Frédéric Martinon

Affiliations

Université Paris-Saclay, Inserm, CEA, Center for Immunology of Viral, Auto-Immune, Hematological and Bacterial Diseases (IMVA-HB/IDMIT), Fontenay-aux-Roses, France.

Publications (23)

Cell-autonomous inflammation of BRCA1-deficient ovarian cancers drives both tumor-intrinsic immunoreactivity and immune resistance via STING.

Cell reports

Avec: Marine Bruand , David Barras , Marco Mina , Eleonora Ghisoni , Matteo Morotti , Evripidis Lanitis , Noémie Fahr , Mathieu Desbuisson , Alizée Grimm , Hualing Zhang , Chloe Chong , Julien Dagher , Sora Chee , Theodora Tsianou , Julien Dorier , Brian J Stevenson , Christian Iseli , Catherine Ronet , Sara Bobisse , Raphael Genolet , Josephine Walton , Michal Bassani-Sternberg , Lana E Kandalaft , Bing Ren , Iain McNeish , Elizabeth Swisher , Alexandre Harari , Mauro Delorenzi , Giovanni Ciriello , Melita Irving , Sylvie Rusakiewicz , Periklis G Foukas , Fabio Martinon , Denarda Dangaj Laniti , George Coukos

The Route of Vaccine Administration Determines Whether Blood Neutrophils Undergo Long-Term Phenotypic Modifications.

Frontiers in immunology

Avec: Yanis Feraoun , Jean-Louis Palgen , Candie Joly , Nicolas Tchitchek , Ernesto Marcos-Lopez , Nathalie Dereuddre-Bosquet , Anne-Sophie Gallouet , Vanessa Contreras , Yves Lévy , Frédéric Martinon , Roger Le Grand , Anne-Sophie Beignon

Cynomolgus macaques as a translational model of human immune responses to yellow fever 17D vaccination.

Journal of virology

Avec: Nathalie Mantel , Fabienne Piras-Douce , Emilie Chautard , Ernesto Marcos-Lopez , Caroline L Bodinham , Antonio Cosma , Virginie Courtois , Nina Dhooge , Sylviane Gautheron , Stefan H E Kaufmann , Kathleen Pizzoferro , David J M Lewis , Frédéric Martinon , Anke Pagnon , Franck Raynal , Nathalie Dereuddre-Bosquet , Roger Le Grand

CDC42 regulates PYRIN inflammasome assembly.

Cell reports

Avec: Lotte Spel , Lea Zaffalon , Cyrielle Hou , Nicaise Nganko , Chloé Chapuis , Fabio Martinon

ER-trafficking triggers NRF1 ubiquitination to promote its proteolytic activation.

iScience

Avec: Claire Chavarria , Léa Zaffalon , Sérgio T Ribeiro , Mélanie Op , Manfredo Quadroni , Maria Sofia Iatrou , Chloé Chapuis , Fabio Martinon

ENaC-mediated sodium influx exacerbates NLRP3-dependent inflammation in cystic fibrosis.

eLife

Avec: Thomas Scambler , Heledd H Jarosz-Griffiths , Samuel Lara-Reyna , Shelly Pathak , Chi Wong , Jonathan Holbrook , Fabio Martinon , Sinisa Savic , Daniel Peckham , Michael F McDermott

NLRP3 leucine-rich repeats control induced and spontaneous inflammasome activation in cryopyrin-associated periodic syndrome.

The Journal of allergy and clinical immunology

Avec: Katerina Theodoropoulou , Lotte Spel , Léa Zaffalon , Maeva Delacrétaz , Michaël Hofer , Fabio Martinon

Non-human primate models of human respiratory infections.

Molecular immunology

Avec: Julien Lemaitre , Thibaut Naninck , Benoît Delache , Justina Creppy , Philippe Huber , Marion Holzapfel , Camille Bouillier , Vanessa Contreras , Frédéric Martinon , Nidhal Kahlaoui , Quentin Pascal , Sabine Tricot , Frédéric Ducancel , Laurent Vecellio , Roger Le Grand , Pauline Maisonnasse

Metabolic Reprograming of Cystic Fibrosis Macrophages via the IRE1α Arm of the Unfolded Protein Response Results in Exacerbated Inflammation.

Frontiers in immunology

Avec: Samuel Lara-Reyna , Thomas Scambler , Jonathan Holbrook , Chi Wong , Heledd H Jarosz-Griffiths , Fabio Martinon , Sinisa Savic , Daniel Peckham , Michael F McDermott

Tumor-induced reshuffling of lipid composition on the endoplasmic reticulum membrane sustains macrophage survival and pro-tumorigenic activity.

Nature immunology

Avec: Giusy Di Conza , Chin-Hsien Tsai , Hector Gallart-Ayala , Yi-Ru Yu , Fabien Franco , Lea Zaffalon , Xin Xie , Xiaoyun Li , Zhengtao Xiao , Lydia N Raines , Maryline Falquet , Antoine Jalil , Jason W Locasale , Piergiorgio Percipalle , David Masson , Stanley Ching-Cheng Huang , Fabio Martinon , Julijana Ivanisevic , Ping-Chih Ho

The integrin CD11b inhibits MSU-induced NLRP3 inflammasome activation in macrophages and protects mice against MSU-induced joint inflammation.

Arthritis research & therapy

Avec: Driss Ehirchiou , Ilaria Bernabei , Vishnuprabu Durairaj Pandian , Sonia Nasi , Veronique Chobaz , Mariela Castelblanco , Alexander So , Fabio Martinon , Xiaoyun Li , Hans Acha-Orbea , Thomas Hugle , Li Zhang , Nathalie Busso

Vaccine-associated enhanced disease in humans and animal models: Lessons and challenges for vaccine development.

Frontiers in microbiology

Avec: Julie Bigay , Roger Le Grand , Frédéric Martinon , Pauline Maisonnasse

NK cell immune responses differ after prime and boost vaccination.

Journal of leukocyte biology

Avec: Jean-Louis Palgen , Nicolas Tchitchek , Nicolas Huot , Jamila Elhmouzi-Younes , Cécile Lefebvre , Pierre Rosenbaum , Nathalie Dereuddre-Bosquet , Frédéric Martinon , Hakim Hocini , Antonio Cosma , Michaela Müller-Trutwin , Yves Lévy , Roger Le Grand , Anne-Sophie Beignon

Detection of viruses by inflammasomes.

Current opinion in virology

Avec: Lotte Spel , Fabio Martinon

The aspartyl protease DDI2 drives adaptation to proteasome inhibition in multiple myeloma.

Cell death & disease

Avec: Mélanie Op , Sérgio T Ribeiro , Claire Chavarria , Aude De Gassart , Léa Zaffalon , Fabio Martinon

The protease DDI2 regulates NRF1 activation in response to cadmium toxicity.

iScience

Avec: Sérgio T Ribeiro , Aude de Gassart , Sarah Bettigole , Lea Zaffalon , Claire Chavarria , Melanie Op , Kalvin Nugraha , Fabio Martinon

Innate Molecular and Cellular Signature in the Skin Preceding Long-Lasting T Cell Responses after Electroporated DNA Vaccination.

Journal of immunology (Baltimore, Md. : 1950)

Avec: Lucille Adam , Nicolas Tchitchek , Biliana Todorova , Pierre Rosenbaum , Candie Joly , Candice Poux , Catherine Chapon , Anna-Lena Spetz , Mart Ustav , Roger Le Grand , Frédéric Martinon

Innate and secondary humoral responses are improved by increasing the time between MVA vaccine immunizations.

NPJ vaccines

Avec: Jean-Louis Palgen , Nicolas Tchitchek , André Rodriguez-Pozo , Quentin Jouhault , Hadjer Abdelhouahab , Nathalie Dereuddre-Bosquet , Vanessa Contreras , Frédéric Martinon , Antonio Cosma , Yves Lévy , Roger Le Grand , Anne-Sophie Beignon

Inflammasomes contributing to inflammation in arthritis.

Immunological reviews

Avec: Lotte Spel , Fabio Martinon

Different CFTR modulator combinations downregulate inflammation differently in cystic fibrosis.

eLife

Avec: Heledd H Jarosz-Griffiths , Thomas Scambler , Chi H Wong , Samuel Lara-Reyna , Jonathan Holbrook , Fabio Martinon , Sinisa Savic , Paul Whitaker , Christine Etherington , Giulia Spoletini , Ian Clifton , Anil Mehta , Michael F McDermott , Daniel Peckham

Optimize Prime/Boost Vaccine Strategies: Trained Immunity as a New Player in the Game.

Frontiers in immunology

Avec: Jean-Louis Palgen , Yanis Feraoun , Gaëlle Dzangué-Tchoupou , Candie Joly , Frédéric Martinon , Roger Le Grand , Anne-Sophie Beignon

Vaccine Inoculation Route Modulates Early Immunity and Consequently Antigen-Specific Immune Response.

Frontiers in immunology

Avec: Pierre Rosenbaum , Nicolas Tchitchek , Candie Joly , André Rodriguez Pozo , Lev Stimmer , Sébastien Langlois , Hakim Hocini , Leslie Gosse , David Pejoski , Antonio Cosma , Anne-Sophie Beignon , Nathalie Dereuddre-Bosquet , Yves Levy , Roger Le Grand , Frédéric Martinon

HSP90β controls NLRP3 autoactivation.

Science advances

Avec: Lotte Spel , Cyrielle Hou , Katerina Theodoropoulou , Léa Zaffalon , Zhuo Wang , Arinna Bertoni , Stefano Volpi , Michaël Hofer , Marco Gattorno , Fabio Martinon

Réseau de co-auteurs

Fabio Martinon 14 collaborations

Roger Le Grand 9 collaborations

Nicolas Tchitchek 5 collaborations

Nathalie Dereuddre-Bosquet 5 collaborations

Anne-Sophie Beignon 5 collaborations

Lotte Spel 5 collaborations

Jean-Louis Palgen 4 collaborations

Candie Joly 4 collaborations

Antonio Cosma 4 collaborations

Léa Zaffalon 4 collaborations

Vanessa Contreras 3 collaborations

Yves Lévy 3 collaborations

Lea Zaffalon 3 collaborations

Claire Chavarria 3 collaborations

Sérgio T Ribeiro 3 collaborations

Thomas Scambler 3 collaborations

Heledd H Jarosz-Griffiths 3 collaborations

Samuel Lara-Reyna 3 collaborations

Jonathan Holbrook 3 collaborations

Sinisa Savic 3 collaborations

Daniel Peckham 3 collaborations

Michael F McDermott 3 collaborations

Pierre Rosenbaum 3 collaborations

Yanis Feraoun 2 collaborations

Ernesto Marcos-Lopez 2 collaborations

Cyrielle Hou 2 collaborations

Chloé Chapuis 2 collaborations

Mélanie Op 2 collaborations

Chi Wong 2 collaborations

Katerina Theodoropoulou 2 collaborations

Michaël Hofer 2 collaborations

Pauline Maisonnasse 2 collaborations

Xiaoyun Li 2 collaborations

Hakim Hocini 2 collaborations

Marine Bruand 1 collaboration

David Barras 1 collaboration

Marco Mina 1 collaboration

Eleonora Ghisoni 1 collaboration

Matteo Morotti 1 collaboration

Evripidis Lanitis 1 collaboration

Noémie Fahr 1 collaboration

Mathieu Desbuisson 1 collaboration

Alizée Grimm 1 collaboration

Hualing Zhang 1 collaboration

Chloe Chong 1 collaboration

Julien Dagher 1 collaboration

Sora Chee 1 collaboration

Theodora Tsianou 1 collaboration

Julien Dorier 1 collaboration

Brian J Stevenson 1 collaboration

Christian Iseli 1 collaboration

Catherine Ronet 1 collaboration

Sara Bobisse 1 collaboration

Raphael Genolet 1 collaboration

Josephine Walton 1 collaboration

Michal Bassani-Sternberg 1 collaboration

Lana E Kandalaft 1 collaboration

Bing Ren 1 collaboration

Iain McNeish 1 collaboration

Elizabeth Swisher 1 collaboration

Alexandre Harari 1 collaboration

Mauro Delorenzi 1 collaboration

Giovanni Ciriello 1 collaboration

Melita Irving 1 collaboration

Sylvie Rusakiewicz 1 collaboration

Periklis G Foukas 1 collaboration

Denarda Dangaj Laniti 1 collaboration

George Coukos 1 collaboration

Anne-Sophie Gallouet 1 collaboration

Nathalie Mantel 1 collaboration

Fabienne Piras-Douce 1 collaboration

Emilie Chautard 1 collaboration

Caroline L Bodinham 1 collaboration

Virginie Courtois 1 collaboration

Nina Dhooge 1 collaboration

Sylviane Gautheron 1 collaboration

Stefan H E Kaufmann 1 collaboration

Kathleen Pizzoferro 1 collaboration

David J M Lewis 1 collaboration

Anke Pagnon 1 collaboration

Franck Raynal 1 collaboration

Nicaise Nganko 1 collaboration

Manfredo Quadroni 1 collaboration

Maria Sofia Iatrou 1 collaboration

Shelly Pathak 1 collaboration

Maeva Delacrétaz 1 collaboration

Julien Lemaitre 1 collaboration

Thibaut Naninck 1 collaboration

Benoît Delache 1 collaboration

Justina Creppy 1 collaboration

Philippe Huber 1 collaboration

Marion Holzapfel 1 collaboration

Camille Bouillier 1 collaboration

Nidhal Kahlaoui 1 collaboration

Quentin Pascal 1 collaboration

Sabine Tricot 1 collaboration

Frédéric Ducancel 1 collaboration

Laurent Vecellio 1 collaboration

Giusy Di Conza 1 collaboration

Chin-Hsien Tsai 1 collaboration

Hector Gallart-Ayala 1 collaboration

Yi-Ru Yu 1 collaboration

Fabien Franco 1 collaboration

Xin Xie 1 collaboration

Zhengtao Xiao 1 collaboration

Lydia N Raines 1 collaboration

Maryline Falquet 1 collaboration

Antoine Jalil 1 collaboration

Jason W Locasale 1 collaboration

Piergiorgio Percipalle 1 collaboration

David Masson 1 collaboration

Stanley Ching-Cheng Huang 1 collaboration

Julijana Ivanisevic 1 collaboration

Ping-Chih Ho 1 collaboration

Driss Ehirchiou 1 collaboration

Ilaria Bernabei 1 collaboration

Vishnuprabu Durairaj Pandian 1 collaboration

Sonia Nasi 1 collaboration

Veronique Chobaz 1 collaboration

Mariela Castelblanco 1 collaboration

Alexander So 1 collaboration

Hans Acha-Orbea 1 collaboration

Thomas Hugle 1 collaboration

Li Zhang 1 collaboration

Nathalie Busso 1 collaboration

Julie Bigay 1 collaboration

Nicolas Huot 1 collaboration

Jamila Elhmouzi-Younes 1 collaboration

Cécile Lefebvre 1 collaboration

Michaela Müller-Trutwin 1 collaboration

Aude De Gassart 1 collaboration

Aude de Gassart 1 collaboration

Sarah Bettigole 1 collaboration

Melanie Op 1 collaboration

Kalvin Nugraha 1 collaboration

Lucille Adam 1 collaboration

Biliana Todorova 1 collaboration

Candice Poux 1 collaboration

Catherine Chapon 1 collaboration

Anna-Lena Spetz 1 collaboration

Mart Ustav 1 collaboration

André Rodriguez-Pozo 1 collaboration

Quentin Jouhault 1 collaboration

Hadjer Abdelhouahab 1 collaboration

Chi H Wong 1 collaboration

Paul Whitaker 1 collaboration

Christine Etherington 1 collaboration

Giulia Spoletini 1 collaboration

Ian Clifton 1 collaboration

Anil Mehta 1 collaboration

Gaëlle Dzangué-Tchoupou 1 collaboration

André Rodriguez Pozo 1 collaboration

Lev Stimmer 1 collaboration

Sébastien Langlois 1 collaboration

Leslie Gosse 1 collaboration

David Pejoski 1 collaboration

Yves Levy 1 collaboration

Zhuo Wang 1 collaboration

Arinna Bertoni 1 collaboration

Stefano Volpi 1 collaboration

Marco Gattorno 1 collaboration