H Schorle

Affiliations

Department of Developmental Pathology, Institute of Pathology, Bonn University Medical School, Bonn, Germany.

ORCID: 0000-0001-8272-0076

Publications (35)

TCam-2 Cells Deficient for SOX2 and FOXA2 Are Blocked in Differentiation and Maintain a Seminoma-Like Cell Fate In Vivo.

Cancers

Avec: Daniel Nettersheim , Saskia Vadder , Sina Jostes , Alena Heimsoeth , Hubert Schorle

Human sFLT1 Leads to Severe Changes in Placental Differentiation and Vascularization in a Transgenic hsFLT1/rtTA FGR Mouse Model.

Frontiers in endocrinology

Avec: Rebekka Vogtmann , Elisabeth Kühnel , Nikolai Dicke , Rikst Nynke Verkaik-Schakel , Torsten Plösch , Hubert Schorle , Violeta Stojanovska , Florian Herse , Angela Köninger , Rainer Kimmig , Elke Winterhager , Alexandra Gellhaus

Brain and Breast Cancer Cells with PTEN Loss of Function Reveal Enhanced Durotaxis and RHOB Dependent Amoeboid Migration Utilizing 3D Scaffolds and Aligned Microfiber Tracts.

Cancers

Avec: Annalena Wieland , Pamela L Strissel , Hannah Schorle , Ezgi Bakirci , Dieter Janzen , Matthias W Beckmann , Markus Eckstein , Paul D Dalton , Reiner Strick

COVID-19 Infection Induce miR-371a-3p Upregulation Resulting in Influence on Male Fertility.

Biomedicines

Avec: Heike Goebel , Barbara Koeditz , Manuel Huerta , Ersen Kameri , Tim Nestler , Thomas Kamphausen , Johannes Friemann , Matthias Hamdorf , Timo Ohrmann , Philipp Koehler , Oliver A Cornely , Manuel Montesinos-Rongen , David Nicol , Hubert Schorle , Peter Boor , Alexander Quaas , Christian Pallasch , Axel Heidenreich , Melanie von Brandenstein

Genome-scale CRISPR screen reveals neddylation to contribute to cisplatin resistance of testicular germ cell tumours.

British journal of cancer

Avec: Kai Funke , Ulf Einsfelder , Aylin Hansen , Lena Arévalo , Simon Schneider , Daniel Nettersheim , Valentin Stein , Hubert Schorle

Targeting EpCAM by a Bispecific Trifunctional Antibody Exerts Profound Cytotoxic Efficacy in Germ Cell Tumor Cell Lines.

Cancers

Avec: Stefan Schönberger , Daniela Kraft , Daniel Nettersheim , Hubert Schorle , Anna Casati , Rogerio B Craveiro , Mahsa Mir Mohseni , Gabriele Calaminus , Dagmar Dilloo

Filamin A Orchestrates Cytoskeletal Structure, Cell Migration and Stem Cell Characteristics in Human Seminoma TCam-2 Cells.

Cells

Avec: Harald Welter , Carola Herrmann , Thomas Fröhlich , Florian Flenkenthaler , Katja Eubler , Hubert Schorle , Daniel Nettersheim , Artur Mayerhofer , Annette Müller-Taubenberger

Frontiers in cell and developmental biology

Avec: Lucia A Torres-Fernández , Jana Emich , Yasmine Port , Sibylle Mitschka , Marius Wöste , Simon Schneider , Daniela Fietz , Manon S Oud , Sara Di Persio , Nina Neuhaus , Sabine Kliesch , Michael Hölzel , Hubert Schorle , Corinna Friedrich , Frank Tüttelmann , Waldemar Kolanus

SPAG17 mediates nuclear translocation of protamines during spermiogenesis.

Frontiers in cell and developmental biology

Avec: Clara Agudo-Rios , Amber Rogers , Isaiah King , Virali Bhagat , Le My Tu Nguyen , Carlos Córdova-Fletes , Diego Krapf , Jerome F Strauss , Lena Arévalo , Gina Esther Merges , Hubert Schorle , Eduardo R S Roldan , Maria Eugenia Teves

Overexpression of Human sFLT1 in the Spongiotrophoblast Is Sufficient to Induce Placental Dysfunction and Fetal Growth Restriction in Transgenic Mice.

International journal of molecular sciences

Avec: Rebekka Vogtmann , Alina Riedel , Ivanka Sassmannshausen , Sarah Langer , Elisabeth Kühnel-Terjung , Rainer Kimmig , Hubert Schorle , Elke Winterhager , Alexandra Gellhaus

Cultivation of Testicular Germ Cell Cancer Cell Lines and Establishment of Gene-Edited Subclones Using CRISPR/Cas9.

Methods in molecular biology (Clifton, N.J.)

Avec: Sina Jostes , Daniel Nettersheim , Simon Schneider , Hubert Schorle

Loss of Profilin3 Impairs Spermiogenesis by Affecting Acrosome Biogenesis, Autophagy, Manchette Development and Mitochondrial Organization.

Frontiers in cell and developmental biology

Avec: Naila Umer , Lena Arévalo , Sharang Phadke , Keerthika Lohanadan , Gregor Kirfel , Dominik Sons , Denise Sofia , Walter Witke , Hubert Schorle

Cultivation of Clear Cell Renal Cell Carcinoma Patient-Derived Organoids in an Air-Liquid Interface System as a Tool for Studying Individualized Therapy.

Frontiers in oncology

Avec: Laura K Esser , Vittorio Branchi , Sonia Leonardelli , Natalie Pelusi , Adrian G Simon , Niklas Klümper , Jörg Ellinger , Stefan Hauser , Maria A Gonzalez-Carmona , Manuel Ritter , Glen Kristiansen , Hubert Schorle , Michael Hölzel , Marieta I Toma

Overexpression of Parkin in clear cell renal cell carcinoma decreases tumor aggressiveness by regulating CKS2 levels.

International journal of oncology

Avec: Laura Kristin Esser , Vittorio Branchi , Farhad Shakeri , Adrian Georg Simon , Carsten Stephan , Glen Kristiansen , Andreas Buness , Hubert Schorle , Marieta Ioana Toma

PFN4 is required for manchette development and acrosome biogenesis during mouse spermiogenesis.

Development (Cambridge, England)

Avec: Naila Umer , Sharang Phadke , Farhad Shakeri , Lena Arévalo , Keerthika Lohanadan , Gregor Kirfel , Marc Sylvester , Andreas Buness , Hubert Schorle

Protamine 2 Deficiency Results In Septin 12 Abnormalities.

bioRxiv : the preprint server for biology

Avec: Ondrej Sanovec , Michaela Frolikova , Veronika Kraus , Jana Vondrakova , Maryam Qasemi , Daniela Spevakova , Ondrej Simonik , Lindsay Moritz , Drew Lewis Caswell , Frantisek Liska , Lukas Ded , Jiri Cerny , Tomer Avidor-Reiss , Saher Sue Hammoud , Hubert Schorle , Pavla Postlerova , Klaus Steger , Katerina Komrskova

Unique and redundant roles of SOX2 and SOX17 in regulating the germ cell tumor fate.

International journal of cancer

Avec: Sina V Jostes , Martin Fellermeyer , Lena Arévalo , Gina E Merges , Glen Kristiansen , Daniel Nettersheim , Hubert Schorle

Epigenetic drugs and their molecular targets in testicular germ cell tumours.

Nature reviews. Urology

Avec: Sina Jostes , Daniel Nettersheim , Hubert Schorle

Mammalian germ cells are determined after PGC colonization of the nascent gonad.

Proceedings of the National Academy of Sciences of the United States of America

Avec: Peter K Nicholls , Hubert Schorle , Sahin Naqvi , Yueh-Chiang Hu , Yuting Fan , Michelle A Carmell , Ina Dobrinski , Adrienne L Watson , Daniel F Carlson , Scott C Fahrenkrug , David C Page

Protamine-2 Deficiency Initiates a Reactive Oxygen Species (ROS)-Mediated Destruction Cascade during Epididymal Sperm Maturation in Mice.

Cells

Avec: Simon Schneider , Farhad Shakeri , Christian Trötschel , Lena Arévalo , Alexander Kruse , Andreas Buness , Ansgar Poetsch , Klaus Steger , Hubert Schorle

Induction of Rosette-to-Lumen stage embryoids using reprogramming paradigms in ESCs.

Nature communications

Avec: Jan Langkabel , Arik Horne , Lorenzo Bonaguro , Lisa Holsten , Tatiana Hesse , Alexej Knaus , Yannick Riedel , Matthias Becker , Kristian Händler , Tarek Elmzzahi , Kevin Bassler , Nico Reusch , Leon Harootoonovtch Yeghiazarian , Tal Pecht , Adem Saglam , Thomas Ulas , Anna C Aschenbrenner , Franziska Kaiser , Caroline Kubaczka , Joachim L Schultze , Hubert Schorle

Loss of Prm1 leads to defective chromatin protamination, impaired PRM2 processing, reduced sperm motility and subfertility in male mice.

Development (Cambridge, England)

Avec: Gina Esther Merges , Julia Meier , Simon Schneider , Alexander Kruse , Andreas Christian Fröbius , Gregor Kirfel , Klaus Steger , Lena Arévalo , Hubert Schorle

High success rate of first proficiency testing for RET fusions and RET mutations in lung and thyroid cancer samples by various methods.

Virchows Archiv : an international journal of pathology

Avec: Udo Siebolts , Roberto Pappesch , Marcus Bauer , Wolfgang Dietmaier , Mareike Ernst , Anja Haak , Nils Hartmann , Katharina Ilm , Stavros Kalbourtzis , Thomas Krause , Daniel Kazdal , Hubert Schorle , Kirsten Utpatel , Sabine Merkelbach-Bruse

Myoglobin regulates fatty acid trafficking and lipid metabolism in mammary epithelial cells.

PloS one

Avec: Julia Armbruster , Mostafa A Aboouf , Max Gassmann , Angela Egert , Hubert Schorle , Veit Hornung , Tobias Schmidt , Jonathan L Schmid-Burgk , Glen Kristiansen , Anne Bicker , Thomas Hankeln , Hao Zhu , Thomas A Gorr

Cylicins are a structural component of the sperm calyx being indispensable for male fertility in mice and human.

eLife

Avec: Simon Schneider , Andjela Kovacevic , Michelle Mayer , Ann-Kristin Dicke , Lena Arévalo , Sophie A Koser , Jan N Hansen , Samuel Young , Christoph Brenker , Sabine Kliesch , Dagmar Wachten , Gregor Kirfel , Timo Struenker , Frank Tüttelmann , Hubert Schorle

N6-Methyladenosine detected in RNA of testicular germ cell tumors is controlled by METTL3, ALKBH5, YTHDC1/F1/F2, and HNRNPC as writers, erasers, and readers.

Andrology

Avec: D Nettersheim , D Berger , S Jostes , G Kristiansen , G Lochnit , H Schorle

Deciphering the molecular effects of romidepsin on germ cell tumours: DHRS2 is involved in cell cycle arrest but not apoptosis or induction of romidepsin effectors.

Journal of cellular and molecular medicine

Avec: Daniel Nettersheim , Daniel Berger , Sina Jostes , Margaretha Skowron , Hubert Schorle

Persistent Human KIT Receptor Signaling Disposes Murine Placenta to Premature Differentiation Resulting in Severely Disrupted Placental Structure and Functionality.

International journal of molecular sciences

Avec: Franziska Kaiser , Julia Hartweg , Selina Jansky , Natalie Pelusi , Caroline Kubaczka , Neha Sharma , Dominik Nitsche , Jan Langkabel , Hubert Schorle

Choice of factors and medium impinge on success of ESC to TSC conversion.

Placenta

Avec: Franziska Kaiser , Caroline Kubaczka , Monika Graf , Nina Langer , Jan Langkabel , Lena Arévalo , Hubert Schorle

On the origin of germ cell neoplasia in situ: Dedifferentiation of human adult Sertoli cells in cross talk with seminoma cells in vitro.

Neoplasia (New York, N.Y.)

Avec: Cornelia Fink , Nelli Baal , Jochen Wilhelm , Poonam Sarode , Roswitha Weigel , Valérie Schumacher , Daniel Nettersheim , Hubert Schorle , Carmen Schröck , Martin Bergmann , Sabine Kliesch , Monika Kressin , Rajkumar Savai

The signal transducer CD24 suppresses the germ cell program and promotes an ectodermal rather than mesodermal cell fate in embryonal carcinomas.

Molecular oncology

Avec: Margaretha A Skowron , Teresa K Becker , Lukas Kurz , Sina Jostes , Felix Bremmer , Florian Fronhoffs , Kai Funke , Gamal A Wakileh , Melanie R Müller , Aaron Burmeister , Thomas Lenz , Anja Stefanski , Kai Stühler , Patrick Petzsch , Karl Köhrer , Peter Altevogt , Peter Albers , Glen Kristiansen , Hubert Schorle , Daniel Nettersheim

Transcriptional CDK Inhibitors as Potential Treatment Option for Testicular Germ Cell Tumors.

Cancers

Avec: Kai Funke , Robert Düster , Prince De-Graft Wilson , Lena Arévalo , Matthias Geyer , Hubert Schorle

Protamines: lessons learned from mouse models.

Reproduction (Cambridge, England)

Avec: Lena Arévalo , Gina Esther Merges , Simon Schneider , Hubert Schorle

Loss of the cleaved-protamine 2 domain leads to incomplete histone-to-protamine exchange and infertility in mice.

PLoS genetics

Avec: Lena Arévalo , Gina Esther Merges , Simon Schneider , Franka Enow Oben , Isabelle Sophie Neumann , Hubert Schorle

Actl7b deficiency leads to mislocalization of LC8 type dynein light chains and disruption of murine spermatogenesis.

Development (Cambridge, England)

Avec: Gina E Merges , Lena Arévalo , Andjela Kovacevic , Keerthika Lohanadan , Dirk G de Rooij , Carla Simon , Melanie Jokwitz , Walter Witke , Hubert Schorle

Réseau de co-auteurs

Hubert Schorle 33 collaborations

Lena Arévalo 13 collaborations

Daniel Nettersheim 10 collaborations

Simon Schneider 8 collaborations

Sina Jostes 5 collaborations

Glen Kristiansen 5 collaborations

Gina Esther Merges 4 collaborations

Gregor Kirfel 4 collaborations

Kai Funke 3 collaborations

Sabine Kliesch 3 collaborations

Keerthika Lohanadan 3 collaborations

Farhad Shakeri 3 collaborations

Andreas Buness 3 collaborations

Klaus Steger 3 collaborations

Jan Langkabel 3 collaborations

Franziska Kaiser 3 collaborations

Caroline Kubaczka 3 collaborations

Rebekka Vogtmann 2 collaborations

Rainer Kimmig 2 collaborations

Elke Winterhager 2 collaborations

Alexandra Gellhaus 2 collaborations

Michael Hölzel 2 collaborations

Frank Tüttelmann 2 collaborations

Naila Umer 2 collaborations

Sharang Phadke 2 collaborations

Walter Witke 2 collaborations

Vittorio Branchi 2 collaborations

Natalie Pelusi 2 collaborations

Gina E Merges 2 collaborations

Alexander Kruse 2 collaborations

Andjela Kovacevic 2 collaborations

Saskia Vadder 1 collaboration

Alena Heimsoeth 1 collaboration

Elisabeth Kühnel 1 collaboration

Nikolai Dicke 1 collaboration

Rikst Nynke Verkaik-Schakel 1 collaboration

Torsten Plösch 1 collaboration

Violeta Stojanovska 1 collaboration

Florian Herse 1 collaboration

Angela Köninger 1 collaboration

Annalena Wieland 1 collaboration

Pamela L Strissel 1 collaboration

Hannah Schorle 1 collaboration

Ezgi Bakirci 1 collaboration

Dieter Janzen 1 collaboration

Matthias W Beckmann 1 collaboration

Markus Eckstein 1 collaboration

Paul D Dalton 1 collaboration

Reiner Strick 1 collaboration

Heike Goebel 1 collaboration

Barbara Koeditz 1 collaboration

Manuel Huerta 1 collaboration

Ersen Kameri 1 collaboration

Tim Nestler 1 collaboration

Thomas Kamphausen 1 collaboration

Johannes Friemann 1 collaboration

Matthias Hamdorf 1 collaboration

Timo Ohrmann 1 collaboration

Philipp Koehler 1 collaboration

Oliver A Cornely 1 collaboration

Manuel Montesinos-Rongen 1 collaboration

David Nicol 1 collaboration

Peter Boor 1 collaboration

Alexander Quaas 1 collaboration

Christian Pallasch 1 collaboration

Axel Heidenreich 1 collaboration

Melanie von Brandenstein 1 collaboration

Ulf Einsfelder 1 collaboration

Aylin Hansen 1 collaboration

Valentin Stein 1 collaboration

Stefan Schönberger 1 collaboration

Daniela Kraft 1 collaboration

Anna Casati 1 collaboration

Rogerio B Craveiro 1 collaboration

Mahsa Mir Mohseni 1 collaboration

Gabriele Calaminus 1 collaboration

Dagmar Dilloo 1 collaboration

Harald Welter 1 collaboration

Carola Herrmann 1 collaboration

Thomas Fröhlich 1 collaboration

Florian Flenkenthaler 1 collaboration

Katja Eubler 1 collaboration

Artur Mayerhofer 1 collaboration

Annette Müller-Taubenberger 1 collaboration

Lucia A Torres-Fernández 1 collaboration

Jana Emich 1 collaboration

Yasmine Port 1 collaboration

Sibylle Mitschka 1 collaboration

Marius Wöste 1 collaboration

Daniela Fietz 1 collaboration

Manon S Oud 1 collaboration

Sara Di Persio 1 collaboration

Nina Neuhaus 1 collaboration

Corinna Friedrich 1 collaboration

Waldemar Kolanus 1 collaboration

Clara Agudo-Rios 1 collaboration

Amber Rogers 1 collaboration

Isaiah King 1 collaboration

Virali Bhagat 1 collaboration

Le My Tu Nguyen 1 collaboration

Carlos Córdova-Fletes 1 collaboration

Diego Krapf 1 collaboration

Jerome F Strauss 1 collaboration

Eduardo R S Roldan 1 collaboration

Maria Eugenia Teves 1 collaboration

Alina Riedel 1 collaboration

Ivanka Sassmannshausen 1 collaboration

Sarah Langer 1 collaboration

Elisabeth Kühnel-Terjung 1 collaboration

Dominik Sons 1 collaboration

Denise Sofia 1 collaboration

Laura K Esser 1 collaboration

Sonia Leonardelli 1 collaboration

Adrian G Simon 1 collaboration

Niklas Klümper 1 collaboration

Jörg Ellinger 1 collaboration

Stefan Hauser 1 collaboration

Maria A Gonzalez-Carmona 1 collaboration

Manuel Ritter 1 collaboration

Marieta I Toma 1 collaboration

Laura Kristin Esser 1 collaboration

Adrian Georg Simon 1 collaboration

Carsten Stephan 1 collaboration

Marieta Ioana Toma 1 collaboration

Marc Sylvester 1 collaboration

Ondrej Sanovec 1 collaboration

Michaela Frolikova 1 collaboration

Veronika Kraus 1 collaboration

Jana Vondrakova 1 collaboration

Maryam Qasemi 1 collaboration

Daniela Spevakova 1 collaboration

Ondrej Simonik 1 collaboration

Lindsay Moritz 1 collaboration

Drew Lewis Caswell 1 collaboration

Frantisek Liska 1 collaboration

Lukas Ded 1 collaboration

Jiri Cerny 1 collaboration

Tomer Avidor-Reiss 1 collaboration

Saher Sue Hammoud 1 collaboration

Pavla Postlerova 1 collaboration

Katerina Komrskova 1 collaboration

Sina V Jostes 1 collaboration

Martin Fellermeyer 1 collaboration

Peter K Nicholls 1 collaboration

Sahin Naqvi 1 collaboration

Yueh-Chiang Hu 1 collaboration

Yuting Fan 1 collaboration

Michelle A Carmell 1 collaboration

Ina Dobrinski 1 collaboration

Adrienne L Watson 1 collaboration

Daniel F Carlson 1 collaboration

Scott C Fahrenkrug 1 collaboration

David C Page 1 collaboration

Christian Trötschel 1 collaboration

Ansgar Poetsch 1 collaboration

Arik Horne 1 collaboration

Lorenzo Bonaguro 1 collaboration

Lisa Holsten 1 collaboration

Tatiana Hesse 1 collaboration

Alexej Knaus 1 collaboration

Yannick Riedel 1 collaboration

Matthias Becker 1 collaboration

Kristian Händler 1 collaboration

Tarek Elmzzahi 1 collaboration

Kevin Bassler 1 collaboration

Nico Reusch 1 collaboration

Leon Harootoonovtch Yeghiazarian 1 collaboration

Tal Pecht 1 collaboration

Adem Saglam 1 collaboration

Thomas Ulas 1 collaboration

Anna C Aschenbrenner 1 collaboration

Joachim L Schultze 1 collaboration

Julia Meier 1 collaboration

Andreas Christian Fröbius 1 collaboration

Udo Siebolts 1 collaboration

Roberto Pappesch 1 collaboration

Marcus Bauer 1 collaboration

Wolfgang Dietmaier 1 collaboration

Mareike Ernst 1 collaboration

Anja Haak 1 collaboration

Nils Hartmann 1 collaboration

Katharina Ilm 1 collaboration

Stavros Kalbourtzis 1 collaboration

Thomas Krause 1 collaboration

Daniel Kazdal 1 collaboration

Kirsten Utpatel 1 collaboration

Sabine Merkelbach-Bruse 1 collaboration

Julia Armbruster 1 collaboration

Mostafa A Aboouf 1 collaboration

Max Gassmann 1 collaboration

Angela Egert 1 collaboration

Veit Hornung 1 collaboration

Tobias Schmidt 1 collaboration

Jonathan L Schmid-Burgk 1 collaboration

Anne Bicker 1 collaboration

Thomas Hankeln 1 collaboration

Hao Zhu 1 collaboration

Thomas A Gorr 1 collaboration

Michelle Mayer 1 collaboration

Ann-Kristin Dicke 1 collaboration

Sophie A Koser 1 collaboration

Jan N Hansen 1 collaboration

Samuel Young 1 collaboration

Christoph Brenker 1 collaboration

Dagmar Wachten 1 collaboration

Timo Struenker 1 collaboration

D Nettersheim 1 collaboration

D Berger 1 collaboration

S Jostes 1 collaboration

G Kristiansen 1 collaboration

G Lochnit 1 collaboration

Daniel Berger 1 collaboration

Margaretha Skowron 1 collaboration

Julia Hartweg 1 collaboration

Selina Jansky 1 collaboration

Neha Sharma 1 collaboration

Dominik Nitsche 1 collaboration

Monika Graf 1 collaboration

Nina Langer 1 collaboration

Cornelia Fink 1 collaboration

Nelli Baal 1 collaboration

Jochen Wilhelm 1 collaboration

Poonam Sarode 1 collaboration

Roswitha Weigel 1 collaboration

Valérie Schumacher 1 collaboration

Carmen Schröck 1 collaboration

Martin Bergmann 1 collaboration

Monika Kressin 1 collaboration

Rajkumar Savai 1 collaboration

Margaretha A Skowron 1 collaboration

Teresa K Becker 1 collaboration

Lukas Kurz 1 collaboration

Felix Bremmer 1 collaboration

Florian Fronhoffs 1 collaboration

Gamal A Wakileh 1 collaboration

Melanie R Müller 1 collaboration

Aaron Burmeister 1 collaboration

Thomas Lenz 1 collaboration

Anja Stefanski 1 collaboration

Kai Stühler 1 collaboration

Patrick Petzsch 1 collaboration

Karl Köhrer 1 collaboration

Peter Altevogt 1 collaboration

Peter Albers 1 collaboration

Robert Düster 1 collaboration

Prince De-Graft Wilson 1 collaboration

Matthias Geyer 1 collaboration

Franka Enow Oben 1 collaboration

Isabelle Sophie Neumann 1 collaboration

Dirk G de Rooij 1 collaboration

Carla Simon 1 collaboration

Melanie Jokwitz 1 collaboration