Francois Ghiringhelli

Affiliations
  • Medical Oncology Department, Centre Georges-François Leclerc, Dijon, France.

Publications (85)

Immunodynamics of explanted human tumors for immuno-oncology.

EMBO molecular medicine
Avec: Agathe Dubuisson , Jean-Eudes Fahrner , Anne-Gaëlle Goubet , Safae Terrisse , Nicolas Voisin , Charles Bayard , Sebastien Lofek , Damien Drubay , Delphine Bredel , Séverine Mouraud , Sandrine Susini , Alexandria Cogdill , Lucas Rebuffet , Elise Ballot , Nicolas Jacquelot , Vincent Thomas de Montpreville , Odile Casiraghi , Camélia Radulescu , Sophie Ferlicot , David J Figueroa , Sapna Yadavilli , Jeremy D Waight , Marc Ballas , Axel Hoos , Thomas Condamine , Bastien Parier , Christophe Gaudillat , Bertrand Routy , François Ghiringhelli , Lisa Derosa , Ingrid Breuskin , Mathieu Rouanne , Fabrice André , Cédric Lebacle , Hervé Baumert , Marie Wislez , Elie Fadel , Isabelle Cremer , Laurence Albiges , Birgit Geoerger , Jean-Yves Scoazec , Yohann Loriot , Guido Kroemer , Aurélien Marabelle , Mélodie Bonvalet , Laurence Zitvogel

Understanding Inflammasomes and PD-1/PD-L1 Crosstalk to Improve Cancer Treatment Efficiency.

Cancers
Avec: Anaïs Perrichet , François Ghiringhelli , Cédric Rébé

FOLFOX alone or combined with rilotumumab or panitumumab as first-line treatment for patients with advanced gastroesophageal adenocarcinoma (PRODIGE 17-ACCORD 20-MEGA): a randomised, open-label, three-arm phase II trial.

European journal of cancer (Oxford, England : 1990)
Avec: David Malka , Eric François , Frédérique Penault-Llorca , Florence Castan , Olivier Bouché , Jaafar Bennouna , François Ghiringhelli , Christelle de la Fouchardière , Christophe Borg , Emmanuelle Samalin , Jean-Baptiste Bachet , Jean-Luc Raoul , Laurent Miglianico , Leila Bengrine-Lefèvre , Laetitia Dahan , Cédric Lecaille , Thomas Aparicio , Trevor Stanbury , Hervé Perrier , Anne Cayre , Pierre Laurent-Puig , Sophie Gourgou , Jean-François Emile , Julien Taïeb

Everolimus after hepatic arterial embolisation therapy of metastases from gastrointestinal neuroendocrine tumours: The FFCD 1104-EVACEL-GTE phase II study.

European journal of cancer (Oxford, England : 1990)
Avec: Thomas Walter , Come Lepage , Romain Coriat , Emilie Barbier , Guillaume Cadiot , Francois-Xavier Caroli-Bosc , Thomas Aparicio , Karine Bouhier-Leporrier , Olivia Hentic-Dhome , Frédérique Gay , Anne-Claire Dupont-Gossart , Muriel Duluc , Céline Lepere , Thierry Lecomte , Denis Smith , Caroline Petorin , Frédéric Di-Fiore , Francois Ghiringhelli , Jean-Louis Legoux , Rosine Guimbaud , Eric Baudin , Catherine Lombard-Bohas , Thierry de Baère , Auteur inconnu

STAT3, a Master Regulator of Anti-Tumor Immune Response.

Cancers
Avec: Cédric Rébé , François Ghiringhelli

Correction: Prognostic and predictive role of CD8 and PD-L1 determination in lung tumor tissue of patients under anti-PD-1 therapy.

British journal of cancer
Avec: Jean-David Fumet , Corentin Richard , Fanny Ledys , Quentin Klopfenstein , Philippe Joubert , Bertrand Routy , Caroline Truntzer , Andréanne Gagné , Marc-André Hamel , Camila Figueiredo Guimaraes , Bruno Coudert , Laurent Arnould , Laure Favier , Aurélie Lagrange , Sylvain Ladoire , Pierre Saintigny , Sandra Ortiz-Cuaran , Maurice Perol , Pascal Foucher , Paul Hofman , Marius Ilie , Sandy Chevrier , Romain Boidot , Valentin Derangere , François Ghiringhelli

Modal instabilities in high power fiber laser oscillators.

Optics express
Avec: V Scarnera , F Ghiringhelli , A Malinowski , C A Codemard , M K Durkin , M N Zervas

The Role of Molecular Profiling to Predict the Response to Immune Checkpoint Inhibitors in Lung Cancer.

Cancers
Avec: Courèche Kaderbhaï , Zoé Tharin , François Ghiringhelli

Cell lines and immune classification of glioblastoma define patient's prognosis.

British journal of cancer
Avec: Quentin Klopfenstein , Caroline Truntzer , Julie Vincent , Francois Ghiringhelli

The Direct Conversion of α-Hydroxyketones to Alkynes.

The Journal of organic chemistry
Avec: Francesca Ghiringhelli , Lukas Nattmann , Sabine Bognar , Manuel van Gemmeren

Platinum Derivatives Effects on Anticancer Immune Response.

Biomolecules
Avec: Cédric Rébé , Lucie Demontoux , Thomas Pilot , François Ghiringhelli

Chemotherapy-induced ileal crypt apoptosis and the ileal microbiome shape immunosurveillance and prognosis of proximal colon cancer.

Nature medicine
Avec: Maria Paula Roberti , Satoru Yonekura , Connie P M Duong , Marion Picard , Gladys Ferrere , Maryam Tidjani Alou , Conrad Rauber , Valerio Iebba , Christian H K Lehmann , Lukas Amon , Diana Dudziak , Lisa Derosa , Bertrand Routy , Caroline Flament , Corentin Richard , Romain Daillère , Aurélie Fluckiger , Isabelle Van Seuningen , Mathias Chamaillard , Audrey Vincent , Stephanie Kourula , Paule Opolon , Pierre Ly , Eugénie Pizzato , Sonia Becharef , Juliette Paillet , Christophe Klein , Florence Marliot , Filippo Pietrantonio , Stéphane Benoist , Jean-Yves Scoazec , Peggy Dartigues , Antoine Hollebecque , David Malka , Franck Pagès , Jérôme Galon , Ivo Gomperts Boneca , Patricia Lepage , Bernard Ryffel , Didier Raoult , Alexander Eggermont , Tom Vanden Berghe , François Ghiringhelli , Peter Vandenabeele , Guido Kroemer , Laurence Zitvogel

Tumor Infiltrating Lymphocytes Signature as a New Pan-Cancer Predictive Biomarker of Anti PD-1/PD-L1 Efficacy.

Cancers
Avec: Elise Ballot , Sylvain Ladoire , Bertrand Routy , Caroline Truntzer , François Ghiringhelli

Health-Related Quality of Life Analysis in Metastatic Colorectal Cancer Patients Treated by Second-Line Chemotherapy, Associated With Either Cetuximab or Bevacizumab: The PRODIGE 18 Randomized Phase II Study.

Clinical colorectal cancer
Avec: Aurelie Bertaut , Yann Touchefeu , Julie Blanc , Olivier Bouché , Eric François , Thierry Conroy , Pascal Artru , Antoine Adenis , Jessica Gobbo , Christophe Borg , François Ghiringhelli , Jaafar Bennouna

Deep learning for colon cancer histopathological images analysis.

Computers in biology and medicine
Avec: A Ben Hamida , M Devanne , J Weber , C Truntzer , V Derangère , F Ghiringhelli , G Forestier , C Wemmert

Targeting HGF/c-Met Axis Decreases Circulating Regulatory T Cells Accumulation in Gastric Cancer Patients.

Cancers
Avec: Juliette Palle , Laure Hirsch , Alexandra Lapeyre-Prost , David Malka , Morgane Bourhis , Simon Pernot , Elie Marcheteau , Thibault Voron , Florence Castan , Ariane Lacotte , Nadine Benhamouda , Corinne Tanchot , Eric François , François Ghiringhelli , Christelle de la Fouchardière , Aziz Zaanan , Eric Tartour , Julien Taieb , Magali Terme

New Artificial Intelligence Score and Immune Infiltrates as Prognostic Factors in Colorectal Cancer With Brain Metastases.

Frontiers in immunology
Avec: Violaine Randrian , Amandine Desette , Sheik Emambux , Valentin Derangere , Pauline Roussille , Eric Frouin , Julie Godet , Lucie Karayan-Tapon , François Ghiringhelli , David Tougeron

Using a convolutional neural network for classification of squamous and non-squamous non-small cell lung cancer based on diagnostic histopathology HES images.

Scientific reports
Avec: Anne Laure Le Page , Elise Ballot , Caroline Truntzer , Valentin Derangère , Alis Ilie , David Rageot , Frederic Bibeau , Francois Ghiringhelli

Impact of Glucocorticoid Use in Oncology in the Immunotherapy Era.

Cells
Avec: Laura Kalfeist , Loïck Galland , Fanny Ledys , François Ghiringhelli , Emeric Limagne , Sylvain Ladoire

MER4 endogenous retrovirus correlated with better efficacy of anti-PD1/PD-L1 therapy in non-small cell lung cancer.

Journal for immunotherapy of cancer
Avec: Julie Lecuelle , Laure Favier , Cléa Fraisse , Aurélie Lagrange , Coureche Kaderbhai , Romain Boidot , Sandy Chevrier , Philippe Joubert , Bertrand Routy , Caroline Truntzer , Francois Ghiringhelli

Association of Anti-EGFR Antibody and MEK Inhibitor in Gynecological Cancer Harboring RAS Mutation: A Case Series.

International journal of molecular sciences
Avec: Julie Niogret , Valentin Derangère , Corentin Richard , Lisa Nuttin , François Ghiringhelli , Laure Favier , Leila Bengrine Lefevre , Anthony Bergeron , Laurent Arnould , Romain Boidot

Metronomic Cyclophosphamide With Cisplatin and Bevacizumab for Refractory Anaplastic Ependymoma: A Retrospective Study.

Anticancer research
Avec: Xavier Choderlos DE Laclos , Didier Frappaz , Guido Ahle , Charlotte Bronnimann , Isabelle Catry-Thomas , Anthony Joncour , Francois Ghiringhelli , Elodie Vauleon

Uncommon EGFR mutations in lung carcinoma: features and treatment outcomes in a retrospective French cohort.

Journal of thoracic disease
Avec: Pierre Tankere , Romain Boidot , Philippe Bonniaud , Ayoube Zouak , Pascal Foucher , Alice Milliere , Aurélie Bertaut , Laure Favier , Aurélie Lagrange , François Ghiringhelli , Courèche Guillaume Kaderbhai , Cléa Fraisse

Custom scoring based on ecological topology of gut microbiota associated with cancer immunotherapy outcome.

Cell
Avec: Lisa Derosa , Valerio Iebba , Carolina Alves Costa Silva , Gianmarco Piccinno , Guojun Wu , Leonardo Lordello , Bertrand Routy , Naisi Zhao , Cassandra Thelemaque , Roxanne Birebent , Federica Marmorino , Marine Fidelle , Meriem Messaoudene , Andrew Maltez Thomas , Gerard Zalcman , Sylvie Friard , Julien Mazieres , Clarisse Audigier-Valette , Denis Moro- Sibilot , François Goldwasser , Arnaud Scherpereel , Hervé Pegliasco , François Ghiringhelli , Nicole Bouchard , Cissé Sow , Ines Darik , Silvia Zoppi , Pierre Ly , Anna Reni , Romain Daillère , Eric Deutsch , Karla A Lee , Laura A Bolte , Johannes R Björk , Rinse K Weersma , Fabrice Barlesi , Lucas Padilha , Ana Finzel , Morten L Isaksen , Bernard Escudier , Laurence Albiges , David Planchard , Fabrice André , Chiara Cremolini , Stéphanie Martinez , Benjamin Besse , Liping Zhao , Nicola Segata , Jérôme Wojcik , Guido Kroemer , Laurence Zitvogel

Datasets for gene expression profiles of head and neck squamous cell carcinoma and lung cancer treated or not by PD1/PD-L1 inhibitors.

Data in brief
Avec: Jean-Philippe Foy , Andy Karabajakian , Sandra Ortiz-Cuaran , Maxime Boussageon , Lucas Michon , Jebrane Bouaoud , Dorssafe Fekiri , Marie Robert , Kim-Arthur Baffert , Geneviève Hervé , Pauline Quilhot , Valéry Attignon , Angélique Girod , André Chaine , Mourad Benassarou , Philippe Zrounba , Christophe Caux , François Ghiringhelli , Sylvie Lantuejoul , Carole Crozes , Isabelle Brochériou , Maurice Pérol , Jérôme Fayette , Chloé Bertolus , Pierre Saintigny

Conception and Evaluation of Fluorescent Phosphine-Gold Complexes: From Synthesis to in vivo Investigations.

ChemMedChem
Avec: Benjamin Rousselle , Aurélie Massot , Malorie Privat , Lucile Dondaine , Audrey Trommenschlager , Florence Bouyer , Jérôme Bayardon , François Ghiringhelli , Ali Bettaieb , Christine Goze , Catherine Paul , Raluca Malacea-Kabbara , Ewen Bodio

Phase II INTERACT-ION study: ezabenlimab (BI 754091) and mDCF (docetaxel, cisplatin, and 5-fluorouracil) followed by chemoradiotherapy in patients with Stage III squamous cell anal carcinoma.

Frontiers in oncology
Avec: Stefano Kim , Jihane Boustani , Dewi Vernerey , Véronique Vendrely , Ludovic Evesque , Eric Francois , Laurent Quero , Francois Ghiringhelli , Christelle de la Fouchardière , Laëtitia Dahan , Oliver Bouché , Benoist Chibaudel , Farid El Hajbi , Chloé Vernet , Magali Rebucci-Peixoto , Alexandra Feuersinger , Christophe Maritaz , Christophe Borg

The "extreme phenotype approach" applied to male breast cancer allows the identification of rare variants of ATR as potential breast cancer susceptibility alleles.

Oncotarget
Avec: Martin Chevarin , Diana Alcantara , Juliette Albuisson , Marie-Agnès Collonge-Rame , Céline Populaire , Zohair Selmani , Amandine Baurand , Caroline Sawka , Geoffrey Bertolone , Patrick Callier , Yannis Duffourd , Philippe Jonveaux , Yves-Jean Bignon , Isabelle Coupier , François Cornelis , Christophe Cordier , Monique Mozelle-Nivoix , Jean-Baptiste Rivière , Paul Kuentz , Christel Thauvin , Romain Boidot , François Ghiringhelli , Marc O'Driscoll , Laurence Faivre , Sophie Nambot

Complete pathological response after chemotherapy or immune checkpoint inhibitors in deficient MMR metastatic colorectal cancer: Results of a retrospective multicenter study.

International journal of cancer
Avec: Pauline Marolleau , David Tougeron , Benoit Allignet , Romain Cohen , David Sefrioui , Blandine Gallet , Frédéric Dumont , Rosine Guimbaud , Emily Alouani , Guillaume Passot , Grégoire Desolneux , François Ghiringhelli , Frédéric Marchal , Farouk Mourthadhoi , Romain Coriat , Romain Desgrippes , Christophe Locher , Gaël Goujon , Gaëtan Des Guetz , Thomas Aparicio , Etienne Paubelle , Aurélien Dupré , Christelle de la Fouchardière

First-line durvalumab and tremelimumab with chemotherapy in RAS-mutated metastatic colorectal cancer: a phase 1b/2 trial.

Nature medicine
Avec: Marion Thibaudin , Jean-David Fumet , Benoist Chibaudel , Jaafar Bennouna , Christophe Borg , Jerome Martin-Babau , Romain Cohen , Marianne Fonck , Julien Taieb , Emeric Limagne , Julie Blanc , Elise Ballot , Léa Hampe , Marjorie Bon , Susy Daumoine , Morgane Peroz , Hugo Mananet , Valentin Derangère , Romain Boidot , Henri-Alexandre Michaud , Caroline Laheurte , Olivier Adotevi , Aurélie Bertaut , Caroline Truntzer , François Ghiringhelli

FGF/FGFR genomic amplification as a predictive biomarker for immune checkpoint blockade resistance: a short report.

Journal for immunotherapy of cancer
Avec: Nicolas Roussot , Julie Lecuelle , Lorraine Dalens , Caroline Truntzer , Francois Ghiringhelli

Targeting CTLA-4: a possible solution for microsatellite-stable colorectal cancer.

Genes and immunity
Avec: François Ghiringhelli , Marion Thibaudin

CD3-CD8 immune score associated with a clinical score stratifies PDAC prognosis regardless of adjuvant or neoadjuvant chemotherapy.

Oncoimmunology
Avec: Coralie Schoumacher , Valentin Derangère , Gwladys Gaudillière-Le Dain , Titouan Huppe , David Rageot , Alis Ilie , Angélique Vienot , Christophe Borg , Franck Monnien , Frederic Bibeau , Caroline Truntzer , François Ghiringhelli , Auteur inconnu

First-in-human study of AMG 193, an MTA-cooperative PRMT5 inhibitor, in patients with MTAP-deleted solid tumors: results from phase 1 dose exploration.

Annals of oncology : official journal of the European Society for Medical Oncology
Avec: J Rodon , H Prenen , A Sacher , M Villalona-Calero , N Penel , A El Helali , S Rottey , N Yamamoto , F Ghiringhelli , M E Goebeler , T Doi , S Postel-Vinay , C-C Lin , C Liu , C-H Chuang , K Keyvanjah , T Eggert , B H O'Neil

Targeting mTOR signaling for the treatment of intrahepatic cholangiocarcinoma with TSC1/ARID1A mutations: a case report with an unexpected response.

Therapeutic advances in medical oncology
Avec: Clémentine Daugan , Romain Boidot , François Ghiringhelli , Christophe Borg , Angélique Vienot

Cathepsin B Is Required for NLRP3 Inflammasome Activation in Macrophages, Through NLRP3 Interaction.

Frontiers in cell and developmental biology
Avec: Angélique Chevriaux , Thomas Pilot , Valentin Derangère , Harmonie Simonin , Pierre Martine , Fanny Chalmin , François Ghiringhelli , Cédric Rébé

Atezolizumab plus modified docetaxel-cisplatin-5-fluorouracil (mDCF) regimen versus mDCF in patients with metastatic or unresectable locally advanced recurrent anal squamous cell carcinoma: a randomized, non-comparative phase II SCARCE GERCOR trial.

BMC cancer
Avec: Stefano Kim , Bruno Buecher , Thierry André , Marine Jary , François-Clément Bidard , François Ghiringhelli , Éric François , Julien Taieb , Denis Smith , Christelle de la Fouchardière , Jérôme Desramé , Emmanuelle Samalin , Aurélie Parzy , Nabil Baba-Hamed , Olivier Bouché , David Tougeron , Laëtitia Dahan , Farid El Hajbi , Marion Jacquin , Magali Rebucci-Peixoto , Laurie Spehner , Véronique Vendrely , Dewi Vernerey , Christophe Borg

Tumour mutational burden as a biomarker for immunotherapy: Current data and emerging concepts.

European journal of cancer (Oxford, England : 1990)
Avec: Jean-David Fumet , Caroline Truntzer , Mark Yarchoan , Francois Ghiringhelli

Sterically Controlled C-H Olefination of Heteroarenes.

Angewandte Chemie (International ed. in English)
Avec: Hao Chen , Mirxan Farizyan , Francesca Ghiringhelli , Manuel van Gemmeren

Immune Th17 lymphocytes play a critical role in the multiple beneficial properties of resveratrol.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
Avec: Dominique Delmas , Emeric Limagne , François Ghiringhelli , Virginie Aires

T-cell bispecific antibodies in node-positive breast cancer: novel therapeutic avenue for MHC class I loss variants.

Annals of oncology : official journal of the European Society for Medical Oncology
Avec: M Messaoudene , T P Mourikis , J Michels , Y Fu , M Bonvalet , M Lacroix-Trikki , B Routy , A Fluckiger , S Rusakiewicz , M P Roberti , S Cotteret , C Flament , V Poirier-Colame , N Jacquelot , F Ghiringhelli , A Caignard , A M M Eggermont , G Kroemer , A Marabelle , M Arnedos , C Vicier , S Dogan , F Jaulin , S-J Sammut , W Cope , C Caldas , S Delaloge , N McGranahan , F André , L Zitvogel

Optimized fractionated radiotherapy with anti-PD-L1 and anti-TIGIT: a promising new combination.

Journal for immunotherapy of cancer
Avec: Mathieu Grapin , Corentin Richard , Emeric Limagne , Romain Boidot , Véronique Morgand , Aurélie Bertaut , Valentin Derangere , Pierre-Antoine Laurent , Marion Thibaudin , Jean David Fumet , Gilles Crehange , François Ghiringhelli , Céline Mirjolet

Safety and efficacy of a docetaxel-5FU-oxaliplatin regimen with or without trastuzumab in neoadjuvant treatment of localized gastric or gastroesophageal junction cancer: A retrospective study.

World journal of gastrointestinal oncology
Avec: Valeria Basso , David Orry , Jean Fraisse , Julie Vincent , Audrey Hennequin , Leila Bengrine , Francois Ghiringhelli

Hepatic arterial chemotherapy with raltitrexed and oxaliplatin versus standard chemotherapy in unresectable liver metastases from colorectal cancer after conventional chemotherapy failure (HEARTO): a randomized phase-II study.

Journal of cancer research and clinical oncology
Avec: Francois Ghiringhelli , Julie Vincent , Leila Bengrine , Christophe Borg , Jean Louis Jouve , Romaric Loffroy , Boris Guiu , Julie Blanc , Aurélie Bertaut

Therapeutic drug monitoring as a tool to optimize 5-FU-based chemotherapy in gastrointestinal cancer patients older than 75 years.

European journal of cancer (Oxford, England : 1990)
Avec: Pauline Macaire , Katarzyna Morawska , Julie Vincent , Valérie Quipourt , Sophie Marilier , François Ghiringhelli , Leila Bengrine-Lefevre , Antonin Schmitt

Deciphering the Roles of Innate Lymphoid Cells in Cancer.

Frontiers in immunology
Avec: Melanie Bruchard , Francois Ghiringhelli

Cancer cells induce immune escape via glycocalyx changes controlled by the telomeric protein TRF2.

The EMBO journal
Avec: Julien Cherfils-Vicini , Charlene Iltis , Ludovic Cervera , Sabrina Pisano , Olivier Croce , Nori Sadouni , Balázs Győrffy , Romy Collet , Valérie M Renault , Martin Rey-Millet , Carlo Leonetti , Pasquale Zizza , Fabrice Allain , Francois Ghiringhelli , Nicolas Soubeiran , Marina Shkreli , Eric Vivier , Annamaria Biroccio , Eric Gilson

Partial splenic embolization with Glubran

Quantitative imaging in medicine and surgery
Avec: Romaric Loffroy , Nicolas Falvo , Motoki Nakaï , Lorenzo Pescatori , Serge Aho-Gléglé , Sophie Gehin , Pierre-Emmanuel Berthod , Romaric Né , Julie Vincent , François Ghiringhelli , Marco Midulla , Olivier Chevallier

Anti-MEK and Anti-EGFR mAbs in RAS-Mutant Metastatic Colorectal Cancer: Case Series and Rationale.

Advances in therapy
Avec: Fanny Ledys , Valentin Derangère , Manon Réda , Jean-Florian Guion , Romily Milliex , Valérie Roux , Emeric Limagne , Laurent Arnould , Leila Bengrine , François Ghiringhelli , Cédric Rébé

A Randomized Phase II Trial (TAMIGA) Evaluating the Efficacy and Safety of Continuous Bevacizumab Through Multiple Lines of Treatment for Recurrent Glioblastoma.

The oncologist
Avec: Alba A Brandes , Miguel Gil-Gil , Frank Saran , Antoine F Carpentier , Anna K Nowak , Warren Mason , Vittorina Zagonel , François Dubois , Gaetano Finocchiaro , George Fountzilas , Dana Michaela Cernea , Oliver Chinot , Rodica Anghel , Francois Ghiringhelli , Patrick Beauchesne , Giuseppe Lombardi , Enrico Franceschi , Martina Makrutzki , Chiedzo Mpofu , Hans-Joerg Urban , Josef Pichler

Artificial intelligence-guided tissue analysis combined with immune infiltrate assessment predicts stage III colon cancer outcomes in PETACC08 study.

Gut
Avec: Cynthia Reichling , Julien Taieb , Valentin Derangere , Quentin Klopfenstein , Karine Le Malicot , Jean-Marc Gornet , Hakim Becheur , Francis Fein , Oana Cojocarasu , Marie Christine Kaminsky , Jean Paul Lagasse , Dominique Luet , Suzanne Nguyen , Pierre-Luc Etienne , Mohamed Gasmi , Andre Vanoli , Hervé Perrier , Pierre-Laurent Puig , Jean-François Emile , Come Lepage , François Ghiringhelli

Targeting BRAF and RAS in Colorectal Cancer.

Cancers
Avec: Helene Bellio , Jean David Fumet , Francois Ghiringhelli

Modified FOLFIRINOX Versus CISGEM Chemotherapy for Patients With Advanced Biliary Tract Cancer (PRODIGE 38 AMEBICA): A Randomized Phase II Study.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology
Avec: Jean Marc Phelip , Jérôme Desrame , Julien Edeline , Emilie Barbier , Eric Terrebonne , Pierre Michel , Hervé Perrier , Laetitia Dahan , Vincent Bourgeois , Faiza Khemissa Akouz , Emilie Soularue , Valérie Lebrun Ly , Yann Molin , Thierry Lecomte , François Ghiringhelli , Romain Coriat , Samy Louafi , Cindy Neuzillet , Sylvain Manfredi , David Malka , Auteur inconnu

A Natural Polyphenol Exerts Antitumor Activity and Circumvents Anti-PD-1 Resistance through Effects on the Gut Microbiota.

Cancer discovery
Avec: Meriem Messaoudene , Reilly Pidgeon , Corentin Richard , Mayra Ponce , Khoudia Diop , Myriam Benlaifaoui , Alexis Nolin-Lapalme , Florent Cauchois , Julie Malo , Wiam Belkaid , Stephane Isnard , Yves Fradet , Lharbi Dridi , Dominique Velin , Paul Oster , Didier Raoult , François Ghiringhelli , Romain Boidot , Sandy Chevrier , David T Kysela , Yves V Brun , Emilia Liana Falcone , Geneviève Pilon , Florian Plaza Oñate , Oscar Gitton-Quent , Emmanuelle Le Chatelier , Sylvere Durand , Guido Kroemer , Arielle Elkrief , André Marette , Bastien Castagner , Bertrand Routy

Phase I Dose-Escalation Trial of an Innovative Chemotherapy Regimen Combining a Fractionated Dose of Irinotecan Plus Bevacizumab, Oxaliplatin, 5-Fluorouracil, and Folinic Acid (bFOLFIRINOX-3) in Chemorefractory Metastatic Colorectal Cancer.

Cancers
Avec: Hélène Bellio , Aurélie Bertaut , Alice Hervieu , Sylvie Zanetta , Audrey Hennequin , Julie Vincent , Rémi Palmier , Leila Bengrine-Lefevre , François Ghiringhelli , Jean-David Fumet

Seroprevalence of SARS-CoV-2 among the staff and patients of a French cancer centre after first lockdown: The canSEROcov study.

European journal of cancer (Oxford, England : 1990)
Avec: Sylvain Ladoire , Vincent Goussot , Emilie Redersdorff , Adele Cueff , Elise Ballot , Caroline Truntzer , Siavoshe Ayati , Leila Bengrine-Lefevre , Nathalie Bremaud , Bruno Coudert , Isabelle Desmoulins , Laure Favier , Cléa Fraisse , Jean-David Fumet , Roxana Hanu , Audrey Hennequin , Alice Hervieu , Silvia Ilie , Courèche Kaderbhai , Aurélie Lagrange , Nils Martin , Irina Mazilu , Didier Mayeur , Rémi Palmier , Anne-Laure Simonet-Lamm , Julie Vincent , Sylvie Zanetta , Laurent Arnould , Charles Coutant , Aurélie Bertaut , François Ghiringhelli

Pooled analysis of 115 patients from updated data of Epitopes-HPV01 and Epitopes-HPV02 studies in first-line advanced anal squamous cell carcinoma.

Therapeutic advances in medical oncology
Avec: Stefano Kim , Aurélia Meurisse , Laurie Spehner , Morgane Stouvenot , Eric François , Bruno Buecher , Thierry André , Emmanuelle Samalin , Marine Jary , Thierry Nguyen , Farid El Hajbi , Nabil Baba-Hamed , Simon Pernot , Marie-Christine Kaminsky , Olivier Bouché , Jerome Desrame , Mustapha Zoubir , François Ghiringhelli , Aurélie Parzy , Christelle de la Fouchardiere , Fatiha Boulbair , Zaher Lakkis , Elodie Klajer , Marion Jacquin , Julien Taieb , Véronique Vendrely , Dewi Vernerey , Christophe Borg

Immunological features of coronavirus disease 2019 in patients with cancer.

European journal of cancer (Oxford, England : 1990)
Avec: Marion Thibaudin , Jean-David Fumet , Marjorie Bon , Léa Hampe , Emeric Limagne , Francois Ghiringhelli

Immunogenic Cell Death and Elimination of Immunosuppressive Cells: A Double-Edged Sword of Chemotherapy.

Cancers
Avec: Jean-David Fumet , Emeric Limagne , Marion Thibaudin , Francois Ghiringhelli

Targeting PD-L1 and TIGIT could restore intratumoral CD8 T cell function in human colorectal cancer.

Cancer immunology, immunotherapy : CII
Avec: Marion Thibaudin , Emeric Limagne , Léa Hampe , Elise Ballot , Caroline Truntzer , Francois Ghiringhelli

Mitophagy: a new actor in the efficacy of chemo-immunotherapy.

Autophagy
Avec: Emeric Limagne , François Ghiringhelli

Hematopoietic Prostaglandin D2 Synthase Controls Tfh/Th2 Communication and Limits Tfh Antitumor Effects.

Cancer immunology research
Avec: Romain Mary , Fanny Chalmin , Théo Accogli , Mélanie Bruchard , Christophe Hibos , Joséphine Melin , Caroline Truntzer , Emeric Limagne , Valentin Derangère , Marion Thibaudin , Etienne Humblin , Romain Boidot , Sandy Chevrier , Laurent Arnould , Corentin Richard , Quentin Klopfenstein , Antoine Bernard , Yoshihiro Urade , James A Harker , Lionel Apetoh , François Ghiringhelli , Frédérique Végran

Venous thrombotic events in patients treated with immune checkpoint inhibitors for non-small cell lung cancer: A retrospective multicentric cohort study.

Thrombosis research
Avec: Xavier Deschênes-Simard , Corentin Richard , Loïck Galland , Florence Blais , Antoine Desilets , Julie Malo , Lena Cvetkovic , Wiam Belkaid , Arielle Elkrief , Andréanne Gagné , Marc-André Hamel , Michèle Orain , Philippe Joubert , François Ghiringhelli , Bertrand Routy , Normand Blais

Downregulation of Elovl5 promotes breast cancer metastasis through a lipid-droplet accumulation-mediated induction of TGF-β receptors.

Cell death & disease
Avec: Trinh-Le-Vi Kieu , Léa Pierre , Valentin Derangère , Sabrina Perrey , Caroline Truntzer , Antoine Jalil , Sébastien Causse , Emma Groetz , Adélie Dumont , Laura Guyard , Laurent Arnould , Jean-Paul Pais de Barros , Lionel Apetoh , Cédric Rébé , Emeric Limagne , Tony Jourdan , Laurent Demizieux , David Masson , Charles Thomas , François Ghiringhelli , Mickaël Rialland

A Phase II Study Evaluating the Interest to Combine UCPVax, a Telomerase CD4 T

Frontiers in oncology
Avec: Magali Rebucci-Peixoto , Angélique Vienot , Olivier Adotevi , Marion Jacquin , Francois Ghiringhelli , Christelle de la Fouchardière , Benoit You , Tristan Maurina , Elsa Kalbacher , Fernando Bazan , Guillaume Meynard , Anne-Laure Clairet , Christine Fagnoni-Legat , Laurie Spehner , Adeline Bouard , Dewi Vernerey , Aurélia Meurisse , Stefano Kim , Christophe Borg , Laura Mansi

Using immunogenic cell death to improve anticancer efficacy of immune checkpoint inhibitors: From basic science to clinical application.

Immunological reviews
Avec: François Ghiringhelli , Cédric Rébé

Protocol for simultaneous analysis of peripheral and intratumoral lymphocyte function by flow cytometry.

STAR protocols
Avec: Susy Daumoine , Léa Hampe , Emeric Limagne , François Ghiringhelli , Marion Thibaudin

Exome-Based Genomic Markers Could Improve Prediction of Checkpoint Inhibitor Efficacy Independently of Tumor Type.

International journal of molecular sciences
Avec: Lorraine Dalens , Julie Lecuelle , Laure Favier , Cléa Fraisse , Aurélie Lagrange , Courèche Kaderbhai , Romain Boidot , Sandy Chevrier , Hugo Mananet , Valentin Derangère , Caroline Truntzer , François Ghiringhelli

FOLFIRI-bevacizumab as a second-line treatment for advanced biliary tract cancer after gemcitabine-based chemotherapy.

Frontiers in oncology
Avec: Nicolas Roussot , Julie Vincent , Remi Palmier , Guillaume Constantin , Leila Bengrine , Jean-David Fumet , François Ghiringhelli

Inflammasome-independent NLRP3 function enforces ATM activity in response to genotoxic stress.

Life science alliance
Avec: Mélanie Bodnar-Wachtel , Anne-Laure Huber , Julie Gorry , Sabine Hacot , Delphine Burlet , Laetitia Gérossier , Baptiste Guey , Nadège Goutagny , Birke Bartosch , Elise Ballot , Julie Lecuelle , Caroline Truntzer , François Ghiringhelli , Bénédicte F Py , Yohann Couté , Annabelle Ballesta , Sylvie Lantuejoul , Janet Hall , Agnès Tissier , Virginie Petrilli

Predictive Factors of Local Recurrence after Colorectal Cancer Liver Metastases Thermal Ablation.

Journal of imaging
Avec: Julien Odet , Julie Pellegrinelli , Olivier Varbedian , Caroline Truntzer , Marco Midulla , François Ghiringhelli , David Orry

Clinical Utility of Genomic Tests Evaluating Homologous Recombination Repair Deficiency (HRD) for Treatment Decisions in Early and Metastatic Breast Cancer.

Cancers
Avec: Loïck Galland , Nicolas Roussot , Isabelle Desmoulins , Didier Mayeur , Courèche Kaderbhai , Silvia Ilie , Audrey Hennequin , Manon Reda , Juliette Albuisson , Laurent Arnould , Romain Boidot , Caroline Truntzer , François Ghiringhelli , Sylvain Ladoire

Simultaneous isolation of CD45 tumor-infiltrating lymphocytes, tumor cells, and associated fibroblasts from murine breast tumor model by MACS.

STAR protocols
Avec: Laura Kalfeist , Stacy Petit , Loïck Galland , François Ghiringhelli , Sylvain Ladoire , Emeric Limagne

Integrative Clinical and DNA Methylation Analyses in a Population-Based Cohort Identifies

Cancers
Avec: Benjamin Tournier , Romain Aucagne , Caroline Truntzer , Cyril Fournier , François Ghiringhelli , Caroline Chapusot , Laurent Martin , Anne Marie Bouvier , Sylvain Manfredi , Valérie Jooste , Mary B Callanan , Côme Lepage

Further knowledge and developments in resistance mechanisms to immune checkpoint inhibitors.

Frontiers in immunology
Avec: Léa Berland , Zeina Gabr , Michelle Chang , Marius Ilié , Véronique Hofman , Guylène Rignol , François Ghiringhelli , Baharia Mograbi , Mohamad Rashidian , Paul Hofman

AMG 193, a Clinical Stage MTA-Cooperative PRMT5 Inhibitor, Drives Antitumor Activity Preclinically and in Patients With MTAP-Deleted Cancers.

Cancer discovery
Avec: Brian Belmontes , Katherine K Slemmons , Chun Su , Siyuan Liu , Antonia N Policheni , Jodi Moriguchi , Hong Tan , Fang Xie , Daniel Andrew Aiello , Yajing Yang , Raul Lazaro , Famke Aeffner , Matthew G Rees , Melissa M Ronan , Jennifer A Roth , Mikkel Vestergaard , Sanne Cowland , Jan Andersson , Ian Sarvary , Qing Chen , Pooja Sharma , Patricia Lopez , Nuria Tamayo , Liping H Pettus , Sudipa Ghimire-Rijal , Susmith Mukund , Jennifer R Allen , Jason DeVoss , Angela Coxon , Jordi Rodon , Francois Ghiringhelli , Nicolas Penel , Hans Prenen , Sanne Glad , Chen-Hua Chuang , Kiana Keyvanjah , Danielle M Townsley , John R Butler , Matthew P Bourbeau , Sean Caenepeel , Paul E Hughes

Clinical Interest in Exome-Based Analysis of Somatic Mutational Signatures for Non-Small Cell Lung Cancer.

Cancers
Avec: Morgane Peroz , Hugo Mananet , Nicolas Roussot , Courèche Guillaume Kaderbhai , Valentin Derangère , Caroline Truntzer , François Ghiringhelli

Case report: Immune response characterization of a pseudoprogression in a PD-L1-negative, TMB-low,

Frontiers in immunology
Avec: Nicolas Roussot , Marion Thibaudin , Jean-David Fumet , Susy Daumoine , Léa Hampe , Cédric Rébé , Emeric Limagne , Aurélie Lagrange , Victor Herreros , Julie Lecuelle , Hugo Mananet , Alis Ilie , David Rageot , Romain Boidot , Vincent Goussot , Anthony Comte , Pierre Jacob , Françoise Beltjens , Anthony Bergeron , Céline Charon-Barra , Laurent Arnould , Valentin Derangère , Sylvain Ladoire , Caroline Truntzer , François Ghiringhelli

Survival Outcomes Associated With First-Line Procarbazine, CCNU, and Vincristine or Temozolomide in Combination With Radiotherapy in IDH-Mutant 1p/19q-Codeleted Grade 3 Oligodendroglioma.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology
Avec: Salah Eddine O Kacimi , Caroline Dehais , Loïc Feuvret , Olivier Chinot , Catherine Carpentier , Charlotte Bronnimann , Elodie Vauleon , Apolline Djelad , Elizabeth Cohen-Jonathan Moyal , Olivier Langlois , Mario Campone , Mathilde Ducloie , Georges Noel , Stefania Cuzzubbo , Luc Taillandier , Carole Ramirez , Nadia Younan , Philippe Menei , Frédéric Dhermain , Christine Desenclos , François Ghiringhelli , Veronique Bourg , Damien Ricard , Thierry Faillot , Romain Appay , Emeline Tabouret , Lucia Nichelli , Bertrand Mathon , Alice Thomas , Suzanne Tran , Franck Bielle , Agusti Alentorn , J Bryan Iorgulescu , Pierre-Yves Boëlle , Karim Labreche , Khê Hoang-Xuan , Marc Sanson , Ahmed Idbaih , Dominique Figarella-Branger , François Ducray , Mehdi Touat , Auteur inconnu

Precision medicine phase II study evaluating the efficacy of a double immunotherapy by durvalumab and tremelimumab combined with olaparib in patients with solid cancers and carriers of homologous recombination repair genes mutation in response or stable after olaparib treatment.

BMC cancer
Avec: Jean-David Fumet , Emeric Limagne , Marion Thibaudin , Caroline Truntzer , Aurélie Bertaut , Emilie Rederstorff , Francois Ghiringhelli

Predictive factors for early progression during induction chemotherapy and chemotherapy-free interval: analysis from PRODIGE 9 trial.

British journal of cancer
Avec: Thomas Aparicio , Jaafar Bennouna , Karine Le Malicot , Valérie Boige , Julien Taieb , Olivier Bouché , Jean-Marc Phelip , Eric François , Christian Borel , Roger Faroux , Laetitia Dahan , Jean-Baptiste Bachet , Joelle Egreteau , Marie-Christine Kaminsky , Jean-Marc Gornet , Oana Cojocarasu , Mohamed Gasmi , Véronique Guerin-Meyer , Côme Lepage , François Ghiringhelli , Auteur inconnu

Baseline Splenic Volume as a Prognostic Biomarker of FOLFIRI Efficacy and a Surrogate Marker of MDSC Accumulation in Metastatic Colorectal Carcinoma.

Cancers
Avec: Julie Niogret , Emeric Limagne , Marion Thibaudin , Julie Blanc , Aurelie Bertaut , Karine Le Malicot , Yves Rinaldi , François-Xavier Caroli-Bosc , Franck Audemar , Suzanne Nguyen , Corinne Sarda , Catherine Lombard-Bohas , Christophe Locher , Miguel Carreiro , Jean-Louis Legoux , Pierre-Luc Etienne , Mathieu Baconnier , Marc Porneuf , Thomas Aparicio , Francois Ghiringhelli

Direct β- and γ-C(sp

Angewandte Chemie (International ed. in English)
Avec: Francesca Ghiringhelli , Alexander Uttry , Kiron Kumar Ghosh , Manuel van Gemmeren

Trifluridine/Tipiracil plus Oxaliplatin Improves PD-1 Blockade in Colorectal Cancer by Inducing Immunogenic Cell Death and Depleting Macrophages.

Cancer immunology research
Avec: Emeric Limagne , Marion Thibaudin , Lisa Nuttin , Aodrenn Spill , Valentin Derangère , Jean-David Fumet , Nadia Amellal , Elisa Peranzoni , Valérie Cattan , François Ghiringhelli

Hypotonic stress enhances colon cancer cell death induced by platinum derivatives and immunologically improves antitumor efficacy of intraperitoneal chemotherapy.

International journal of cancer
Avec: Lucie Demontoux , Valentin Derangère , Thomas Pilot , Chloé Thinselin , Angélique Chevriaux , Fanny Chalmin , Florence Bouyer , François Ghiringhelli , Cédric Rébé

Réseau de co-auteurs

François Ghiringhelli 57 collaborations
Caroline Truntzer 21 collaborations
Emeric Limagne 17 collaborations
Romain Boidot 13 collaborations
Valentin Derangère 13 collaborations
Marion Thibaudin 12 collaborations
Jean-David Fumet 11 collaborations
Christophe Borg 10 collaborations
Cédric Rébé 9 collaborations
Bertrand Routy 8 collaborations
Laurent Arnould 8 collaborations
Julie Vincent 8 collaborations
Elise Ballot 7 collaborations
Corentin Richard 7 collaborations
Sylvain Ladoire 7 collaborations
Aurélie Bertaut 7 collaborations
Christelle de la Fouchardière 6 collaborations
Laure Favier 6 collaborations
Aurélie Lagrange 6 collaborations
Julien Taieb 6 collaborations
Eric François 5 collaborations
Olivier Bouché 5 collaborations
Thomas Aparicio 5 collaborations
None None 5 collaborations
Sandy Chevrier 5 collaborations
Julie Lecuelle 5 collaborations
Léa Hampe 5 collaborations
Nicolas Roussot 5 collaborations
Guido Kroemer 4 collaborations
David Malka 4 collaborations
Jaafar Bennouna 4 collaborations
Quentin Klopfenstein 4 collaborations
Valentin Derangere 4 collaborations
F Ghiringhelli 4 collaborations
Julie Blanc 4 collaborations
Loïck Galland 4 collaborations
Cléa Fraisse 4 collaborations
Stefano Kim 4 collaborations
Dewi Vernerey 4 collaborations
Hugo Mananet 4 collaborations
Audrey Hennequin 4 collaborations
Leila Bengrine 4 collaborations
Lisa Derosa 3 collaborations
Laurence Zitvogel 3 collaborations
Emmanuelle Samalin 3 collaborations
Laetitia Dahan 3 collaborations
Hervé Perrier 3 collaborations
Romain Coriat 3 collaborations
Fanny Ledys 3 collaborations
Philippe Joubert 3 collaborations
Francesca Ghiringhelli 3 collaborations
Manuel van Gemmeren 3 collaborations
Thomas Pilot 3 collaborations
David Tougeron 3 collaborations
Alis Ilie 3 collaborations
David Rageot 3 collaborations
Véronique Vendrely 3 collaborations
Farid El Hajbi 3 collaborations
Magali Rebucci-Peixoto 3 collaborations
Susy Daumoine 3 collaborations
Angélique Vienot 3 collaborations
Fanny Chalmin 3 collaborations
Marion Jacquin 3 collaborations
Laurie Spehner 3 collaborations
Leila Bengrine-Lefevre 3 collaborations
Karine Le Malicot 3 collaborations
Courèche Kaderbhai 3 collaborations
Fabrice André 2 collaborations
Laurence Albiges 2 collaborations
Jean-Yves Scoazec 2 collaborations
Florence Castan 2 collaborations
Jean-Baptiste Bachet 2 collaborations
Jean-François Emile 2 collaborations
Come Lepage 2 collaborations
Emilie Barbier 2 collaborations
Thierry Lecomte 2 collaborations
Denis Smith 2 collaborations
Jean-Louis Legoux 2 collaborations
Rosine Guimbaud 2 collaborations
Catherine Lombard-Bohas 2 collaborations
Andréanne Gagné 2 collaborations
Marc-André Hamel 2 collaborations
Bruno Coudert 2 collaborations
Pierre Saintigny 2 collaborations
Sandra Ortiz-Cuaran 2 collaborations
Pascal Foucher 2 collaborations
Paul Hofman 2 collaborations
Lucie Demontoux 2 collaborations
Valerio Iebba 2 collaborations
Romain Daillère 2 collaborations
Pierre Ly 2 collaborations
Didier Raoult 2 collaborations
Aurelie Bertaut 2 collaborations
Simon Pernot 2 collaborations
Frederic Bibeau 2 collaborations
Laura Kalfeist 2 collaborations
Julie Niogret 2 collaborations
Lisa Nuttin 2 collaborations
Anthony Bergeron 2 collaborations
Charlotte Bronnimann 2 collaborations
Elodie Vauleon 2 collaborations
Courèche Guillaume Kaderbhai 2 collaborations
Meriem Messaoudene 2 collaborations
Sylvie Lantuejoul 2 collaborations
Florence Bouyer 2 collaborations
Laëtitia Dahan 2 collaborations
Benoist Chibaudel 2 collaborations
Juliette Albuisson 2 collaborations
Romain Cohen 2 collaborations
Christophe Locher 2 collaborations
Marjorie Bon 2 collaborations
Morgane Peroz 2 collaborations
Olivier Adotevi 2 collaborations
Lorraine Dalens 2 collaborations
Angélique Chevriaux 2 collaborations
Bruno Buecher 2 collaborations
Thierry André 2 collaborations
Marine Jary 2 collaborations
Aurélie Parzy 2 collaborations
Nabil Baba-Hamed 2 collaborations
Jean David Fumet 2 collaborations
David Orry 2 collaborations
Romaric Loffroy 2 collaborations
Marco Midulla 2 collaborations
Jean-Marc Gornet 2 collaborations
Oana Cojocarasu 2 collaborations
Suzanne Nguyen 2 collaborations
Pierre-Luc Etienne 2 collaborations
Mohamed Gasmi 2 collaborations
Sylvain Manfredi 2 collaborations
Julie Malo 2 collaborations
Wiam Belkaid 2 collaborations
Arielle Elkrief 2 collaborations
Alice Hervieu 2 collaborations
Sylvie Zanetta 2 collaborations
Rémi Palmier 2 collaborations
Vincent Goussot 2 collaborations
Isabelle Desmoulins 2 collaborations
Silvia Ilie 2 collaborations
Didier Mayeur 2 collaborations
Aurélia Meurisse 2 collaborations
Marie-Christine Kaminsky 2 collaborations
Lionel Apetoh 2 collaborations
Côme Lepage 2 collaborations
Agathe Dubuisson 1 collaboration
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Marie Wislez 1 collaboration
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Anne Cayre 1 collaboration
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Rinse K Weersma 1 collaboration
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Ana Finzel 1 collaboration
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Liping Zhao 1 collaboration
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C Liu 1 collaboration
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T Eggert 1 collaboration
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Y Fu 1 collaboration
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B Routy 1 collaboration
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S Cotteret 1 collaboration
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N Jacquelot 1 collaboration
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A Marabelle 1 collaboration
M Arnedos 1 collaboration
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S Delaloge 1 collaboration
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Francis Fein 1 collaboration
Marie Christine Kaminsky 1 collaboration
Jean Paul Lagasse 1 collaboration
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Helene Bellio 1 collaboration
Jean Marc Phelip 1 collaboration
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Julien Edeline 1 collaboration
Eric Terrebonne 1 collaboration
Pierre Michel 1 collaboration
Vincent Bourgeois 1 collaboration
Faiza Khemissa Akouz 1 collaboration
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Valérie Lebrun Ly 1 collaboration
Yann Molin 1 collaboration
Samy Louafi 1 collaboration
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Khoudia Diop 1 collaboration
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