Frank-Gerrit Klärner

Affiliations

Faculty of Chemistry, University of Duisburg-Essen, Essen, Germany.

Publications (15)

Molecular Lysine Tweezers Counteract Aberrant Protein Aggregation.

Frontiers in chemistry

Avec: Inesa Hadrovic , Philipp Rebmann , Frank-Gerrit Klärner , Gal Bitan , Thomas Schrader

Advanced Molecular Tweezers with Lipid Anchors against SARS-CoV-2 and Other Respiratory Viruses.

JACS Au

Avec: Tatjana Weil , Abbna Kirupakaran , My-Hue Le , Philipp Rebmann , Joel Mieres-Perez , Leila Issmail , Carina Conzelmann , Janis A Müller , Lena Rauch , Andrea Gilg , Lukas Wettstein , Rüdiger Groß , Clarissa Read , Tim Bergner , Sandra Axberg Pålsson , Nadja Uhlig , Valentina Eberlein , Heike Wöll , Frank-Gerrit Klärner , Steffen Stenger , Beate M Kümmerer , Hendrik Streeck , Giorgio Fois , Manfred Frick , Peter Braubach , Anna-Lena Spetz , Thomas Grunwald , James Shorter , Elsa Sanchez-Garcia , Thomas Schrader , Jan Münch

Different Inhibitors of Aβ42-Induced Toxicity Have Distinct Metal-Ion Dependency.

ACS chemical neuroscience

Avec: Ashley J Mason , Ian Hurst , Ravinder Malik , Ibrar Siddique , Inna Solomonov , Irit Sagi , Frank-Gerrit Klärner , Thomas Schrader , Gal Bitan

Lysine-selective molecular tweezers are cell penetrant and concentrate in lysosomes.

Communications biology

Avec: Zizheng Li , Ibrar Siddique , Inesa Hadrović , Abbna Kirupakaran , Jiwen Li , Ye Zhang , Frank-Gerrit Klärner , Thomas Schrader , Gal Bitan

The Amyloid Inhibitor CLR01 Relieves Autophagy and Ameliorates Neuropathology in a Severe Lysosomal Storage Disease.

Molecular therapy : the journal of the American Society of Gene Therapy

Avec: Antonio Monaco , Veronica Maffia , Nicolina Cristina Sorrentino , Irene Sambri , Yulia Ezhova , Teresa Giuliano , Vincenzo Cacace , Edoardo Nusco , Maria De Risi , Elvira De Leonibus , Thomas Schrader , Frank-Gerrit Klärner , Gal Bitan , Alessandro Fraldi

Inhibition of Staphylococcus aureus biofilm-forming functional amyloid by molecular tweezers.

Cell chemical biology

Avec: Ravit Malishev , Nir Salinas , James Gibson , Angela Bailey Eden , Joel Mieres-Perez , Yasser B Ruiz-Blanco , Orit Malka , Sofiya Kolusheva , Frank-Gerrit Klärner , Thomas Schrader , Elsa Sanchez-Garcia , Chunyu Wang , Meytal Landau , Gal Bitan , Raz Jelinek

Supramolecular Mechanism of Viral Envelope Disruption by Molecular Tweezers.

Journal of the American Chemical Society

Avec: Tatjana Weil , Rüdiger Groß , Annika Röcker , Kenny Bravo-Rodriguez , Christian Heid , Andrea Sowislok , My-Hue Le , Nelli Erwin , Mridula Dwivedi , Stephen M Bart , Paul Bates , Lukas Wettstein , Janis A Müller , Mirja Harms , Konstantin Sparrer , Yasser B Ruiz-Blanco , Christina M Stürzel , Jens von Einem , Sina Lippold , Clarissa Read , Paul Walther , Marco Hebel , Florian Kreppel , Frank-Gerrit Klärner , Gal Bitan , Michael Ehrmann , Tanja Weil , Roland Winter , Thomas Schrader , James Shorter , Elsa Sanchez-Garcia , Jan Münch

The molecular tweezer CLR01 reduces aggregated, pathologic, and seeding-competent α-synuclein in experimental multiple system atrophy.

Biochimica et biophysica acta. Molecular basis of disease

Avec: Marcos Herrera-Vaquero , Danielle Bouquio , Martin Kallab , Karl Biggs , Gayatri Nair , Jessica Ochoa , Antonio Heras-Garvin , Christian Heid , Inesa Hadrovic , Werner Poewe , Gregor K Wenning , Frank-Gerrit Klärner , Thomas Schrader , Gal Bitan , Nadia Stefanova

Characterization of Molecular Tweezer Binding on α-Synuclein with Native Top-Down Mass Spectrometry and Ion Mobility-Mass Spectrometry Reveals a Mechanism for Aggregation Inhibition.

Journal of the American Society for Mass Spectrometry

Avec: Carter Lantz , Jaybree Lopez , Andrew K Goring , Muhammad A Zenaidee , Karl Biggs , Julian P Whitelegge , Rachel R Ogorzalek Loo , Frank-Gerrit Klärner , Thomas Schrader , Gal Bitan , Joseph A Loo

Molecular Tweezers: Supramolecular Hosts with Broad-Spectrum Biological Applications.

Pharmacological reviews

Avec: Hedieh Shahpasand-Kroner , Ibrar Siddique , Ravinder Malik , Gabriel R Linares , Magdalena I Ivanova , Justin Ichida , Tatjana Weil , Jan Münch , Elsa Sanchez-Garcia , Frank-Gerrit Klärner , Thomas Schrader , Gal Bitan

Major Differences between the Self-Assembly and Seeding Behavior of Heparin-Induced and in Vitro Phosphorylated Tau and Their Modulation by Potential Inhibitors.

ACS chemical biology

Avec: Clément Despres , Jing Di , François-Xavier Cantrelle , Zizheng Li , Isabelle Huvent , Béatrice Chambraud , Jing Zhao , Jianle Chen , Shiguo Chen , Guy Lippens , Fuming Zhang , Robert Linhardt , Chunyu Wang , Frank-Gerrit Klärner , Thomas Schrader , Isabelle Landrieu , Gal Bitan , Caroline Smet-Nocca

The molecular tweezer CLR01 inhibits aberrant superoxide dismutase 1 (SOD1) self-assembly

The Journal of biological chemistry

Avec: Ravinder Malik , Helen Meng , Piriya Wongkongkathep , Christian I Corrales , Niki Sepanj , Ryan S Atlasi , Frank-Gerrit Klärner , Thomas Schrader , Melissa J Spencer , Joseph A Loo , Martina Wiedau , Gal Bitan

Native Top-Down Mass Spectrometry and Ion Mobility Spectrometry of the Interaction of Tau Protein with a Molecular Tweezer Assembly Modulator.

Journal of the American Society for Mass Spectrometry

Avec: Michael Nshanian , Carter Lantz , Piriya Wongkongkathep , Thomas Schrader , Frank-Gerrit Klärner , Anika Blümke , Clément Despres , Michael Ehrmann , Caroline Smet-Nocca , Gal Bitan , Joseph A Loo

The molecular tweezer CLR01 improves behavioral deficits and reduces tau pathology in P301S-tau transgenic mice.

Alzheimer's research & therapy

Avec: Jing Di , Ibrar Siddique , Zizheng Li , Ghattas Malki , Simon Hornung , Suman Dutta , Ian Hurst , Ella Ishaaya , Austin Wang , Sally Tu , Ani Boghos , Ida Ericsson , Frank-Gerrit Klärner , Thomas Schrader , Gal Bitan

CLR01 protects dopaminergic neurons in vitro and in mouse models of Parkinson's disease.

Nature communications

Avec: Nora Bengoa-Vergniory , Emilie Faggiani , Paula Ramos-Gonzalez , Ecem Kirkiz , Natalie Connor-Robson , Liam V Brown , Ibrar Siddique , Zizheng Li , Siv Vingill , Milena Cioroch , Fabio Cavaliere , Sarah Threlfell , Bradley Roberts , Thomas Schrader , Frank-Gerrit Klärner , Stephanie Cragg , Benjamin Dehay , Gal Bitan , Carlos Matute , Erwan Bezard , Richard Wade-Martins

Réseau de co-auteurs

Thomas Schrader 15 collaborations

Gal Bitan 14 collaborations

Ibrar Siddique 5 collaborations

Elsa Sanchez-Garcia 4 collaborations

Zizheng Li 4 collaborations

Tatjana Weil 3 collaborations

Jan Münch 3 collaborations

Ravinder Malik 3 collaborations

Joseph A Loo 3 collaborations

Inesa Hadrovic 2 collaborations

Philipp Rebmann 2 collaborations

Abbna Kirupakaran 2 collaborations

My-Hue Le 2 collaborations

Joel Mieres-Perez 2 collaborations

Janis A Müller 2 collaborations

Lukas Wettstein 2 collaborations

Rüdiger Groß 2 collaborations

Clarissa Read 2 collaborations

James Shorter 2 collaborations

Ian Hurst 2 collaborations

Yasser B Ruiz-Blanco 2 collaborations

Chunyu Wang 2 collaborations

Christian Heid 2 collaborations

Michael Ehrmann 2 collaborations

Karl Biggs 2 collaborations

Carter Lantz 2 collaborations

Clément Despres 2 collaborations

Jing Di 2 collaborations

Caroline Smet-Nocca 2 collaborations

Piriya Wongkongkathep 2 collaborations

Leila Issmail 1 collaboration

Carina Conzelmann 1 collaboration

Lena Rauch 1 collaboration

Andrea Gilg 1 collaboration

Tim Bergner 1 collaboration

Sandra Axberg Pålsson 1 collaboration

Nadja Uhlig 1 collaboration

Valentina Eberlein 1 collaboration

Heike Wöll 1 collaboration

Steffen Stenger 1 collaboration

Beate M Kümmerer 1 collaboration

Hendrik Streeck 1 collaboration

Giorgio Fois 1 collaboration

Manfred Frick 1 collaboration

Peter Braubach 1 collaboration

Anna-Lena Spetz 1 collaboration

Thomas Grunwald 1 collaboration

Ashley J Mason 1 collaboration

Inna Solomonov 1 collaboration

Irit Sagi 1 collaboration

Inesa Hadrović 1 collaboration

Jiwen Li 1 collaboration

Ye Zhang 1 collaboration

Antonio Monaco 1 collaboration

Veronica Maffia 1 collaboration

Nicolina Cristina Sorrentino 1 collaboration

Irene Sambri 1 collaboration

Yulia Ezhova 1 collaboration

Teresa Giuliano 1 collaboration

Vincenzo Cacace 1 collaboration

Edoardo Nusco 1 collaboration

Maria De Risi 1 collaboration

Elvira De Leonibus 1 collaboration

Alessandro Fraldi 1 collaboration

Ravit Malishev 1 collaboration

Nir Salinas 1 collaboration

James Gibson 1 collaboration

Angela Bailey Eden 1 collaboration

Orit Malka 1 collaboration

Sofiya Kolusheva 1 collaboration

Meytal Landau 1 collaboration

Raz Jelinek 1 collaboration

Annika Röcker 1 collaboration

Kenny Bravo-Rodriguez 1 collaboration

Andrea Sowislok 1 collaboration

Nelli Erwin 1 collaboration

Mridula Dwivedi 1 collaboration

Stephen M Bart 1 collaboration

Paul Bates 1 collaboration

Mirja Harms 1 collaboration

Konstantin Sparrer 1 collaboration

Christina M Stürzel 1 collaboration

Jens von Einem 1 collaboration

Sina Lippold 1 collaboration

Paul Walther 1 collaboration

Marco Hebel 1 collaboration

Florian Kreppel 1 collaboration

Tanja Weil 1 collaboration

Roland Winter 1 collaboration

Marcos Herrera-Vaquero 1 collaboration

Danielle Bouquio 1 collaboration

Martin Kallab 1 collaboration

Gayatri Nair 1 collaboration

Jessica Ochoa 1 collaboration

Antonio Heras-Garvin 1 collaboration

Werner Poewe 1 collaboration

Gregor K Wenning 1 collaboration

Nadia Stefanova 1 collaboration

Jaybree Lopez 1 collaboration

Andrew K Goring 1 collaboration

Muhammad A Zenaidee 1 collaboration

Julian P Whitelegge 1 collaboration

Rachel R Ogorzalek Loo 1 collaboration

Hedieh Shahpasand-Kroner 1 collaboration

Gabriel R Linares 1 collaboration

Magdalena I Ivanova 1 collaboration

Justin Ichida 1 collaboration

François-Xavier Cantrelle 1 collaboration

Isabelle Huvent 1 collaboration

Béatrice Chambraud 1 collaboration

Jing Zhao 1 collaboration

Jianle Chen 1 collaboration

Shiguo Chen 1 collaboration

Guy Lippens 1 collaboration

Fuming Zhang 1 collaboration

Robert Linhardt 1 collaboration

Isabelle Landrieu 1 collaboration

Helen Meng 1 collaboration

Christian I Corrales 1 collaboration

Niki Sepanj 1 collaboration

Ryan S Atlasi 1 collaboration

Melissa J Spencer 1 collaboration

Martina Wiedau 1 collaboration

Michael Nshanian 1 collaboration

Anika Blümke 1 collaboration

Ghattas Malki 1 collaboration

Simon Hornung 1 collaboration

Suman Dutta 1 collaboration

Ella Ishaaya 1 collaboration

Austin Wang 1 collaboration

Sally Tu 1 collaboration

Ani Boghos 1 collaboration

Ida Ericsson 1 collaboration

Nora Bengoa-Vergniory 1 collaboration

Emilie Faggiani 1 collaboration

Paula Ramos-Gonzalez 1 collaboration

Ecem Kirkiz 1 collaboration

Natalie Connor-Robson 1 collaboration

Liam V Brown 1 collaboration

Siv Vingill 1 collaboration

Milena Cioroch 1 collaboration

Fabio Cavaliere 1 collaboration

Sarah Threlfell 1 collaboration

Bradley Roberts 1 collaboration

Stephanie Cragg 1 collaboration

Benjamin Dehay 1 collaboration

Carlos Matute 1 collaboration

Erwan Bezard 1 collaboration

Richard Wade-Martins 1 collaboration