Shimura , Yuka Okajima , Song-Iee Han , Yuichi Aita , Yuhei Mizunoe , Yoshinori Osaki , Hitoshi Iwasaki , Shigeru Yatoh , Hiroaki Suzuki , Hirohito Sone , Yoshinori Takeuchi , Naoya Yahagi , Takafumi Miyamoto , Motohiro Sekiya , Yoshimi Nakagawa , Masatsugu Ema , Satoru Takahashi , Hiroaki Tokiwa , Hitoshi Shimano

The transcriptional corepressor CtBP2 serves as a metabolite sensor orchestrating hepatic glucose and lipid homeostasis.

Nature communications

Avec: Motohiro Sekiya , Kenta Kainoh , Takehito Sugasawa , Ryunosuke Yoshino , Takatsugu Hirokawa , Hiroaki Tokiwa , Shogo Nakano , Satoru Nagatoishi , Kouhei Tsumoto , Yoshinori Takeuchi , Takafumi Miyamoto , Takashi Matsuzaka , Hitoshi Shimano

Rhomboid protease RHBDL4/RHBDD1 cleaves SREBP-1c at endoplasmic reticulum monitoring and regulating fatty acids.

PNAS nexus

Avec: Song-Iee Han , Masanori Nakakuki , Yoshimi Nakagawa , Yunong Wang , Masaya Araki , Yuta Yamamoto , Hiroaki Tokiwa , Hiroyuki Takeda , Yuhei Mizunoe , Kaori Motomura , Hiroshi Ohno , Kenta Kainoh , Yuki Murayama , Yuichi Aita , Yoshinori Takeuchi , Yoshinori Osaki , Takafumi Miyamoto , Motohiro Sekiya , Takashi Matsuzaka , Naoya Yahagi , Hirohito Sone , Hiroaki Daitoku , Ryuichiro Sato , Hiroyuki Kawano , Hitoshi Shimano

Genetic and Functional Analyses of Patients with Marked Hypo-High-Density Lipoprotein Cholesterolemia.

Journal of atherosclerosis and thrombosis

Avec: Yasuhisa Furuta , Yoshinori Osaki , Yoshimi Nakagawa , Song-Iee Han , Masaya Araki , Akito Shikama , Nami Ohuchi , Daichi Yamazaki , Erika Matsuda , Seitaro Nohara , Yuhei Mizunoe , Kenta Kainoh , Yasuhito Suehara , Hiroshi Ohno , Yoshinori Takeuchi , Takafumi Miyamoto , Yuki Murayama , Yoko Sugano , Hitoshi Iwasaki , Ken-Ichi Hirano , Masahiro Koseki , Shogo Nakano , Hiroaki Tokiwa , Motohiro Sekiya , Naoya Yahagi , Takashi Matsuzaka , Kiyotaka Nakamagoe , Yasushi Tomidokoro , Jun Mitsui , Shoji Tsuji , Hiroaki Suzuki , Hitoshi Shimano

Competitive Binding Assay with an Umbelliferone-Based Fluorescent Rexinoid for Retinoid X Receptor Ligand Screening.

Journal of medicinal chemistry

Avec: Shoya Yamada , Mayu Kawasaki , Michiko Fujihara , Masaki Watanabe , Yuta Takamura , Maho Takioku , Hiromi Nishioka , Yasuo Takeuchi , Makoto Makishima , Tomoharu Motoyama , Sohei Ito , Hiroaki Tokiwa , Shogo Nakano , Hiroki Kakuta

Animal morbilliviruses and their cross-species transmission potential.

Current opinion in virology

Avec: Makoto Takeda , Fumio Seki , Yuta Yamamoto , Naganori Nao , Hiroaki Tokiwa

Measles Virus Hemagglutinin Protein Establishes a Specific Interaction With the Extreme N-Terminal Region of Human Signaling Lymphocytic Activation Molecule to Enhance Infection.

Frontiers in microbiology

Avec: Fumio Seki , Yuta Yamamoto , Hideo Fukuhara , Kazue Ohishi , Tadashi Maruyama , Katsumi Maenaka , Hiroaki Tokiwa , Makoto Takeda

Réseau de co-auteurs

Hiroaki Tokiwa 14 collaborations

Yuta Yamamoto 8 collaborations

Shogo Nakano 7 collaborations

Eiki Takimoto 7 collaborations

Genri Numata 6 collaborations

Kazutaka Ueda 6 collaborations

Sohei Ito 5 collaborations

Hitoshi Shimano 5 collaborations

Issei Komuro 5 collaborations

Sundaram Arulmozhiraja 4 collaborations

Yoshimi Nakagawa 4 collaborations

Takashi Matsuzaka 4 collaborations

Yoshinori Takeuchi 4 collaborations

Takafumi Miyamoto 4 collaborations

Motohiro Sekiya 4 collaborations

Taro Kariya 3 collaborations

Yusuke Adachi 3 collaborations

Masayuki Toyoda 3 collaborations

Yasuteru Shigeta 3 collaborations

Nobuaki Fukuma 3 collaborations

Fumio Seki 3 collaborations

Makoto Takeda 3 collaborations

Hiroshi Ohno 3 collaborations

Song-Iee Han 3 collaborations

Yuhei Mizunoe 3 collaborations

Yoshinori Osaki 3 collaborations

Naoya Yahagi 3 collaborations

Kenta Kainoh 3 collaborations

Mayu Kawasaki 2 collaborations

Shun Nakamura 2 collaborations

Seitaro Nomura 2 collaborations

Michiko Fujihara 2 collaborations

Hiroki Kakuta 2 collaborations

Takashi Ikawa 2 collaborations

Miyu Tajima 2 collaborations

Yukio Hiroi 2 collaborations

James K Liao 2 collaborations

Makoto Makishima 2 collaborations

Pang-Yen Liu 2 collaborations

Mutsuo Harada 2 collaborations

Haruhiro Toko 2 collaborations

Kaori Motomura 2 collaborations

Yuichi Aita 2 collaborations

Hitoshi Iwasaki 2 collaborations

Hiroaki Suzuki 2 collaborations

Hirohito Sone 2 collaborations

Masaya Araki 2 collaborations

Yuki Murayama 2 collaborations

Akira Kambe 1 collaboration

Toshihiro Yamaguchi 1 collaboration

Yasutomi Higashikuni 1 collaboration

Tetsuo Sasano 1 collaboration

Ryo Mafune 1 collaboration

Yoshihiro Saito 1 collaboration

Yuichi Ikeda 1 collaboration

Takaki Tokiwa 1 collaboration

Takeshi Ishikawa 1 collaboration

Vladimir Sladek 1 collaboration

Kaori Fukuzawa 1 collaboration

Yuji Mochizuki 1 collaboration

Fuminori Misaizu 1 collaboration

Yurina Miyashita 1 collaboration

Nobutaka Numoto 1 collaboration

Naoya Matsuo 1 collaboration

Kanade Shimizu 1 collaboration

Osamu Shibahara 1 collaboration

Teikichi Ikura 1 collaboration

Nobutoshi Ito 1 collaboration

Akito Heguri 1 collaboration

Yutaka Fukumoto 1 collaboration

Tomonari Murakami 1 collaboration

Akira Takagi 1 collaboration

Yuto Masuda 1 collaboration

Kenzo Yahata 1 collaboration

Hiroshi Aoyama 1 collaboration

Shuji Akai 1 collaboration

Pangyen Liu 1 collaboration

Yu Otsu 1 collaboration

Kazuki Maekawa 1 collaboration

Michiyasu Ishizawa 1 collaboration

Hironao Sajiki 1 collaboration

Taro Matsumoto 1 collaboration

Sachiko Yamada 1 collaboration

Saki Ito 1 collaboration

Taiki Kitamura 1 collaboration

Kei Manabe 1 collaboration

Yumiko Suzuki 1 collaboration

Akira Otani 1 collaboration

Masaki Hashimoto 1 collaboration

Taisuke Hamada 1 collaboration

Tasuku Nishihara 1 collaboration

Yosuke Mizuno 1 collaboration

Teruki Kidani 1 collaboration

Hiroki Tokiwa 1 collaboration

Naoki Abe 1 collaboration

Keisuke Sekiya 1 collaboration

Sakiko Kitamura 1 collaboration

Yasushi Takasaki 1 collaboration

Hiromasa Miura 1 collaboration

Toshihiro Yorozuya 1 collaboration

Takayuki Fujiwara 1 collaboration

Norifumi Takeda 1 collaboration

Hironori Hara 1 collaboration

Satoshi Ishii 1 collaboration

Manami Katoh 1 collaboration

Sonoko Maemura 1 collaboration

Takaaki Suzuki 1 collaboration

Hiroshi Takiguchi 1 collaboration

Tomonobu Yanase 1 collaboration

Yoshiaki Kubota 1 collaboration

Masaru Hatano 1 collaboration

Hiroshi Akazawa 1 collaboration

Hiroyuki Morita 1 collaboration

Satoshi Nishimura 1 collaboration

Akiko Kunita 1 collaboration

Yuxin Li 1 collaboration

Kensuke Noma 1 collaboration

Tetsuo Ushiku 1 collaboration

Yoshimitsu Kanai 1 collaboration

Motoko Kuba 1 collaboration

Saori Koyasu 1 collaboration

Rahul Sharma 1 collaboration

Takuya Shimura 1 collaboration

Yuka Okajima 1 collaboration

Shigeru Yatoh 1 collaboration

Masatsugu Ema 1 collaboration

Satoru Takahashi 1 collaboration

Takehito Sugasawa 1 collaboration

Ryunosuke Yoshino 1 collaboration

Takatsugu Hirokawa 1 collaboration

Satoru Nagatoishi 1 collaboration

Kouhei Tsumoto 1 collaboration

Masanori Nakakuki 1 collaboration

Yunong Wang 1 collaboration

Hiroyuki Takeda 1 collaboration

Hiroaki Daitoku 1 collaboration

Ryuichiro Sato 1 collaboration

Hiroyuki Kawano 1 collaboration

Yasuhisa Furuta 1 collaboration

Akito Shikama 1 collaboration

Nami Ohuchi 1 collaboration

Daichi Yamazaki 1 collaboration

Erika Matsuda 1 collaboration

Seitaro Nohara 1 collaboration

Yasuhito Suehara 1 collaboration

Yoko Sugano 1 collaboration

Ken-Ichi Hirano 1 collaboration

Masahiro Koseki 1 collaboration

Kiyotaka Nakamagoe 1 collaboration

Yasushi Tomidokoro 1 collaboration

Jun Mitsui 1 collaboration

Shoji Tsuji 1 collaboration

Shoya Yamada 1 collaboration

Masaki Watanabe 1 collaboration

Yuta Takamura 1 collaboration

Maho Takioku 1 collaboration

Hiromi Nishioka 1 collaboration

Yasuo Takeuchi 1 collaboration

Tomoharu Motoyama 1 collaboration

Naganori Nao 1 collaboration

Hideo Fukuhara 1 collaboration

Kazue Ohishi 1 collaboration

Tadashi Maruyama 1 collaboration

Katsumi Maenaka 1 collaboration