Giovanni Ligresti

Affiliations

Department of Physiology & Biomedical Engineering, Mayo Clinic, Rochester, MN 55905, USA.

Publications (29)

TGFβ-induced fibroblast activation requires persistent and targeted HDAC-mediated gene repression.

Journal of cell science

Avec: Dakota L Jones , Andrew J Haak , Nunzia Caporarello , Kyoung M Choi , Zhenqing Ye , Huihuang Yan , Xaralabos Varelas , Tamas Ordog , Giovanni Ligresti , Daniel J Tschumperlin

Nascent Lung Organoids Reveal Epithelium- and Bone Morphogenetic Protein-mediated Suppression of Fibroblast Activation.

American journal of respiratory cell and molecular biology

Avec: Qi Tan , Xiao Yin Ma , Wei Liu , Jeffrey A Meridew , Dakota L Jones , Andrew J Haak , Delphine Sicard , Giovanni Ligresti , Daniel J Tschumperlin

Dysfunctional ERG signaling drives pulmonary vascular aging and persistent fibrosis.

Nature communications

Avec: Nunzia Caporarello , Jisu Lee , Tho X Pham , Dakota L Jones , Jiazhen Guan , Patrick A Link , Jeffrey A Meridew , Grace Marden , Takashi Yamashita , Collin A Osborne , Aditya V Bhagwate , Steven K Huang , Roberto F Nicosia , Daniel J Tschumperlin , Maria Trojanowska , Giovanni Ligresti

Pim-1 kinase is a positive feedback regulator of the senescent lung fibroblast inflammatory secretome.

American journal of physiology. Lung cellular and molecular physiology

Avec: Ashley Y Gao , Ana M Diaz Espinosa , Fiorenza Gianì , Tho X Pham , Chase M Carver , Aja Aravamudhan , Colleen M Bartman , Giovanni Ligresti , Nunzia Caporarello , Marissa J Schafer , Andrew J Haak

Mesenchymal cells in the Lung: Evolving concepts and their role in fibrosis.

Gene

Avec: Giovanni Ligresti , Ahmed A Raslan , Jeongmin Hong , Nunzia Caporarello , Marco Confalonieri , Steven K Huang

Transbronchial lung cryobiopsy and pulmonary fibrosis: A never-ending story?

Heliyon

Avec: Barbara Ruaro , Stefano Tavano , Paola Confalonieri , Riccardo Pozzan , Michael Hughes , Luca Braga , Maria Concetta Volpe , Giovanni Ligresti , Alessia Giovanna Andrisano , Selene Lerda , Pietro Geri , Marco Biolo , Elisa Baratella , Marco Confalonieri , Francesco Salton

Myofibroblast dedifferentiation proceeds via distinct transcriptomic and phenotypic transitions.

JCI insight

Avec: Sean M Fortier , Loka R Penke , Dana King , Tho X Pham , Giovanni Ligresti , Marc Peters-Golden

ZNF416 is a pivotal transcriptional regulator of fibroblast mechanoactivation.

The Journal of cell biology

Avec: Dakota L Jones , Jeffrey A Meridew , Patrick A Link , Merrick T Ducharme , Katherine L Lydon , Kyoung M Choi , Nunzia Caporarello , Qi Tan , Ana Maria Diaz Espinosa , Yuning Xiong , Jeong-Heon Lee , Zhenqing Ye , Huihuang Yan , Tamas Ordog , Giovanni Ligresti , Xaralabos Varelas , Daniel J Tschumperlin

Transcriptional analysis of lung fibroblasts identifies PIM1 signaling as a driver of aging-associated persistent fibrosis.

JCI insight

Avec: Tho X Pham , Jisu Lee , Jiazhen Guan , Nunzia Caporarello , Jeffrey A Meridew , Dakota L Jones , Qi Tan , Steven K Huang , Daniel J Tschumperlin , Giovanni Ligresti

Endothelial Erg Regulates Expression of Pulmonary Lymphatic Junctional and Inflammation Genes in Mouse Lungs Impacting Lymphatic Transport.

Research square

Avec: Adri Chakraborty , Alex Kim , Salam AlAbdullatif , Joshua Campbell , Yuriy Alekseyev , Ulas Kaplan , Vrinda Dambal , Giovanni Ligresti , Maria Trojanowska

ERG regulates lymphatic vessel specification genes and its deficiency impairs wound healing-associated lymphangiogenesis.

Arthritis & rheumatology (Hoboken, N.J.)

Avec: Takashi Yamashita , Ulas Kaplan , Adri Chakraborty , Grace Marden , Sami Gritli , Daniel Roh , Andreea Bujor , Marcin Trojanowski , Giovanni Ligresti , Jeffrey L Browning , Maria Trojanowska

Vascular dysfunction in aged mice contributes to persistent lung fibrosis.

Aging cell

Avec: Nunzia Caporarello , Jeffrey A Meridew , Aja Aravamudhan , Dakota L Jones , Susan A Austin , Tho X Pham , Andrew J Haak , Kyoung Moo Choi , Qi Tan , Adil Haresi , Steven K Huang , Zvonimir S Katusic , Daniel J Tschumperlin , Giovanni Ligresti

PGC1α repression in IPF fibroblasts drives a pathologic metabolic, secretory and fibrogenic state.

Thorax

Avec: Nunzia Caporarello , Jeffrey A Meridew , Dakota L Jones , Qi Tan , Andrew J Haak , Kyoung M Choi , Logan J Manlove , Y S Prakash , Daniel J Tschumperlin , Giovanni Ligresti

Muscularis macrophages establish cell-to-cell contacts with telocytes/PDGFRα-positive cells and smooth muscle cells in the human and mouse gastrointestinal tract.

Neurogastroenterology and motility

Avec: Sihan Ji , Chiara Traini , Magdalini Mischopoulou , Simon J Gibbons , Giovanni Ligresti , Maria-Simonetta Faussone-Pellegrini , Lei Sha , Gianrico Farrugia , Maria Giuliana Vannucchi , Gianluca Cipriani

The matricellular protein CCN3 supports lung endothelial homeostasis and function.

American journal of physiology. Lung cellular and molecular physiology

Avec: Kalpana R Betageri , Patrick A Link , Andrew J Haak , Giovanni Ligresti , Daniel J Tschumperlin , Nunzia Caporarello

Single Cell Transcriptomics of Fibrotic Lungs Unveils Aging-associated Alterations in Endothelial and Epithelial Cell Regeneration.

bioRxiv : the preprint server for biology

Avec: Ahmed A Raslan , Tho X Pham , Jisu Lee , Jeongmin Hong , Jillian Schmottlach , Kristina Nicolas , Taha Dinc , Andreea M Bujor , Nunzia Caporarello , Aude Thiriot , Ulrich H von Andrian , Steven K Huang , Roberto F Nicosia , Maria Trojanowska , Xaralabos Varelas , Giovanni Ligresti

Vascular Contribution to Lung Repair and Fibrosis.

American journal of respiratory cell and molecular biology

Avec: Nunzia Caporarello , Giovanni Ligresti

Targeted regulation of fibroblast state by CRISPR-mediated CEBPA expression.

Respiratory research

Avec: Wei Liu , Jeffrey A Meridew , Aja Aravamudhan , Giovanni Ligresti , Daniel J Tschumperlin , Qi Tan

CBX5/G9a/H3K9me-mediated gene repression is essential to fibroblast activation during lung fibrosis.

JCI insight

Avec: Giovanni Ligresti , Nunzia Caporarello , Jeffrey A Meridew , Dakota L Jones , Qi Tan , Kyoung Moo Choi , Andrew J Haak , Aja Aravamudhan , Anja C Roden , Y S Prakash , Gwen Lomberk , Raul A Urrutia , Daniel J Tschumperlin

TBK1 regulates YAP/TAZ and fibrogenic fibroblast activation.

American journal of physiology. Lung cellular and molecular physiology

Avec: Aja Aravamudhan , Andrew J Haak , Kyoung Moo Choi , Jeffrey A Meridew , Nunzia Caporarello , Dakota L Jones , Qi Tan , Giovanni Ligresti , Daniel J Tschumperlin

Role of the Transcription Factor Yin Yang 1 and Its Selectively Identified Target Survivin in High-Grade B-Cells Non-Hodgkin Lymphomas: Potential Diagnostic and Therapeutic Targets.

International journal of molecular sciences

Avec: Silvia Vivarelli , Luca Falzone , Giovanni Ligresti , Saverio Candido , Adriana Garozzo , Gaetano Giuseppe Magro , Benjamin Bonavida , Massimo Libra

Selective YAP/TAZ inhibition in fibroblasts via dopamine receptor D1 agonism reverses fibrosis.

Science translational medicine

Avec: Andrew J Haak , Enis Kostallari , Delphine Sicard , Giovanni Ligresti , Kyoung Moo Choi , Nunzia Caporarello , Dakota L Jones , Qi Tan , Jeffrey Meridew , Ana M Diaz Espinosa , Aja Aravamudhan , Jessica L Maiers , Rodney D Britt , Anja C Roden , Christina M Pabelick , Y S Prakash , Seyed Mehdi Nouraie , Xiaoyun Li , Yingze Zhang , Daniel J Kass , David Lagares , Andrew M Tager , Xaralabos Varelas , Vijay H Shah , Daniel J Tschumperlin

Wet-dry-wet drug screen leads to the synthesis of TS1, a novel compound reversing lung fibrosis through inhibition of myofibroblast differentiation.

Cell death & disease

Avec: Nadja Anneliese Ruth Ring , Maria Concetta Volpe , Tomaž Stepišnik , Maria Grazia Mamolo , Panče Panov , Dragi Kocev , Simone Vodret , Sara Fortuna , Antonella Calabretti , Michael Rehman , Andrea Colliva , Pietro Marchesan , Luca Camparini , Thomas Marcuzzo , Rossana Bussani , Sara Scarabellotto , Marco Confalonieri , Tho X Pham , Giovanni Ligresti , Nunzia Caporarello , Francesco S Loffredo , Daniele Zampieri , Sašo Džeroski , Serena Zacchigna

Spontaneous Lung Fibrosis Resolution Reveals Novel Antifibrotic Regulators.

American journal of respiratory cell and molecular biology

Avec: Qi Tan , Patrick A Link , Jeffrey A Meridew , Tho X Pham , Nunzia Caporarello , Giovanni Ligresti , Daniel J Tschumperlin

COVID-19 Vasculopathy: Mounting Evidence for an Indirect Mechanism of Endothelial Injury.

The American journal of pathology

Avec: Roberto F Nicosia , Giovanni Ligresti , Nunzia Caporarello , Shreeram Akilesh , Domenico Ribatti

Crystal ribcage: a platform for probing real-time lung function at cellular resolution.

Nature methods

Avec: Rohin Banerji , Gabrielle N Grifno , Linzheng Shi , Dylan Smolen , Rob LeBourdais , Johnathan Muhvich , Cate Eberman , Bradley E Hiller , Jisu Lee , Kathryn Regan , Siyi Zheng , Sue Zhang , John Jiang , Ahmed A Raslan , Julia C Breda , Riley Pihl , Katrina Traber , Sarah Mazzilli , Giovanni Ligresti , Joseph P Mizgerd , Béla Suki , Hadi T Nia

Kidney endothelial cell heterogeneity, angiocrine activity and paracrine regulatory mechanisms.

Vascular pharmacology

Avec: Domenico Ribatti , Giovanni Ligresti , Roberto F Nicosia

Rapid Generation of Hpsc-Derived High Endothelial Venule Organoids with In Vivo Ectopic Lymphoid Tissue Capabilities.

Advanced materials (Deerfield Beach, Fla.)

Avec: X Wang , X F Li , J Zhao , Y Li , S R Shin , G Ligresti , A H M Ng , J S Bromberg , G Church , D R Lemos , R Abdi

Lung injury-induced activated endothelial cell states persist in aging-associated progressive fibrosis.

Nature communications

Avec: Ahmed A Raslan , Tho X Pham , Jisu Lee , Konstantinos Kontodimas , Andrew Tilston-Lunel , Jillian Schmottlach , Jeongmin Hong , Taha Dinc , Andreea M Bujor , Nunzia Caporarello , Aude Thiriot , Ulrich H von Andrian , Steven K Huang , Roberto F Nicosia , Maria Trojanowska , Xaralabos Varelas , Giovanni Ligresti

Réseau de co-auteurs

Nunzia Caporarello 18 collaborations

Daniel J Tschumperlin 13 collaborations

Dakota L Jones 10 collaborations

Qi Tan 10 collaborations

Jeffrey A Meridew 10 collaborations

Andrew J Haak 9 collaborations

Tho X Pham 9 collaborations

Steven K Huang 6 collaborations

Aja Aravamudhan 6 collaborations

Xaralabos Varelas 5 collaborations

Jisu Lee 5 collaborations

Roberto F Nicosia 5 collaborations

Maria Trojanowska 5 collaborations

Patrick A Link 4 collaborations

Ahmed A Raslan 4 collaborations

Kyoung Moo Choi 4 collaborations

Kyoung M Choi 3 collaborations

Jeongmin Hong 3 collaborations

Marco Confalonieri 3 collaborations

Y S Prakash 3 collaborations

Zhenqing Ye 2 collaborations

Huihuang Yan 2 collaborations

Tamas Ordog 2 collaborations

Wei Liu 2 collaborations

Delphine Sicard 2 collaborations

Jiazhen Guan 2 collaborations

Grace Marden 2 collaborations

Takashi Yamashita 2 collaborations

Ana M Diaz Espinosa 2 collaborations

Maria Concetta Volpe 2 collaborations

Adri Chakraborty 2 collaborations

Ulas Kaplan 2 collaborations

Jillian Schmottlach 2 collaborations

Taha Dinc 2 collaborations

Andreea M Bujor 2 collaborations

Aude Thiriot 2 collaborations

Ulrich H von Andrian 2 collaborations

Anja C Roden 2 collaborations

Domenico Ribatti 2 collaborations

Xiao Yin Ma 1 collaboration

Collin A Osborne 1 collaboration

Aditya V Bhagwate 1 collaboration

Ashley Y Gao 1 collaboration

Fiorenza Gianì 1 collaboration

Chase M Carver 1 collaboration

Colleen M Bartman 1 collaboration

Marissa J Schafer 1 collaboration

Barbara Ruaro 1 collaboration

Stefano Tavano 1 collaboration

Paola Confalonieri 1 collaboration

Riccardo Pozzan 1 collaboration

Michael Hughes 1 collaboration

Luca Braga 1 collaboration

Alessia Giovanna Andrisano 1 collaboration

Selene Lerda 1 collaboration

Pietro Geri 1 collaboration

Marco Biolo 1 collaboration

Elisa Baratella 1 collaboration

Francesco Salton 1 collaboration

Sean M Fortier 1 collaboration

Loka R Penke 1 collaboration

Dana King 1 collaboration

Marc Peters-Golden 1 collaboration

Merrick T Ducharme 1 collaboration

Katherine L Lydon 1 collaboration

Ana Maria Diaz Espinosa 1 collaboration

Yuning Xiong 1 collaboration

Jeong-Heon Lee 1 collaboration

Alex Kim 1 collaboration

Salam AlAbdullatif 1 collaboration

Joshua Campbell 1 collaboration

Yuriy Alekseyev 1 collaboration

Vrinda Dambal 1 collaboration

Sami Gritli 1 collaboration

Daniel Roh 1 collaboration

Andreea Bujor 1 collaboration

Marcin Trojanowski 1 collaboration

Jeffrey L Browning 1 collaboration

Susan A Austin 1 collaboration

Adil Haresi 1 collaboration

Zvonimir S Katusic 1 collaboration

Logan J Manlove 1 collaboration

Sihan Ji 1 collaboration

Chiara Traini 1 collaboration

Magdalini Mischopoulou 1 collaboration

Simon J Gibbons 1 collaboration

Maria-Simonetta Faussone-Pellegrini 1 collaboration

Lei Sha 1 collaboration

Gianrico Farrugia 1 collaboration

Maria Giuliana Vannucchi 1 collaboration

Gianluca Cipriani 1 collaboration

Kalpana R Betageri 1 collaboration

Kristina Nicolas 1 collaboration

Gwen Lomberk 1 collaboration

Raul A Urrutia 1 collaboration

Silvia Vivarelli 1 collaboration

Luca Falzone 1 collaboration

Saverio Candido 1 collaboration

Adriana Garozzo 1 collaboration

Gaetano Giuseppe Magro 1 collaboration

Benjamin Bonavida 1 collaboration

Massimo Libra 1 collaboration

Enis Kostallari 1 collaboration

Jeffrey Meridew 1 collaboration

Jessica L Maiers 1 collaboration

Rodney D Britt 1 collaboration

Christina M Pabelick 1 collaboration

Seyed Mehdi Nouraie 1 collaboration

Xiaoyun Li 1 collaboration

Yingze Zhang 1 collaboration

Daniel J Kass 1 collaboration

David Lagares 1 collaboration

Andrew M Tager 1 collaboration

Vijay H Shah 1 collaboration

Nadja Anneliese Ruth Ring 1 collaboration

Tomaž Stepišnik 1 collaboration

Maria Grazia Mamolo 1 collaboration

Panče Panov 1 collaboration

Dragi Kocev 1 collaboration

Simone Vodret 1 collaboration

Sara Fortuna 1 collaboration

Antonella Calabretti 1 collaboration

Michael Rehman 1 collaboration

Andrea Colliva 1 collaboration

Pietro Marchesan 1 collaboration

Luca Camparini 1 collaboration

Thomas Marcuzzo 1 collaboration

Rossana Bussani 1 collaboration

Sara Scarabellotto 1 collaboration

Francesco S Loffredo 1 collaboration

Daniele Zampieri 1 collaboration

Sašo Džeroski 1 collaboration

Serena Zacchigna 1 collaboration

Shreeram Akilesh 1 collaboration

Rohin Banerji 1 collaboration

Gabrielle N Grifno 1 collaboration

Linzheng Shi 1 collaboration

Dylan Smolen 1 collaboration

Rob LeBourdais 1 collaboration

Johnathan Muhvich 1 collaboration

Cate Eberman 1 collaboration

Bradley E Hiller 1 collaboration

Kathryn Regan 1 collaboration

Siyi Zheng 1 collaboration

Sue Zhang 1 collaboration

John Jiang 1 collaboration

Julia C Breda 1 collaboration

Riley Pihl 1 collaboration

Katrina Traber 1 collaboration

Sarah Mazzilli 1 collaboration

Joseph P Mizgerd 1 collaboration

Béla Suki 1 collaboration

Hadi T Nia 1 collaboration

X Wang 1 collaboration

X F Li 1 collaboration

J Zhao 1 collaboration

Y Li 1 collaboration

S R Shin 1 collaboration

G Ligresti 1 collaboration

A H M Ng 1 collaboration

J S Bromberg 1 collaboration

G Church 1 collaboration

D R Lemos 1 collaboration

R Abdi 1 collaboration

Konstantinos Kontodimas 1 collaboration

Andrew Tilston-Lunel 1 collaboration